Trimethylamine N-Oxide increases soluble fms-like tyrosine Kinase-1 in human placenta via NADPH oxidase dependent ROS accumulation

Differential Effect of Short-Term Popular Diets on TMAO and Other Cardio-metabolic Risk Markers

(2019) Ji Eun Park et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

(2019) Mingjing Hu et al.   Nature Communications

Early-Onset Preeclampsia Is Associated With Gut Microbial Alterations in Antepartum and Postpartum Women

(2019) Li-Juan Lv et al.   Frontiers in Cellular and Infection Microbiology

Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A

(2019) Liang Zhao et al.   NEUROCHEMICAL RESEARCH

Gut Microbiota Dysbiosis and Increased Plasma LPS and TMAO Levels in Patients With Preeclampsia

(2019) Jing Wang et al.   Frontiers in Cellular and Infection Microbiology

Trimethylamine-N -oxide promotes brain aging and cognitive impairment in mice

(2018) Dang Li et al.   AGING CELL

Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

(2018) Arash Haghikia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The gut microbiome and elevated cardiovascular risk in obesity and autoimmunity

(2018) Lora J. Kasselman et al.   ATHEROSCLEROSIS

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

(2018) Tao Yang et al.   Nature Reviews Nephrology

Plasma concentration of trimethylamine-N-oxide and risk of gestational diabetes mellitus

(2018) Peiyun Li et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Maternal serum trimethylamine-N-oxide is significantly increased in cases with established preeclampsia

(2018) Yuwen Wen et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial DysfunctionNovelty and Significance

(2017) Kenji Onda et al.   HYPERTENSION

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Remodeling of the gut microbiota and structural shifts in Preeclampsia patients in South China

(2016) J. Liu et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Prepregnancy dietary patterns and risk of developing hypertensive disorders of pregnancy: results from the Australian Longitudinal Study on Women’s Health

(2015) Danielle AJM Schoenaker et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

(2015) Siegfried Ussar et al.   Cell Metabolism

Activation of PAR-1/NADPH Oxidase/ROS Signaling Pathways is Crucial for the Thrombin-Induced sFlt-1 Production in Extravillous Trophoblasts: Possible Involvement in the Pathogenesis of Preeclampsia

(2015) Qi-tao Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

(2015) Francesca De Filippis et al.   GUT

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

(2015) J. R. Stubbs et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia

(2014) Heather D. Major et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: A possible therapeutic approach to preeclampsia

(2014) Y. Zhao et al.   PLACENTA

Advanced glycation end products as an upstream molecule triggers ROS-induced sFlt-1 production in extravillous trophoblasts: A novel bridge between oxidative stress and preeclampsia

(2013) Q.T. Huang et al.   PLACENTA

Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia

(2012) Yin Zhao et al.   FERTILITY AND STERILITY

The vascular endothelial growth factor family in adverse pregnancy outcomes

(2012) P. H. Andraweera et al.   HUMAN REPRODUCTION UPDATE

Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia

(2011) Ravi Thadhani et al.   CIRCULATION

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET