Article
Biophysics
Kun Wang, Chaoye Gan, Huaying Wang, Meiying Ao, Youlong Fan, Yong Chen
Summary: Research shows that acidification causes changes in size and biomechanical properties of LDL/oxLDL particles, with significant decreases in hardness, potentially explaining their role in atherosclerosis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Ali Ahmadi, Yunes Panahi, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Cardiovascular disease is a leading cause of mortality globally, and diabetic patients are at a greater risk of developing atherosclerosis. Antidiabetic drugs exert various mechanisms to counter the undesirable effects of oxLDL, which can be extremely beneficial in controlling atherosclerosis in diabetic patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Xu Zhi, Yufen Sun, Fangjian Cai, Sisi Wang, Hu Gao, Fan Wu, Lei Zhang, Zhen Shen
Summary: A highly specific Ox-LDL-triggered fluorogenic-colorimetric probe Pro-P1 has been developed to visualize the oxidation and aggregation progress of lipoproteins and plaque. This probe is able to directly visualize ferroptosis and Cu2+-mediated LDL oxidative aggregation in living cells. The plaque area and size can be delineated by colorimetric fluorescence imaging and fluorescence lifetime imaging.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Jesus S. Aguilar Diaz De Leon, Honor L. Glenn, Mark Knappenberger, Chad R. Borges
Summary: The oxidation and desialylation of LDL in atherosclerotic processes significantly affect the cytotoxicity of LAK cells against K562 cells.
Review
Cardiac & Cardiovascular Systems
Christin G. Hong, Elizabeth Florida, Haiou Li, Philip M. Parel, Nehal N. Mehta, Alexander V. Sorokin
Summary: This systematic review and meta-analysis explored the relationship between oxidized LDL and cardiovascular disease in patients with chronic inflammatory conditions. The findings indicate that oxidized LDL levels are significantly elevated in participants with cardiovascular disease in the presence of chronic inflammation. This suggests that oxidized LDL may serve as a useful biomarker for risk stratification of cardiovascular disease in patients with chronic inflammation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Immunology
Yonghang He, Tingting Liu
Summary: Atherosclerosis is the pathological basis of acute cardiovascular and cerebrovascular diseases, with oxidized LDL being recognized as a major factor in its development. Numerous studies have shown that oxidized LDL can modulate the phenotypes of macrophages in atherosclerosis. This review summarizes the research progress on how oxidized LDL regulates macrophage polarization, which may provide new targets for the treatment of atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Alexander Sorokin, Christin G. Hong, Angel M. Aponte, Elizabeth M. Florida, Jingrong Tang, Nidhi Patel, Irina N. Baranova, Haiou Li, Philip M. Parel, Vicky Chen, Sierra R. Wilson, Emily L. Ongstad, Anna Collen, Martin P. Playford, Thomas L. Eggerman, Marcus Y. Chen, Kazuhiko Kotani, Alexander Bocharov, Alan T. Remaley
Summary: In this study, we found that oxidized apolipoprotein B and oxidized ApoA-I are associated with high-risk coronary plaque features and progression in patients with cardiovascular disease.
Article
Biochemistry & Molecular Biology
Adam Hartley, Magapu Pradeep, Victor Van den Berg, Ameer Hamid Ahmed Khan, Hasan Ali Shah, Mohammed Allaf, Anna Chow, Mikhail Caga-Anan, Joseph Shalhoub, Wolfgang Koenig, Michael Fisher, Dorian O. Haskard, Ramzi Y. Khamis
Summary: This study aimed to investigate the effects of major vascular surgery on LDL oxidation and the dynamic changes of antibodies against MDA-LDL. The findings suggest that major vascular surgery increases plasma MDA-LDL levels while decreasing antibody and complex levels, possibly due to antibody binding and removal from circulation. The study provides novel insights into the role of the immune system during the oxidative stress of major surgery and highlights the potential clearance role of IgG antibodies, particularly in relation to adverse events.
Article
Biochemistry & Molecular Biology
Hitomi Ohinata, Takashi Obama, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe
Summary: This study found that high-density lipoproteins (HDL) partially decreased neutrophil extracellular trap (NET) formation induced by copper-oxidized low-density lipoprotein (oxLDL). It was also discovered that oxidized phosphatidylcholines and lysophosphatidylcholine in oxLDL promoted NET formation, which could be completely blocked by native HDL. Furthermore, an electronegative subfraction of LDL, LDL(-), was found to promote NET formation. These findings suggest that plasma lipoproteins and their oxidative modifications play multiple roles in promoting NET formation, and HDL acts as a suppressor of this response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Samata S. Pandey, Adam Hartley, Mikhail Caga-Anan, Tareq Ammari, Ameer Hamid Ahmed Khan, Bao Anh Vu Nguyen, Chiari Kojima, Jon Anderson, Steven Lynham, Michael Johns, Dorian O. Haskard, Ramzi Y. Khamis
Summary: This study introduces a sensitive novel enzyme-linked immunosorbent assay for the detection of malondialdehyde-modified low-density lipoprotein (MDA-LDL), a key component of oxidized LDL. The assay is capable of accurately measuring MDA-LDL levels in human plasma and serum, with high inter-operator reproducibility.
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luscher
Summary: LOX-1, as a scavenger receptor, plays a crucial role in the development of atherosclerosis, with implications in various cell types, making it a promising diagnostic and therapeutic target for certain cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luescher
Summary: LOX-1, a scavenger receptor that promotes atherosclerotic plaque formation, plays a critical role in the development of cardiovascular diseases. Its expression in various cell types underscores its significance in disease progression, highlighting the potential for LOX-1 as a novel therapeutic target in CVDs prevention and treatment.
EUROPEAN HEART JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Uzma Saqib, Masood A. Khan, Manikandan Alagumuthu, Suraj P. Parihar, Mirza S. Baig
Summary: Atherosclerosis, a widespread pathological coronary heart disease, is primarily caused by the accumulation of cholesterol-laden macrophages in the artery wall, leading to the formation of foam-cells. Increased influx of oxidized LDL and decreased efflux of free cholesterol from macrophages are major factors in the progression of the disease. Studies on natural compounds effective for AS have increased, with an emphasis on plant-based compounds with potential therapeutic implications.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hui-Lin Hu, Hui-Xiu Zheng, Na Yuan, Chang-Lin Zhai, Hao Chen, Hai-Hua Pan, Gang Qian
Summary: circUSP9X promotes the proliferation and migration of oxidized low-density lipoprotein-treated vascular smooth muscle cells by regulating the expression of miR-599 and STIM1.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Review
Cardiac & Cardiovascular Systems
Hui Jiang, Yongwen Zhou, Seyed M. Nabavi, Amirhossein Sahebkar, Peter J. Little, Suowen Xu, Jianping Weng, Jianjun Ge
Summary: Atherosclerosis is an immuno-metabolic disease involving chronic inflammation, oxidative stress, epigenetics, and metabolic dysfunction. Oxidation of low-density lipoprotein (LDL) is a primary modification in atherosclerosis, leading to pathophysiological changes and plaque formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Food Science & Technology
Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, Mehran Amirizadeh, Kiumarth Amini, Maciej Banach, Jianbo Xiao, Safieh Aghaabdollahian, Seyed Mohammad Nabavi
Summary: Vascular diseases are caused by abnormal endothelial response, resulting in atherosclerosis, hypercholesterolemia, etc. Polyphenols have antioxidative, anti-inflammatory, and anti-hypertensive properties, beneficial for preventing endothelial dysfunction.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Multidisciplinary
Fan-Shun Zhang, Qing-Ze He, Chengxue Helena Qin, Peter J. Little, Jian-Ping Weng, Suo-Wen Xu
Summary: Colchicine is an ancient herbal drug with unique anti-inflammatory effects and prominent cardiovascular actions. Clinical trials have confirmed its curative effect in treating cardiovascular diseases, and its anti-inflammatory mechanisms have been studied.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Meiming Su, Wenqi Zhao, Suowen Xu, Jianping Weng
Summary: Diabetes mellitus (DM) is a common chronic disease with significant complications. Resveratrol, a plant-derived compound, has shown protective effects against diabetes and its cardiovascular complications. These effects are mediated through various signaling pathways.
Editorial Material
Biochemistry & Molecular Biology
Xiaojun Feng, Suowen Xu, Jianping Weng
Summary: A recent study found that soy isoflavone genistein attenuates the cardiovascular side effects caused by marijuana by antagonizing cannabinoid receptor 1, suggesting a potential therapeutic approach for ameliorating these effects.
TRENDS IN MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Iqra Ilyas, Peter J. Little, Zhiping Liu, Yanyong Xu, Danielle Kamato, Bradford C. Berk, Jianping Weng, Suowen Xu
Summary: This article reviews the current use and translational potential of mouse models in atherosclerosis research and drug discovery. Atherosclerotic cardiovascular disease is a chronic and progressive metabolic and inflammatory disease that causes premature human mortality. Despite promising preclinical studies, many drug candidates have not been translated to clinical use due to the complex disease mechanisms involved.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Editorial Material
Endocrinology & Metabolism
Xiumei Wu, Suowen Xu, Jianping Weng
Summary: In a recent article published in Nature, Chen et al. reported that pregestational hyperglycemia resulted in offspring's vulnerability to glucose intolerance due to insufficient TET3-mediated 5-methylcytosine oxidation and DNA demethylation, leading to hypermethylation and reduction of insulin-secreting genes.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Review
Chemistry, Multidisciplinary
Suo-wen Xu, Iqra Ilyas, Jian-ping Weng
Summary: This review examines the impact of COVID-19 on endothelial cell function and provides a comprehensive summary of biomarkers associated with endothelial cell activation in COVID-19. COVID-19 is considered a vascular and endothelial disease, and several drugs have shown potential in improving clinical manifestations of patients. Further research using cellular and animal models can accelerate the discovery of new drugs targeting endothelial dysfunction in COVID-19 patients.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Mengyun Xu, Xiumei Wu, Zhenghong Liu, Yu Ding, Weian Kong, Peter J. Little, Suowen Xu, Jianping Weng
Summary: This study successfully established a novel mouse model of diabetes, atherosclerosis, and fatty liver disease by injecting AAV8-PCSK9 vectors in db/db mice. The model exhibits characteristics of hyperlipidemia, aneurysm, and atherosclerotic plaque, making it suitable for studying the pathological mechanisms of cardiometabolic disease and its complications.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Food Science & Technology
Meijie Chen, Jianbo Xiao, Hesham R. El-Seedi, Krystyna Skalicka Wozniak, Maria Daglia, Peter J. Little, Jianping Weng, Suowen Xu
Summary: Natural product kaempferol possesses pleiotropic cardiovascular protective effects due to its anti-oxidation, anti-inflammation, and anti-thrombotic properties. This review highlights the antioxidant, anti-inflammatory, and cardio-protective activities of kaempferol, focusing on its potential as a drug candidate for preventing and treating atherosclerosis, the underlying pathology of most cardiovascular diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Xiumei Wu, Mengyun Xu, Tong Yue, Ping Ling, Tingyu Fang, Sihui Luo, Suowen Xu, Jianping Weng
Summary: This study conducted hepatic and serum proteomic analysis in a diabetic mouse model to identify differentially expressed proteins (DEPs). The analysis revealed the involvement of these DEPs in various pathways and biological processes. Validation of mRNA expression of related genes further confirmed the results obtained from proteomic screening. These findings potentially provide sensitive non-invasive serum biomarkers for diabetes and NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Meiming Su, Wenqi Zhao, Yujie Li, Hong Li, Suowen Xu, Jianping Weng
Summary: Atherosclerosis is a chronic inflammatory vascular disease in which endothelial cells play a crucial role. Resveratrol, a polyphenol, prevents cardiovascular disease by regulating multiple signaling pathways. The study suggests that resveratrol may serve as a shear stress mimetic drug for combating atherosclerosis.
Article
Pharmacology & Pharmacy
Peng Jiang, Zhenghong Liu, Tingyu Fang, Zhidan Zhang, Yu Zhang, Dongdong Wang, Peter J. Little, Suowen Xu, Jianping Weng
Summary: Despite an increase in Gdf15 levels after APAP overdose, this study concluded that Gdf15 is not involved in APAP-induced liver injury. The study also suggests that genomic analysis of mRNA expression after APAP overdose is of limited relevance unless followed up by a functional analysis of candidate genes in vivo.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Qiuping Wang, Kui Chen, Hui Jiang, Cai Chen, Can Xiong, Min Chen, Jie Xu, Xiaoping Gao, Suowen Xu, Huang Zhou, Yuen Wu
Summary: This study presents a design of biomimetic cascade catalysis system, where metal sites are immobilized on the inner and outer layers of nanocapsules to enable efficient enzymatic cascade reactions. The biomimetic catalysis system exhibits higher activity enhancement compared to conventional systems and is successfully applied in glucose detection.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lijing Kang, Juanjuan Yi, Chi-Wai Lau, Lei He, Qinghua Chen, Suowen Xu, Jun Li, Yin Xia, Yuanting Zhang, Yu Huang, Li Wang
Summary: Hyperglycemia activates Yes-associated protein 1 (YAP) by suppressing AMPK activity, leading to obesity-associated endothelial dysfunction and inflammation. Metformin improves vascular dysfunction by activating AMPK and promoting YAP phosphorylation.
Review
Biochemistry & Molecular Biology
Xiumei Wu, Mengyun Xu, Mengya Geng, Shuo Chen, Peter J. Little, Suowen Xu, Jianping Weng
Summary: The increasing prevalence of noncommunicable diseases (NCDs) has become a significant global public health burden. Metabolic diseases, the most common form of NCDs, have life-threatening cardiovascular complications and affect people of all ages. Protein posttranslational modification (PTM) greatly enhances the functional diversity of proteins and plays a crucial role in common metabolic diseases such as diabetes, obesity, and fatty liver diseases. Understanding the mechanisms of PTMs in metabolic diseases will provide new insights for therapeutic intervention and improvement of therapies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
