The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

(2020) Eric S. Diffenderfer et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

(2020) Joseph D. Wilson et al.   Frontiers in Oncology

Investigation of digital electronics for the NPL Bonner Sphere Spectrometer

(2020) N.J. Roberts et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

The challenge of ionisation chamber dosimetry in ultra-short pulsed high dose-rate Very High Energy Electron beams

(2020) M. McManus et al.   Scientific Reports

Biological effects in normal cells exposed to FLASH dose rate protons

(2019) Manuela Buonanno et al.   RADIOTHERAPY AND ONCOLOGY

Late Morbidity and Mortality Among Medulloblastoma Survivors Diagnosed Across Three Decades: A Report From the Childhood Cancer Survivor Study

(2019) Ralph Salloum et al.   JOURNAL OF CLINICAL ONCOLOGY

Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken

(2019) M.-C. Vozenin et al.   CLINICAL ONCOLOGY

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species

(2019) Pierre Montay-Gruel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses

(2019) Douglas R. Spitz et al.   RADIOTHERAPY AND ONCOLOGY

Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates

(2019) Steven van de Water et al.   ACTA ONCOLOGICA

Microdosimetric Spectra Measurements on a Clinical Carbon Beam at Nominal Therapeutic Fluence Rate With Silicon Cylindrical Microdosimeters

(2019) Juan Prieto-Pena et al.   IEEE TRANSACTIONS ON NUCLEAR SCIENCE

A computational model of radiolytic oxygen depletion during FLASH irradiation and its effect on the oxygen enhancement ratio

(2019) Guillem Pratx et al.   PHYSICS IN MEDICINE AND BIOLOGY

Feasibility of proton FLASH effect tested by zebrafish embryo irradiation

(2019) Elke Beyreuther et al.   RADIOTHERAPY AND ONCOLOGY

Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation

(2019) Danielle A. Simmons et al.   RADIOTHERAPY AND ONCOLOGY

Clinical translation of FLASH radiotherapy: Why and how?

(2019) Jean Bourhis et al.   RADIOTHERAPY AND ONCOLOGY

Treatment of a first patient with FLASH-radiotherapy

(2019) Jean Bourhis et al.   RADIOTHERAPY AND ONCOLOGY

PHASER: A platform for clinical translation of FLASH cancer radiotherapy

(2019) Peter G. Maxim et al.   RADIOTHERAPY AND ONCOLOGY

Dosimetric and preparation procedures for irradiating biological models with pulsed electron beam at ultra-high dose-rate

(2019) Patrik Gonçalves Jorge et al.   RADIOTHERAPY AND ONCOLOGY

Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

(2019) K. Kokurewicz et al.   Scientific Reports

Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein

(2019) E. Bayart et al.   Scientific Reports

Determination of W air in high‐energy electron beams using graphite detectors

(2019) Alexandra Bourgouin et al.   MEDICAL PHYSICS

Bringing FLASH to the clinic: treatment planning considerations for ultrahigh dose-rate proton beams

(2019) P. van Marlen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons

(2019) K. Polin et al.   Journal of Instrumentation

Ultra high dose rate (35 Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome

(2019) Bhanu Prasad Venkatesulu et al.   Scientific Reports

The European radiation dosimetry group – Review of recent scientific achievements

(2019) W. Rühm et al.   RADIATION PHYSICS AND CHEMISTRY

The advantage of Flash radiotherapy confirmed in mini-pig and cat-cancer patients

(2018) Marie-Catherine Vozenin et al.   CLINICAL CANCER RESEARCH

Experimental set-up for FLASH proton irradiation of small animals using a clinical system

(2018) Annalisa Patriarca et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

High dose-per-pulse electron beam dosimetry: Commissioning of the Oriatron eRT6 prototype linear accelerator for preclinical use

(2018) Maud Jaccard et al.   MEDICAL PHYSICS

First application studies at the laser-driven LIGHT beamline: Improving proton beam homogeneity and imaging of a solid target

(2018) D. Jahn et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Near-100 MeV protons via a laser-driven transparency-enhanced hybrid acceleration scheme

(2018) A. Higginson et al.   Nature Communications

Pharmacological ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer

(2018) Matthew S Alexander et al.   CANCER RESEARCH

Diagnostics and Dosimetry Solutions for Multidisciplinary Applications at the ELIMAIA Beamline

(2018) Valentina Scuderi et al.   Applied Sciences-Basel

Developments in Stereotactic Body Radiotherapy

(2018) Anoop Haridass   Cancers

Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator

(2017) Emil Schüler et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

(P003) Delivery of Ultra-Rapid Flash Radiation Therapy and Demonstration of Normal Tissue Sparing After Abdominal Irradiation of Mice

(2017) Billy W. Loo et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The radiobiology of laser-driven particle beams: focus on sub-lethal responses of normal human cells

(2017) L. Manti et al.   Journal of Instrumentation

Traceable charge measurement of the pulses of a 27 MeV electron beam from a linear accelerator

(2017) A. Schüller et al.   Journal of Instrumentation

OA24.05 The Nordic HILUS-Trial - First Report of a Phase II Trial of SBRT of Centrally Located Lung Tumors

(2017) Karin Lindberg et al.   Journal of Thoracic Oncology

Aerrow: A probe-format graphite calorimeter for absolute dosimetry of high-energy photon beams in the clinical environment

(2017) James Renaud et al.   MEDICAL PHYSICS

High dose-per-pulse electron beam dosimetry - A model to correct for the ion recombination in the Advanced Markus ionization chamber

(2017) Kristoffer Petersson et al.   MEDICAL PHYSICS

The CLEAR user facility at CERN

(2017) D. Gamba et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Characterization and performances of DOSION, a dosimetry equipment dedicated to radiobiology experiments taking place at GANIL

(2017) Guillaume Boissonnat et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Towards swift ion bunch acceleration by high-power laser pulses at the Centre for Advanced Laser Applications (CALA)

(2017) F.H. Lindner et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

A new model for volume recombination in plane-parallel chambers in pulsed fields of high dose-per-pulse

(2017) Malte Gotz et al.   PHYSICS IN MEDICINE AND BIOLOGY

A light-weight compact proton gantry design with a novel dose delivery system for broad-energetic laser-accelerated beams

(2017) U Masood et al.   PHYSICS IN MEDICINE AND BIOLOGY

EP-1467: IPEM Code of Practice for proton and ion beam dosimetry: update on work in progress

(2017) S. Green et al.   RADIOTHERAPY AND ONCOLOGY

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

(2017) Pierre Montay-Gruel et al.   RADIOTHERAPY AND ONCOLOGY

Clinical radiation therapy measurements with a new commercial synthetic single crystal diamond detector

(2017) Wolfram U. Laub et al.   Journal of Applied Clinical Medical Physics

Sci-Sat AM: Radiation Dosimetry and Practical Therapy Solutions - 03: Energy dependence of a clinical probe-format calorimeter and its pertinence to absolute photon and electron beam dosimetry

(2016) James Renaud et al.   MEDICAL PHYSICS

TU-H-CAMPUS-TeP2-02: FLASH Irradiation Improves the Therapeutic Index Following GI Tract Irradiation

(2016) E Schueler et al.   MEDICAL PHYSICS

The ELIMED transport and dosimetry beamline for laser-driven ion beams

(2016) F. Romano et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Maximum Proton Energy above 85 MeV from the Relativistic Interaction of Laser Pulses with Micrometer ThickCH2Targets

(2016) F. Wagner et al.   PHYSICAL REVIEW LETTERS

Dosimetric characteristics of four PTW microDiamond detectors in high-energy proton beams

(2016) F Marsolat et al.   PHYSICS IN MEDICINE AND BIOLOGY

How many new cancer patients in Europe will require radiotherapy by 2025? An ESTRO-HERO analysis

(2016) Josep M. Borras et al.   RADIOTHERAPY AND ONCOLOGY

Role of palliative radiotherapy in the management of mural cardiac metastases: who, when and how to treat? A case series of 10 patients

(2016) Alireza Fotouhi Ghiam et al.   Cancer Medicine

Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams

(2016) S. Raschke et al.   Scientific Reports

3D cylindrical silicon microdosimeters: fabrication, simulation and charge collection study

(2015) C. Fleta et al.   Journal of Instrumentation

Treatment planning for radiotherapy with very high-energy electron beams and comparison of VHEE and VMAT plans

(2015) Magdalena Bazalova-Carter et al.   MEDICAL PHYSICS

A novel technique for compensation of space charge effects in the LUPIN-II detector

(2015) C. Cassell et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Characterization of a microDiamond detector in high-dose-per-pulse electron beams for intra operative radiation therapy

(2015) C. Di Venanzio et al.   Physica Medica-European Journal of Medical Physics

The physics of proton therapy

(2015) Wayne D Newhauser et al.   PHYSICS IN MEDICINE AND BIOLOGY

Comparison study of in vivo dose response to laser-driven versus conventional electron beam

(2015) Melanie Oppelt et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Biological Effects of Passive Versus Active Scanning Proton Beams on Human Lung Epithelial Cells

(2015) Daila S. Gridley et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

CLARA conceptual design report

(2014) J A Clarke et al.   Journal of Instrumentation

Timepix3: a 65K channel hybrid pixel readout chip with simultaneous ToA/ToT and sparse readout

(2014) T Poikela et al.   Journal of Instrumentation

Whither whole brain radiotherapy for primary CNS lymphoma?

(2014) L. M. DeAngelis   NEURO-ONCOLOGY

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

(2014) Marco Marinelli et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

A new version of the LUPIN detector: Improvements and latest experimental verification

(2014) M. Caresana et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

(2014) V. Favaudon et al.   Science Translational Medicine

Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

(2014) Ken Ledingham et al.   Applied Sciences-Basel

Dependence of diode sensitivity on the pulse rate of delivered radiation

(2013) Paul A. Jursinic   MEDICAL PHYSICS

Evaluation of the dosimetric properties of a synthetic single crystal diamond detector in high energy clinical proton beams

(2013) A. K. Mandapaka et al.   MEDICAL PHYSICS

Development of a graphite probe calorimeter for absolute clinical dosimetry

(2013) James Renaud et al.   MEDICAL PHYSICS

Characterization of a synthetic single crystal diamond Schottky diode for radiotherapy electron beam dosimetry

(2013) C. Di Venanzio et al.   MEDICAL PHYSICS

LUPIN, a new instrument for pulsed neutron fields

(2013) M. Caresana et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Characterization and performances of a monitoring ionization chamber dedicated to IBA-universal irradiation head for Pencil Beam Scanning

(2013) C. Courtois et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Shaping laser accelerated ions for future applications – The LIGHT collaboration

(2013) S. Busold et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Intercomparison of radiation protection instrumentation in a pulsed neutron field

(2013) M. Caresana et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Instrumentation for diagnostics and control of laser-accelerated proton (ion) beams

(2013) P.R. Bolton et al.   Physica Medica-European Journal of Medical Physics

Radiotherapy electron beams collimated by small tubular applicators: characterization by silicon and diamond diodes

(2013) P Bagalà et al.   PHYSICS IN MEDICINE AND BIOLOGY

Reference dosimetry for light-ion beams based on graphite calorimetry

(2013) S. Rossomme et al.   RADIATION PROTECTION DOSIMETRY

Ion acceleration by superintense laser-plasma interaction

(2013) Andrea Macchi et al.   REVIEWS OF MODERN PHYSICS

Dose-controlled irradiation of cancer cells with laser-accelerated proton pulses

(2012) K. Zeil et al.   APPLIED PHYSICS B-LASERS AND OPTICS

A laser-driven nanosecond proton source for radiobiological studies

(2012) Jianhui Bin et al.   APPLIED PHYSICS LETTERS

A systematic review of stereotactic radiotherapy ablation for primary renal cell carcinoma

(2012) Shankar Siva et al.   BJU INTERNATIONAL

A synthetic diamond detector as transfer dosimeter forDwmeasurements in photon beams with small field sizes

(2012) M Pimpinella et al.   METROLOGIA

Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961

(2012) Roger J. Packer et al.   NEURO-ONCOLOGY

3D silicon sensors: Design, large area production and quality assurance for the ATLAS IBL pixel detector upgrade

(2012) Cinzia Da Via et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Relative response of alanine dosemeters for high-energy electrons determined using a Fricke primary standard

(2012) Sándor Vörös et al.   PHYSICS IN MEDICINE AND BIOLOGY

Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

(2012) D. Doria et al.   AIP Advances

Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

(2011) A. Yogo et al.   APPLIED PHYSICS LETTERS

Secondary particle yields from 400MeV/u carbon ion and 250MeV proton beams incident on thick targets

(2011) A. Ferrari et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

Dosimetry and spectral analysis of a radiobiological experiment using laser-driven proton beams

(2011) F Fiorini et al.   PHYSICS IN MEDICINE AND BIOLOGY

A dosimetric system for quantitative cell irradiation experiments with laser-accelerated protons

(2011) C Richter et al.   PHYSICS IN MEDICINE AND BIOLOGY

Survival of tumor cells after proton irradiation with ultra-high dose rates

(2011) Susanne Auer et al.   Radiation Oncology

The Effectiveness of 20 MeV Protons at Nanosecond Pulse Lengths in Producing Chromosome Aberrations in Human-Hamster Hybrid Cells

(2011) T. E. Schmid et al.   RADIATION RESEARCH

SU-GG-T-459: Laser-Based Particle Acceleration for Future Ion Therapy: Current Status of the Joint Project OnCOOPtics with Special Focus on Beam Delivery and Dosimetry

(2010) C Richter et al.   MEDICAL PHYSICS

Dose-dependent biological damage of tumour cells by laser-accelerated proton beams

(2010) S D Kraft et al.   NEW JOURNAL OF PHYSICS

Relative biological effectiveness of pulsed and continuous 20MeV protons for micronucleus induction in 3D human reconstructed skin tissue

(2010) Thomas E. Schmid et al.   RADIOTHERAPY AND ONCOLOGY

Primary standards of absorbed dose for electron beams

(2009) M R McEwen et al.   METROLOGIA

Photon absorbed dose standards

(2009) Jan Seuntjens et al.   METROLOGIA

Treatment planning for laser-accelerated very-high energy electrons

(2009) T Fuchs et al.   PHYSICS IN MEDICINE AND BIOLOGY

No Evidence for a Different RBE between Pulsed and Continuous 20 MeV Protons

(2009) T. E. Schmid et al.   RADIATION RESEARCH