Article
Biotechnology & Applied Microbiology
Qian Wang, Qingshan Shi, Yulian Li, Shunying Lu, Xiaobao Xie
Summary: This study developed a visible light-induced anti-pathogen agent to eliminate biofilms. By utilizing the complementary effects of cationic polymers and ROS, the agent demonstrated significant inhibitory and ablative effects on various pathogens, while maintaining good biocompatibility.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mirella R. V. Bertolo, Lucas D. Dias, Alessandra R. Lima, Antonio S. N. Aguiar, Fernanda Alves, Mariana de Souza, Hamilton B. Napolitano, Vanderlei S. Bagnato, Stanislau Bogusz Jr
Summary: This study investigated the application of biopolymeric materials and antimicrobial photodynamic therapy (aPDT) on the safety of strawberries. The materials showed potential as photosensitizers and effectively reduced the survival of Staphylococcus aureus on the surface of the films. The materials were also shown to be safe for use as films without posing a risk to humans and the environment. The photoactive coatings on strawberries maintained their weight and effectively delayed fungal contamination. The antimicrobial effects of aPDT combined with the photoactive coatings were enhanced, while the quality of the strawberries was maintained.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Qian Wang, Dandan Zhang, Jin Feng, Tingli Sun, Cailing Li, Xiaobao Xie, Qingshan Shi
Summary: In this study, a chlorine-loaded polyethyleneimine-based micelle photosensitizer was constructed for enhanced photoinactivation activities on Gram-negative bacteria through electrostatic and hydrophobic interactions between nanoparticles and the bacterial surface. The light-triggered generation of reactive oxygen species caused irreversible damage to the bacterial outer membrane, achieving enhanced bactericidal efficiency. This antimicrobial alternative holds great potential for human healthcare and environmental remediation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Oncology
Azole Sindelo, Pinar Sen, Tebello Nyokong
Summary: Antimicrobial photodynamic inactivation (aPDI) is an effective method for eradicating drug-resistant microorganisms due to its minimal possibility of microbial resistance. This study focuses on the preparation and characterization of novel neutral and cationic morpholine containing Schiff base phthalocyanines. The cationic complexes show promising photodynamic activity against various microorganisms, while the neutral complexes are not suitable for antimicrobial studies. The effectiveness of aPDI is dependent on the concentration and light dose.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Orlando Santoro, Miryam Chiara Malacarne, Francesco Sarcone, Luca Scapinello, Stefania Pragliola, Enrico Caruso, Viviana Teresa Orlandi, Lorella Izzo
Summary: In this study, two compounds from the BODIPY family were bound to amino-pendant groups of three random copolymers with varying amounts of MMA and DMAEMA. The copolymers showed inherent bactericidal activity due to the presence of amino groups and quaternized nitrogens bound to BODIPY. Coated filter paper discs with copolymers conjugated to BODIPY inhibited the growth of E. coli and S. aureus under green light irradiation, with the highest efficiency observed in the copolymer containing 43% DMAEMA and approximately 0.70 wt/wt% BODIPY. The copolymers also exhibited residual antimicrobial activity after dark incubation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yuling Xu, Wei Tuo, Liang Yang, Yan Sun, Chonglu Li, Xiaoqiang Chen, Wenchao Yang, Guangfu Yang, Peter J. Stang, Yao Sun
Summary: This study developed a supramolecular photosensitizer that can precisely monitor and effectively treat infected sites through the interaction between a metal cycle and host-guest chemistry. The photosensitizer showed potential for biomedical applications by tracking infection sites and performing efficient photodynamic inactivation in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Multidisciplinary
Laura McShea, Harjot S. Kambo, Michelle Maclean, Maki E. Sandison
Summary: Healthcare-associated infection through transmission of pathogenic bacteria poses a huge threat to public health. This study investigates the potential to enhance the antimicrobial efficacy of 405 nm light for surface decontamination through use of a photocatalytic TiO2-doped elastomer. Results suggest that this doping and etching strategy shows significant potential for facilitating decontamination of elastomer-based biomaterials.
MATERIALS RESEARCH EXPRESS
(2022)
Article
Multidisciplinary Sciences
Denisse Fuentes-Lopez, Daniel Ortega-Zambrano, Maria Antonieta Fernandez-Herrera, Hilda Mercado-Uribe
Summary: Photodynamic inactivation is a promising method that utilizes photosensitizers to generate reactive oxygen species and inhibit the growth of pathogenic microorganisms. In this study, pheomelanin nanoparticles were used as sensitizers to successfully inhibit the growth of E. coli. The results suggest that this method is effective against E. coli and could potentially be applied to other bacteria.
Article
Environmental Sciences
Xiaoyu Cong, Peter Krolla, Umer Zeb Khan, Mykhailo Savin, Thomas Schwartz
Summary: This study quantified the frequencies of facultative pathogenic bacteria and antibiotic resistance genes in wastewater from poultry and pig slaughterhouses. The researchers found that the wastewater was contaminated with both bacteria and clinically relevant antibiotic resistance genes. They also investigated the use of antimicrobial BlueLight (aBL) and a porphyrin photo-sensitizer to enhance the killing effect of the light.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Xiaoyu Cong, Peter Krolla, Umer Zeb Khan, Mykhailo Savin, Thomas Schwartz
Summary: The contamination of wastewater from poultry and pig slaughterhouses by ESKAPE bacteria and antibiotic resistance genes was studied. Conventional and advanced oxidative wastewater treatments reduced the concentration of genes but did not eliminate them completely. The combination of antimicrobial blue light with a porphyrin photosensitizer enhanced the biocidal impact on non-sensitive bacteria.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Polymer Science
Pauline Sautrot-Ba, Vlasta Brezova, Jean-Pierre Malval, Annalisa Chiappone, Louise Breloy, Samir Abbad-Andaloussi, Davy-Louis Versace
Summary: The study presents the synthesis and application of new visible-light photosensitizers derived from purpurin in type II photoinitiating systems for various photopolymerization reactions and thiol-ene reactions. It demonstrates the photochemical properties of these systems, showing that purpurin derivatives can act as electron donors or proton/proton-coupled electron transfer promoters with appropriate additives. Triallyl purpurin is shown for the first time to produce 3D objects using 3D photoprinting technology, and photosensitizers incorporating triallyl-purpurin exhibit significant antibacterial properties under visible-light exposure, even after multiple antibacterial cycling experiments, indicating their potential for recyclability.
Article
Engineering, Environmental
Jenny Flores, Alberto Blazquez-Moraleja, Mariles Bonet-Aracil, Pilar Moya, Francisco Bosca, Luisa Marin
Summary: Heterogeneous photocatalysts based on fabric materials have great relevance for water disinfection. This study focuses on determining the best percentage of a photosensitizer on fabric for efficient bacterial inactivation. Polyamide fabrics dyed at different Rose Bengal percentages were tested, and the results showed that fabrics with 1% Rose Bengal showed 100% inactivation efficiency against Enterococcus faecalis in just 15 minutes. Optimizing the percentage of dye is crucial to avoid aggregation of photosensitizers and achieve an adequate net negative charge distribution for antimicrobial fabrics.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Physical
Gourab Das, Suman Nayak, Dinesh Kumar Kotness, Prolay Das
Summary: In this study, DNA-nanoparticles (DNA-NP) were synthesized from onion genomic DNA as a biomass source through controlled hydrothermal pyrolysis. The resulting DNA-NPs were then crosslinked to form a hydrogel, which exhibited remarkable mechanical strength and self-healing properties. The hydrogel also displayed the ability to generate reactive oxygen species (ROS) with visible light irradiation, making it potentially useful for biofilm destruction. Furthermore, the hydrogel demonstrated high loading efficiency and controlled release of a model drug. This study addresses the challenge of sustainability in developing novel nanomaterials from biomass sources and showcases the potential applications of the hydrogel in antibiotic-antibacterial photodynamic treatment.
Article
Food Science & Technology
Yuchen Zhang, Zhaoyang Ding, Changbo Shao, Jing Xie
Summary: This study evaluated the effect of chlorophyllin-based photodynamic inactivation (Chl-PDI) on biofilm formation and fresh-cut pakchoi quality. The results showed that Chl-PDI reduced biofilm formation, inactivated food spoilage bacteria, and improved the quality of fresh-cut pakchoi. These findings have significant implications for effective processing and traditional vegetable preservation.
Article
Agriculture, Multidisciplinary
Luciano Dibona-Villanueva, Denis Fuentealba
Summary: A novel chemical conjugate between chitosan and riboflavin was synthesized and characterized, showing enhanced antifungal effect through antimicrobial photodynamic therapy. The conjugate exhibited the highest fungal growth inhibition at a dose of 0.5% w/v, suggesting it could be a promising alternative for fungicides used in citrus fruits postharvest.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Caetano P. Sabino, Martha S. Ribeiro, Mark Wainwright, Carolina Dos Anjos, Fabio P. Sellera, Milena Dropa, Nathalia B. Nunes, Guilherme T. P. Brancini, Gilberto U. L. Braga, Victor E. Arana-Chavez, Raul O. Freitas, Nilton Lincopan, Mauricio S. Baptista
Summary: The uncontrolled spread of multidrug-resistant pathogens is a major global health threat. Antimicrobial photodynamic therapy (aPDT) offers a promising approach to treating localized infections without being limited by drug resistance. In this study, various techniques were used to investigate the biochemical mechanisms of aPDT. The results suggest that protein degradation correlates with microbial inactivation kinetics, providing important insights for the development of optimized photosensitizing drugs and combination therapies with antimicrobial chemotherapy.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucas M. O. S. Martins, Xuhui Wang, Gustavo T. M. Silva, Helena C. Junqueira, Barbara Fornaciari, Lohanna F. Lopes, Cassio P. Silva, Peng Zhou, Victor F. Cavalcante, Mauricio S. Baptista, Frank H. Quina
Summary: Hydroxypyranoflavylium (HPF) cations are synthetic analogs with excellent photophysical properties and can serve as sensitizers for photodynamic therapy (PDT). The study found that HPF cations have phototoxic effects on human cervical adenocarcinoma cells at lower concentrations, and even small structural differences can lead to significant variations in phototoxicity. Therefore, HPF cations are potential PDT sensitizers that deserve further evaluation.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lohanna de Faria Lopes, Jana Jandova, Rebecca Justiniano, Jessica Perer, Mauricio S. Baptista, Georg T. Wondrak
Summary: Cellular oxidative stress plays a significant role in solar ultraviolet radiation-induced skin photoaging and photocarcinogenesis. Methylglyoxal (MG), a metabolic byproduct, has been found to act as a UVA-photosensitizer, causing photooxidative stress and caspase-dependent cell death in human keratinocytes. Additionally, MG induces gene expression changes related to proteotoxic and oxidative stress response. Further investigation into the role of MG photosensitizer activity in human skin photodamage is crucial.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tania M. Yoshimura, Fernanda Cabral, Fabio P. Sellera, Lorena Pozzo, Martha S. Ribeiro
Summary: This article systematically reviews the impact of combining stem cell and photobiomodulation therapy (PBM) in the repair of skin wounds. The meta-analysis shows that the combination of SCs and PBM has a positive influence on wound closure and strength, although there is heterogeneity and bias in the included studies.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Bruno L. Raposo, Sueden Souza, Gleyciane S. Santana, Max T. A. Lima, Jose F. Sarmento-Neto, Julio S. Reboucas, Goreti Pereira, Beate S. Santos, Paulo E. Cabral Filho, Martha S. Ribeiro, Adriana Fontes
Summary: Researchers proposed a novel method of using polyvinylpyrro-lidone (PVP) coated silver nanoparticles (AgNPs) in combination with cationic Zn(II) porphyrins (ZnPs) for photodynamic inactivation (PDI) of Candida albicans infections. The AgNPs-ZnPs system achieved complete eradication of Candida albicans at lower porphyrin concentrations, reducing the risk of antifungal drug resistance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Optics
Fernanda V. Cabral, Tania M. Yoshimura, Daniela De Fatima Teixeira da Silva, Mauro Cortez, Martha S. Ribeiro
Summary: Photodynamic therapy (PDT) mediated by methylene blue (MB) has shown potential in treating cutaneous leishmaniasis, as it can overcome drug resistance and effectively destroy the parasite.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2023)
Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Oncology
G. A. Novaes, M. H. Blank, T. M. Yoshimura, M. S. Ribeiro, R. J. G. Pereira
Summary: Artificial insemination in poultry often leads to high levels of bacterial contamination in the semen. This study explored the potential use of antimicrobial photodynamic therapy (PDT) as an alternative to antibiotics in preserving semen quality. The results showed that incubation with methylene blue (MB) did not affect sperm motility, but increasing light dose during the PDT process resulted in greater reductions in sperm parameters. However, the conditions that were less harmful to spermatozoa were not effective in reducing bacterial colonies in chicken semen.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Jesica A. Dimmer, Fernanda V. Cabral, Susana C. Nunez Montoya, Martha S. Ribeiro
Summary: This study investigated the potential of three natural anthraquinones on cutaneous leishmaniasis induced by Leishmania amazonensis. The results showed that G5ClSor-gL was able to sustain low levels of parasite burden over time, and GSor-bL inhibited disease progression, demonstrating their potential as promising compounds for treating the disease.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Environmental Sciences
Danny Fuentes-Castillo, Daniela Castro-Tardon, Fernanda Esposito, Ingrith Neves, Larissa Rodrigues, Herrison Fontana, Bruna Fuga, Jose L. Catao-Dias, Nilton Lincopan
Summary: A study found ESBL-producing Escherichia coli in wild birds from a remote island in Chilean Patagonia, indicating the potential transhemispheric movement of international clones of critical priority ESBL-producing pathogens. These strains carried a wide range of resistance and virulence genes associated with human and animal infections.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Editorial Material
Immunology
Gerson Nakazato, Renata Katsuko Takayama Kobayashi, Marcia Regina Eches Perugini, Nilton Lincopan, Eliana Carolina Vespero
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Carolina dos Anjos, Leon G. Leanse, Martha S. Ribeiro, Fabio P. Sellera, Milena Dropa, Victor E. Arana-Chavez, Nilton Lincopan, Mauricio S. Baptista, Fabio C. Pogliani, Tianhong Dai, Caetano P. Sabino
Summary: Antimicrobial drug development is under scrutiny due to the worldwide antibiotic crisis. Antimicrobial blue light (aBL) has been recognized as a potential therapy for infections, but the specific targets for bacterial killing by aBL are still poorly understood and may vary depending on the bacterial species.
MICROBIOLOGY SPECTRUM
(2023)
Review
Chemistry, Multidisciplinary
Erick L. Bastos, Frank H. Quina, Mauricio S. Baptista
Summary: Endogenous photosensitizers play a crucial role in light-induced transformations in biological systems. This comprehensive review focuses on their mode of action and its implications in various fields, such as photomedicine, photoredox catalysis, and the development of sun care products. The analysis reveals the potential causes of the increase in skin cancer cases and highlights the limitations of current sun protection approaches.
Article
Multidisciplinary Sciences
Fernanda V. Cabral, Michela Cerone, Saydulla Persheyev, Cheng Lian, Ifor D. W. Samuel, Martha S. Ribeiro, Terry K. Smith
Summary: The emergence of drug resistance in cutaneous leishmaniasis has become a major problem. Photodynamic therapy has shown effectiveness against drug-resistant strains and may be an attractive strategy for treatment.