Article
Medicine, General & Internal
Bruna de Paula Duarte, Vera Lucia Jornada Krebs, Valdenise Martins Laurindo Tuma Calil, Werther Brunow de Carvalho, Maria Augusta Bento Cicaroni Gibelli, Rossana Pulcineli Vieira Francisco
Summary: Pregnant women with COVID-19 can have a significant impact on the clinical characteristics and evolution of neonates. Cesarean section is the main method of delivery, and most newborns require respiratory support and other therapeutic interventions during hospitalization.
Article
Pediatrics
Anastasios Goulioumis, Maria Angelopoulou, Konstantinos Kourelis, Konstantinos Mourtzouchos, Magdalini Tsiakou, Athanasios Asimakopoulos
Summary: This study aimed to investigate whether babies born to mothers infected with COVID-19 during pregnancy were at risk of congenital hearing loss. After screening the hearing of 111 newborns born to COVID-19 positive mothers, there was no evidence to suggest that COVID-19 infection is associated with hearing loss.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Sushma Malik, Dipty Jain, Chandrakant M. Bokade, Shakira Savaskar, Laxmikant S. Deshmukh, Poonam Wade, Abhishek D. Madhura, Milind Suryawanshi, Sachin T. Bandichhode, Sachin B. Bodhgire, Sarika Zala, Smita D. Mahale, Deepak N. Modi, Rakesh Waghmare, Suchitra Surve, Rahul K. Gajbhiye
Summary: The study examined outcomes in neonates of mothers with COVID-19 during the first and second waves of the pandemic. The second wave resulted in higher rates of preterm birth, neonatal ICU admissions, neonatal complications, birth asphyxia, prematurity, and neonatal resuscitation compared to the first wave. However, the prevalence of SARS-CoV-2 infection in neonates was comparable between the two waves.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Kiran More, Deepak Chawla, Srinivas Murki, Baswaraj Tandur, Ashok K. Deorari, Praveen Kumar
Summary: Limited evidence exists on perinatal transmission and outcomes of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in neonates. A large cohort study in India found that there was a perinatal transmission rate of 8%, with most infected neonates being asymptomatic. Neonates roomed-in with mother had a higher risk of transmission, and infected neonates were more likely to be symptomatic and require resuscitation, with morbidities mainly related to prematurity and perinatal events.
Article
Pediatrics
Ling-Kong Zeng, Hua-Ping Zhu, Tian-Tian Xiao, Si-Cong Peng, Wen-Hao Yuan, Jian-Bo Shao, Lai-Shuan Wang, Fei-Fan Xiao, Shi-Wen Xia, Shoo K. Lee, Kai Yan, Wen-Hao Zhou
Summary: The study found that some neonates born to mothers with COVID-19 had abnormal brain MRI findings, but they did not show poor physical growth. Further research is needed to evaluate the association between abnormal MRI findings and SARS-CoV-2 exposure.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Antonius H. Pudjiadi, Nina Dwi Putri, Hikari Ambara Sjakti, Piprim Basarah Yanuarso, Hartono Gunardi, Rosalina Dewi Roeslani, Ade Djanwardi Pasaribu, Lies Dewi Nurmalia, Catharine Mayung Sambo, I. Dewa Gede Ugrasena, Santoso Soeroso, Armijn Firman, Heru Muryawan, Darmawan Budi Setyanto, Endah Citraresmi, Jaya Ariheriyanto Effendi, Lathiefatul Habibah, Prillye Deasy Octaviantie, Indriyanti Natasya Ayu Utami, Yogi Prawira, Nastiti Kaswandani, Anggraini Alam, Kurniawan Taufiq Kadafi, Aman B. Pulungan
Summary: The case fatality rate of confirmed COVID-19 cases in children in Indonesia is high, especially among those aged 10-18 years. The most common comorbidity found was malignancy, and respiratory failure was the most common diagnosis.
FRONTIERS IN PEDIATRICS
(2021)
Article
Clinical Neurology
David Garcia-Azorin, Maria Jose Abenza Abildua, Maria Elena Erro Aguirre, Santiago Fernandez Fernandez, Juan Carlos Garcia Monco, Cristina Guijarro-Castro, Montserrat Gonzalez Platas, Fernando Romero Delgado, Jose Miguel Lainez Andres, David Ezpeleta
Summary: The findings from the Spanish Society of Neurology's NeuroCOVID-19 Registry revealed diverse neurological manifestations of COVID-19, including stroke, neuromuscular symptoms, altered mental status, anosmia, headache, and seizures. Some symptoms had different onset times. COVID-19 could cause persistent and disabling neurological symptoms, with certain symptoms associated with greater severity.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Katarzyna Wroblewska-Seniuk, Agnieszka Basiukajc, Dobrochna Wojciechowska, Mayanthi Telge, Izabela Miechowicz, Jan Mazela
Summary: Infants born to SARS-CoV-2-positive mothers are more likely to experience respiratory distress and require respiratory support, with a significant decrease in breastfeeding rates due to mother-baby separation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Roghayeh Babaei, Farah Bokharaei-Salim, Khadijeh Khanaliha, Seyed Jalal Kiani, Arezoo Marjani, Saba Garshasbi, Farzaneh Dehghani-Dehej, Sara Chavoshpour
Summary: This study evaluated the presence of SARS-CoV-2 infection in neonates born to mothers or relatives with COVID-19 in Iran. Out of 98 neonates studied, 6 (6.1%) tested positive for SARS-CoV-2 infection in PCR results. The study showed that the rate of COVID-19 in neonates born to mothers or relatives with SARS-CoV-2 infection in the Iranian population is about 6.1%.
BMC INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Katharina Goeral, Renate Fuiko, Julia Binder, Claudia Lindtner, Raphaela Jernej, Judith Rittenschober-Boehm, Katrin Klebermass-Schrehof, Angelika Berger, Agnes Grill
Summary: This study evaluated the neurodevelopmental outcomes of infants born with a birth weight <= 500g, showing that 50% exhibited normal or mildly impaired mental development and 75% showed favorable motor development. Taking into account visual and hearing disabilities, as well as cerebral palsy, 35% of patients had a good neurodevelopmental outcome.
Article
Pediatrics
Pradeep Kumar, Fadila, Arun Prasad, Ambrin Akhtar, Bhabesh Kant Chaudhary, Lokesh Kumar Tiwari, Neha Chaudhry
Summary: This study found that vertical transmission of SARS-CoV-2 from COVID-19-positive mothers to their neonates is possible, but with a low risk. The majority of neonates born to infected mothers remain asymptomatic with good clinical outcomes during their hospital stay.
BMJ PAEDIATRICS OPEN
(2021)
Article
Clinical Neurology
Santiago Fernandez Fernandez, Javier Ricardo Perez Sanchez, Guillermo Hernandez Perez, Maria Rabasa Perez, Cristina Guijarro Castro, David Garcia-Azorin, David Ezpeleta
Summary: This article describes a study on seizures in patients with COVID-19. Among the 232 reported cases, 26 (11.2%) had seizures, with most seizures occurring on days 0 and 7 after the onset of infection. Some patients had no prior history of epilepsy, but most had predisposing factors.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Jayanta Banerjee, Edward Mullins, Julia Townson, Rebecca Playle, Caroline Shaw, Nigel Kirby, Kim Munnery, Tom Bourne, Tg Teoh, Mandish Dhanjal, Liona Poon, Alison Wright, Christoph Lees
Summary: The PAN-COVID registry is an observational study collecting data on pregnant women with suspected COVID-19 or confirmed SARS-CoV-2 infection and their newborns. It aims to evaluate outcomes such as miscarriage, fetal growth restriction, preterm delivery, vertical transmission, and early onset neonatal SARS-CoV-2 infection. The study has received research ethics approval in the UK and will disseminate findings to participants through various channels.
Article
Pediatrics
Pratima Anand, Anita Yadav, Pradeep Debata, Sumitra Bachani, Nitesh Gupta, Rani Gera
Summary: This study found that COVID-19 positive neonates had milder clinical manifestations and the risk of transmission from positive mothers to neonates through rooming-in and breastfeeding was low. Maternal viral load was not associated with the severity of illness or positivity status in neonates.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Manuel Rubio-Rivas, Xavier Corbella, Francesc Formiga, Estela Menendez Fernandez, Maria Dolores Martin Escalante, Isolina Banos Fernandez, Francisco Arnalich Fernandez, Esther Del Corral-Beamonte, Antonio Lalueza, Alejandro Parra Virto, Emilia Roy Vallejo, Jose Loureiro-Amigo, Ana Maria Alvarez Suarez, Jesica Abadia-Otero, Maria Navarro De La Chica, Raquel Estevez Gonzalez, Almudena Hernandez Milian, Maria Areses Manrique, Julio Cesar Blazquez Encinar, Amara Gonzalez Noya, Ruth Gonzalez Ferrer, Maria Perez Aguilera, Ricardo Gil Sanchez, Jesus Millan Nunez-Cortes, Jose Manuel Casas-Rojo
Summary: This study identifies three risk categories for COVID-19 patients based on lymphopenia and inflammatory parameters, with older male patients with various comorbidities at higher risk and requiring more intensive treatments.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Amaia Merino-Hernandez, Laura Sanchez-Barriopedro, Sonia Villar-Castro, Alejandra Aguado-Del Hoyo, Itziar Marsinyach-Ros, Manuel Sanchez-Luna
Summary: This study aimed to evaluate the effectiveness of urine CMV PCR testing and head ultrasound examination in asymptomatic neonates born SGA after 34 weeks' gestation. The results showed that only one newborn in the sample had a positive urine test, but remained asymptomatic throughout the follow-up. Two abnormal findings were found in the head ultrasound examinations, but they were unrelated to congenital CMV infection. The cost-effectiveness analysis indicated that the cumulative cost of the tests was 17,000 euros for the detection of a single asymptomatic positive case. Therefore, screening for congenital CMV infection in asymptomatic late preterm and term newborns with only the risk factor of SGA does not seem to be cost effective.
ANALES DE PEDIATRIA
(2023)
Article
Acoustics
A. Hawkins-Villarreal, K. Castillo, A. Nadal, S. Planas, A. L. Moreno-Espinosa, A. Alarcon, M. Rebollo-Polo, F. Figueras, E. Gratacos, E. Eixarch, A. Gonce
Summary: The study aimed to evaluate the correlation between the periventricular echogenic halo (halo sign) and histopathological findings, as well as its association with other brain imaging abnormalities in fetuses with cytomegalovirus (CMV) infection. The study included CMV-infected fetuses diagnosed with severe CNS abnormalities seen on ultrasound. The halo sign was observed in 91% of the fetuses, with ventriculitis being more frequent in cases with a non-isolated halo sign. Histopathological analysis showed that fetuses with an isolated halo sign had mild ventriculitis without severe brain lesions. The study suggests that detailed neurosonographic follow-up and MRI examination should be considered in the early third trimester for prognostic evaluation of CMV-infected fetuses with the halo sign as an isolated finding. Rating: 8/10.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Pediatrics
Alejandro Perez-Munuzuri, Hector Boix, Maria Dolores Sanchez-Redondo, Maria Cernada, Maria Gracia Espinosa-Fernandez, Noelia Gonzalez-Pacheco, Ana Martin-Ancel, Maria L. Couce, Manuel Sanchez Luna
Summary: The Spanish Society of Neonatology established the care levels of neonatal units in Spain in 2013. Since then, there has been significant growth in the birth rate in the country and the universalization of knowledge, techniques, and patient treatment devices. This situation requires a redefinition of the current care levels based on quality criteria to ensure better comparability between units and to improve the care of newborns.
ANALES DE PEDIATRIA
(2023)
Editorial Material
Pediatrics
Rebeca Gregorio-Hernandez, Paz Chimenti-Camacho, Alejandra Aguado del Hoyo, Manuel Sanchez-Luna
ANALES DE PEDIATRIA
(2023)
Letter
Pediatrics
Daniele De Luca, Almudena Alonso-Ojembarrena, Yasser Elsayed, Francesco Raimondi, Manuel Sanchez-Luna
JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Piedad Alba-Pavon, Lide Alana, Miriam Gutierrez-Jimeno, Susana Garcia-Obregon, Teresa Imizcoz, Elena Panizo, Paula Gonzalez-Urdiales, Aizpea Echebarria-Barona, Ricardo Lopez Almaraz, Laura Zaldumbide, Itziar Astigarraga, Ana Patino-Garcia, Olatz Villate
Summary: Genetic predisposition plays a significant role in pediatric cancer, but the relationship between individual genetic mutations and childhood cancer is still being investigated. Sarcomas are often associated with cancer predisposition syndromes, but this is frequently overlooked due to the rarity and heterogeneity of sarcomas and limited search for genetic syndromes. This study identified potential pathogenic germline variants in several genes associated with cancer predisposition syndromes in pediatric sarcoma patients through tumor profiling and sequencing analysis. The results indicate that somatic testing can help identify individuals at risk of underlying cancer predisposition syndromes.
SCIENTIFIC REPORTS
(2023)
Review
Pediatrics
Anna Parra-Llorca, Alejandro Pinilla-Gonzlez, Laura Torrejon-Rodriguez, Inmaculada Lara-Canton, Julia Kuligowski, Maria Carmen Collado, Maria Gormaz, Marta Aguar, Maximo Vento, Eva Serna, Maria Cernada
Summary: This narrative review discusses the mechanisms of bacterial sepsis in preterm infants, a prevalent and serious illness. It examines the role of the innate immune response and oxidative stress in the pathogenesis and their potential as early biomarkers. Furthermore, it addresses the impact of sepsis-induced mechanisms on dysbiosis and changes in neonatal microbiota.
Article
Medicine, General & Internal
Alba Perez-Perez, Susana E. Zeballos-Sarrato, Isabel Pescador-Chamorro, Manuel Sanchez-Luna
Summary: The importance of sodium changes during the neonatal period is highlighted in this article, which can lead to extreme situations that pose therapeutic challenges and compromise patient lives. Two case reports are presented to demonstrate the potential consequences of sodium alterations in newborns.
REVISTA MEDICA CLINICA LAS CONDES
(2023)
Letter
Pediatrics
Manuel Sanchez Luna, Belen Fernandez Colomer, M. Luz Couce Pico
ANALES DE PEDIATRIA
(2023)
Article
Pediatrics
Belen Fernandez Monteagudo, Sonia Villar Castro, Paula Carrascosa Garcia, Susana Zeballos Sarrato, Manuel Sanchez Luna
Summary: In our study, the antenatal administration of magnesium sulfate to prevent cerebral palsy did not decrease the risk of developing CP. However, we observed a significant reduction in mortality and the risk of severe necrotizing enterocolitis with this protocol.
ANALES DE PEDIATRIA
(2023)
Article
Pediatrics
Ana Alarcon, Linda S. de Vries, Alessandro Parodi, Juan Arnaez, Fernando Cabanas, Sylke J. Steggerda, Monica Rebollo, Luca Ramenghi, Izaskun Dorronsoro, Manuela Lopez-Azorin, Juliane Schneider, Antoni Noguera-Julian, Maria Rios-Barnes, Manuel Recio, Myriam Bickle-Graz, Miriam Martinez-Biarge, Claudia Fortuny, Alfredo Garcia-Alix, Anita C. Truttmann
Summary: This study evaluated the association between neuroimaging and outcome in infants with cCMV. The severity of neuroimaging was found to be correlated with the outcome. Specifically, in infants with isolated WMAs, TPWMAs provided guidance for prognosis.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Pediatrics
Francesco Raimondi, Pasquale Dolce, Claudio Veropalumbo, Enrico Sierchio, Rebeca Gregorio Hernandez, Javier Rodriguez Fanjul, Fabio Meneghin, Roberto Raschetti, Luca Bonadies, Iuri Corsini, Almudena Alonso Ojembarrena, Serena Salome, Lorena Rodeno Fernandez, Manuel Sanchez Luna, Gianluca Lista, Fabio Mosca, Carlo Dani, Eugenio Baraldi, Lucio Giordano, Peter G. Davis, Letizia Capasso
Summary: This study validated a prognostic model based on LUS and SatO(2)/FiO(2) for early, customized surfactant administration in preterm infants, which may improve respiratory outcomes.
Review
Nutrition & Dietetics
Cristina Diez-Arroyo, Monica Garcia-Garcia, Maria Jose Soto-Mendez, Esther Molina-Montes, Mercedes Gil-Campos, Angel Gil, Miriam Gutierrez-Jimeno, Angela Hernandez-Ruiz
Summary: Epilepsy is a common neurological disorder in childhood, and despite antiepileptic drugs being the preferred treatment, a significant number of children continue to experience seizures. This review examines the use of a ketogenic diet (KD) as an alternative treatment for refractory epilepsy in children.
Article
Medicine, Research & Experimental
Iuri Corsini, Javier Rodriguez-Fanjul, Francesco Raimondi, Luca Boni, Alberto Berardi, Victoria Aldecoa-Bilbao, Almudena Alonso-Ojembarrena, Gina Ancora, Salvatore Aversa, Renzo Beghini, Nerea Bilbao Meseguer, Letizia Capasso, Francesca Chesi, Martina Ciarcia, Ana Concheiro, Luigi Corvaglia, Benjamim Ficial, Luca Filippi, Jesus Fuentes Carballal, Monica Fusco, Sara Gatto, Gemma Ginovart, Rebeca Gregorio-Hernandez, Gianluca Lista, Manuel Sanchez-Luna, Silvia Martini, Luca Massenzi, Francesca Miselli, Domenica Mercadante, Fabio Mosca, Marta Teresa Palacio, Alessandro Perri, Francesca Piano, Marcelino Pumarada Prieto, Lorena Rodeno Fernandez, Francesco Maria Risso, Marilena Savoia, Alex Staffler, Giovanni Vento, Carlo Dani
Summary: This study aims to determine whether the use of lung ultrasound score (LUS) as a decision tool for surfactant replacement therapy (SRT) in preterm infants with respiratory distress syndrome (RDS) can reduce the incidence of bronchopulmonary dysplasia (BPD) or death. A total of 668 spontaneously-breathing preterm infants, born at 25+0 to 29+6 weeks' gestation, will be randomized into a control group and a study group. The control group will receive SRT only when the fraction of inspired oxygen (FiO2) exceeds 0.3, while the study group will receive SRT if the LUS score is higher than 8 or the FiO2 requirements exceed 0.3. The primary outcome will be the difference in proportion of infants with BPD or death between the study and control groups.
Article
Obstetrics & Gynecology
Sara Vigil-Vazquez, Angela Manzanares, Alicia Hernanz-Lobo, Itziar Carrasco-Garcia, Clara Zamora del Pozo, Alba Perez-Perez, Elena Maria Rincon-Lopez, Begona Santiago-Garcia, Maria del Pilar Pintado-Recarte, Roberto Alonso-Fernandez, Manuel Sanchez-Luna, Maria Luisa Navarro-Gomez
Summary: This prospective study investigates the transplacental transfer of SARS-CoV-2 antibodies from pregnant women to their infants. The study finds that newborns can acquire SARS-CoV-2 antibodies from their mothers, but these antibodies decrease after birth. The levels of infant's antibodies are related to the maternal antibody levels at delivery. Further research is needed to understand the protective role of maternal antibodies in infants.
BMC PREGNANCY AND CHILDBIRTH
(2023)