Critical Review and Research Needs of Ozone Applications Related to Virus Inactivation: Potential Implications for SARS-CoV-2

Ozone disinfection has demonstrated high efficacy against enveloped and non-enveloped viruses, including viruses similar in morphology to SARS-CoV-2. Due to this efficacy, numerous gaseous and aqueous phase ozone applications have emerged to potentially inhibit virus persistence in aerosols, surfaces, and water. This review identifies the exposure requirements for virus inactivation and important safety considerations for applications within the built environment (i.e. occupied/unoccupied spaces, air/water/wastewater treatment) and healthcare settings (i.e. ozone therapy, dentistry, handwashing, treatment of personal protection equipment (PPE)). Current research needs are presented to advance the utilization of ozone as a mitigation strategy.

Automated summary

Ozone disinfection has shown high efficacy against enveloped and non-enveloped viruses, including those similar in morphology to SARS-CoV-2, making it a potential strategy to inhibit virus persistence in aerosols, surfaces, and water. This review outlines exposure requirements for virus inactivation and important safety considerations in various environments, presenting research needs to further enhance the utilization of ozone as a mitigation strategy.