Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors
Authors
Keywords
-
Journal
Oxidative Medicine and Cellular Longevity
Volume 2020, Issue -, Pages 1-11
Publisher
Hindawi Limited
Online
2020-12-09
DOI
10.1155/2020/4984927
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- PHASE 2 STUDY OF THE SAFETY AND EFFICACY OF BRIMONIDINE DRUG DELIVERY SYSTEM (BRIMO DDS) GENERATION 1 IN PATIENTS WITH GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION
- (2020) Baruch D. Kuppermann et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease
- (2020) Valérie Fontaine et al. Aging-US
- Pharmacological effects of saffron and its constituents in ocular disorders from in vitro studies to clinical trials; a systematic review
- (2020) Samaneh Sepahi et al. Current Neuropharmacology
- Crocetin Prevents RPE Cells from Oxidative Stress through Protection of Cellular Metabolic Function and Activation of ERK1/2
- (2020) Padideh Karimi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Complement inhibition as a therapeutic strategy in retinal disorders
- (2019) Enoch Kassa et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration
- (2019) Pravin U. Dugel et al. OPHTHALMOLOGY
- Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration.
- (2019) David S. Liao et al. OPHTHALMOLOGY
- Visual Function Metrics in Early and Intermediate Dry Age-related Macular Degeneration for Use as Clinical Trial Endpoints
- (2018) Kimberly J. Cocce et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Supplementation with macular carotenoids improves visual performance of transgenic mice
- (2018) Binxing Li et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- What do we know about the macular pigment in AMD: the past, the present, and the future
- (2018) Ranganathan Arunkumar et al. EYE
- The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration
- (2018) Monika Fleckenstein et al. OPHTHALMOLOGY
- Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT
- (2018) Srinivas R. Sadda et al. OPHTHALMOLOGY
- Modulatory effect of carotenoid supplement constituting lutein and zeaxanthin (10:1) on anti-oxidant enzymes and macular pigments level in rats
- (2018) Jayashree Madhavan et al. Pharmacognosy Magazine
- Attenuation of choroidal neovascularization by dietary intake of ω-3 long-chain polyunsaturated fatty acids and lutein in mice
- (2018) Ryoji Yanai et al. PLoS One
- MACULAR ATROPHY INCIDENCE IN ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR–TREATED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
- (2018) Irmela Mantel et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Subretinal Drusenoid Deposits AKA Pseudodrusen
- (2018) Richard F. Spaide et al. SURVEY OF OPHTHALMOLOGY
- Lutein and Zeaxanthin Isomers Protect against Light-Induced Retinopathy via Decreasing Oxidative and Endoplasmic Reticulum Stress in BALB/cJ Mice
- (2018) Minzhong Yu et al. Nutrients
- Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration
- (2018) Eunyoung Cho et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration
- (2018) Robert P. Finger et al. OPHTHALMOLOGICA
- Saffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trial
- (2018) Geoffrey K. Broadhead et al. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Characterization of Poor Visual Outcomes of Neovascular Age-related Macular Degeneration Treated with Anti–Vascular Endothelial Growth Factor Agents
- (2018) Chu Luan Nguyen et al. OPHTHALMOLOGY
- CUTICULAR DRUSEN
- (2018) Yoichi Sakurada et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects
- (2017) Miguel Roehrs et al. FOOD RESEARCH INTERNATIONAL
- Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells
- (2017) Katja Frede et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration
- (2017) Inês Laíns et al. OPHTHALMOLOGY
- The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
- (2017) Sayantan Datta et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model
- (2017) Mehmet Tuzcu et al. BMC Ophthalmology
- Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment
- (2017) Jean-François Korobelnik et al. JAMA Ophthalmology
- Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease
- (2016) Paul S. Bernstein et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Saffron reduces ATP-induced retinal cytotoxicity by targeting P2X7 receptors
- (2016) Lucia Corso et al. Purinergic Signalling
- Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo
- (2016) Valérie Fontaine et al. PLoS One
- Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling
- (2015) Ulrike Friedrich et al. HUMAN MOLECULAR GENETICS
- Parainflammation, chronic inflammation, and age-related macular degeneration
- (2015) M. Chen et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Impairments in Dark Adaptation Are Associated with Age-Related Macular Degeneration Severity and Reticular Pseudodrusen
- (2015) Jason Flamendorf et al. OPHTHALMOLOGY
- Longitudinal Changes in Microperimetry and Low Luminance Visual Acuity in Age-Related Macular Degeneration
- (2015) Zhichao Wu et al. JAMA Ophthalmology
- Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser Ophthalmoscopy
- (2014) Yuhua Zhang et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration
- (2014) Goldis Malek et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats
- (2014) Miguel Roehrs et al. International Journal of Endocrinology
- Secondary Analyses of the Effects of Lutein/Zeaxanthin on Age-Related Macular Degeneration Progression
- (2014) Emily Y. Chew et al. JAMA Ophthalmology
- Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
- (2014) Wan Ling Wong et al. Lancet Global Health
- CCR2+monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation inCx3cr1deficient mice
- (2013) Florian Sennlaub et al. EMBO Molecular Medicine
- The synergistic effect of exposure to alcohol, tobacco smoke and other risk factors for age-related macular degeneration
- (2013) Giuseppe La Torre et al. EUROPEAN JOURNAL OF EPIDEMIOLOGY
- Effective isolation protocol for secondary metabolites from Saffron: Semi-preparative scale preparation of crocin-1 and trans-crocetin
- (2013) Marcus Lautenschläger et al. FITOTERAPIA
- Nutrient Supplementation with n3 Polyunsaturated Fatty Acids, Lutein, and Zeaxanthin Decrease A2E Accumulation and VEGF Expression in the Retinas of Ccl2/Cx3cr1-Deficient Mice on Crb1rd8 Background
- (2013) Hema L. Ramkumar et al. JOURNAL OF NUTRITION
- Mechanisms of age-related macular degeneration and therapeutic opportunities
- (2013) Menno van Lookeren Campagne et al. JOURNAL OF PATHOLOGY
- Radical Scavenging Activity-Based and AP-1-Targeted Anti-Inflammatory Effects of Lutein in Macrophage-Like and Skin Keratinocytic Cells
- (2013) Jueun Oh et al. MEDIATORS OF INFLAMMATION
- New hope for dry AMD?
- (2013) James B. Evans et al. NATURE REVIEWS DRUG DISCOVERY
- Clinical Classification of Age-related Macular Degeneration
- (2013) Frederick L. Ferris et al. OPHTHALMOLOGY
- A Longitudinal Follow-Up Study of Saffron Supplementation in Early Age-Related Macular Degeneration: Sustained Benefits to Central Retinal Function
- (2012) M. Piccardi et al. Evidence-based Complementary and Alternative Medicine
- Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis
- (2012) ENRICA BIANCHI et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo
- (2012) Kazuhiro Tsuruma et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration
- (2011) Kati Kinnunen et al. ACTA OPHTHALMOLOGICA
- Age related macular degeneration and drusen: Neuroinflammation in the retina
- (2011) Elisa Buschini et al. PROGRESS IN NEUROBIOLOGY
- Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells
- (2010) Kyong Nyon Nam et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity
- (2010) Mika Yamauchi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Smoking history and the incidence of age-related macular degeneration—Results from the Muenster Aging and Retina Study (MARS) cohort and systematic review and meta-analysis of observational longitudinal studies
- (2009) Bruno Neuner et al. ADDICTIVE BEHAVIORS
- Forecasting Age-Related Macular Degeneration Through the Year 2050
- (2009) David B. Rein ARCHIVES OF OPHTHALMOLOGY
- Saffron yellow: characterization of carotenoids by high performance liquid chromatography with electrospray mass spectrometric detection
- (2009) Katarzyna Lech et al. JOURNAL OF MASS SPECTROMETRY
- Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration
- (2009) Marisol Cano et al. VISION RESEARCH
- Antioxidant supplements to prevent or slow down the progression of AMD: a systematic review and meta-analysis
- (2008) J Evans EYE
- Oxidative damage–induced inflammation initiates age-related macular degeneration
- (2008) Joe G Hollyfield et al. NATURE MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now