Acyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination

We describe a novel reagent system to obtain acyl fluorides directly from three different functional group precursors: carboxylic acids, aldehydes, or alcohols. The transformation is achieved via a combination of trichloroisocyanuric acid and cesium fluoride, which facilitates the synthesis of various acyl fluorides in high yield (up to 99%). It can be applied to the late-stage functionalization of natural products and drug molecules that contain a carboxylic acid, an aldehyde, or an alcohol group.

Automated summary

A novel reagent system allows for the direct synthesis of acyl fluorides from carboxylic acids, aldehydes, or alcohols with high yields up to 99%. This transformation is useful for late-stage functionalization of natural products and drug molecules containing a carboxylic acid, aldehyde, or alcohol group.