Article
Chemistry, Multidisciplinary
Ramona Clemen, Eric Freund, Daniel Mrochen, Lea Miebach, Anke Schmidt, Bernhard H. Rauch, Jan-Wilm Lackmann, Ulrike Martens, Kristian Wende, Michael Lalk, Mihaela Delcea, Barbara M. Broker, Sander Bekeschus
Summary: The study shows that reactive oxygen species (ROS/RNS) modifications play a crucial role in enhancing T cell activation. By using gas plasma technology to generate a variety of ROS/RNS, the research mimics inflammation and investigates their immunological significance, providing insights for future research in inflammation and oncology vaccination strategies.
Review
Immunology
Peng Zhang, Yuwen Su, Siying Li, Hui Chen, Ruifang Wu, Haijing Wu
Summary: This paper reviews the different subtypes of T lymphocytes and their functions in psoriasis, as well as provides an overview of targeted therapies for treating psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Qi An, Jingwen Zhao, Xueqing Zhu, Baoqi Yang, Zewen Wu, Yazhen Su, Liyun Zhang, Ke Xu, Dan Ma
Summary: This article explores the pathogenesis of Sjogrens syndrome caused by autoantibodies attacking salivary and lacrimal gland tissues, focusing on the role of T cells and therapeutic targeting of T cells for treatment of patients with SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiayi Tian, Chaoying Yan, Yanfang Jiang, Haohan Zhou, Liyuan Li, Jingjing Shen, Jian Wang, Hongyu Sun, Guang Yang, Wei Sun
Summary: The study found that mucosal-associated invariant T (MAIT) cells accumulate in the inflammatory intestinal tissues of necrotizing enterocolitis (NEC) patients, while the percentage of CD8αα(+) MAIT cells is significantly reduced. After treatment, the frequency of circulating MAIT cells in NEC patients significantly increases. The research results indicate the important role of MAIT cells in the pathogenesis of NEC.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Chen Dong
Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Review
Immunology
Ivon Johanna Rodriguez, Nicolas Lalinde Ruiz, Manuela Llano Leon, Laura Martinez Enriquez, Maria del Pilar Montilla Velasquez, Juan Pablo Ortiz Aguirre, Oscar Mauricio Rodriguez Bohorquez, Esteban Alejandro Velandia Vargas, Edgar Debray Hernandez, Carlos Alberto Parra Lopez
Summary: Aging leads to alterations in immune response, termed immunosenescence, characterized by decreased naive T cells and increased expression of CD57 and KLRG1 in memory T cells in older adults. Proinflammatory cytokines increase and telomere length decrease in old adult T cells. The heterogeneity and biases among studies hinder robust statistical analysis for identifying flow cytometry markers of T cell immunosenescence phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Christian Seebauer, Eric Freund, Tobias Dieke, Sybille Hasse, Maria Segebarth, Christoph Rautenberg, Hans-Robert Metelmann, Sander Bekeschus
Summary: This study investigates the potential therapeutic application of cold physical plasma technology in oral leukoplakia. The results demonstrate that cold plasma treatment can reduce lymphocyte infiltration and inflammation-related molecules in oral leukoplakia tissues. However, it is important to note that in idiopathically inflamed tissues, the treatment may also increase the secretion of another cytokine. These findings suggest that cold physical plasma technology has immunomodulatory properties that could be therapeutically significant in oral leukoplakia, but further research is needed to determine its efficacy in a larger cohort.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Oncology
Kevin Dang, Giulia Castello, Starlynn C. Clarke, Yuping Li, Aarti Balasubramani, Andrew Boudreau, Laura Davison, Katherine E. Harris, Duy Pham, Preethi Sankaran, Harshad S. Ugamraj, Rong Deng, Serena Kwek, Alec Starzinski, Suhasini Iyer, Wim van Schooten, Ute Schellenberger, Wenchao Sun, Nathan D. Trinklein, Roland Buelow, Ben Buelow, Lawrence Fong, Pranjali Dalvi
Summary: TNB-585, an anti-CD3xPSMA TCE, shows promising efficacy in vitro in inducing activation and proliferation of human T cells, killing PSMA(+) prostate tumor cells, and reducing cytokine release and regulatory T cell activation. In addition, TNB-585 demonstrates potent efficacy against patient-derived prostate tumors ex vivo and in vivo, suggesting it may be a promising therapy for mCRPC with lower incidence and severity of CRS compared to TCEs with high-affinity anti-CD3 domains.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Cornelia Schuster, Badr Kiaf, Teri Hatzihristidis, Anna Ruckdeschel, Janice Nieves-Bonilla, Yuki Ishikawa, Bin Zhao, Peilin Zheng, Paul E. Love, Stephan Kissler
Summary: CD5 is a negative regulator of lymphocyte function and plays a crucial role in modulating gut immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Vedika Mehra, Giulia Agliardi, Juliana Dias Alves Pinto, Manar S. Shafat, Amaia Cadinanos Garai, Louisa Green, Alastair Hotblack, Fred Arce Vargas, Karl S. Peggs, Anniek B. van der Waart, Harry Dolstra, Martin A. Pule, Claire Roddie
Summary: This study evaluated the use of AKT inhibitor (VIII) to enrich Tscm/Tcm subsets, aiming to improve the expansion and persistence of AUTO1. The results showed that AUTO1 manufactured with VIII exhibited Tscm/Tcm enrichment, improved expansion, and cytotoxicity in vitro, as well as superior antitumor activity in vivo. Moreover, VIII-induced AUTO1 showed Th1/Th17 skewing, increased polyfunctionality, and had a unique metabolic profile and autophagy signature, supporting enhanced expansion and cytotoxicity. Overall, AUTO1 generated with VIII may help overcome CD19+relapse.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Karen Anne-Marie Ullrich, Julia Derdau, Carsten Baltes, Alice Battistella, Gonzalo Rosso, Stefan Uderhardt, Lisa Lou Schulze, Li-Juan Liu, Mark Dedden, Marta Spocinska, Lucina Kainka, Marketa Kubankova, Tanja Martina Mueller, Nina-Maria Schmidt, Emily Becker, Oumaima Ben Brahim, Imke Atreya, Susetta Finotto, Iryna Prots, Stefan Wirtz, Benno Weigmann, Rocio Lopez-Posadas, Raja Atreya, Arif Buelent Ekici, Franziska Lautenschlaeger, Jochen Guck, Markus F. Neurath, Sebastian Zundler
Summary: IL-3 plays an important regulatory role in inflammatory bowel disease by altering the mechanical properties and migratory ability of T cells through changes in kinase phosphorylation and actin cytoskeleton structure. This results in increased deformability and enhanced egress of Tregs from the inflamed colon mucosa, leading to increased mucosal Treg abundance.
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Katherine Kelda Gomes de Castro, Pedro Henrique Lopes da Silva, Luciana Nahar dos Santos, Julia Monteiro Pereira Leal, Mylena Masseno de Pinho Pereira, Iris Maria Peixoto Alvim, Danuza Esquenazi
Summary: The study found that Treg cells decrease during leprosy reactional episodes, indicating an enhanced immune response. Changes in cytokine profile were also observed during reactional episodes.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Melanie Humeau, Katia Boniface, Charles Bodet
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dysregulated immune response and increased colonization of Staphylococcus aureus. The interaction between T cells and keratinocytes through cytokine release plays a key role in AD pathogenesis, with potential impact from virulence factors produced by Staphylococcus aureus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Atefeh Afsar, Min Chen, Zhenyu Xuan, Li Zhang
Summary: This article discusses the role of CD4(+) and CD8(+) T cells in Alzheimer's disease and their potential associations with amyloid beta protein, heme oxygenase, and impaired mitochondria. It also mentions the mathematical models of AD as an autoimmune disease involving these T cell types and the application of machine learning models considering CD4(+) and CD8(+) T cells.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Anatomy & Morphology
Stefan Kindler, Stefanie Samietz, Steffen Dickel, Maria Mksoud, Thomas Kocher, Christian Lucas, Christian Seebauer, Philine Doberschuetz, Birte Holtfreter, Henry Voelzke, Hans-Robert Metelmann, Till Ittermann
Summary: In a population-based sample in Northern Germany, the prevalence of potentially malignant disorders (PMD) was 0.9%, with homogenous leukoplakia being the most prevalent type. Risk factors for PMD included smoking, male sex, type 2 diabetes mellitus, and obesity. Recommendations were made for photographic documentation and enhanced training of medical and dental staff for the detection and monitoring of PMD.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)