Journal
DOMESTIC ANIMAL ENDOCRINOLOGY
Volume 56, Issue -, Pages S133-S146Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.domaniend.2016.03.005
Keywords
Mitochondrial DNA; Haplotype; Development; Genetic diversity; Somatic cell nuclear transfer
Funding
- Australian Pork Ltd. [APL2012-1024]
- Australian National Health and Medical Research Council [GNT1041471]
- Victorian Government's Operational Infrastructure Support Program
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The vast majority of cellular energy is generated through the process of oxidative phosphorylation, which takes place in the electron transport chain in the mitochondria. The electron transport chain is encoded by 2 genomes, the chromosomal and the mitochondrial genomes. Mitochondrial DNA is associated with a number of traits, which include tolerance to heat, growth and physical performance, meat and milk quality, and fertility. Mitochondrial genomes can be clustered into groups known as mtDNA haplotypes. Mitochondrial DNA haplotypes are a potential genetic source for manipulating phenotypes in farm animals. The use of assisted reproductive technologies, such as nuclear transfer, allows favorable chromosomal genetic traits to be mixed and matched with sought after mtDNA haplotype traits. As a result super breeds can be generated. (C) 2016 Elsevier Inc. All rights reserved.
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