Article
Oncology
Nuria Vaquero-Siguero, Nikolai Schleussner, Julia Volk, Manuel Mastel, Jasmin Meier, Rene Jackstadt
Summary: Colorectal cancer is one of the deadliest cancers globally, with metastasis being the main cause of patient mortality. The complex tumor ecosystem undergoes compositional changes at virtually every stage of CRC progression. However, clonal dynamics and associated niche-dependencies at these stages are currently unknown.
Article
Biochemistry & Molecular Biology
Yuan Li, Ling Wang, Xiaofeng Liu, Chunfeng Zhang, Xiaojuan Du, Baocai Xing
Summary: The study showed that NIR promotes progression of colorectal cancer by regulating RB function, potentially through inhibiting RB acetylation and promoting RB degradation. Downregulation of NIR may contribute to maintaining cellular homeostasis under DNA damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shuyu Yu, Weicheng Zang, Yuchong Qiu, Liming Liao, Xiaofeng Zheng
Summary: Aberrant regulation of ubiquitination can lead to metabolic reprogramming in tumor cells. OTUB2, an OTU deubiquitinase, is upregulated in colorectal cancer and exacerbates its progression by modulating aerobic glycolysis. Depletion of OTUB2 reduces glucose consumption, lactate production, and cellular ATP production, as well as sensitizing CRC cells to chemotherapy drugs.
Article
Oncology
Tengyang Ni, Zewen Chu, Li Tao, Yang Zhao, Miao Zhu, Yuanyuan Luo, Masataka Sunagawa, Haibo Wang, Yanqing Liu
Summary: PTBP1 is aberrantly highly expressed in gastric cancer and plays a crucial role in tumorigenesis and maintenance of stem-cell characteristics through stabilizing c-Myc protein. This study provides insights into the oncogenic role of PTBP1 and its involvement in gastric cancer progression.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Shi-Hai Yan, Li-Mu Hu, Xue-Hui Hao, Jiang Liu, Xi-Ying Tan, Zhi-Rong Geng, Jing Ma, Zhi-Lin Wang
Summary: This study revealed the direct binding target protein of berberine in colorectal cancer cells, which is pyruvate kinase isozyme type M2 (PKM2). Berberine inhibits the progression of colorectal cancer through hydrophobic interaction and pi-pi interaction, and it also inhibits the reprogramming of glucose metabolism.
Article
Oncology
William Tzu-Liang Chen, Han-Bin Yang, Tao-Wei Ke, Wen-Ling Liao, Shih-Ya Hung
Summary: Colorectal cancer is a common cancer in Taiwan, and DJ-1 plays a crucial role in predicting TNM stage and promoting cancer progression in colorectal cancer. Therefore, DJ-1 inhibition may be a potential therapeutic strategy for colorectal cancer treatment.
Article
Medicine, Research & Experimental
Chunqi Liu, Liang Wang, Xiaocong Liu, Yuping Tan, Lei Tao, Yuzhou Xiao, Pengchi Deng, Huijuan Wang, Qianyi Deng, Yiyun Lin, Hui Jie, Huaqin Zhang, Jing Zhang, Yong Peng, Hu Zhang, Zongguang Zhou, Qingxiang Sun, Xiaobo Cen, Yinglan Zhao
Summary: The study revealed a novel nonmetabolic function of SHMT2 in stabilizing beta-catenin to prevent its ubiquitylation-mediated degradation, providing a potential therapeutic strategy for colorectal cancer therapy.
Article
Biochemistry & Molecular Biology
Gang Zhao, Hang Yuan, Qin Li, Jie Zhang, Yafei Guo, Tianyu Feng, Rui Gu, Deqiong Ou, Siqi Li, Kai Li, Ping Lin
Summary: This study uncovers the significant role of DDX39B in modulating glycolytic reprogramming and aggressive progression in colorectal cancer (CRC). The upregulation of DDX39B is associated with liver metastases and aggressive phenotypes in CRC patients. Mechanistically, DDX39B activates PKM2 by suppressing its ubiquitination and degradation, leading to enhanced glucose uptake and lactate production. DDX39B also accelerates the nuclear translocation of PKM2 to transactivate oncogenes and glycolysis-related genes, promoting CRC growth and metastasis. Furthermore, blocking PKM2 nuclear translocation or glycolytic inhibition efficiently abolishes DDX39B-triggered malignant development in CRC, highlighting DDX39B as a potential therapeutic target.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Diyuan Zhou, Yizhou Yao, Liang Zong, Guoqiang Zhou, Min Feng, Junjie Chen, Ganggang Liu, Guoliang Chen, Kang Sun, Huihui Yao, Yu Liu, Xinyu Shi, Weigang Zhang, Bo Shi, Qingliang Tai, Guanting Wu, Liang Sun, Wenqing Hu, Xinguo Zhu, Songbing He
Summary: Intestinal inflammation is a key factor in the development of colorectal cancer (CRC). Recent studies have shown that TBK1, a downstream enzyme of inflammatory signals, plays a role in CRC progression by inhibiting mTORC1 signaling and increasing GLUT1 expression and translocation, leading to enhanced glucose consumption. This finding provides a new therapeutic strategy for CRC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qing Xiao, Yaqi Gan, Yimin Li, Lili Fan, Jiaqi Liu, Pengyan Lu, Jiaxin Liu, Aoao Chen, Guang Shu, Gang Yin
Summary: The study identified MEF2A as a critical oncogene in promoting growth and metastasis of CRC, with potential as a novel therapeutic target for intervention. Aberrant expression of MEF2A in CRC clinical specimens was significantly associated with poor prognosis and metastasis, indicating its important role in the disease progression.
Article
Oncology
Xinyu Jiang, Wenfei Du, Chenglong Yang, Shuying Wang, Yifei Li, Xinzhuang Shen, Xiaowen Yang, Jie Yao, Renle Du, Xiaoyuan Zhang, Yongming Huang, Wenzhi Shen
Summary: This study found that the expression of TBX21 is significantly decreased in colorectal cancer and negatively correlated with tumor stages. Ectopic expression of TBX21 inhibits cell proliferation and promotes apoptosis. Furthermore, TBX21 inhibits colorectal tumor progression through the ARHGAP29/RSK/GSK3 beta signaling pathway.
Article
Cell Biology
Peng Yang, Dongsheng Zhang, Tuo Wang, Jiangzhou Ji, Chi Jin, Chaofan Peng, Yuqian Tan, Jiahui Zhou, Lu Wang, Yifei Feng, Yueming Sun
Summary: In this study, it was found that WEE2-AS1 is highly expressed in CAF-derived sEVs in the tumor microenvironment. The level of WEE2-AS1 is elevated in plasma sEVs of CRC patients, which is associated with advanced pathological staging and poor survival. Functional experiments revealed that elevated expression of WEE2-AS1 in sEVs increases CRC cell proliferation and promotes tumor formation and progression. Mechanistically, WEE2-AS1 interacts with MOB1A, inhibits the Hippo pathway, and facilitates the growth of CRC cells.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Bohan Chen, Yiping Ma, Jinfang Bi, Wenbin Wang, Anshun He, Guangsong Su, Zhongfang Zhao, Jiandang Shi, Lei Zhang
Summary: The study revealed the regulatory network of colorectal-cancer-specific enhancers, which are associated with changes in over 50% of the topological associated domains (TADs) and interact with 152 genes that are significantly highly expressed in colorectal cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jia Hu, Xueliang Ding, Shaobo Tian, Yanan Chu, Zhibo Liu, Yuqin Li, Xiaoqiong Li, Guobin Wang, Lin Wang, Zheng Wang
Summary: TRIM39, upregulated in colorectal cancer tissues, plays a crucial role in promoting cancer progression by regulating autophagy pathway and p53 degradation, establishing a functional relationship between autophagy and CRC progression.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jie Cui, Jiale Tian, Weiwei Wang, Tao He, Xin Li, Chenzheng Gu, Lixin Wang, Jian Wu, Anquan Shang
Summary: IGF2BP2 activates ErbB2 expression by recognizing the m6A modification of YAP, thus promoting proliferation and invasion of CRC cells while inhibiting apoptosis.