Review
Chemistry, Multidisciplinary
Nayeon Kang, Subin Son, Sunhong Min, Hyunsik Hong, Chowon Kim, Jusung An, Jong Seung Kim, Heemin Kang
Summary: Ferroptosis, an iron-dependent programmed cell death mechanism, can be regulated by intracellular iron supplementation and glutathione synthesis inhibition. Utilizing various endogenous and exogenous stimuli, such as tumor microenvironment conditions and external energy sources, can provide precise control and controllability for ferroptosis-based cancer therapy. The utilization of dual stimuli provides a new direction for efficient cancer therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Cell Biology
Nicole Rufo, Yihan Yang, Steven De Vleeschouwer, Patrizia Agostinis
Summary: Disrupted endoplasmic reticulum (ER) homeostasis in cancer cells is characterized by maladaptive unfolded protein response (UPR) signaling, which sustains proteostasis and metabolism reprogramming, and fosters proinflammatory pathways promoting tissue repair and protumorigenic immune responses. However, when cancer cells are exposed to conditions causing irreparable ER homeostasis, the UPR switches to a cell death program, eliciting immunogenic cell death (ICD) with proinflammatory traits.
Review
Genetics & Heredity
Marco Corazzari, Licio Collavin
Summary: Cancer cells within tumor masses are exposed to various stressors and accumulate mutations, contributing to their adaptation to chronic stress. One extreme outcome of chronic stress is ferroptosis, a form of cell death mediated by lipid peroxidation. The tumor suppressor p53 and its cancer-related mutants play a role in modulating ferroptosis, potentially impacting cancer treatment options.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Krishan Kumar Saini, Priyank Chaturvedi, Abhipsa Sinha, Manish Pratap Singh, Muqtada Ali Khan, Ayushi Verma, Mushtaq Ahmad Nengroo, Saumya Ranjan Satrusal, Sanjeev Meena, Akhilesh Singh, Sameer Srivastava, Jayanta Sarkar, Dipak Datta
Summary: Ferroptosis is a distinct form of programmed cell death characterized by iron-dependent accumulation of lipid peroxides. Therapy-resistant tumor cells are vulnerable to ferroptosis. Modulating the balance of unfolded protein response (UPR) in cancer cells to make them susceptible to ferroptotic cell death could be a promising therapeutic strategy.
Article
Immunology
Jin'en Wu, Zhihui Zhang, Zhidong Teng, Sahibzada Waheed Abdullah, Shiqi Sun, Huichen Guo
Summary: The study revealed the important role of ER stress and autophagy in foot-and-mouth disease virus (FMDV) infection, with Sec62 playing a crucial regulatory role in this process. Sec62 promotes maintaining and restoring ER homeostasis by activating the IRE1α-JNK pathway and delivering autophagosomes into lysosomes, ultimately facilitating FMDV clearance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoguang Lv, Zheyu Fan, Fangqi Cao, Wenbin Liu, Zhiwei Huang, Ping Shi
Summary: The study found that CQ induces autophagy and S-phase cell cycle arrest by decreasing intracellular Ca2+ concentration and down-regulating CRT expression. This study provides the first evidence of the cellular signal pathways regulating CQ-induced autophagy by modulating CRT expression in neurotypic cells, and highlights the potential therapeutic application of CQ in neurodegenerative disorders.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Marine & Freshwater Biology
Ye Zhao, Huiling Wang, Priscilla Agyemang Duah, Vladimir Retyunskiy, Yizheng Liu, Guoguang Chen
Summary: This study investigates the embryonic toxicogenomic responses induced by Zinc pyrithione (ZPT) in zebrafish. The results show that ZPT treatment causes embryogenesis toxicity, including irregular cell division and rearrangement, delayed differentiations of eyes and notochords, and defects in epiboly and germ ring formation and somite segmentation. ZPT exposure also alters gene expression during early embryonic development, leading to morphological abnormalities and metabolic dysfunctions. Additionally, ZPT induces oxidative stress, apoptosis, endoplasmic reticulum (ER) stress, and autophagy.
AQUATIC TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francisco Jose Martinez-Amaro, Carlos Garcia-Padilla, Diego Franco, Houria Daimi
Summary: The endoplasmic reticulum (ER) is crucial for protein quality control and maintaining protein homeostasis. ER stress triggers various molecular mechanisms such as ERAD, UPR, and reticulophagy to restore protein balance. Failure to alleviate ER stress leads to apoptosis and cardiovascular diseases. The roles of microRNAs, as well as lncRNAs and circRNAs, in modulating ER stress response and their impact on cardiovascular diseases are discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jingbo Li, Jiao Liu, Yinghua Xu, Runliu Wu, Xin Chen, Xinxin Song, Herbert Zeh, Rui Kang, Daniel J. Klionsky, Xiaoyan Wang, Daolin Tang
Summary: Autophagy plays a complex role in cellular stress and can either promote survival or trigger death. Recent evidence suggests that the molecular machinery of autophagy facilitates ferroptosis, a regulated cell death process. The study found tumor heterogeneity in autophagy-dependent ferroptosis, showing different biological behaviors in terms of cell death dynamics.
Article
Cell Biology
Pau Munoz-Guardiola, Josefina Casas, Elisabet Megias-Roda, Sonia Sole, Hector Perez-Montoyo, Marc Yeste-Velasco, Tatiana Erazo, Nora Dieguez-Martinez, Sergio Espinosa-Gil, Cristina Munoz-Pinedo, Guillermo Yoldi, Jose L. Abad, Miguel F. Segura, Teresa Moran, Margarita Romeo, Joaquim Bosch-Barrera, Ana Oaknin, Jose Alfon, Carles Domenech, Gemma Fabrias, Guillermo Velasco, Jose M. Lizcano
Summary: ABTL0812 induces cytotoxic autophagy in cancer cells by increasing cellular long-chain dihydroceramides and impairing DEGS1 activity, leading to sustained ER stress and activation of the unfolded protein response (UPR). This discovery suggests that manipulation of dihydroceramide levels could be a new therapeutic strategy for targeting cancer.
Article
Plant Sciences
Ning Han, Zi-Yi Yang, Zhong-Xiong Xie, Hua-Zhen Xu, Ting-Ting Yu, Qi-Rui Li, Liu-Gen Li, Xing-Chun Peng, Xiao-Xin Yang, Jun Hu, Xiang Xu, Xiao Chen, Mei-Fang Wang, Tong-Fei Li
Summary: This study demonstrates that DHA can promote immunogenic cell death in lung cancer by inducing ferroptosis and increasing endoplasmic reticulum stress and DNA damage. These findings provide novel insights into the regulation of the immune microenvironment for cancer immunotherapy by Chinese medicine phytopharmaceuticals.
Article
Pharmacology & Pharmacy
Tarek Khamis, Abdelalim F. Abdelalim, Ahmed A. Saeed, Nagah M. Edress, Alaa Nafea, Huda F. Ebian, Reem Algendy, Doaa M. Hendawy, Ahmed Hamed Arisha, Somia Hassan Abdallah
Summary: The study revealed that intraperitoneally transplanted Br-MSCs homed to the diabetic islet, improving fasting blood glucose, serum insulin level, and pancreatic oxidative stress, and modulated various molecular pathways involved in beta-cell dysfunction, indicating their potential as a new insight in beta cell regenerative therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Shuang Wang, Guangsuo Wang, Weiqing Wu, Zhenglei Xu, Jing Yang, Min Cao, Qi Wang, Jigang Wang, Chuanbin Yang, Wei Zhang
Summary: This study finds that piceatannol, a dietary phenolic compound, can enhance the anticancer immune response induced by the chemotherapy drug oxaliplatin (OXA) through inducing autophagy. Piceatannol promotes the release of immune response-triggering substances and improves the efficacy of chemotherapy. Additionally, piceatannol induces endoplasmic reticulum stress, leading to increased cell surface exposure of calreticulin. The combination of piceatannol and OXA also enhances the anticancer effects in immunocompetent mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Rashedul Alam, Mohammad Fazlul Kabir, Hyung-Ryong Kim, Han-Jung Chae
Summary: Cancer cells adapt autophagy as a protective mechanism to counter stress, but the role of autophagy in tumorigenesis and drug resistance is complex and controversial. Accelerated autophagy poses a challenge for anticancer therapy, and addressing noncanonical ER stress or UPR components is an effective approach to suppress cytoprotective autophagy.
Article
Multidisciplinary Sciences
Lanlan Tang, Yan Yu, Wenjun Deng, Jiao Liu, Yichun Wang, Fanghua Ye, Rui Kang, Daolin Tang, Qingnan He
Summary: A study has identified a mechanism of ferroptosis resistance involving the upregulation of TXNDC12, which inhibits lipid peroxidation without affecting iron accumulation during ferroptosis. The study also found that the absence of TXNDC12 enhances the tumor-suppressive effects of ferroptosis induction. These findings demonstrate a potential translational application in cancer treatment.
Article
Biochemistry & Molecular Biology
Yu Zhou, Xuehong Chen, Xiao Li, Yantao Han, Yanan Wang, Ruyong Yao, Shangyong Li
Article
Chemistry, Medicinal
Yanan Wang, Xuehong Chen, Xiaolin Bi, Yining Ren, Qi Han, Yu Zhou, Yantao Han, Ruyong Yao, Shangyong Li
Review
Biochemistry & Molecular Biology
He Miao, Xuehong Chen, Yepeng Luan
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Food Science & Technology
Xi Zeng, Xuehong Chen, Huan Qin, Yantao Han, Xiuping Chen, Zhiwu Han, Wenwen Zhao
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yuliang Dong, Wenjuan Ding, Changli Sun, Xiaoqi Ji, Chunyao Ling, Zhenbin Zhou, Zhiyun Chen, Xuehong Chen, Jianhua Ju
CHEMISTRY & BIODIVERSITY
(2020)
Article
Chemistry, Medicinal
Dandan Li, Shangyong Li, Yanhong Wu, Mengfei Jin, Yu Zhou, Yanan Wang, Xuehong Chen, Yantao Han
Review
Materials Science, Biomaterials
Xinlong Zang, Jingyi Zhou, Xiaoxu Zhang, Yantao Han, Xuehong Chen
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Pharmacology & Pharmacy
Xinlong Zang, Jingyi Zhou, Xiaoxu Zhang, Dawei Chen, Yantao Han, Xuehong Chen
Summary: CaZOL@BMNPs is a dual-targeting drug delivery system that reduced angiogenesis, reprogrammed the immunosuppressive tumor microenvironment, and inhibited the progression of NSCLC with negligible systemic toxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Microbiology
Qiuling Zheng, Xiangjun Meng, Mingyang Cheng, Yanfeng Li, Yuanpeng Liu, Xuehong Chen
Summary: Chitosanase CsnS, cloned from a deep-sea bacterium and over-expressed in E. coli, is a cold-adapted enzyme with high activity at 60°C. It exhibits an endo-type cleavage pattern and can hydrolyze chitosan polymers to yield disaccharides and trisaccharides, making it a potential candidate for industrial production of COS.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kangkang Li, Xinlong Zang, Mingyang Cheng, Xuehong Chen
Summary: Recent progresses in fighting against cancer include better understanding of tumor microenvironment and rapid development in nanoscale drug delivery system. Nanocarriers based on polymeric acrylic derivatives have shown high drug encapsulation rate and satisfactory therapeutic outcome in tumor treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Yanan Wang, Wenyan Wang, Xuejiao Yang, Wenshi Chen, Xian Yang, Xiaojing Pan, Peilong Xu, Wei Zhu, Yantao Han, Xuehong Chen
Summary: Cells expressing ITGA8 in the Schlemm's canal region exhibit more properties as Schlemm's canal endothelial cells, indicating a crucial role of ITGA8 in regulating aqueous humor outflow resistance.
Article
Pharmacology & Pharmacy
Xiaojing Fu, Wenwen Zhao, Kangkang Li, Jingyi Zhou, Xuehong Chen
Summary: The study reveals the anticancer effects of cryptotanshinone (CPT) in colorectal cancer (CRC) by activating autophagy signaling mediated by ER stress. CPT selectively inhibits the growth and proliferation of HCT116 and SW620 cells while having little effect on SW480 cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xinlong Zang, Mingyang Cheng, Xiaoxu Zhang, Xuehong Chen
Summary: Phytochemicals like quercetin are being explored for their potential in preventing and treating diseases, particularly cancer. While quercetin faces limitations as an antitumor drug, nanoparticles have shown promise in delivering it to diseased tissues, with high encapsulation efficiency, stability, sustained release, and improved therapeutic efficiency.
Review
Materials Science, Biomaterials
Xinlong Zang, Mingyang Cheng, Xiaoxu Zhang, Xuehong Chen
Summary: Atherosclerosis is a major vascular disease worldwide, with macrophages playing a crucial role in its development and inflammatory responses. Targeting macrophages with nanoparticle-based drugs can improve therapeutic outcomes and reduce toxicity.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
