4.3 Article

Beyond nosology? Molecular tumor boards, singularization, and the conflation of diagnosis and therapy

Journal

NEW GENETICS AND SOCIETY
Volume 40, Issue 1, Pages 95-111

Publisher

ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/14636778.2020.1853512

Keywords

Molecular tumour boards; precision oncology; diagnosis; theranostics; targeted therapies; singularization

Funding

  1. French National Cancer Institute [INCa 2014-123, SHSESP 19-044]
  2. Canadian Institutes of Health Research [MOP-133687, PJT-162252]

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The article explores the role of Molecular Tumor Boards in precision oncology, highlighting how they enable innovative treatments and connect individual patient diagnoses to the revision of diagnostic categories. These categories now serve as predictive guides to therapy, shifting beyond traditional diagnostic roles.
This article partakes in a number of recent attempts to map the reconfiguration of clinical work as part of the deployment of precision oncology. We focus on the platforms, in particular Molecular Tumor Boards, that act as a condition of possibility for implementing innovative experimental interventions, and which are part of the emergence, beyond the traditional confines of diagnosis, of a data ecosystem geared towards increasing patient access to drugs matched to their genomic profile. MTBs are a key component of this singularization process, and their activities are central to the looping mechanisms that connect the diagnosis of individual patients to the revision of diagnostic categories. These categories are no longer merely diagnostic but operate as predictive guides to therapy.

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