Review
Biochemistry & Molecular Biology
Francesco Bruno, Alessia Pellerino, Luca Bertero, Riccardo Soffietti, Roberta Ruda
Summary: This article reviews recent progress in the molecular understanding of and therapeutic options for rare brain tumors in both children and adults, showing how specific molecular treatments can improve neurological symptoms and quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Patricia M. R. Pereira, Jalen Norfleet, Jason S. Lewis, Freddy E. Escorcia
Summary: In this study, the utility of RTK-targeted immuno-PET was demonstrated in annotating RTK changes in protein expression and informing tumor response to targeted therapies. Targeted treatments affecting tumor growth and RTK protein levels were observed, highlighting the importance of annotating changes in RTK expression for targeted therapy.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Oncology
Maheetha Bharadwaj, Mounica Vallurupalli, Franklin W. Huang
Summary: The article calls for improving access to precision oncology therapies in lower- and middle-income countries, highlighting lack of diagnostic ability, trained providers, and drug availability as significant barriers to cancer care delivery. It draws upon lessons from international efforts in oncology and infectious disease to make this urgent call to action.
Review
Pharmacology & Pharmacy
Riya Joshi, Hemi Missong, Jayapriya Mishra, Satinder Kaur, Sumant Saini, Ramesh Kandimalla, P. Hemachandra Reddy, Arockia Babu, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti
Summary: This review provides a comprehensive analysis of the latest advancements in the field of nanotheranostics for the treatment and monitoring of neurological disorders. It explores targeted drug delivery systems, gene therapy, and non-invasive imaging techniques, and discusses the potential and challenges of nanotheranostics in revolutionizing the management of neurological disorders. The review also outlines future research directions and potential strategies to overcome limitations, paving the way for the clinical translation of nanotheranostics.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Oncology
Apostolia M. Tsimberidou, Michael Kahle, Henry Hiep Vo, Mehmet A. Baysal, Amber Johnson, Funda Meric-Bernstam
Summary: In the past 15 years, significant progress has been made in developmental therapeutics, particularly in the use of matched targeted therapies against specific molecular alterations in cancer. Molecular tumour boards (MTBs) have emerged as crucial platforms for reviewing and interpreting molecular-profiling data to match patients with appropriate targeted therapies in precision oncology.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Oncology
S. L. Groenland, R. A. G. van Eerden, K. Westerdijk, M. Meertens, S. L. W. Koolen, D. J. A. R. Moes, N. de Vries, H. Rosing, H. Otten, A. J. E. Vulink, I. M. E. Desar, A. L. T. Imholz, H. Gelderblom, N. P. van Erp, J. H. Beijnen, R. H. J. Mathijssen, A. D. R. Huitema, N. Steeghs, Dutch Pharmacology Oncology Grp DPOG
Summary: Pharmacokinetically guided dose optimization of oral targeted therapies is feasible in clinical practice and significantly reduces the proportion of underexposed patients.
ANNALS OF ONCOLOGY
(2022)
Review
Oncology
Selene Cipri, Giada Del Baldo, Francesco Fabozzi, Luigi Boccuto, Andrea Carai, Angela Mastronuzzi
Summary: Significant advancements have been made in the discovery of targetable lesions in pediatric low-grade gliomas (pLGGs) in the past decade. The latest WHO classification of pLGGs emphasizes molecular characterization for prognosis, diagnosis, management, and potential target treatment. Molecular characterization has revealed that pLGGs with similar appearances can have different genetic and molecular characteristics, leading to the classification of distinct subtypes. This approach holds great promise for improving outcomes for pLGGs patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anthony Tarabay, Alice Boileve, Cristina Smolenschi, Leony Antoun, Marine Valery, Alina Fuerea, Audrey Perret, Pascal Burtin, Simona Cosconea, Hichem Belkhodja, David Malka, Valerie Boige, Antoine Hollebecque, Michel Ducreux
Summary: This retrospective study analyzed the use of molecular profiling for personalized medicine in advanced PDAC patients. It found that more than a quarter of patients had actionable gene alterations, but targeted therapies did not improve overall survival. However, specific gene alterations and targeted therapy combinations were associated with better outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ning Zhao, Yangjie Huang, Yung-hua Wang, Ryan K. Muir, Ying-Chu Chen, Junnian Wei, Nima Hooshdaran, Pavithra Viswanath, Youngho Seo, Davide Ruggero, Adam R. Renslo, Michael J. Evans
Summary: New chemical reactions have recently emerged to exploit the altered state of iron in cancer cells therapeutically, by targeting the expanded cytosolic labile iron pool (LIP) to induce cytotoxic effects or trigger ferroptosis. Implementing LIP-targeted therapies effectively will require biomarkers to identify tumors with the highest LIP levels and thus the most likely to respond to such interventions.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Xubin Li, Elisabeth K. Dowling, Gonghong Yan, Zeynep Dereli, Behnaz Bozorgui, Parisa Imanirad, Jacob H. Elnaggar, Augustin Luna, David G. Menter, Patrick G. Pilie, Timothy A. Yap, Scott Kopetz, Chris Sander, Anil Korkut
Summary: The study presents a comprehensive resource of precision combination therapies tailored to oncogenic coalterations. The resource is generated using the REFLECT method, which integrates machine learning and cancer informatics algorithms. Validations show that REFLECT-selected therapies have significantly improved efficacy and patient survival outcomes.
Article
Oncology
Stefanie L. Groenland, Remy B. Verheijen, Markus Joerger, Ron H. J. Mathijssen, Alex Sparreboom, Jos H. Beijnen, Jan H. Beumer, Neeltje Steeghs, Alwin D. R. Huitema
Summary: In the era of precision medicine, personalized dosing based on pharmacokinetic exposure is rational and supported by evidence. The debate on whether randomized studies are needed to confirm the clinical value of precision dosing in oncology continues. Personalized dosing, extrapolating from selected patient populations to each individual with suboptimal exposure, could potentially lead to better treatment outcomes without the need for confirmatory trials.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Rille Pihlak, Caroline Fong, Naureen Starling
Summary: Stomach cancer is an aggressive disease with poor survival outcomes, but in the past two decades, clinical research has made significant progress in understanding targets and potential targeted treatments for advanced stomach cancer. This article summarizes the recent advancements in targeted therapies and precision medicine in gastric cancer and discusses new potential treatments.
Review
Endocrinology & Metabolism
Katharina Wang, Joakim Crona, Felix Beuschlein, Ashley B. Grossman, Karel Pacak, Svenja Noelting
Summary: Molecular targeted therapy plays an important role in the treatment of metastatic pheochromocytomas and paragangliomas. Some therapies are already in use with promising results, while others are still under evaluation in clinical trials. The development of molecular targeted therapies is of great significance for future tumor treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Oncology
Ilaria Bertacca, Francesco Pegoraro, Annalisa Tondo, Claudio Favre
Summary: The treatment of childhood solid cancer has evolved with refined molecular characterization and the use of targeted drugs. Larger sequencing studies have identified different mutations in pediatric tumors compared to adults. However, targeted drugs have shown inconsistent results in preclinical and clinical studies, and many have been tested only in relapsed or refractory patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Alexandra Foster, Shubhanchi Nigam, David S. Tatum, Itay Raphael, Jide Xu, Rajeev Kumar, Elizabeth Plakseychuk, Joseph D. Latoche, Sarah Vincze, Bo Li, Rajan Giri, Lauren H. McCarl, Robert Edinger, Murat Ak, Vishal Peddagangireddy, Lesley M. Foley, T. Kevin Hitchens, Rivka R. Colen, Ian F. Pollack, Ashok Panigrahy, Darren Magda, Carolyn J. Anderson, W. Barry Edwards, Gary Kohanbash
Summary: Researchers successfully labeled CD11b antibody using a bifunctional chelator Lumi804 to image and treat TAMCs in murine gliomas. The Lu-177-Lumi804-alpha CD11b treatment not only reduced TAMC population but also improved the efficacy of immunotherapy.
Correction
History & Philosophy Of Science
Etienne Vignola-Gagne, Peter Keating, Alberto Cambrosio
HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES
(2018)
Article
History & Philosophy Of Science
Etienne Vignola-Gagne, Peter Keating, Alberto Cambrosio
HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES
(2017)
Article
Computer Science, Interdisciplinary Applications
Oriana Rainho Bras, Jean-Philippe Cointet, Alberto Cambrosio, Leonor David, Joao Arriscado Nunes, Fatima Cardoso, Carmen Jeronimo
Article
Biotechnology & Applied Microbiology
Alberto Cambrosio, Peter Keating, Etienne Vignola-Gagne, Sylvain Besle, Pascale Bourret
NEW GENETICS AND SOCIETY
(2018)
Editorial Material
Oncology
Stephanie Cox, Marina Rousseau-Tsangaris, Nancy Abou-Zeid, Stephane Dalle, Pierre Leurent, Arnaud Cutivet, Hai-Ha Le, Shady Kotb, Brenda Bogaert, Robert Gardette, Yusuf Baran, Jean-Marc Holder, Larisa Lerner, Jean-Yves Blay, Alberto Cambrosio, Olivier Tredan, Patrice Denefle
BULLETIN DU CANCER
(2019)
Article
Public, Environmental & Occupational Health
Alberto Cambrosio, Jonah Campbell, Peter Keating, Pascale Bourret
Summary: This paper examines the development and marketing strategies of five multi-gene tests, also known as tumor signatures, which are designed to assist clinicians and cancer patients in making therapeutic decisions and avoiding overtreatment. It expands on the previous research by analyzing the scripts embedded in these tests and considering the multi-polar nature of the space within which they position themselves. The study also explores the valuation processes and debates surrounding the comparison criteria for these assays. It highlights the involvement of the cancer diagnostic industry in reconfiguring the socio-technical, techno-scientific, and regulatory environment that combines commercial and scientific considerations.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Alberto Cambrosio, Jonah Campbell, Peter Keating, Jessica B. Polk, Adriana Aguilar-Mahecha, Mark Basik
Summary: This paper examines how oncologists enact policies in precision oncology projects, focusing on trials in the US, the Netherlands, Canada, and Scandinavia. These trials aim to transform evidential processes, provide access to biomarker-driven treatments, and recenter professional organizations around research. By analyzing the design and implementation of these trials, the paper sees them as a form of (onco)policy by other means.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Alberto Cambrosio, Jonah Campbell, Alexander E. Drilon, Peter Keating, Jess B. Polk
Summary: Based on fieldwork at a cancer institution, this study explores decision-making processes in the early stages of drug development. The research reveals that these decision-making practices integrate technical-scientific concerns with patient-oriented clinical ones, as part of the institutional assetization of biomedical knowledge production. These practices shape the socio-material ecosystem of precision oncology, defining the conditions for care provision.
SOCIOLOGY OF HEALTH & ILLNESS
(2023)
Article
Information Science & Library Science
Alberto Cambrosio, Jean-Philippe Cointet, Alexandre Hannud Abdo
QUANTITATIVE SCIENCE STUDIES
(2020)
Article
Public, Environmental & Occupational Health
Pascale Bourret, Alberto Cambrosio
SOCIOLOGY OF HEALTH & ILLNESS
(2019)
Article
History & Philosophy Of Science
Peter Keating, Alberto Cambrosio, Nicole C. Nelson
STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C-STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDICAL SCIENCES
(2016)