Article
Clinical Neurology
Andrew J. Ross, Alexandra L. Roule, Christen M. Deveney, Kenneth E. Towbin, Melissa A. Brotman, Ellen Leibenluft, Wan-Ling Tseng
Summary: In response to frustration, youths with bipolar disorder (BD) exhibit positive connectivity between the inferior frontal gyrus (IFG) and ventromedial prefrontal cortex (vmPFC) but lack negative connectivity between the striatum and insula. Following frustration, BD youths show elevated connectivity between the IFG and parahippocampal gyrus (PHG)/periaqueductal gray (PAG) and decreased connectivity between the amygdala and cerebellum during attention orienting.
Review
Neurosciences
Corey Horien, Dorothea L. Floris, Abigail S. Greene, Stephanie Noble, Max Rolison, Link Tejavibulya, David O'Connor, James C. McPartland, Dustin Scheinost, Katarzyna Chawarska, Evelyn M. R. Lake, R. Todd Constable
Summary: This article reviews the use of predictive modeling in understanding autism through measures of functional connectivity and symptoms, and discusses how different frameworks can improve our understanding of the neural basis of complex symptoms. The article highlights the need to consider factors such as data decay and sampling biases in study interpretation, and suggests exciting future directions for predictive modeling in autism.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Danting Meng, Suiping Wang, Patrick C. M. Wong, Gangyi Feng
Summary: This study aimed to identify the neural signatures underlying individual differences in semantic processing (SP) by analyzing functional connectivity patterns. The results showed that functional connectivity patterns within a semantic brain network were predictive of individual SP scores. These findings contribute to our understanding of the neural sources of individual differences in SP and have implications for personalized education and intervention.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Virginia Carter Leno, Georgia Forth, Susie Chandler, Philippa White, Isabel Yorke, Tony Charman, Andrew Pickles, Emily Simonoff
Summary: The study found an association between irritability and the slope of behavioral and physiological responses, with higher levels of irritability being associated with a dampened response. This suggests that a non-adaptive response to frustration may be a biological mechanism underlying irritability in autistic youth.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2021)
Article
Clinical Neurology
Alaa K. Mohamed, Paul E. Croarkin, Manish K. Jha, Jennifer L. Vande Voort
Summary: This study aimed to evaluate whether early improvement in irritability predicts improvement in depression severity. The results showed that reduction in irritability was associated with better outcomes in depressive symptoms. Further research is needed to assess the burden of irritability, explore it as a measurement-based care tool, and develop targeted treatments for irritability.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Developmental
Michael S. Gaffrey, Deanna M. Barch, Joan L. Luby, Steven E. Petersen
Summary: The study found that right amygdala-medial PFC functional connectivity is positively associated with child emotion regulation ability, negatively associated with child negative affect, and negatively associated with right amygdala reactivity to facial expressions of emotion. Right amygdala-mPFC functional connectivity also statistically mediated the relationship between heightened right amygdala reactivity and elevated child negative affect, suggesting an important role in early emotional development.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Anesthesiology
Natoshia R. Cunningham, Hadas Nahman-Averbuch, Gregory R. Lee, Christopher D. King, Robert C. Coghill
Summary: Pediatric functional abdominal pain disorders (FAPD) are common and challenging to diagnose and treat. This study investigated changes in brain connectivity and activity in youth with FAPD during a water load symptom provocation task (WL-SPT). The findings suggest that these changes may be related to pain unpleasantness and intensity. The study provides insights into the mechanisms of pain and treatment response in FAPD.
Article
Biochemistry & Molecular Biology
Karim Ibrahim, Stephanie Noble, George He, Cheryl Lacadie, Michael J. Crowley, Gregory McCarthy, Dustin Scheinost, Denis G. Sukhodolsky
Summary: Disruptions in frontoparietal networks supporting emotion regulation are associated with maladaptive childhood aggression. This study found that connectivity predictive of aggression was identified within and between networks implicated in cognitive control, social functioning, and emotion processing. Internal and external validation demonstrated the predictability of these connections, advancing the identification of neural biomarkers for targeted treatments in children with aggressive behavior.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Diana O. Svaldi, Joaquin Goni, Kausar Abbas, Enrico Amico, David G. Clark, Charanya Muralidharan, Mario Dzemidzic, John D. West, Shannon L. Risacher, Andrew J. Saykin, Liana G. Apostolova
Summary: The study combines connectome predictive modeling and differential identifiability frameworks to enhance individual fingerprints of resting state functional connectomes for more accurate identification of functional networks associated with cognitive outcomes and improve prediction accuracy of cognitive outcomes. By examining a broad spectrum of cognitive outcomes associated with Alzheimer's disease, specific functional networks related to cognitive deficits exhibited in AD were identified and characterized.
HUMAN BRAIN MAPPING
(2021)
Article
Computer Science, Artificial Intelligence
Jichao Ma, Yanjiang Wang, Baodi Liu, Weifeng Liu
Summary: The study explores the relationship between the structural connectivity (SC) and functional connectivity (FC) in human brain networks, proposing a model based on hypergraph Laplacian to simulate brain functional correlations, including negative correlations. By utilizing the SC of human brain networks, the model can accurately simulate empirical data and outperform the state-of-art graph diffusion model.
Article
Neurosciences
Zhiting Ren, Richard J. Daker, Liang Shi, Jiangzhou Sun, Roger E. Beaty, Xinran Wu, Qunlin Chen, Wenjing Yang, Ian M. Lyons, Adam E. Green, Jiang Qiu
Summary: This study delves into anxiety barriers in creative cognition, uncovering a neural network associated with creativity anxiety and demonstrating its distinction from networks related to divergent creative ability. Additionally, the research developed a Chinese version of the Creativity Anxiety Scale and showed the replicability of key findings across cultures and languages.
Article
Neurosciences
Anurima Mummaneni, Omid Kardan, Andrew J. Stier, Taylor A. Chamberlain, Alfred F. Chao, Marc G. Berman, Monica D. Rosenberg
Summary: Sleep is crucial for cognitive functions and inadequate sleep can affect mood and behavior. This study used functional connectivity patterns to predict sleep duration and found that common functional brain networks are associated with sleep duration in both youth and young adults.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Die Zhang, Lan Yu, Yingying Chen, Jing Shen, Lina Du, Lin Lin, Jianlin Wu
Summary: This preliminary study aimed to investigate whether connectome-based predictive modeling (CPM) can predict paranoia scores of young men with paranoid personality disorder (PPD) using whole-brain resting-state functional connectivity (rs-FC). The model constructed based on the negative prediction network involving the limbic system-temporal lobe was observed to have significant predictive ability for paranoia scores, whereas the model constructed using the positive and combined prediction network had no significant predictive ability.
Review
Neurosciences
Andrew D. Snyder, Liangsuo Ma, Joel L. Steinberg, Kyle Woisard, Frederick G. Moeller
Summary: Dynamic causal modeling (DCM) is a method used for analyzing the directionality of brain connectivity, but there may be a historical trend of underreporting self-connectivity findings in neuropsychiatric fMRI DCM literature. These self-connectivity findings play an important role in regulating neural activity.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Luigi Albano, Silvia Basaia, Daniele Emedoli, Roberta Balestrino, Edoardo Pompeo, Lina Raffaella Barzaghi, Antonella Castellano, Andrea Falini, Sandro Iannaccone, Pietro Mortini, Massimo Filippi, Federica Agosta
Summary: This study aimed to assess the resting-state functional connectivity between thalamic ventral intermediate nucleus (Vim) and the rest of the brain before and after thalamotomy in Parkinson's disease (PD) patients. The results showed that the functional connectivity between Vim and visual areas increased before treatment and was restored after 1 year of treatment. Furthermore, the reduction in connectivity between left Vim and left visual cortex was associated with the improvement of tremor symptoms.
JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Clinical
Maria K. Wilson, Danielle Cornacchio, Melissa A. Brotman, Jonathan S. Comer
Summary: In this age range, ARI-P scores showed large associations with other irritability index and small-to-large associations with aggression, anxiety, depression, and attention problems, supporting the convergent and concurrent validity of the ARI-P when used with children in this younger age range.
Article
Neurosciences
Gang Chen, Daniel S. Pine, Melissa A. Brotman, Ashley R. Smith, Robert W. Cox, Paul A. Taylor, Simone P. Haller
Summary: Trials play a crucial role in task-based neuroimaging, impacting statistical efficiency and condition-level generalizability. Increasing both trial and subject sample sizes can improve statistical efficiency more effectively than focusing on subjects alone, and trial-level modeling may be necessary for accurately assessing effect estimates with small trial size.
Article
Psychology, Developmental
Sanjana Ravi, Mazneen Havewala, Katharina Kircanski, Melissa A. Brotman, Leslie Schneider, Kathryn Degnan, Alisa Almas, Nathan Fox, Daniel S. Pine, Ellen Leibenluft, Courtney Filippi
Summary: Prolonged irritability in childhood may predict later psychopathology, and negative parenting behaviors may moderate the developmental trajectory of childhood irritability. Negative emotion socialization and control behaviors of parents significantly influence irritability.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Neurosciences
Simone P. Haller, Gang Chen, Elizabeth R. Kitt, Ashley R. Smith, Joel Stoddard, Rany Abend, Sofia Cardenas, Olga Revzina, Daniel Coppersmith, Ellen Leibenluft, Melissa A. Brotman, Daniel S. Pine, David Pagliaccio
Summary: Assessing and improving test-retest reliability is critical for addressing concerns about replicability in fMRI studies. This study examined the influence of scanner and task-related factors on the reliability of neural response to face-emotion viewing. The results showed that activated regions had higher reliability than non-activated regions, and contrasts involving distinct visual stimuli and cognitive demands had greater reliability.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Cedric Huchuan Xia, Ian Barnett, Tinashe M. Tapera, Azeez Adebimpe, Justin T. Baker, Danielle S. Bassett, Melissa A. Brotman, Monica E. Calkins, Zaixu Cui, Ellen Leibenluft, Sophia Linguiti, David M. Lydon-Staley, Melissa Lynne Martin, Tyler M. Moore, Kristin Murtha, Kayla Piiwaa, Adam Pines, David R. Roalf, Sage Rush-Goebel, Daniel H. Wolf, Lyle H. Ungar, Theodore D. Satterthwaite
Summary: Researchers have found that mobility patterns captured by smartphones represent unique individual differences and are associated with age, sex, affect, and circadian patterns. Furthermore, brain functional connectivity is also linked to individual differences in mobility patterns.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Reut Naim, Simone P. Haller, Julia O. Linke, Allison Jaffe, Joel Stoddard, Matt Jones, Anita Harrewijn, Katharina Kircanski, Yair Bar-Haim, Melissa A. Brotman
Summary: Irritability is a common reason for seeking psychiatric care among youth. This study investigated the attentional bias to angry faces and the associated neural mechanisms in irritable youth. The results showed that both irritability level and attention bias influenced the connectivity between the amygdala and various brain regions, including the inferior frontal gyrus, insula, caudate, and thalamus/pulvinar.
NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Psychology, Developmental
Melissa A. Brotman, Katharina Kircanski
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Psychology, Developmental
Ka Shu Lee, Cheyanne N. Hagan, Mina Hughes, Grace Cotter, Eva McAdam Freud, Katharina Kircanski, Ellen Leibenluft, Melissa A. Brotman, Wan-Ling Tseng
Summary: This study aims to summarize the methods and results of using functional magnetic resonance imaging (fMRI) to investigate neural dysfunction in childhood irritability. The findings showed small sample sizes, heterogeneous sample characteristics, and a lack of neural activation convergence. Therefore, there is a need for standardized irritability assessments and more homogeneous fMRI tasks to study the neural mechanisms of irritability.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Simone P. Haller, Camille Archer, Annie Jeong, Allison Jaffe, Emily L. Jones, Anita Harrewijn, Reut Naim, Julia O. Linke, Joel Stoddard, Melissa A. Brotman
Summary: The COVID-19 pandemic has led to a significant increase in anxiety and depression symptoms among youth, partially mediated by pandemic-related stress and worries. Increased prefrontal activity in response to neutral faces pre-pandemic may predict more intense anxiety during the pandemic. This study expands on the role of psychological stress as a mediator of anxiety and depression symptoms in youth.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2022)
Article
Psychology, Clinical
Reut Naim, Shannon Shaughnessy, Ashley Smith, Sarah L. Karalunas, Katharina Kircanski, Melissa A. Brotman
Summary: This study utilized ecological momentary assessment to investigate emotional lability in a transdiagnostic pediatric sample. The results showed significant levels of both positive and negative emotional lability in pediatric psychopathology, particularly in youth with disruptive mood dysregulation disorder (DMDD). Emotional lability was found to be associated with functional impairment.
DEPRESSION AND ANXIETY
(2022)
Review
Psychology, Developmental
Alecia C. Vogel, Melissa A. Brotman, Amy Krain Roy, Susan B. Perlman
Summary: This study highlights the importance of studying positive emotion dysregulation and proposes a developmental approach to examining it within the context of temperament. The research findings suggest that dysregulation of positive emotion is associated with externalizing symptoms and clinical impairment in youth.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Editorial Material
Psychology, Developmental
Douglas K. Novins, Robert R. Althoff, Melissa A. Brotman, Samuele Cortese, Melissa DelBello, Alysa Doyle, Stacy S. Drury, Lisa Fortuna, Jean A. Frazier, Mary Fristad, Schuyler W. Henderson, Elizabeth McCauley, Christel Middeldorp, Wanjiku F. M. Njoroge, Cynthia E. Rogers, Tonya White
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Jason Smucny, Tyler A. A. Lesh, Tara A. A. Niendam, J. Daniel Ragland, Laura M. M. Tully, Cameron S. S. Carter
Summary: This study found that in individuals with recent onset schizophrenia, deficits in reward anticipation can be reversed after one year of coordinated specialty care treatment, and this improvement is associated with a reduction in positive symptoms of the illness.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Wan-Ling Tseng, Reut Naim, Amanda Chue, Shannon Shaughnessy, Jennifer Meigs, Daniel S. Pine, Ellen Leibenluft, Katharina Kircanski, Melissa A. Brotman
Summary: This study used a network analytic approach and smartphone-based ecological momentary assessment to investigate the relationship between irritability and other anxiety and mood symptoms. The results showed that frustration was the most central node in the networks of between-prompt symptoms, while sadness and anger were the most central nodes in the networks of momentary symptoms. Furthermore, anger was broadly positively related to sadness, mood lability, and worry across individuals.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Reut Naim, Shannon Shaughnessy, Ashley Smith, Sarah L. Karalunas, Katharina Kircanski, Melissa A. Brotman
NEUROPSYCHOPHARMACOLOGY
(2022)