Article
Respiratory System
Istvan Vadasz, Faeq Husain-Syed, Peter Dorfmueller, Fritz C. Roller, Khodr Tello, Matthias Hecker, Rory E. Morty, Stefan Gattenloehner, Hans-Dieter Walmrath, Friedrich Grimminger, Susanne Herold, Werner Seeger
Summary: Various forms of diffuse parenchymal lung disease have been proposed as potential consequences of severe COVID-19, including severe organising pneumonia. Understanding these implications may help improve therapeutic modalities in the late-phase of severe COVID-19, and shed light on why a subgroup of patients benefit from systemic corticosteroids.
Article
Virology
Yuji Yamamoto, Takayuki Shiroyama, Haruhiko Hirata, Tomoki Kuge, Kinnosuke Matsumoto, Midori Yoneda, Makoto Yamamoto, Akinori Uchiyama, Yoshito Takeda, Atsushi Kumanogoh
Summary: In patients with severe COVID-19 treated with systemic corticosteroid therapy, monitoring cytomegalovirus (CMV) infection is important for preventing secondary infections. The presence of CMV infection is associated with increased risk of mortality during the ICU stay.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Otorhinolaryngology
Raymond J. So, Hannah Kavookjian, Esther Ben Or, Grace E. Snow, Lee M. Akst, Alexander T. Hillel, Simon R. A. Best
Summary: This study aimed to analyze the risk factors for posterior glottic injury (PGI) in COVID-19 patients who underwent prolonged intubation. The results showed that cardiovascular disease, non-COVID-19 respiratory illnesses, and diabetes mellitus were associated with the development of PGI.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Critical Care Medicine
Lindsey Gurin, Megan Evangelist, Patricia Laverty, Kaitlin Hanley, John Corcoran, Jodi Herbsman, Brian Im, Jennifer Frontera, Steven Flanagan, Steven Galetta, Ariane Lewis
Summary: During the COVID-19 pandemic in New York City, implementing early neurorehabilitation protocols helped more than half of severe patients with prolonged unresponsiveness achieve a minimally conscious state or better. Factors like body mass index, serum C-reactive protein levels, oxygen partial pressure, and medication discontinuation were associated with recovery in these patients.
NEUROCRITICAL CARE
(2022)
Article
Allergy
Galam Leem, Shinhye Cheon, Hoyoung Lee, Seong Jin Choi, Seongju Jeong, Eui-Soon Kim, Hye Won Jeong, Hyeongseok Jeong, Su-Hyung Park, Yeon-Sook Kim, Eui-Cheol Shin
Summary: This study provides insights into the phenotypic and functional changes of NK cells in COVID-19 patients, revealing an expansion of unconventional CD56(dim) CD16(neg) NK-cell population associated with decreased NK cell cytotoxicity. NK cell population normalized rapidly in mild COVID-19 cases but slowly in severe cases, shedding light on the pathogenesis of COVID-19.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Kerstin Renner, Tobias Schwittay, Sophia Chaabane, Johanna Gottschling, Christine Mueller, Charlotte Tiefenboeck, Jan-Niklas Salewski, Frederike Winter, Simone Buchtler, Saidou Balam, Maximilian V. Malfertheiner, Matthias Lubnow, Dirk Lunz, Bernhard Graf, Florian Hitzenbichler, Frank Hanses, Hendrik Poeck, Marina Kreutz, Evelyn Orso, Ralph Burkhardt, Tanja Niedermair, Christoph Brochhausen, Andre Gessner, Bernd Salzberger, Matthias Mack
Summary: This study reveals the presence of T cell hyporeactivity in COVID-19 patients, predominantly influenced by plasma factors, and associated with poor prognosis and viral persistence. Monocytes in males exhibit stronger responses to COVID-19, and IL-2 can partially restore T cell activation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Cameron Spencer Olezene, Elizabeth Hansen, Hannah K. Steere, Joseph T. Giacino, Ginger R. Polich, Joanne Borg-Stein, Ross D. Zafonte, Jeffrey C. Schneider
Summary: The study found that COVID-19 patients admitted to inpatient rehabilitation exhibited deficits in mobility, cognition, speech, and swallowing upon admission, but showed significant improvements in these domains by discharge. However, a significant number of patients still had residual deficits at discharge, highlighting the post-acute care needs of this patient population.
Article
Psychology, Multidisciplinary
Tegan Cruwys, Polly Fong, Olivia Evans, Joanne A. A. Rathbone
Summary: Social cohesion is crucial for population wellbeing, and large-scale interventions can build resilience and protect people's wellbeing during times of collective change or crisis. However, the majority of current research is correlational and lacks evaluation of interventions.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Zhiheng Xu, Yonghao Xu, Dongdong Liu, Xuesong Liu, Liang Zhou, Yongbo Huang, Yimin Li, Xiaoqing Liu
Summary: This case report demonstrates the successful use of prolonged VV-ECMO (111 days) in a 61-year-old man with severe COVID-19, providing evidence for the efficacy of prolonged VV-ECMO as supportive care in patients with severe COVID-19.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Maria Dolores Folgueira, Joanna Luczkowiak, Fatima Lasala, Alfredo Perez-Rivilla, Rafael Delgado
Summary: This study compared the infectivity of SARS-CoV-2 in respiratory samples from patients with mild COVID-19 and those with severe bilateral pneumonia. Results showed that severe patients might shed viable virus for up to 4 weeks after symptom onset, even with high cycle threshold values and high neutralizing antibody titres.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Hematology
Noriko Nara, Mie Shimizu, Masahiro Yamamoto, Tomoki Nakamizo, Azusa Hayakawa, Ken Johkura
Summary: Platelet hyperactivity persists for at least 40 days in patients with COVID-19, even after acute inflammation subsides, and may contribute to thromboembolic complications in post-COVID-19 patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Wendong Hao, Meimei Liu, Cairong Bai, Xin Liu, Siqian Niu, Xiushan Chen
Summary: The objective of this study was to identify potential predictors of clinical outcome in severe COVID-19 patients and investigate the relationship between immunological parameters and duration of illness. A single-center retrospective study recruited 73 patients with severe or critical COVID-19. The results showed that CX3CL1, D-dimer, PCT, and IL-6 could effectively predict mortality in severe COVID-19 patients, and only CX3CL1 and D-dimer levels were significantly associated with duration of illness.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
John J. Byrne, Amir A. Shamshirsaz, Alison G. Cahill, Mark A. Turrentine, Angela R. Seasely, Joe Eid, Caroline E. Rouse, Michael Richley, Nandini Raghuraman, Mariam Naqvi, Yasser Y. El-Sayed, Martina L. Badell, CeCe Cheng, James Liu, Emily H. Adhikari, Soha S. Patel, Erika R. O'Neil, Patrick S. Ramsey
Summary: This retrospective multicenter cohort study examined the maternal and perinatal outcomes associated with ECMO used for COVID-19 with respiratory failure during pregnancy. The study found that most pregnant and postpartum patients survived after ECMO treatment but experienced a high frequency of serious maternal morbidity.
Article
Medicine, General & Internal
George Karlis, Despina Markantonaki, Sotirios Kakavas, Dimitra Bakali, Georgia Katsagani, Theodora Katsarou, Christos Kyritsis, Vasiliki Karaouli, Paraskevi Athanasiou, Mary Daganou
Summary: Extending the duration of prone position ventilation in COVID-19-associated ARDS is as safe and effective as conventional prone ventilation, but does not improve survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jenny Valentina Garmendia, Alexis Hipolito Garcia, Claudia Valentina De Sanctis, Marian Hajduch, Juan Bautista De Sanctis
Summary: SARS-CoV-2 causes COVID-19, a complex respiratory illness that can also harm multiple organs and lead to long-lasting effects. While most individuals have mild symptoms or are asymptomatic, around 20% develop severe respiratory illness and organ failure. Compromised immune response, caused by immunodeficiency and autoimmunity, allows the virus to replicate and escape. Autoantibodies against various proteins have been reported, with their type and level depending on age and gender. Screening for immunodeficiency and autoimmunity is important in identifying risk factors for severe or prolonged COVID-19.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Neuroimaging
Nerea Arrarte Terreros, Agnetha A. E. Bruggeman, Henk van Voorst, Praneeta R. Konduri, Ivo G. H. Jansen, Manon Kappelhof, Manon L. Tolhuisen, Nikki Boodt, Diederik W. J. Dippel, Aad van der Lugt, Wim H. van Zwam, Robert J. van Oostenbrugge, H. Bart van der Worp, Bart J. Emmer, Frederick J. A. Meijer, Yvo B. W. E. M. Roos, Ed van Bavel, Henk A. Marquering, Charles B. L. M. Majoie
Summary: There were no significant differences in EVT procedural and clinical outcomes between bifurcated and main stem thrombus patterns in MCA occlusion.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Medicine, General & Internal
Mahsa Mojtahedi, Manon Kappelhof, Elena Ponomareva, Manon Tolhuisen, Ivo Jansen, Agnetha A. E. Bruggeman, Bruna G. Dutra, Lonneke Yo, Natalie LeCouffe, Jan W. Hoving, Henk van Voorst, Josje Brouwer, Nerea Arrarte Terreros, Praneeta Konduri, Frederick J. A. Meijer, Auke Appelman, Kilian M. Treurniet, Jonathan M. Coutinho, Yvo Roos, Wim van Zwam, Diederik Dippel, Efstratios Gavves, Bart J. Emmer, Charles Majoie, Henk Marquering
Summary: This study aimed to create an automated pipeline for consistent and fast full thrombus segmentation, using convolutional neural networks to evaluate thrombus imaging characteristics. The pipeline was trained and tested on multi-center, multi-scanner datasets, resulting in high spatial accuracy segmentation results.
Article
Clinical Neurology
Thijs R. J. Landman, Yvonne Schoon, Michiel C. Warle, Frederick J. A. Meijer, Frank-Erik De Leeuw, Dick H. J. Thijssen
Summary: This study found no significant improvement in infarct size or clinical outcome in patients with an acute ischemic stroke who were treated with repeated remote ischemic postconditioning.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Letter
Clinical Neurology
Frederick J. A. Meijer, Bram Geurts, Stefan C. A. Steens, Floris H. B. M. Schreuder
Article
Clinical Neurology
Marc Vervuurt, Anna M. M. de Kort, Lieke Jakel, Iris Kersten, Wilson F. F. Abdo, Floris H. B. M. Schreuder, Ingeborg Rasing, Gisela M. M. Terwindt, Marieke J. H. Wermer, Steven M. M. Greenberg, Catharina J. M. Klijn, H. Bea Kuiperij, Marcel M. M. Verbeek
Summary: This study investigates the potential of cerebrospinal fluid (CSF) levels of matrix metalloproteinases and tissue-type inhibitors (MMP; TIMP) as biomarkers for cerebral amyloid angiopathy (CAA). The results suggest that CSF MMP-2/TIMP-2 and MMP-14/TIMP-2 ratios are consistently decreased in sporadic CAA patients, compared to controls. Additionally, MMP-14/TIMP-2 levels are also decreased in symptomatic hereditary CAA patients, compared to pre-symptomatic patients and controls, and can be considered a biomarker for late-stage forms of CAA.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
J. W. Hoving, H. van Voorst, M. Kappelhof, M. Tolhuisen, K. M. Treurniet, N. E. LeCouffe, L. A. Rinkel, M. S. Koopman, F. Cavalcante, P. R. Konduri, I. R. van den Wijngaard, E. Ghariq, F. J. Anton Meijer, J. M. Coutinho, H. A. Marquering, Y. B. W. E. M. Roos, B. J. Emmer, C. B. L. M. Majoie
Summary: It was found that there was no significant difference in infarct evolution between patients who received IV alteplase and endovascular treatment versus patients who underwent endovascular treatment alone. However, in patients who underwent endovascular treatment, collateral status and occlusion location were associated with the prognosis of infarct evolution.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Multidisciplinary Sciences
E. S. van Ede, J. Scheerhoorn, M. P. Buise, R. A. E. Bouwman, S. W. E. Nienhuijs, Steven E. Wolf
Summary: This study aimed to evaluate the non-inferiority and feasibility of an outpatient recovery pathway after bariatric surgery, supported by remote monitoring compared to standard care. The results showed that outpatient surgery supported with telemonitoring is clinically comparable to standard overnight bariatrics in terms of treatment outcomes. Same-day discharge reduced hospitalization days while maintaining patient satisfaction and safety.
Review
Oncology
Dylan Henssen, Lars Leijten, Frederick J. A. Meijer, Anja van der Kolk, Anne I. J. Arens, Mark ter Laan, Robert J. Smeenk, Anja Gijtenbeek, Elsmarieke M. van de Giessen, Nelleke Tolboom, Daniela E. Oprea-Lager, Marion Smits, James Nagarajah
Summary: Sophisticated imaging techniques have been suggested for distinguishing tumor progression (TP) from treatment-related abnormalities (TRA) in post-treatment surveillance of gliomas. However, it remains unclear if any technique holds diagnostic superiority. This meta-analysis compared the diagnostic accuracy of different imaging techniques and found no superior technique.
Article
Medicine, General & Internal
Max Tigo Rietberg, Van Bach Nguyen, Jeroen Geerdink, Onno Vijlbrief, Christin Seifert
Summary: This study aims to understand the reasons for performing MRI scans on Multiple Sclerosis (MS) patients by extracting information from their free-form reports, specifically diagnosis, progression, or monitoring. By comparing general language models with domain expert opinions and using Explainable Artificial Intelligence (XAI) techniques, the reliability of the models is verified. BERTje, a Dutch Bidirectional Encoder Representations from Transformers (BERT) model, outperforms other models in terms of accuracy and reliability, showing that domain-specific models are not always superior. The validation of BERTje in a small prospective study shows promising results for its potential practical applications.
Article
Multidisciplinary Sciences
Sander E. Temmen, Marinus J. Becks, Steven Schalekamp, Kicky G. van Leeuwen, Frederick J. A. Meijer
Summary: This study evaluated the diagnostic performance of the Automation Platform (AP) for intracranial large vessel occlusion (LVO) detection on CT angiography (CTA) and the processing time of CT in acute stroke patients. The AP showed shorter processing time but lower sensitivity for LVO detection compared to radiologists.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Evelien A. J. van Genugten, Theresa J. van Lith, Frederik M. A. van den Heuvel, Josee L. van Steenis, Romy M. ten Heggeler, Monique Brink, Laura Rodwell, Frederick J. A. Meijer, Daphne Lobeek, Wanda Hagmolen Of ten Have, Frank L. van de Veerdonk, Mihai G. Netea, Mathias Prokop, Robin Nijveldt, Anil M. Tuladhar, Erik H. J. G. Aarntzen
Summary: In COVID-19 patients, endothelial cells play a central role and inadequate response is associated with vascular complications. PET imaging with Ga-68-RGD can quantify endothelial activation and has shown increased activation in lung parenchyma and myocardium of COVID-19 patients.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Rik van den Elshout, Siem D. A. Herings, Manoj Mannil, Anja M. M. Gijtenbeek, Mark ter Laan, Robert J. Smeenk, Frederick J. A. Meijer, Tom W. J. Scheenen, Dylan J. H. A. Henssen
Summary: Distinguishing treatment-related abnormalities (TRA) from tumor progression (TP) in glioblastoma patients is challenging. This study investigates the diagnostic accuracy of the apparent diffusion coefficient (ADC) in differentiating between the two. The results show that ADC values have limited discriminative power and significant overlap between TP and TRA. The area under the curve (AUC) for distinguishing TP from TRA using ADC values is 0.71, with a sensitivity of 65% and specificity of 70% at a cutoff value of 1.47 x 10-3 mm2/s. These findings suggest that ADC maps should not be solely relied upon for distinguishing between TP and TRA without considering the temporal evolution of the lesion.
Article
Multidisciplinary Sciences
K. G. van Leeuwen, M. J. Becks, D. Grob, F. de Lange, J. H. E. Rutten, S. Schalekamp, M. J. C. M. Rutten, B. van Ginneken, M. de Rooij, F. J. A. Meijer
Summary: This study prospectively evaluated the use of AI software to detect intracranial large vessel occlusions on CT angiography (CTA) in clinical practice. The AI-tool showed an overall accuracy of 87.6%, with sensitivity of 69.1% and specificity of 91.2%. Users found the product user-friendly, but diagnostic confidence for LVO detection remained the same over the year. The usage of the AI-tool fluctuated and showed a declining trend.
Article
Critical Care Medicine
Sanne P. C. van Oosterhout, Anneke G. van der Niet, W. Farid Abdo, Marianne Boenink, Thomas G. V. Cherpanath, Jelle L. L. Epker, Angela M. M. Kotsopoulos, Walther N. K. A. van Mook, Hans P. C. Sonneveld, Meint Volbeda, Gert Olthuis, Jelle L. P. van Gurp
Summary: The study examines how clinicians discuss patients' donor registrations in donor conversations in the first years of the opt-out system in the Netherlands. It highlights the complex interplay between donor registrations and clinician-family interactions, and suggests incorporating different routes in clinical training and promoting public conversations about donation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanneke M. Keijzer, Marco Duering, Ofer Pasternak, Frederick J. A. Meijer, Marlous M. L. H. Verhulst, Bart A. R. Tonino, Michiel J. Blans, Cornelia W. E. Hoedemaekers, Catharina J. M. Klijn, Jeannette Hofmeijer
Summary: This study evaluates the potential value of free water corrected mean diffusivity (MD) and fractional anisotropy (FA) based on diffusion tensor imaging (DTI), for predicting the neurological recovery of comatose patients after cardiac arrest. The results show that MD and FA can discriminate between patients with good and poor outcomes, indicating their potential in multimodal outcome prediction.
EUROPEAN RADIOLOGY
(2023)
