Article
Computer Science, Artificial Intelligence
Ozlem Karabiber Cura, Aydin Akan, Hatice Sabiha Ture
Summary: The majority of psychogenic nonepileptic seizures (PNESs) are often misdiagnosed due to their symptom similarity with epilepsy. EEG recordings alone are not enough for accurate diagnosis, and video EEG data and patient history are necessary. This study proposes a technique using short-term EEG data and time-frequency methods to classify different seizure segments.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2023)
Article
Behavioral Sciences
Michael Lloyd, Toby T. Winton-Brown, Anthony Hew, Genevieve Rayner, Emma Foster, Maria Rychkova, Rashida Ali, Dennis Velakoulis, Terence J. O'Brien, Patrick Kwan, Charles B. Malpas
Summary: This study aimed to compare the multidimensional psychopathological profiles of patients with PNES and ES. The results showed that PNES patients reported more overall psychopathology, particularly in childhood trauma, dissociation, and depression. These psychopathological profiles have limited usefulness as standalone screening tools for differentiating PNES and ES.
EPILEPSY & BEHAVIOR
(2022)
Article
Behavioral Sciences
Filiz Azman Iste, M. Ilker Yon, F. Irsel Tezer, Serap Saygi
Summary: This study investigated the frequency of ictal crying in epileptic seizures (ESs) and psychogenic nonepileptic seizures (PNESs), highlighting the differences between the two. The study also analyzed the etiology, symptoms, treatment options, and prognosis of ictal crying in ESs. Results showed that all patients in the ES group had refractory focal epilepsy, and some achieved good outcomes through surgical treatment.
EPILEPSY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Steven Lenio, Sarah Baker, Meagan Watson, Randi Libbon, Stefan Sillau, Laura Strom
Summary: Nonepileptic seizures are commonly associated with psychiatric comorbidities, particularly PTSD. Patients evaluated at a clinic for nonepileptic seizures showed higher rates of comorbid psychiatric diseases or symptoms after initial intake, with effective treatments available for depression, anxiety, and PTSD. Identifying and treating these psychiatric comorbidities may be a more scalable treatment approach for patients who lack access to specialized providers for managing nonepileptic seizures.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Alceste Deli, Yi-Ge Huang, Mark Toynbee, Susan Towle, Jane E. Adcock, Tomasz Bajorek, David Okai, Arjune Sen
Summary: The study aimed to differentiate patients with mixed symptomatology from those with epileptic seizures (ES) or functional/psychogenic nonepileptic seizures (PNES), and explore the differences in symptoms. Mixed cases were found to be more similar to ES patients in terms of symptom number, while PNES patients tended to over-report ictal symptoms.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Maryon Jones, Jared Gaskell, Alexander Lehn
Summary: Video-electroencephalography (VEEG) is valuable in differentiating psychogenic nonepileptic seizures (PNES) from epileptic seizures (ES), preventing unnecessary antiepileptic drug therapy for PNES patients. The majority of PNES patients subsequently ceased their AEDs, highlighting the clinical diagnostic value of VEEG.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Steven Lenio, Wesley T. Kerr, Meagan Watson, Sarah Baker, Chad Bush, Alex Rajic, Laura Strom
Summary: Dissociative seizures are a common neurological disorder that can be difficult to distinguish from epileptic seizures, but the DSLS score can accurately predict the diagnosis and play an important role in clinical decision making.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Alexander Lehn, Emily Watson, Elizabeth G. Ryan, Maryon Jones, Vince Cheah, Sasha Dionisio
Summary: A significant portion of patients presenting to emergency departments with symptoms resembling epileptic seizures are actually diagnosed with PNES, particularly those with prolonged or multiple events. Early recognition and accurate diagnosis of patients with psychogenic nonepileptic seizures are crucial to prevent unnecessary iatrogenic harm and provide appropriate treatment.
Article
Behavioral Sciences
Jonah Fox, Slavina B. Goleva, Kevin F. Haas, Lea K. Davis
Summary: This study investigates the relationship between functional seizures (FSe), cerebrovascular disease (CVD), and functional stroke. The results show that stroke is more common in patients with epileptic seizures (ES) compared to those with FSe. However, FSe is associated with both CVD and stroke when compared to nonepileptic controls. Functional stroke is more common in patients with FSe than in those with ES. Patients with FSe are also younger, more likely to be female, and more likely to have comorbid mental health needs including anxiety, PTSD or history of trauma, and bipolar disorder.
EPILEPSY & BEHAVIOR
(2022)
Review
Clinical Neurology
Lorenzo Ricci, Marilisa Boscarino, Giovanni Assenza, Mario Tombini, Jacopo Lanzone, Vincenzo Di Lazzaro, Sara Casciato, Alfredo D'Aniello, Alessandra Morano, Giancarlo Di Gennaro
Summary: Using home-video recordings (HVRs) to support physicians in the differential diagnosis of paroxysmal seizure-like episodes (PSLE) has shown consistent improvements in diagnostic and clinical decision-making, as well as reducing stress levels in families and improving quality of life. Training in performing good-quality videos is necessary and increases the diagnostic value of HVRs.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Lise Heylen, Duc-Hung Pham, Ann-Sofie De Meulemeester, Eric Samarut, Adrianna Skiba, Danielle Copmans, Youcef Kazwiny, Pieter Vanden Berghe, Peter A. M. de Witte, Aleksandra Siekierska
Summary: Zebrafish present a novel model for epilepsy research, offering unique insights for studying epileptogenic processes in vivo and suitable for high-throughput AED screening and rapid genetic investigations.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Gabriela S. Gilmour, Ryan MacIsaac, Arsenije Subotic, Samuel Wiebe, Colin B. Josephson
Summary: Different clinical features have limited ability to distinguish between psychogenic nonepileptic attacks (PNEA) and epileptic seizures (ES). There is a need for the development of multisource predictive tools to optimize diagnostic likelihood ratios.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Christina Mueller, Adam M. Goodman, Jane B. Allendorfer, Rodolphe Nenert, Tyler E. Gaston, Leslie E. Grayson, Stephen Correia, Noah S. Philip, W. Curt LaFrance, Jerzy P. Szaflarski
Summary: This study aimed to quantify changes in white matter morphology using neurite orientation dispersion and density imaging (NODDI) after neurobehavioral therapy (NBT) for functional seizures (FS). The results showed that patients with FS exhibited white matter plasticity in specific regions, which correlated with improvements in psychosocial functioning. NODDI could be considered for future assessments of interventions in patients with FS.
ANNALS OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Mikhail Zinchuk, Massimiliano Beghi, Silvia Diotti, Evgenii Pashnin, Georgii Kustov, Flora Rider, Lina Urh, Alla Guekht, Cesare Maria Cornaggia
Summary: This study examined the validity of conversational analysis (CA) in Russian patients with seizures using a scoring table for the Simplified Linguistic Evaluation (SLE). The results showed that CA combined with SLE could effectively differentiate between patients with epilepsy and psychogenic nonepileptic seizures, demonstrating a high diagnostic accuracy.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Roxane Dilcher, Charles B. Malpas, Mark Walterfang, Patrick Kwan, Terence J. O'Brien, Dennis Velakoulis, Lucy Vivash
Summary: This study aimed to compare cognitive profiles between patients with epilepsy and those with nonepileptic seizures using a brief cognitive screening tool. Patients with epilepsy, especially with bilateral temporal lobe epilepsy, and those on specific anti-seizure medications showed lower cognitive performance. The results suggest that the Neuropsychiatry Unit Cognitive Assessment Tool is sensitive in detecting cognitive impairment in patients with seizure disorders.
EPILEPSY & BEHAVIOR
(2021)