Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species

Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice

(2020) Mathieu E. Wimmer et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression

(2020) Orna Issler et al.   NEURON

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex

(2020) Veronica C. Galvin et al.   NEURON

Effects of Dexmedetomidine on Postoperative Delirium and Expression of IL-1β, IL-6, and TNF-α in Elderly Patients After Hip Fracture Operation

(2020) Wenchao Zhang et al.   Frontiers in Pharmacology

Neurological manifestations and COVID-19: Experiences from a tertiary care center at the Frontline

(2020) Pranusha Pinna et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

(2020) Michael T. Heneka et al.   Alzheimers Research & Therapy

Guanfacine Augmentation of a Combined Intervention of Computerized Cognitive Remediation Therapy and Social Skills Training for Schizotypal Personality Disorder

(2019) Margaret M. McClure et al.   AMERICAN JOURNAL OF PSYCHIATRY

Rating of the Effectiveness of 26 Psychiatric and Seizure Medications for Autism Spectrum Disorder: Results of a National Survey

(2019) Devon M. Coleman et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Severe childhood trauma and clinical and neurocognitive features in schizotypal personality disorder

(2019) T. Velikonja et al.   ACTA PSYCHIATRICA SCANDINAVICA

Role of inflammation in the pathogenesis of schizophrenia: A review of the evidence, proposed mechanisms and implications for treatment

(2019) David Mongan et al.   Early Intervention in Psychiatry

Guanfacine extended-release for cannabis use disorder: a pilot feasibility trial

(2019) Elias Dakwar et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

Cannabis use and psychosis: a review of reviews

(2019) Alkomiet Hasan et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers

(2018) Margaret Haney et al.   ADDICTION BIOLOGY

Core Differences in Synaptic Signaling Between Primary Visual and Dorsolateral Prefrontal Cortex

(2018) Sheng-Tao Yang et al.   CEREBRAL CORTEX

Guanfacine Attenuates Adverse Effects of Dronabinol (THC) on Working Memory in Adolescent-Onset Heavy Cannabis Users: A Pilot Study

(2018) David S. Mathai et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Mild Traumatic Brain Injury Reduces Spine Density of Projection Neurons in the Medial Prefrontal Cortex and Impairs Extinction of Contextual Fear Memory

(2018) Jing Zhao et al.   JOURNAL OF NEUROTRAUMA

Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial

(2018) Nicole M. Barcelos et al.   NEUROBIOLOGY OF AGING

A randomized, placebo-controlled trial of extended-release guanfacine in children with autism spectrum disorder and ADHD symptoms: an analysis of secondary outcome measures

(2018) Laura C. Politte et al.   NEUROPSYCHOPHARMACOLOGY

Managing disruptive behaviour in autism-spectrum disorder with guanfacine

(2018) Lukas Propper   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Specialized Representations of Value in the Orbital and Ventrolateral Prefrontal Cortex: Desirability versus Availability of Outcomes

(2017) Peter H. Rudebeck et al.   NEURON

Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion

(2017) Chloe U. Wallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A computational psychiatry approach identifies how alpha-2A noradrenergic agonist Guanfacine affects feature-based reinforcement learning in the macaque

(2017) S. A. Hassani et al.   Scientific Reports

Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk

(2017) S M Saini et al.   Translational Psychiatry

Guanfacine promotes neuronal survival in medial prefrontal cortex under hypobaric hypoxia

(2016) H. Kauser et al.   BRAIN RESEARCH

Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory

(2016) R. Havekes et al.   JOURNAL OF NEUROSCIENCE

Combined Stimulant and Guanfacine Administration in Attention-Deficit/Hyperactivity Disorder: A Controlled, Comparative Study

(2016) James T. McCracken et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Trauma-specific Grey Matter Alterations in PTSD

(2016) Linghui Meng et al.   Scientific Reports

Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

(2015) Nao J. Gamo et al.   BIOLOGICAL PSYCHIATRY

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

(2015) Tyrone D. Cannon et al.   BIOLOGICAL PSYCHIATRY

Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish

(2015) Lewis A. Opler et al.   CNS SPECTRUMS

Altered Regulation of Protein Kinase A Activity in the Medial Prefrontal Cortex of Normal and Brain-Injured Animals Actively Engaged in a Working Memory Task

(2015) Nobuhide Kobori et al.   JOURNAL OF NEUROTRAUMA

Guanfacine enhances inhibitory control and attentional shifting in early abstinent cocaine-dependent individuals

(2015) Helen Fox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Stress weakens prefrontal networks: molecular insults to higher cognition

(2015) Amy F T Arnsten   NATURE NEUROSCIENCE

Stimulation of postsynapse adrenergic α2A receptor improves attention/cognition performance in an animal model of attention deficit hyperactivity disorder

(2014) Kazuaki Kawaura et al.   BEHAVIOURAL BRAIN RESEARCH

Efficacy and safety of extended-release guanfacine hydrochloride in children and adolescents with attention-deficit/hyperactivity disorder: A randomized, controlled, Phase III trial

(2014) Amaia Hervas et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Guanfacine Extended Release Adjunctive to a Psychostimulant in the Treatment of Comorbid Oppositional Symptoms in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

(2014) Robert L. Findling et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation

(2014) Sherry A McKee et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Insights into Human Behavior from Lesions to the Prefrontal Cortex

(2014) Sara M. Szczepanski et al.   NEURON

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

(2014) Becky C. Carlyle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Norepinephrine Modulates the Motility of Resting and Activated Microglia via Different Adrenergic Receptors

(2013) Stefka Gyoneva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Open-Label Study of Guanfacine Extended Release for Traumatic Stress Related Symptoms in Children and Adolescents

(2013) Daniel F. Connor et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

The Organization of Prefrontal-Subthalamic Inputs in Primates Provides an Anatomical Substrate for Both Functional Specificity and Integration: Implications for Basal Ganglia Models and Deep Brain Stimulation

(2013) W. I. A. Haynes et al.   JOURNAL OF NEUROSCIENCE

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

(2013) Min Wang et al.   NEURON

Guanfacine is an effective countermeasure for hypobaric hypoxia-induced cognitive decline

(2013) H. Kauser et al.   NEUROSCIENCE

Nicotinic  7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions

(2012) Emily B. Ansell et al.   BIOLOGICAL PSYCHIATRY

Gray Matter Correlates of Posttraumatic Stress Disorder: A Quantitative Meta-Analysis

(2012) Simone Kühn et al.   BIOLOGICAL PSYCHIATRY

Sex Differences in Molecular and Cellular Substrates of Stress

(2012) Debra A. Bangasser et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia

(2012) Constantinos D. Paspalas et al.   CEREBRAL CORTEX

Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings

(2012) Helen C Fox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Distinct neural mechanisms of distractor suppression in the frontal and parietal lobe

(2012) Mototaka Suzuki et al.   NATURE NEUROSCIENCE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses

(2012) Amy F.T. Arnsten et al.   NEURON

Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: Altered working memory and BOLD response

(2011) Thomas W. McAllister et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Evidence for Reduced Experience-Dependent Dendritic Spine Plasticity in the Aging Prefrontal Cortex

(2011) E. B. Bloss et al.   JOURNAL OF NEUROSCIENCE

Stimulation of α2A-adrenoceptors promotes the maturation of dendritic spines in cultured neurons of the medial prefrontal cortex

(2011) Wen-Wen Ren et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuronal basis of age-related working memory decline

(2011) Min Wang et al.   NATURE

Effects of α-2A adrenergic receptor agonist on time and risk preference in primates

(2011) Soyoun Kim et al.   PSYCHOPHARMACOLOGY

Frontal pole cortex: encoding ends at the end of the endbrain

(2011) Satoshi Tsujimoto et al.   TRENDS IN COGNITIVE SCIENCES

“Cool” Inferior Frontostriatal Dysfunction in Attention-Deficit/Hyperactivity Disorder Versus “Hot” Ventromedial Orbitofrontal-Limbic Dysfunction in Conduct Disorder: A Review

(2010) Katya Rubia   BIOLOGICAL PSYCHIATRY

Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway

(2010) R. M. Shansky et al.   CEREBRAL CORTEX

Attention deficits following ADEM ameliorated by guanfacine

(2010) V. Singh-Curry et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunction

(2010) N. Kobori et al.   NEUROSCIENCE

Development of Cortical Asymmetry in Typically Developing Children and Its Disruption in Attention-Deficit/Hyperactivity Disorder

(2009) Philip Shaw et al.   ARCHIVES OF GENERAL PSYCHIATRY

Guanfacine Potentiates the Activation of Prefrontal Cortex Evoked by Warning Signals

(2009) Suzanne M. Clerkin et al.   BIOLOGICAL PSYCHIATRY

Guanfacine Extended Release in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Placebo-Controlled Trial

(2009) Floyd R. Sallee et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress

(2009) A. B. Hains et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Psychosocial stress reversibly disrupts prefrontal processing and attentional control

(2009) C. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effects of Guanfacine on Working Memory Performance in Patients With Localization-Related Epilepsy and Healthy Controls

(2008) Barbara E. Swartz et al.   CLINICAL NEUROPHARMACOLOGY

A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder

(2008) J. Biederman et al.   PEDIATRICS

Forward frontal fields: phylogeny and fundamental function

(2008) Steven P. Wise   TRENDS IN NEUROSCIENCES