Journal
DNA REPAIR
Volume 44, Issue -, Pages 159-168Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2016.05.022
Keywords
Telomeres; DNA damage; DNA repair; Double strand break repair; Nucleotide excision repair; Base excision repair; Shelterin proteins; G-quadruplex
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Funding
- National Institute of Environmental Health [ES R01E5022944, R21/33ES025606]
- National Institute of General Medicine [R43GM108187]
- National Institute on Aging [R21AG045545]
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Telomeres at chromosome ends are nucleoprotein structures consisting of tandem TTAGGG repeats and a complex of proteins termed shelterin. DNA damage and repair at telomeres is uniquely influenced by the ability of telomeric DNA to form alternate structures including loops and G-quadruplexes, coupled with the ability of shelterin proteins to interact with and regulate enzymes in every known DNA repair pathway. The role of shelterin proteins in preventing telomeric ends from being falsely recognized and processed as DNA double strand breaks is well established. Here we focus instead on recent developments in understanding the roles of shelterin proteins and telomeric DNA sequence and structure in processing genuine damage at telomeres induced by endogenous and exogenous DNA damage agents. We will highlight advances in double strand break repair, base excision repair and nucleotide excision repair at telomeres, and will discuss important questions remaining in the field. (C) 2016 Elsevier B.V. All rights reserved.
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