Article
Biochemistry & Molecular Biology
Sarah Julien, Douangsone Vadysirisack, Camil Sayegh, Sharan Ragunathan, Yalan Tang, Emma Briand, Marion Carrette, Laetitia Jean, Rachid Zoubairi, Henri Gonde, Olivier Benveniste, Yves Allenbach, Laurent Drouot, Olivier Boyer
Summary: In a humanized mouse model of IMNM, early administration of zilucoplan was found to prevent the onset of myopathy and significantly inhibit complement activation.
Article
Oncology
Mika Kamata-Sakurai, Yoshinori Narita, Yuji Hori, Takayuki Nemoto, Ryo Uchikawa, Masaki Honda, Naoka Hironiwa, Kenji Taniguchi, Meiri Shida-Kawazoe, Shoichi Metsugi, Taro Miyazaki, Naoko A. Wada, Yuki Ohte, Shun Shimizu, Hirofumi Mikami, Tatsuhiko Tachibana, Natsuki Ono, Kenji Adachi, Tetsushi Sakiyama, Tomochika Matsushita, Shojiro Kadono, Shun-ichiro Komatsu, Akihisa Sakamoto, Sayuri Horikawa, Ayano Hirako, Koki Hamada, Sotaro Naoi, Nasa Savory, Yasuko Satoh, Motohiko Sato, Yuki Noguchi, Junko Shinozuka, Haruka Kuroi, Ami Ito, Tetsuya Wakabayashi, Masaki Kamimura, Fumihisa Isomura, Yasushi Tomii, Noriaki Sawada, Atsuhiko Kato, Otoya Ueda, Yoshito Nakanishi, Mika Endo, Kou-ichi Jishage, Yoshikii Kawabe, Takehisa Kitazawa, Tomoyuki Igawa
Summary: The novel anti-CD137 switch antibody STA551 shows strong and broad antitumor efficacy by targeting extracellular ATP in the tumor microenvironment, providing a potential treatment option for a wide variety of cancers regardless of antigen expression. The antibody demonstrates potent tumor inhibition without systemic toxicity or dependence on antigen expression in both mouse and human tumor models, supporting its further clinical testing and potential application to other cancer therapy targets.
Article
Urology & Nephrology
Anna Gouin, David Ribes, Magali Colombat, Dominique Chauveau, Gregoire Prevot, Olivier Lairez, Gregory Pugnet, Veronique Fremeaux-Bacchi, Antoine Huart, Julie Belliere, Stanislas Faguer
Summary: This study evaluated kidney pathology and outcomes of TMA patients related to inflammatory myopathy or scleroderma renal crisis. Different renal phenotypes were observed, with different treatment approaches and outcomes. C5 blocking may reverse hematologic abnormalities in IIM- and SRC-TMA, while early and aggressive immunosuppressive regimen may improve the survival of IIM-TMA, and underlying chronic vascular and interstitial lesions mitigate renal response in SRC-TMA.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Cell Biology
Lili Qu, Baihai Jiao
Summary: Kidney disease affects approximately 10% of the global population and encompasses a range of disorders with different underlying causes. These disorders are characterized by immune system dysregulation and metabolic disturbances, which contribute to kidney inflammation and progressive fibrosis. Recent studies have highlighted the importance of the interplay between immune and metabolic pathways in kidney diseases, revealing potential therapeutic targets for intervention.
Article
Multidisciplinary Sciences
Roshini Fernando, Oshadi Caldera, Terry J. Smith
Summary: Thyroid-associated ophthalmopathy (TAO) is a disfiguring and potentially blinding autoimmune component of Graves' disease, driven by autoantibodies targeting the TSHR/IGF-IR complex. Teprotumumab, an anti-IGF-IR inhibitor, attenuates expressions of MHC II and B7 proteins in CD34(+) fibrocytes, potentially by reducing gene transcriptional activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Ludmila Lupu, Klemens Horst, Johannes Greven, Uemit Mert, Judith A. K. Ludviksen, Kristin Pettersen, Corinna Lau, Yang Li, Annette Palmer, Kang Qin, Xing Zhang, Benjamin Mayer, Martijn van Griensven, Markus Huber-Lang, Frank Hildebrand, Tom Eirik Mollnes
Summary: In this study, the combined inhibition therapy of complement factor C5 and TLR co-receptor CD14 was used to reduce thrombo-inflammation and organ damage in a polytrauma pig model. The therapy significantly decreased the levels of terminal complement complex (TCC), CRP, and IL-6 in the blood. It also prevented platelet consumption and TAT formation, and reduced the requirements for norepinephrine. Moreover, the therapy limited organ damage and reduced the levels of blood lipase, LDH, AST, and NGAL.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Liming Chang, Wei Zhu, Jianping Jiang
Summary: The albino phenotype of the Chinese giant salamander may be associated with MHC I variants, which could serve as a convenient model for studying vitiligo or other autoimmune diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Bashir Lawal, Sung-Hui Tseng, Janet Olayemi Olugbodi, Sitthichai Iamsaard, Omotayo B. Ilesanmi, Mohamed H. Mahmoud, Sahar H. Ahmed, Gaber El-Saber Batiha, Alexander T. H. Wu
Summary: The study found that complement components are associated with tumor immune evasion, prognosis, and therapy response in various cancer types, primarily through impacting dysfunctional T-cell phenotypes, and are linked to context-dependent chemotherapy, lymphocyte-mediated tumor killing, and immunotherapy outcomes. The findings suggest that C3, C5, C3AR1, and C5AR1 could serve as potential targets for cancer immunotherapy and follow-up.
Article
Immunology
Rong Huang, Wenjia Wang, Ziyi Chen, Jing Chai, Qin Qi, Handan Zheng, Bingli Chen, Huangan Wu, Huirong Liu
Summary: This study investigated the molecular immune mechanisms associated with Crohn's disease (CD) and its fibrosis through bioinformatics analysis. The results identified MMP2, COL1A1, CXCL10, and FGF2 as key genes for CD, with COL1A1 also being a potential diagnostic biomarker.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Justin Ferdinandus, Anne Zaremba, Lisa Zimmer, Lale Umutlu, Robert Seifert, Francesco Barbato, Selma Ugurel, Eleftheria Chorti, Viktor Gruenwald, Ken Herrmann, Dirk Schadendorf, Wolfgang Peter Fendler, Elisabeth Livingstone
Summary: This study aimed to determine the potential added value of FDG-PET in identifying melanoma patients at higher risk of relapse following discontinuation of ICB therapy. The results showed that FDG-PET was more effective in evaluating complete metabolic response compared to CT imaging. These findings may have clinical relevance for patients with residual tumor burden.
Article
Multidisciplinary Sciences
Thomas Liechti, Yaser Iftikhar, Massimo Mangino, Margaret Beddall, Charles W. Goss, Jane A. O'Halloran, Philip A. Mudd, Mario Roederer
Summary: This study identified immune cell signatures associated with severe COVID-19 using high-dimensional flow cytometry. The findings suggest that reduced frequencies of specific immune cell subsets and altered chemokine receptor expression could contribute to the severity of the disease.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Aviram Kogot-Levin, Yael Riahi, Ifat Abramovich, Ofri Mosenzon, Bella Agranovich, Liat Kadosh, Rachel Ben-Haroush Schyr, Doron Kleiman, Liad Hinden, Erol Cerasi, Danny Ben-Zvi, Ernesto Bernal-Mizrachi, Joseph Tam, Eyal Gottlieb, Gil Leibowitz
Summary: Diabetes is associated with an increased risk of kidney disease, heart failure, and mortality. The use of SGLT2 inhibitors (SGLT2i) can prevent these adverse outcomes; however, the mechanisms involved are not well understood. This study generated a metabolic roadmap of the changes that occur in different organs in diabetes and in response to SGLT2i. The findings suggest that SGLT2i induces metabolic reprogramming through AMPK-mTORC1 signaling, leading to protective effects against kidney, liver, and heart diseases.
Article
Gastroenterology & Hepatology
Garazi Pena Alzua, Anne Finne Pihl, Anna Offersgaard, Carlos Rene Duarte Hernandez, Zhe Duan, Shan Feng, Ulrik Fahnoe, Christina Solund, Nina Weis, Mansun Law, Jannick C. Prentoe, Jan Pravsgaard Christensen, Jens Bukh, Judith Margarete Gottwein
Summary: Cell culture-based inactivated genotype 1-3 HCV vaccine candidates were developed, which successfully induced the production of broadly neutralising antibodies in mice.
Review
Immunology
Alex E. Wolfe, Kate A. Markey
Summary: Allogenic hematopoietic stem-cell transplantation is an immunotherapy for high-risk hematological malignancies and immune deficiencies. Immune recovery and the relationship with gut microbiome are important factors for transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Selena K. Tavener, Dennis E. Jewell, Kiran S. Panickar
Summary: Chronic low-grade inflammation is a significant factor in the progression of kidney disease, and activation of pro-inflammatory genes may contribute to renal inflammation and fibrosis. Blocking their activation could be important in ameliorating the initiation and/or progression of renal disease.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Dermatology
Claire Q. Wang, Sokol Haxhinasto, Sandra Garcet, Norma Kunjravia, Inna Cueto, Juana Gonzalez, Darshna Rambhia, Olivier Harari, Matthew A. Sleeman, Jennifer D. Hamilton, Wei Keat Lim, Jan Freudenberg, George D. Kalliolias, Paresh Thakker, Robert Bissonnette, James G. Krueger
Summary: Palmoplantar pustular psoriasis (PPPP) and non-pustular palmoplantar psoriasis (NPPP) are localized, debilitating forms of psoriasis. This study found that NPPP shows more pronounced T helper 1-mediated inflammation, while PPPP exhibits stronger neutrophil-associated activity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Transplantation
Erdem Cebisli, Nazan Ulgen-Tekerek, Oguz Dursun, Alper Koker, Abdullah Kisaoglu, Reha Artan, Erdogan Soyucen, Gulsum Ozlem Elpek
Summary: In this case report, a 3-year-old female patient developed mucormycosis infection after liver transplant, which can lead to severe morbidity and mortality. Early recognition of the disease is crucial for timely treatment, and empirical antifungal therapy can be initiated for suspected cases. Diagnostic tests with accurate and fast results are needed, and more effective therapeutic methods should be developed for better outcomes.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Pediatrics
Mehmet Kocaoglu, Burcu Ezgi Kocaoglu, Selma Erol Aytekin, Dogukan Mustafa Keskin, Sukru Nail Guner, Sevgi Keles, Ismail Reisli
Summary: This study examined the demographic, clinical, and laboratory results of pediatric cases with IgG subclass deficiency. It found that concomitant main-group immunoglobulin deficiencies may increase the number and severity of infections in cases with IgG subclass deficiencies, leading to hospitalizations, antibiotic prophylaxis, and immunoglobulin therapy.
PEDIATRICS AND NEONATOLOGY
(2023)
Article
Pediatrics
Arzu Aras, Ali Avanaz, Nurel Inan Aydemir, Ece Kayaalp, Nazan Ulgen Tekerek, Abdullah Kisaoglu, Ismail Demiryilmaz, Erdogan Soyucen, Oguz Dursun, Aygen Yilmaz, Reha Artan, Bulent Aydinli
Summary: This study analyzed the data of 12 MSUD patients who underwent liver transplantation and found that there were no significant changes in their development, psychometric and mental status, motor ability, intellectual ability, and nutritional status after transplantation. It was also observed that none of the patients experienced metabolic attacks. These findings suggest that liver transplantation is an effective treatment option for MSUD, improving the quality of life and growth of patients.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Hematology
Sevgi Kostel Bal, Sarah Giuliani, Jana Block, Peter Repiscak, Christoph Hafemeister, Tala Shahin, Nurhan Kasap, Bernhard Ransmayr, Yirun Miao, Cheryl van de Wetering, Alexandra Frohne, Raul Jimenez Heredia, Michael Schuster, Samaneh Zoghi, Vanessa Hertlein, Marini Thian, Aleksandr Bykov, Royala Babayeva, Sevgi Bilgic Eltan, Elif Karakoc-Aydiner, Lisa E. Shaw, Iftekhar Chowdhury, Markku Varjosalo, Rafael J. Arguello, Matthias Farlik, Ahmet Ozen, Edgar Serfling, Loic Dupre, Christoph Bock, Florian Halbritter, J. Thomas Hannich, Irinka Castanon, Michael J. Kraakman, Safa Baris, Kaan Boztug
Summary: In this study, the researchers investigated the role of NFATC1 mutations in human immunity and found evidence of metabolic plasticity in patient T cells. The study also demonstrated that metformin and rosiglitazone can improve the effector functions of patient T cells.
Meeting Abstract
Immunology
Asena Pinar Sefer, Salim Can, Alper Bulutoglu, Dilek Baser, Ali Islek, Derya Ufuk Altintas, Safa Baris, Elif Karakoc Aydiner, Bernice Lo, Ahmet Ozen
CLINICAL IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Erol Demirkan, Murat Celik, Reha Artan
Summary: This study presents the slope deflection method for small-scaled axially functionally graded beams with a variable cross section based on the nonlocal elasticity theory. The nonlocal effect is considered due to the small-scale size of the structures. The stiffness coefficients and fixed-end moments are calculated using the method of initial values, reducing the problem to a linear equation system. The transfer matrix is obtained using Cauchy's repeated integration formula, replacing the double integrals with single integrals for easier numerical or analytical calculations.
APPLIED SCIENCES-BASEL
(2023)
Article
Gastroenterology & Hepatology
Jyoti Mani, Shira Levy, Angelina Angelova, Sahel Hazrati, Ryan Fassnacht, Poorani Subramanian, Tiana Richards, John E. Niederhuber, George L. Maxwell, Suchitra K. Hourigan
Summary: This longitudinal cohort study investigated the prevalence, risk factors, and microbiome characteristics of toxigenic C. diff carriage in infants. The study found that the prevalence of toxigenic C. diff carriage increased as infants grew older, but it was a transient component of the dynamic infant microbiome. Breastfeeding was associated with a lower carriage rate.
Article
Gastroenterology & Hepatology
Richard J. Thompson, Reha Artan, Ulrich Baumann, Pier Luigi Calvo, Piotr Czubkowski, Buket Dalgic, Lorenzo D'Antiga, Angelo Di Giorgio, Ozlem Durmaz, Emmanuel Gonzales, Tassos Grammatikopoulos, Girish Gupte, Winita Hardikar, Roderick H. J. Houwen, Binita M. Kamath, Saul J. Karpen, Florence Lacaille, Alain Lachaux, Elke Lainka, Kathleen M. Loomes, Cara L. Mack, Jan P. Mattsson, Patrick Mckiernan, Quanhong Ni, Hasan Ozen, Sanjay R. Rajwal, Bertrand Roquelaure, Eyal Shteyer, Etienne Sokal, Ronald J. Sokol, Nisreen Soufi, Ekkehard Sturm, Mary Elizabeth Tessier, Wendy L. van der Woerd, Henkjan J. Verkade, Jennifer M. Vittorio, Terese Wallefors, Natalie Warholic, Qifeng Yu, Patrick Horn, Lise Kjems
Summary: The ongoing PEDFIC 2 study evaluated the effectiveness of odevixibat in patients with progressive familial intrahepatic cholestasis. The study found that odevixibat can reduce serum bile acids and alleviate pruritus symptoms. This suggests that odevixibat may be a safe and effective treatment option for patients with progressive familial intrahepatic cholestasis.
Meeting Abstract
Immunology
Ahmet Ozen, Voranush Chongsrisawat, Asena Pinar Sefer, Burcu Kolukisa, Jessica J. Jalbert, Jutta L. Miller, Karoline A. Meagher, Taylor Brackin, Hagit Baris Feldman, Orly Eshach Adiv, Safa Baris, Elif Karakoc-Aydiner, Sevgi Bilgic Eltan, Melek Yorgun Altunbas, Rabia Ergelen, Ivan J. Fuss, Heather Moorman, Mary Magliocco, Helen Matthews, Beatriz E. Marciano, Narissara Suratannon, Pantipa Chatchatee, Kanya Suphapeetiporn, Caryn F. Trbovic, Michael E. Burczynski, Umesh Chaudhari, Lorah Perlee, Olivier A. Harari, Michael J. Lenardo
Article
Gastroenterology & Hepatology
Holm H. Uhlig, Claire Booth, Judy Cho, Marla Dubinsky, Anne M. Griffiths, Bodo Grimbacher, Sophie Hambleton, Ying Huang, Kelsey Jones, Jochen Kammermeier, Hirokazu Kanegane, Sibylle Koletzko, Daniel Kotlarz, Christoph Klein, Michael J. Lenardo, Bernice Lo, Dermot P. B. Mcgovern, Ahmet Ozen, Lissy de Ridder, Frank Ruemmele, Dror S. Shouval, Scott B. Snapper, Simon P. Travis, Dan Turner, David C. Wilson, Aleixo M. Muise
Summary: This Expert Recommendation reviews the therapeutic landscape for monogenic inflammatory bowel disease (mIBD) and proposes recommendations for standardized reporting of clinical outcomes. The field of mIBD lacks randomized controlled trials and relies on retrospective observational data. More than 25 off-label therapeutics and cellular therapies have been reported, but heterogeneous reporting of outcomes hinders the generation of robust therapeutic evidence.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Respiratory System
Esra Karabiber, Ozge Atik, Fatma Merve Tepetam, Bilgehan Ergan, Arzu Ilki, Elif Karakoc Aydiner, Ahmet Ozen, Fatma Ozyer, Safa Baris
Summary: Vaccines against SARS-CoV-2 are effective in patients with inborn errors of immunity, with full immunization associated with lower hospitalization rates and shorter symptomatic duration.
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX
(2023)
Article
Urology & Nephrology
K. Turkmen, M. A. Karaselek, S. C. Celik, H. H. Esen, H. Ozer, I. Baloglu, Y. Ozturk, S. N. Guner, I. Reisli, S. Keles
Summary: This study investigated the peripheral lymphocyte subgroup analysis of patients with Fabry Disease (FD) and compared them with healthy individuals. T, B, NK, and plasma cell analyses were performed in kidney biopsy materials and compared with the results of patients after 4 years of enzyme replacement therapy (ERT) with impaired kidney functions. Results showed that despite long-term ERT, the progression of FD nephropathy and proteinuria increased, possibly due to the negative impact of immune cells, particularly B and plasma cells.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Pediatrics
Abdurrahman Erdem Basaran, Aysen Basaran, Suzan Yilmaz Durmus, Tuba Kazli, Ayse Keven, Aysen Bingol
Summary: This study aims to identify predictive factors for pediatric patients with pulmonary embolism (PE) and evaluate the effectiveness of the Wells criteria, PERC, and pediatric-specific PE (PPE) criteria. The results show that our developed model has relatively higher specificity compared to the Wells and PERC models.
PEDIATRIC PULMONOLOGY
(2023)
Article
Microbiology
Celine M. Kisimba, Jack L. Donahue, Krishna Karthik Chivukula, Poorani Subramanian, Shreni D. Mistry, Anna Wolska, Alan T. Remaley, Jack A. Yanovski, Andrew P. Demidowich
Summary: This study found that obesity-induced systemic inflammation plays a substantial role in the development of insulin resistance and type 2 diabetes. Obesity also leads to gut dysbiosis, further contributing to metabolic dysregulation and systemic inflammation. However, it remains unclear how dysregulation of systemic inflammation in obesity affects the gut microbiome.
BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH
(2023)
