Article
Multidisciplinary Sciences
Jing Hao, Xiangzi Han, Haidong Huang, Xingjiang Yu, Jiangkang Fang, Jianjun Zhao, Richard A. Prayson, Shideng Bao, Jennifer S. Yu
Summary: The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials. In this study, it is shown that Semaphorin 3C plays a role in activating the Wnt pathway through Rac1-dependent β-catenin nuclear accumulation, indicating that dual targeting of Semaphorin 3C and Wnt pathways may achieve clinically significant Wnt pathway inhibition.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Charles A. Ettensohn
Summary: The establishment of early polarity in animal embryos is influenced by the dynamic redistribution of the Wnt signaling effector Dishevelled, a process regulated by the cell cycle and the Wnt receptor Frizzled 1.
Article
Pathology
Natalie M. Rizzo, Lynette M. Sholl, Muhammad T. Idrees, John C. Cheville, Sounak Gupta, Kristine M. Cornejo, Hiroshi Miyamoto, Michelle S. Hirsch, Katrina Collins, Andres M. Acosta
Summary: This study compared the genomic landscape of aggressive and nonaggressive testicular Leydig cell tumors (LCTs) and found that aggressive LCTs are characterized by FH inactivation and multiple copy number changes, while nonaggressive LCTs do not exhibit these characteristics.
Article
Plant Sciences
Ines Carqueijeiro, Konstantinos Koudounas, Thomas Duge de Bernonville, Liuda Johana Sepulveda, Angela Mosquera, Dikki Pedenla Bomzan, Audrey Oudin, Arnaud Lanoue, Sebastien Besseau, Pamela Lemos Cruz, Natalja Kulagina, Emily A. Stander, Sebastien Eymieux, Julien Burlaud-Gaillard, Emmanuelle Blanchard, Marc Clastre, Lucia Atehortua, Benoit St-Pierre, Nathalie Giglioli-Guivarc'h, Nicolas Papon, Dinesh A. Nagegowda, Sarah E. O'Connor, Vincent Courdavault
Summary: Deglycosylation is a crucial step in plant defense mechanisms, catalyzed by enzymes like SGD to produce reactive aglycones. Alternative splicing of the SGD gene in C. roseus leads to the shorter isoform shSGD, which disrupts SGD multimers and inhibits its activity, impacting downstream MIA synthesis. This pseudo-enzyme shSGD acts as a regulator of MIA biosynthesis by interfering with metabolic channeling and recruitment of enzymes.
Article
Virology
Ping Li, Han Ju, Ying Zhang, Jazmin Galvan Achi, Dongwei Kang, Jinmi Zou, Ruikun Du, Qinghua Cui, Xinyong Liu, Lijun Rong, Peng Zhan
Summary: Influenza viruses are a significant threat to public health globally. The emergence of drug-resistant strains has created the need for new antiviral drugs. In this study, a novel influenza virus inhibitor called A9, and its derivatives, were found to have broad-spectrum antiviral properties against influenza A and B viruses. Through various bioassays, it was shown that A9 inhibits the nuclear export of the viral ribonucleoprotein and specifically targets the nucleoprotein. These findings highlight A9 and its derivatives as potential leads for the treatment of influenza infections.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Green & Sustainable Science & Technology
Mohammad Khairul Azhar Abdul Razab, Norazlina Mat Nawi, Fara Hana Mohd Hadzuan, Nor Hakimin Abdullah, Maimanah Muhamad, Rosidah Sunaiwi, Fathirah Ibrahim, Farah Amanina Mohd Zin, An'amt Mohamed Noor
Summary: Radiopharmaceuticals used in nuclear medicine may contaminate surfaces due to spillage or accidents, posing risks to the environment and personnel. This study proposes an alternative method using graphene oxide for decontamination, which proves to have high adsorption efficiency and slow adsorption rate.
Review
Clinical Neurology
Chanan Sukprakun, Supatporn Tepmongkol
Summary: This article reviews the recent developments and future perspectives of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in epilepsy. It covers the advancements in PET radiopharmaceuticals, novel image analysis techniques and software for epileptogenic zone (EZ) localization, and their impact on predicting surgical outcomes and improving the understanding of epilepsy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Frank Schneider, Suresh S. Ramalingam, Shi-Yong Sun, Ahmet F. Coskun
Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays. RapMIF is a rapid multiplexed immunofluorescence method that can measure the spatial protein maps of up to 25 proteins, providing combinatorial signaling states and enabling precision therapy design.
Article
Integrative & Complementary Medicine
Bing-jie Guo, Yi Ruan, Ya-jing Wang, Chu-lan Xiao, Zhi-peng Zhong, Bin-bin Cheng, Juan Du, Bai Li, Wei Gu, Zi-fei Yin
Summary: This study investigated the mechanism of Jiedu Recipe (JR) in hepatocellular carcinoma (HCC) treatment. The results showed that JR inhibits the proliferation, migration and invasion of HCC cells under hypoxia by blocking the Wnt/β-catenin pathway and reducing the expression of tumor stem cells.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Biochemistry & Molecular Biology
S. Zachary Swartz, Tzer Han Tan, Margherita Perillo, Nikta Fakhri, Gary M. Wessel, Athula H. Wikramanayake, Iain M. Cheeseman
Summary: In meiotic oocytes of the sea star Patifia miniata, the distribution dynamics of the Disheveled protein are regulated by meiotic cell cycle progression and influenced by association with Lamp1+ endosomes and pre-localized Frizzled receptors within the oocyte cortex.
Article
Pathology
Stephanie E. Siegmund, Lynette M. Sholl, Harrison K. Tsai, Yiying Yang, Varshini Vasudevaraja, Ivy Tran, Matija Snuderl, Christopher D. M. Fletcher, Kristine M. Cornejo, Muhammad T. Idrees, Khaleel Al-Obaidy, Katrina Collins, Jennifer B. Gordetsky, Sara E. Wobker, Michelle S. Hirsch, Kiril Trpkov, Asli Yilmaz, William J. Anderson, Gabriela Quiroga-Garza, Cristina Magi-Galluzzi, Sofia Canete-Portillo, Andres M. Acosta
Summary: This study evaluated the features of testicular sex cord-stromal tumors (SCST) that could not be classified into a specific subtype. The study found that a subset of these tumors could be reclassified through a combined evaluation of morphology, immunohistochemistry, and molecular data.
Article
Oncology
Yuya Higashi, Shuji Ikeda, Kotaro Matsumoto, Shinsuke Satoh, Aoi Komatsu, Hiroshi Sugiyama, Fuyuhiko Tamanoi
Summary: This study demonstrates the tumor accumulation and nuclear localization ability of KR12, a PIP-based KRAS inhibitor, using a fluorescently labeled derivative in a chicken egg tumor assay. The results also show the inhibition of tumor growth by KR12 in the CAM model.
Article
Cardiac & Cardiovascular Systems
Fereshteh Koosha, Peyman Sheikhzadeh
Summary: This study investigated the cardiotoxicity of Tc-99m-MIBI injection in myocardial perfusion imaging and evaluated the protective effect of the compound HDC. The results showed that HDC could mitigate radiation-induced cardiac damage, reduce fiber rupture and lymphocyte presence, and decrease collagen deposition. In addition, HDC decreased MDA activity and increased SOD activity.
CARDIOVASCULAR TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Nicolas Lepareur, Barthelemy Ramee, Marie Mougin-Degraef, Mickael Bourgeois
Summary: Targeted radionuclide therapy has become prominent in nuclear medicine, aiming to achieve high selectivity at the tumor level while limiting dosage to healthy tissues. Advancements in cancer molecular mechanisms, innovative targeting agents, and new radioisotopes have allowed for better therapeutic efficacy, radiation safety, and personalized treatments. Several radiopharmaceuticals for therapeutic targeting have shown clinical value and will be approved for clinical use.
Article
Cell Biology
Yuchun Liu, Yao Sun, Yonghui Huang, Kang Cheng, Yuming Xu, Qingnan Tian, Shoutao Zhang
Summary: The mutation of CHIP can result in the neurodegenerative disease SCAR16, and this protein is closely associated with Wnt signaling and Arc stability. Research shows that overexpression of CHIP can enhance the activation of Wnt signaling, while silencing CHIP has the opposite effect.
CELL DEATH DISCOVERY
(2021)
Review
Pharmacology & Pharmacy
Win Sen Heng, Reinoud Gosens, Frank A. E. Kruyt
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Win Sen Heng, Shiau-Chuen Cheah
Article
Oncology
Win Sen Heng, Milind Pore, Coby Meijer, T. Jeroen N. Hiltermann, Shiau-Chuen Cheah, Reinoud Gosens, Frank A. E. Kruyt
Summary: The study showed increasing expression of CSC markers, such as MYC, SOX2 and CD44, in association with disease progression in SCLC. Different CSC populations with varying marker expression were found, with GLC-16 and GLC-19 demonstrating higher stem cell properties and therapy resistance compared to GLC-14.
Review
Biochemistry & Molecular Biology
Win Sen Heng, Frank A. E. Kruyt, Shiau-Chuen Cheah
Summary: Lung cancer, one of the deadliest cancers, can be effectively reduced through prevention measures, though treatment improvements are still needed to address therapeutic resistance caused by cancer stem cells; phytochemicals in plant-based diets are believed to have efficacy in targeting lung cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)