Article
Biotechnology & Applied Microbiology
Danni Gong, Fei Yu, Meng Zhou, Wei Dong, Dan Yan, Siyi Zhang, Yan Yan, Huijing Wang, Yao Tan, Ying Chen, Bei Feng, Wei Fu, Yao Fu, Yang Lu
Summary: dcECM hydrogels derived from porcine ears through enzymatic digestion show good biocompatibility for delivering chondrocytes and forming subcutaneous cartilage in vivo. The structural and gelation kinetics of the hydrogels vary with ECM concentrations, with 10 mg/ml hydrogels supporting adhesion and proliferation of chondrocytes in vitro. In vivo, 10 mg/ml dcECM hydrogel grafts exhibit similar qualities to native cartilage, indicating their potential for tissue engineering applications in ear cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chaymaa Hachimi Alaoui, Gildas Rethore, Pierre Weiss, Ahmed Fatimi
Summary: Different techniques have been developed to extract lignin biopolymer from lignocellulosic biomass. Lignin has gained considerable interest in the biomedical field due to its attractive properties and has been used in the preparation of value-added products such as hydrogels. Lignin-based hydrogels have shown great potential for various biomedical applications, and their copolymerization with other polymers and biopolymers further expands their possibilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
M. R. Poorna, R. Jayakumar, Jyh-Ping Chen, Ullas Mony
Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine, and improving culture methods, such as using hydrogels as substrates, can support iPSC adhesion, proliferation, and differentiation. Using hydrogels may help generate large numbers of clinical-grade cells for potential clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Sarah M. Hull, Lucia G. Brunel, Sarah C. Heilshorn
Summary: Using gel-phase materials as bioinks offers advantages in providing cell protection and biological signals. Challenges remain in terms of cell compatibility and biological functionality of bioink materials.
ADVANCED MATERIALS
(2022)
Review
Engineering, Biomedical
Kamil Elkhoury, Margaretha Morsink, Laura Sanchez-Gonzalez, Cyril Kahn, Ali Tamayol, Elmira Arab-Tehrany
Summary: Natural hydrogels are highlighted as promising biomaterials in tissue engineering applications due to their biocompatibility and biodegradability. Innovative biofabrication techniques, such as textile techniques and 3D bioprinting, play a significant role in developing advanced scaffolds for tissue engineering. This review also discusses the emerging applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering.
BIOACTIVE MATERIALS
(2021)
Review
Engineering, Biomedical
Chaojie Yu, Fanglian Yao, Junjie Li
Summary: Recently, injectable conducting polymer-based hydrogels have gained attention in tissue engineering due to their controlled conductivity and minimally invasive procedures. Functional CPs play a crucial role in designing these hydrogels and have potential applications in neurological treatment, myocardial repair, and skeletal muscle regeneration.
ACTA BIOMATERIALIA
(2022)
Review
Biotechnology & Applied Microbiology
Fatemeh Dadkhah Tehrani, Arezoo Firouzeh, Iman Shabani, Azadeh Shabani
Summary: The amniotic membrane, as the innermost layer of the fetal placenta, has unique properties that make it valuable in regenerative medicine applications. Beyond sterilization and preservation, additional modifications are being explored to enhance its properties and durability, presenting a new area of study in its applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Ziba Naghizadeh, Akbar Karkhaneh, Hanieh Nokhbatolfoghahaei, Saeed Farzad-Mohajeri, Maryam Rezai-Rad, Mohammad M. Dehghan, Pouyan Aminishakib, Arash Khojasteh
Summary: An injectable hydrogel/microparticle system containing melatonin and methylprednisolone was developed for chondrogenesis in vitro and in vivo. The system showed promising results in promoting cartilage regeneration, with improved properties and gene expression when loaded with cells. Overall, the study demonstrated the potential of the developed system for cartilage regeneration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yanbing Gao, Xiaobo Zhang, Haiyu Zhou
Summary: Biomimetic hydrogels have great potential in tissue engineering and regenerative medicine for tissue repair and regeneration. They can tune mechanical and biological properties, provide three-dimensional network structures, and imitate normal tissue microenvironments to integrate cells, scaffolds, and bioactive substances. However, further research is needed for the biomedical and clinical trial applications of biomimetic hydrogels.
Article
Materials Science, Multidisciplinary
Mina Shahriari-Khalaji, Muhammad Shafiq, Haitao Cui, Ran Cao, Meifang Zhu
Summary: Cardiovascular diseases (CVDs) are the leading cause of health issues and death globally. Although autografts are the standard treatment, their effectiveness is limited due to various factors. Synthetic vascular grafts have potential for large-diameter blood vessel reconstruction, but lack success for small-diameter substitutes. However, advancements in fabrication technologies have shown promise for small diameter blood vessel manufacturing, offering potential future clinical applications.
APPLIED MATERIALS TODAY
(2023)
Review
Materials Science, Biomaterials
Mymuna Ashna, Neeharika Senthilkumar, Pallab Sanpui
Summary: Regenerative medicine utilizes the regenerative potential of human cells to generate acceptable human tissues and organs, and biomaterial scaffolds play a vital role in this process. Hydrogels, especially keratin-based ones, are versatile materials for tissue engineering and regenerative medicine applications. This review focuses on the suitability and applications of keratin-based hydrogels in regenerative medicine.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Priti Gupta, Shilpa Sharma, Shagufta Jabin, Sapana Jadoun
Summary: Regenerative medicine and tissue engineering have great potential in addressing the limitations of traditional medical approaches. Chitosan, as a naturally derived biocompatible biomaterial, has played a significant role in tissue regeneration. It has unique properties and can be applied in various fields, such as agriculture, nutraceuticals, biomedicine, and food. Chitosan is also an important material for developing next-generation hydrogels and bio-scaffolds. Furthermore, chitosan can be easily modified to enhance its mechanical strength, biodegradability, and controlled release of bioactive molecules. Blending chitosan with other polymers or incorporating nanoparticles expands its possibilities in tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Materials Science, Multidisciplinary
Weiwei Lan, Mengjie Xu, Miao Qin, Yizhu Cheng, Ya Zhao, Di Huang, Xiaochun Wei, Yongchang Guo, Weiyi Chen
Summary: The study developed a bilayer hydrogel with robust interfacial bonding for osteochondral defect regeneration, demonstrating favorable cytocompatibility and the ability to induce osteochondral regeneration. The results also showed well bonding strength between the neo-tissue and native adjacent tissues, suggesting great potential for repairing osteochondral defects.
MATERIALS & DESIGN
(2021)
Review
Engineering, Biomedical
Adrianna Wierzbicka, Marek Krakos, Piotr Wilczek, Dorota Bociaga
Summary: Hydrogel materials have great potential in treating urinary system conditions, including intravesical drug delivery, ureteral stents design, and reconstruction of urinary bladder and urethral defects. They also find applications in educational simulation models for medical personnel training.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Polymer Science
Martyna Gawel, Patrycja Domalik-Pyzik, Timothy E. L. Douglas, Katarzyna Reczynska-Kolman, Elzbieta Pamula, Kinga Pielichowska
Summary: This study proposes and investigates new scaffolds based on whey protein isolate (WPI) and chitosan (CS) for osteochondral tissue repair. The optimal WPI/CS hydrogels were chosen based on various evaluation criteria, and it was found that the hydrogels with CS incorporated in powder form exhibited superior mechanical properties and those with CS incorporated after dissolution showed enhanced wettability. The introduction of CS powder promoted apatite formation and the CS powder modified WPI hydrogels showed good cytocompatibility, indicating their potential for osteochondral tissue repair.
Article
Materials Science, Biomaterials
Esmail Sohouli, Amir Homayoun Keihan, Faezeh Shahdost-fard, Ebrahim Naghian, Marta E. Plonska-Brzezinska, Mehdi Rahimi-Nasrabadi, Farhad Ahmadi
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Physical
Mohammad Amin Marsooli, Mehdi Rahimi Nasrabadi, Mandi Fasihi-Ramandi, Kourosh Adib, Saeid Pourmasoud, Farhad Ahmadi, Mohammad Eghbali, Ali Sobhani Nasab, Monika Tomczykowa, Marta E. Plonska-Brzezinska
Article
Chemistry, Analytical
Esmail Sohouli, Faezeh Shahdost-Fard, Mehdi Rahimi-Nasrabadi, Marta E. Plonska-Brzezinska, Farhad Ahmadi
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Piotr Olejnik, Marianna Gniadek, Luis Echegoyen, Marta E. Plonska-Brzezinska
Summary: In this study, glassy carbon electrodes modified with nanocomposites containing conductive polyaniline nanotubes and carbon nano-onions were used for the sensitive determination of daidzein by linear sweep voltammetry. The electrochemical behavior of daidzein was investigated in different buffer environments, showing direct electrooxidation at specific potentials.
Article
Chemistry, Analytical
Maryam Saleh Mohammadnia, Elnaz Marzi Khosrowshahi, Ebrahim Naghian, Amir Homayoun Keihan, Esmail Sohouli, Marta E. Plonska-Brzezinska, Ali Sobhani-Nasab, Mehdi Rahimi-Nasrabadi, Farhad Ahmadi
MICROCHEMICAL JOURNAL
(2020)
Article
Nanoscience & Nanotechnology
Grzegorz S. Szymanski, Yuka Suzuki, Tomonori Ohba, Bogdan Sulikowski, Kinga Gora-Marek, Karolina A. Tarach, Stanislaw Koter, Piotr Kowalczyk, Anna Ilnicka, Monika Zieba, Luis Echegoyen, Artur P. Terzyk, Marta E. Plonska-Brzezinska
Summary: Defects in nanomaterials are considered as active sites that tune surface properties for catalysis. The study on boron-doped carbon nano-onions (B-CNOs) reveals a close relationship between their defective structures and catalytic properties affected by the experimental conditions such as mass ratio and process. The presence of different types of boron-Lewis sites on B-CNO surface contributes to their catalytic activity, as shown in SO2 oxidation and tert-butanol dehydration.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Electrochemistry
Esmail Sohouli, Masoumeh Ghalkhani, Tahereh Zargar, Yvonne Joseph, Mehdi Rahimi-Nasrabadi, Farhad Ahmadi, Marta E. Plonska-Brzezinska, Hermann Ehrlich
Summary: Staphylococcus aureus (S. aureus) is a common bacterial pathogen that causes infections. A sensitive aptasensor was developed using carbon nano-onions, gold nanoparticles, and modified carbon electrodes for rapid detection of S. aureus. The aptasensor showed good repeatability and stability.
ELECTROCHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Damian Pawelski, Alicja Walewska, Sylwia Ksiezak, Dariusz Sredzinski, Piotr Radziwon, Marcin Moniuszko, Ramesh Gandusekar, Andrzej Eljaszewicz, Ryszard Lazny, Krzysztof Brzezinski, Marta E. Plonska-Brzezinska
Summary: The study aims to synthesize monocarbonyl analogs of curcumin to improve its bioavailability, with ten new analogs successfully synthesized and tested for cytotoxicity and anti-inflammatory properties in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Adam Chyzy, Damian Pawelski, Vladyslav Vivcharenko, Agata Przekora, Michael Bratychak, Olena Astakhova, Joanna Breczko, Pawel Drozdzal, Marta E. Plonska-Brzezinska
Summary: This study utilized well-known oligomers to synthesize a three-dimensional hydrogel (HG) network. The hydrogel network exhibited non-cytotoxic and highly porous characteristics, making it a potential candidate for use in drug reservoirs for in vitro applications. The study also explored the immobilization of methylene blue as a model compound in the HG matrix and examined its release. The results demonstrated the potential of the [P(EMA)-co-(GMA)] and [P(EMA)-co-(GMA)]-Xyl oligomers for biomedical applications.
Article
Biochemistry & Molecular Biology
Anna Puckowska, Magdalena Gawel, Marlena Komorowska, Pawel Drozdzal, Aleksandra Arning, Damian Pawelski, Krzysztof Brzezinski, Marta E. Plonska-Brzezinska
Summary: Derivatives based on pyridine-2-6- and furan-2,5-dicarboxamide scaffolds have diverse chemical properties and biological activities, making them a significant research topic in supramolecular and coordination chemistry, as well as in the discovery of new pharmacologically-active compounds. This study aimed to synthesize a series of symmetrical pyridine-2-6- and furan-2,5-dicarboxamides through the condensation reaction of appropriate acyl chlorides and aromatic amides. Successful syntheses were confirmed using NMR spectroscopy. Crystal structures of seven compounds, including two pyridine and five furan derivatives, were determined, revealing their supramolecular features. Hirshfeld surface analysis provided insights into the distribution of intermolecular contacts within the dicarboxamide crystals.
Article
Materials Science, Multidisciplinary
Gabriela Siemiaszko, Agnieszka Hryniewicka, Joanna Breczko, Olivia Fernandez Delgado, Karolina H. Markiewicz, Luis Echegoyen, Marta E. Plonska-Brzezinska
Summary: The organization of specific pores in carbonaceous networks is crucial for efficient electrocatalytic processes. In this study, porous materials with well-defined pores were synthesized using polymer-templated methods. The incorporation of carbon nanostructures improved the organization of the polymer chains. The physicochemical properties of these porous materials were evaluated for use as supercapacitors.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Damian Pawelski, Olivia Fernandez Delgado, Agnieszka Z. Wilczewska, Jakub W. Strawa, Marta E. Plonska-Brzezinska
Summary: Carbon nanostructures provide an ideal platform for molecular catalysts, and the noncovalent immobilization of aryl boronic acid on carbon nano-onions' surface through pi-pi interaction is achieved in this study. The nanostructured carbon material acts as a catalyst for the direct amide coupling reaction under microwaved heating without a solvent. The high thermal stability and microwave absorption properties of carbon nano-onions contribute to the high catalytic yield of up to 94%. The straightforward recovery process and minimal mass losses make this synthesis method environmentally friendly.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Physical
Damian Pawelski, Marta E. Plonska-Brzezinska
Summary: This review focuses on materials containing defective carbon nanostructures (CNs) and those incorporated into larger systems, discussing their structural defects and how they modify the physical and chemical properties. The method of microwave irradiation is emphasized as a powerful tool for synthesizing and modifying carbon-based solid materials. The review highlights the role of microwave-assisted heating in creating defects in CNs and its implications in designing their properties and applications.
Article
Chemistry, Multidisciplinary
Gabriela Siemiaszko, Agnieszka Hryniewicka, Joanna Breczko, Krzysztof Brzezinski, Marta E. Plonska-Brzezinska
Summary: In this study, mesoporous carbon materials were synthesized from diblock star copolymers derived from polyacrylonitrile. The size of the pores was controlled by manipulating the length of the polymer blocks. Furthermore, the organization of polymers on the carbon nano-onion's surface resulted in materials with higher surface area and superior electrochemical performance.
CHEMICAL COMMUNICATIONS
(2022)
