Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Plant plasma membrane vesicles interaction with keratinocytes reveals their potential as carriers

(2020) Lucía Yepes-Molina et al.   Journal of Advanced Research

State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review

(2020) Javier Donoso-Quezada et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression

(2020) Mao-Ze Wang et al.   JOURNAL OF CONTROLLED RELEASE

Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL–programmed therapy against melanoma

(2020) Li-Hua Peng et al.   Science Advances

Extracellular Vesicles from Fresh and Dried Plants—Simultaneous Purification and Visualization Using Gel Electrophoresis

(2019) Eric Woith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

“Exosomes on the border of species and kingdom intercommunication”

(2019) Christina M.A.P. Schuh et al.   Translational Research

Plant Extracellular Vesicles Contain Diverse Small RNA Species and Are Enriched in 10- to 17-Nucleotide “Tiny” RNAs

(2019) Patricia Baldrich et al.   PLANT CELL

Extracellular Vesicles as Vehicles for the Delivery of Food Bioactives

(2019) Agnes T. Reiner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Surface Engineering of Extracellular Vesicles through Chemical and Biological Strategies

(2019) Joseph J. Richardson et al.   CHEMISTRY OF MATERIALS

Human marrow stromal cells secrete microRNA-375-containing exosomes to regulate glioma progression

(2019) Sheng-Ze Deng et al.   CANCER GENE THERAPY

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate—Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults

(2019) Stéphane Pillet et al.   PLoS One

The Role of Exo-miRNAs in Cancer: A Focus on Therapeutic and Diagnostic Applications

(2019) Francesco Ingenito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles—Connecting Kingdoms

(2019) Eric Woith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

(2019) Liuwan Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

(2019) Francesca Susa et al.   Cancers

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Isolation of Exosome-Like Nanoparticles and Analysis of MicroRNAs Derived from Coconut Water Based on Small RNA High-Throughput Sequencing

(2018) Zhehao Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Extracellular vesicles: a missing component in plant cell wall remodeling

(2018) Laura de la Canal et al.   JOURNAL OF EXPERIMENTAL BOTANY

Protein biocargo of citrus fruit juice sac cells-derived vesicles reveals heterogeneous transport and extracellular vesicle subpopulations

(2018) Gabriella Pocsfalvi et al.   JOURNAL OF PLANT PHYSIOLOGY

Technical challenges of working with extracellular vesicles

(2018) Marcel I. Ramirez et al.   Nanoscale

Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

(2018) Qiang Cai et al.   SCIENCE

Vesicle-based secretion in schistosomes: Analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni

(2018) Vitalie Samoil et al.   Scientific Reports

Biogenesis and Function of Multivesicular Bodies in Plant Immunity

(2018) Xifeng Li et al.   Frontiers in Plant Science

Recent advances in "smart" delivery systems for extended drug release in cancer therapy

(2018) Regina-Veronicka Kalaydina et al.   International Journal of Nanomedicine

Comparison of exosome-mimicking liposomes with conventional liposomes for intracellular delivery of siRNA

(2018) Mei Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression

(2018) Zhefeng Li et al.   Scientific Reports

Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

(2018) Gabriella Andriolo et al.   Frontiers in Physiology

Identification of exosome-like nanoparticle-derived microRNAs from 11 edible fruits and vegetables

(2018) Juan Xiao et al.   PeerJ

Influence of PEG coating on the biodistribution and tumor accumulation of pH-sensitive liposomes

(2018) Shirleide Santos Nunes et al.   Drug Delivery and Translational Research

In Vitro Wound Healing Activity of Wheat-Derived Nanovesicles

(2018) Fikrettin Şahin et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

(2018) Yun Teng et al.   Cell Host & Microbe

Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells

(2018) Daichi Fujita et al.   MOLECULAR PHARMACEUTICS

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Extracellular vesicles in food: Experimental evidence of their secretion in grape fruits

(2017) Pedro Pérez-Bermúdez et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Small Interfering RNA in Milk Exosomes Is Resistant to Digestion and Crosses the Intestinal Barrier In Vitro

(2017) Shruti Shandilya et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

(2017) Helena Costa Verdera et al.   JOURNAL OF CONTROLLED RELEASE

Plant extracellular vesicles are incorporated by a fungal pathogen and inhibit its growth

(2017) Mariana Regente et al.   JOURNAL OF EXPERIMENTAL BOTANY

Plant exosomes: using an unconventional exit to prevent pathogen entry?

(2017) Line Lykke Hansen et al.   JOURNAL OF EXPERIMENTAL BOTANY

Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase

(2017) Zhongbin Deng et al.   MOLECULAR THERAPY

Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease

(2017) Joana Loureiro et al.   MOLECULES

Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis

(2017) Mingzhen Zhang et al.   Nanomedicine

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity

(2017) Odessa Schillaci et al.   Scientific Reports

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

(2016) Mingzhen Zhang et al.   BIOMATERIALS

Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity

(2016) Li-Hua Peng et al.   BIOMATERIALS

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

Sonoporation enhances liposome accumulation and penetration in tumors with low EPR

(2016) Benjamin Theek et al.   JOURNAL OF CONTROLLED RELEASE

Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression

(2016) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy

(2016) Mingzhen Zhang et al.   MOLECULAR THERAPY

Extracellular Vesicles Isolated from the Leaf Apoplast Carry Stress-Response Proteins

(2016) Brian D. Rutter et al.   PLANT PHYSIOLOGY

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From structures to functions: insights into exosomes as promising drug delivery vehicles

(2016) Jinghua Ren et al.   Biomaterials Science

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Cell Membrane Capsules for Encapsulation of Chemotherapeutic and Cancer Cell Targeting in Vivo

(2015) Li-Hua Peng et al.   ACS Applied Materials & Interfaces

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

(2015) Bence György et al.   Annual Review of Pharmacology and Toxicology

Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites

(2015) Q. Wang et al.   CANCER RESEARCH

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Effective detection and quantification of dietetically absorbed plant microRNAs in human plasma

(2015) Hongwei Liang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models

(2015) Onno J. Arntz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

Differential detergent sensitivity of extracellular vesicle subpopulations

(2015) Xabier Osteikoetxea et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Improved Characterization of EV Preparations Based on Protein to Lipid Ratio and Lipid Properties

(2015) Xabier Osteikoetxea et al.   PLoS One

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

(2015) Stefania Raimondo et al.   Oncotarget

Advances and Challenges of Liposome Assisted Drug Delivery

(2015) Lisa Sercombe et al.   Frontiers in Pharmacology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro

(2014) Tyson J. Smyth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Surface Functionalization of Exosomes Using Click Chemistry

(2014) Tyson Smyth et al.   BIOCONJUGATE CHEMISTRY

TAT conjugated cationic noble metal nanoparticles for gene delivery to epidermal stem cells

(2014) Li-Hua Peng et al.   BIOMATERIALS

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

(2014) Roy van der Meel et al.   JOURNAL OF CONTROLLED RELEASE

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles

(2014) Jingyao Mu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting

(2014) Ming-Zhen Zhang et al.   NANOTECHNOLOGY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling

(2013) Wei Dou et al.   BRITISH JOURNAL OF NUTRITION

The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage

(2013) Amr S. Abu Lila et al.   JOURNAL OF CONTROLLED RELEASE

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

(2013) Songwen Ju et al.   MOLECULAR THERAPY

Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit

(2013) Baomei Wang et al.   MOLECULAR THERAPY

Antigen-loaded nanocarriers enhance the migration of stimulated Langerhans cells to draining lymph nodes and induce effective transcutaneous immunization

(2013) Ni Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Tracking the Down-Regulation of Folate Receptor-α in Cancer Cells through Target Specific Delivery of Quantum Dots Coupled with Antisense Oligonucleotide and Targeted Peptide

(2013) Ming-Zhen Zhang et al.   Small

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

(2013) Qilong Wang et al.   Nature Communications

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

Development of liposomal formulations: From concept to clinical investigations

(2013) Yuchen Fan et al.   Asian Journal of Pharmaceutical Sciences

Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration

(2012) Antje Schaefer et al.   BIOCHEMICAL JOURNAL

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

Immune-related MicroRNAs are Abundant in Breast Milk Exosomes

(2012) Qi Zhou et al.   International Journal of Biological Sciences

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Targeted quantum dots fluorescence probes functionalized with aptamer and peptide for transferrin receptor on tumor cells

(2012) Ming-Zhen Zhang et al.   NANOTECHNOLOGY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Plant-derived virus-like particles as vaccines

(2012) Qiang Chen et al.   Human Vaccines & Immunotherapeutics

MicroRNAs, diet, and cancer: New mechanistic insights on the epigenetic actions of phytochemicals

(2011) Mansi A. Parasramka et al.   MOLECULAR CARCINOGENESIS

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Transcutaneous vaccines: Novel advances in technology and delivery for overcoming the barriers

(2011) Ni Li et al.   VACCINE

Emerging role for ERM proteins in cell adhesion and migration

(2011) Monique Arpin et al.   Cell Adhesion & Migration

Structural-Mechanical Characterization of Nanoparticle Exosomes in Human Saliva, Using Correlative AFM, FESEM, and Force Spectroscopy

(2010) Shivani Sharma et al.   ACS Nano

Drug delivery and nanoparticles: Applications and hazards

(2010) de Jong   International Journal of Nanomedicine

Optical and non-optical methods for detection and characterization of microparticles and exosomes

(2010) E. VAN DER POL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Nanostructural and Transcriptomic Analyses of Human Saliva Derived Exosomes

(2010) Viswanathan Palanisamy et al.   PLoS One

Vesicular fractions of sunflower apoplastic fluids are associated with potential exosome marker proteins

(2009) Mariana Regente et al.   FEBS LETTERS

Anti-inflammatory activity of naringin and the biosynthesised naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice

(2009) Maria Inês Amaro et al.   FOOD RESEARCH INTERNATIONAL

Extracellular transport and integration of plant secretory proteins into pathogen-induced cell wall compartments

(2008) Dorit Meyer et al.   PLANT JOURNAL