Article
Agriculture, Dairy & Animal Science
Yuta Seo, Takuya Kubota, Masami Sudo, Naomi Toda, Yasuki Ogawa, Yuji Miyaguchi
Summary: The study found that natto can influence the transcript levels of PPARG, PPARGC1B, and NCOR1 in hens, while the fat and protein/fiber-enriched fractions of natto can also affect the adipose and hepatic PPARG transcript levels.
ANIMAL SCIENCE JOURNAL
(2021)
Article
Agriculture, Dairy & Animal Science
Guoyan Wang, Jun Zhang, Shengru Wu, Senlin Qin, Yining Zheng, Chao Xia, Huijun Geng, Junhu Yao, Lu Deng
Summary: Cattle have a unique mechanism for efficient hepatic gluconeogenesis, involving the high expression of specific genes and the activation of the mTORC1 signaling pathway. These findings are important for understanding the mechanism underlying the quantitative differences in hepatic gluconeogenesis efficiency between cattle and non-ruminant animals.
Article
Environmental Sciences
Jingyuan Zhang, Jinwei Song, Shuang Liu, Yuhan Zhang, Tianming Qiu, Liping Jiang, Jie Bai, Xiaofeng Yao, Ningning Wang, Guang Yang, Xiance Sun
Summary: This study found that the impact of sodium arsenite on hepatic insulin sensitivity can be reversed by inhibiting ferroptosis. Mechanistically, the suppression of PGC-1 alpha reduces the protein expression of GSTK1, leading to increased accumulation of ROS and promotion of ferroptosis. Additionally, arsenic induces hepatic insulin resistance and ferroptosis through METTL14 and YTHDF2-mediated N6-methyladenosine modification of PGC-1 alpha mRNA.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Cell Biology
Youssef Siblini, Fares Namour, Abderrahim Oussalah, Jean-Louis Gueant, Celine Chery
Summary: Stem cells rely on methionine for maintenance and differentiation, with one-carbon metabolism playing a crucial role. Cultivating stem cells under methionine-restricted conditions decreases their stemness capacities and alters the expression of stem cell markers. Genes like SIRT1 and PGC-1 alpha/PPAR-alpha are important in regulating the metabolism of stem cells. Methionine restriction holds potential applications in regenerative medicine and cancer treatment.
Article
Oncology
Lei Wang, Mengmeng Yang, Huihan Jin
Summary: The study demonstrated that PI3K/AKT phosphorylation enhances ERR alpha activity in NOZ cells by upregulating the expression levels of PGC-1 alpha and PGC-1 beta, promoting the invasion and proliferation of gallbladder cancer cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Huanxin Xie, Lei Cao, Linlin Ye, Qiang Li, Yaohua Zhang, Hongyue Zhang, Huaqing Yang
Summary: This study investigated the involvement of miR-29b-3p in osteoporosis and its underlying mechanisms. The results showed that miR-29b-3p suppressed osteogenesis by blocking the SIRT1/PPAR gamma axis. Targeting miR-29b-3p SIRT1/PPAR gamma could be a potential treatment for postmenopausal osteoporosis.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2023)
Article
Obstetrics & Gynecology
Koki Shimura, Yosuke Tarumi, Maya Fujii, Kanae Ogawa, Eiko Maeda, Yukiko Tanaka, Hiroyuki Okimura, Hisashi Kataoka, Osamu Takaoka, Fumitake Ito, Akemi Koshiba, Khaleque N. Khan, Izumi Kusuki, Jo Kitawaki, Taisuke Mori
Summary: This study investigates the effects of a low-nutrient microenvironment on endometriosis. The results show that under the low-nutrient condition, stromal cells from ovarian endometrioma (OESCs) have higher proliferation and exhibit changes in gene and protein expression related to angiogenesis, inflammation, anti-apoptosis, and local estrogen production.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Weilin Xu, Jun Yan, Umut Ocak, Cameron Lenahan, Anwen Shao, Jiping Tang, Jianmin Zhang, John H. Zhang
Summary: Activation of MC1R using BMS-470539 significantly attenuated early brain injury following SAH by suppressing oxidative stress, apoptosis, and mitochondrial fission through the AMPK/SIRT1/PGC-1 alpha signaling pathway, improving neurological deficits and memory impairments.
Article
Agriculture, Dairy & Animal Science
Weiwei Wang, Qinping Yu, Qingyun Cao, Hui Ye, Changming Zhang, Zemin Dong, Dingyuan Feng, Jianjun Zuo
Summary: MicroRNA-27a (miR-27a) regulates the expression of MYH7 and PGC-1a, affecting the composition of muscle fiber types in pigs. MiR-27a inhibits the expression of MYH7 and PGC-1a, along with the downstream targets MEF2C, NRF-1, mtTFA, COX ?, Cytc, and SDH, which are involved in mitochondrial biogenesis and oxidative metabolism. These findings have significant implications for genetic or nutritional control of muscle fiber phenotype and pork quality.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Neurosciences
Jian Zhang, Ya Gao, Lan Zhang, Cong Zhang, Yuan Zhao, Yidan Zhang, Shuyue Li, Cui Chang, Xiangjian Zhang, Guofeng Yang
Summary: This study investigated the neuroprotective effect of alpha-lipoic acid (ALA) and its potential role in the SIRT1 pathway in Parkinson's disease (PD). The results showed that ALA prevented oxidative stress and neurotoxicity, and increased the expression of SIRT1 and PGC-1 alpha in PD models.
NEUROTOXICITY RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Meng Hui, Wang Qi-yan, Li Ning, He Hao, Lu Wen-ji, Wang Qi-xin, Sun Xiao-qian, Jiao Shi-hong, Wang Yong, Tu Peng-fei
Summary: Danqi Tablet (DQT) has a cardioprotective effect on ischemic heart model rats, increasing ATP production in myocardial cells and inhibiting inflammation. It regulates energy metabolism through the AMPK/SIRT1-PGC-1 alpha pathway, suggesting a potential target for treating ischemic heart disease.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Himabindu Beeram, Swapna Siddamalla, Venkat Reddy Tumu, Veena Kv, Akanksha Vidala, Mamata Deenadayal, Shivaji Sisinthy, Manjula Bhanoori
Summary: The genetic variants of VDR and PGC-1 alpha genes were not found to play a significant role in the pathogenesis of endometriosis in Indian women.
DNA AND CELL BIOLOGY
(2022)
Article
Cell Biology
Yun Lu, Jiaqi Mao, Xinxin Han, Weihua Zhang, Yuanyuan Li, Yuehua Liu, Qiang Li
Summary: The study revealed that HIF-1α inhibits myoblast differentiation and damages mitochondrial ultrastructure under hypoxic conditions, while inhibition of the AMPK pathway increases apoptosis. Resveratrol dimer can reverse mitochondrial damage induced by AMPK pathway inhibition and reduce myoblast apoptosis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Akbar Ahmadi, Dariush Sheikholeslami-Vatani, Saeed Ghaeeni, Maryam Baazm
Summary: The research suggests that high intensity interval training (HIIT) induces stronger positive responses in gene expression of monocarboxylate transporter 4 (MCT4), Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), and hypoxia inducible factor-1 alpha (HIF-1 alpha) compared to moderate intensity continuous training (MICT).
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Dermatology
Hyejin Ko, Hyunjung Choi, Yujia Han, Seungchan An, Daejin Min, Won-Seok Park, Sun Hee Jin, Hyoung-June Kim, Minsoo Noh
Summary: The study investigated the molecular target of 3,4,5-trimethoxycinnamate thymol ester (TCTE) and found that TCTE promotes adiponectin secretion by binding to peroxisome proliferator-activated receptor gamma (PPARγ) and increasing the recruitment of coactivator peptides. The anti-melanogenic activity of TCTE is associated with PPARγ partial agonism independent of PGC-1α.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)