Article
Biochemistry & Molecular Biology
Tadataka Takagi, Rina Fujiwara-Tani, Shiori Mori, Shingo Kishi, Yukiko Nishiguchi, Takamitsu Sasaki, Ruiko Ogata, Ayaka Ikemoto, Rika Sasaki, Hitoshi Ohmori, Yi Luo, Ujjal Kumar Bhawal, Masayuki Sho, Hiroki Kuniyasu
Summary: Gemcitabine resistance in pancreatic ductal adenocarcinoma cells is associated with decreased energy production, decreased mitochondrial reactive oxygen species levels, and increased stemness caused by mitochondrial damage. Hypoxia may promote this process. Treatment with lauric acid restores gemcitabine sensitivity by activating oxidative phosphorylation. Further clinical validation of lauric acid in gemcitabine resistance is needed in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Tomas Koltai, Stephan Joel Reshkin, Tiago M. A. Carvalho, Daria Di Molfetta, Maria Raffaella Greco, Khalid Omer Alfarouk, Rosa Angela Cardone
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor with a poor prognosis and inadequate response to treatment. Multiple factors contribute to therapeutic failure, including late diagnosis due to lack of symptoms, early spread, advanced age of patients, hyperfibrotic stroma, genetic heterogeneity, and early resistance to available treatments.
Article
Oncology
Marina Roy-Luzarraga, Louise E. Reynolds, Beatriz de Luxan-Delgado, Oscar Maiques, Laura Wisniewski, Emma Newport, Vinothini Rajeeve, Rebecca J. G. Drake, Jesus Gomez-Escudero, Frances M. Richards, Celine Weller, Christof Dormann, Ya-Ming Meng, Peter B. Vermeulen, Dieter Saur, Victoria Sanz-Moreno, Ping-Pui Wong, Cyrill Geraud, Pedro R. Cutillas, Kairbaan Hodivala-Dilke
Summary: This study reveals that endothelial cell focal adhesion kinase (FAK) plays a role in regulating pancreatic ductal adenocarcinoma (PDAC) metastasis and impacting the outcome of gemcitabine treatment. The findings suggest the potential clinical utility of combinatorial endothelial cell FAK targeting with gemcitabine in controlling metastasis in PDAC patients.
Article
Oncology
Jay Natu, Ganji Purnachandra Nagaraju
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with high chemoresistance. Gemcitabine, one of the primary treatments for PDAC, has limited benefits due to interactions with the tumor microenvironment (TME). Preclinical models have shown that certain schedules of gemcitabine administration can modulate the TME without promoting resistance. Metronomic therapy is a promising strategy to overcome barriers in PDAC treatments.
Article
Oncology
Evelien J. M. de Jong, Quisette P. Janssen, Tessa F. A. Simons, Marc G. Besselink, Bert A. Bonsing, Stefan A. W. Bouwense, Sandra M. E. Geurts, Marjolein Y. Homs, Vincent E. de Meijer, Vivianne C. G. Tjan-Heijnen, Hanneke W. M. van Laarhoven, Liselot B. J. Valkenburg-van Iersel, Johanna W. Wilmink, Lydia G. van der Geest, Bas Groot Koerkamp, Judith de Vos-Geelen
Summary: In a nationwide cohort of patients with pancreatic ductal adenocarcinoma, adjuvant GEMCAP was associated with superior survival compared to GEM monotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Qiu Tu, Xiuyun Liu, Xiaoqing Yao, Ruixue Li, Gaojing Liu, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu, Hong Zhu, Peng Shi, Bo Zhao
Summary: This study identified RETSAT as a novel replication fork protein in pancreatic ductal adenocarcinoma (PDAC) cells. RETSAT functions by interacting with DDX39B to promote fork restarting and increase cellular resistance to replication stresses co-induced by tumor environmental hypoxia and gemcitabine.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Nicolas A. Fraunhoffer, Analia M. Abuelafia, Carlos Teyssedou, Eduardo Chuluyan, Martin Bigonnet, Laurent Palazzo, Odile Gayet, Remy Nicolle, Jerome Cros, Juan Iovanna, Nelson Dusetti
Summary: The study revealed specific transcriptomic characteristics of hepatic metastases in PDAC, which are associated with cell cycle checkpoint, mitochondria activity, and extracellular matrix reorganization. In addition, squamous lineage emerged as a key feature linked to the chemosensitivity profile of PDAC hepatic metastases.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Xiao-Xu Zhu, Jian-Hui Li, Xuhao Ni, Xiao Wu, Xun Hou, Ya-Xiong Li, Shi-Jin Li, Wei Zhao, Xiao-Yu Yin
Summary: LINC00460 is associated with the response to gemcitabine in PDAC patients and PDAC-PDX, and it influences the activity of growth factors and extracellular matrix in PDAC tumor cells. LINC00460 directly binds to PDAP1 and regulates the cellular communication between PDAC tumor cells and CAFs through the PDAP1/PDGFA/PDGFR signaling pathway, thereby affecting the gemcitabine-resistance function of CAFs. PDAC-PDX tumors with lower expression of LINC00460 show a better response to gemcitabine plus crenolanib treatment.
Article
Oncology
Jinsheng Ding, Hui Li, Yang Liu, Yongjie Xie, Jie Yu, Huizhi Sun, Di Xiao, Yizhang Zhou, Li Bao, Hongwei Wang, Chuntao Gao
Summary: This study identified OXCT1 as a key gene leading to GEM resistance in PDAC through the NF-kappa B signaling pathway, with high OXCT1 expression associated with shorter relapse-free survival under GEM treatment. OXCT1 overexpression in PDAC cell lines inhibited apoptosis after GEM treatment, and blocking the NF-kappa B signaling pathway reduced GEM resistance. These findings suggest that OXCT1 could be a potential therapeutic target for patients with PDAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mundla Srilatha, Ramarao Malla, Megha Priya Adem, Jeremy B. Foote, Ganji Purnachandra Nagaraju
Summary: Obesity is closely associated with pancreatic health, and obese individuals have an increased risk for developing pancreatic ductal adenocarcinoma (PDAC). Factors such as chronic inflammation, insulin resistance, metabolic dysfunction, immune suppression, hormone level changes, and genetic mutations contribute to the development and progression of PDAC in obese individuals.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Oncology
Sheron Perera, Gun Ho Jang, Yifan Wang, Deirdre Kelly, Michael Allen, Amy Zhang, Robert E. Denroche, Anna Dodd, Stephanie Ramotar, Shawn Hutchinson, Mustapha Tehfe, Ravi Ramjeesingh, James Biagi, Bernard Lam, Julie Wilson, Sandra E. Fischer, George Zogopoulos, Faiyaz Notta, Steven Gallinger, Robert C. Grant, Jennifer J. Knox, Grainne M. O'Kane
Summary: In advanced PDAC, hENT1 mRNA expression predicts ORR and OS in patients receiving GnP, while no association was observed in patients receiving mFFX.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Fangyu Zhao, Gang Yang, Jiangdong Qiu, Yueze Liu, Jinxin Tao, Guangyu Chen, Dan Su, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor response to gemcitabine. STC1 regulates chemoresistance in pancreatic cancer and may serve as a potential prognostic factor and therapeutic target for PDAC treatment.
MOLECULAR CARCINOGENESIS
(2022)
Article
Cell Biology
Mingyi Shang, Li Weng, Guifang Xu, Shaoqiu Wu, Bingyan Liu, Xiang Yin, Aiwu Mao, Xiaoping Zou, Zhongmin Wang
Summary: TRIM11 expression is upregulated in pancreatic cancer, promoting gemcitabine resistance and inhibiting ferritinophagy through UBE2N-TAX1BP1 signaling pathway, identifying TRIM11 as a key regulator in PDAC development.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Article
Oncology
Deepak Rohila, In Hwan Park, Timothy Pham, Jonathan Weitz, Tatiana Hurtado de Mendoza, Suresh Madheswaran, Mehreen Ishfaq, Cooper Beaman, Elisabette Tapia, Siming Sun, Jay Patel, Pablo Tamayo, Andrew M. Lowy, Shweta Joshi
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with limited treatment options. This study demonstrates that targeting macrophage spleen tyrosine kinase (Syk) can reprogram protumorigenic macrophages to an immunostimulatory phenotype, enhance CD8+ T-cell responses, and improve gemcitabine efficacy in PDAC.
Article
Thermodynamics
Zhongbo Zhang, Qin Liu, Rongchao Zhao, Youpeng Chen, Qichao Qin
Summary: This paper investigates the effects of In-Cylinder Steam Injection (ICSI) on the performance of a turbocompound engine, and finds that ICSI significantly improves the total power and fuel economy of the engine. Adjusting ICSI parameters can further enhance the engine performance.
Article
Medical Laboratory Technology
Pingping Fang, Yiping Wu, Zhongbo Zhang, Cui Cui, Xiaoxue Dong, Ke Hu, Jundong Jia, Xinfei Duan, Ying Zhang, Haoran Huo
Summary: This study found that lnc-GAS5 expression levels were higher in patients with AIS compared to controls, and were positively correlated with disease severity and inflammation, as well as predicting an increased risk of AIS recurrence.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Environmental Sciences
Jing Fu, Yueqi Gong, Wenwu Zheng, Jun Zou, Meng Zhang, Zhongbo Zhang, Jianxin Qin, Jianxiong Liu, Bin Quan
Summary: This study investigated the spatiotemporal variations of terrestrial evapotranspiration (ET) in China from 2000 to 2019 and analyzed the driving factors behind these changes. The results showed that climate variation, including increasing precipitation and wind speed, had a significant impact on ET. The study also found that increasing temperature, decreasing sunshine duration and relative humidity contributed to the increase in ET to some extent. The findings provide valuable insights into the role of climate variability in hydrological processes and the potential impacts of ET variability on the climate system.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Thermodynamics
Zhongbo Zhang, Weijian Wan, Wencan Zhang, Qin Liu, Rongchao Zhao, Youpeng Chen, Qichao Qin
Summary: This study investigates the effects of in-cylinder steam injection (ICSI) on a liquefied petroleum gas (LPG) engine. The results show that steam decreases the laminar flame speed of LPG, while ICSI leads to significant increases in flame development angle and rapid burning angle. By adjusting the ignition timing, ICSI affects the combustion phase of the engine, and with optimum ignition timing, the engine performance and NO characteristic are remarkably improved.
Article
Thermodynamics
Qin Liu, Wencan Zhang, Zhongbo Zhang, Qichao Qin
Summary: This paper proposes a control method for electric vehicle drive system based on energy consumption and battery life, using an optimized acceleration curve to reduce energy consumption and battery capacity loss.
Article
Chemistry, Multidisciplinary
Zhongbo Zhang, Zilong Wang, Naoki Aratani, Xiaozhang Zhu, Qichun Zhang
Summary: Structurally well-defined arenes with higher numbers of linearly-fused six-member rings are important and desirable due to their experimental challenges and fundamental interests. In this research, a novel large N-heteroarene (N20) with 20 linearly-fused six-membered rings was successfully synthesized and confirmed by single-crystal X-ray diffraction analysis. The as-prepared arene exhibits a wave-like framework and shows high molar absorptivity and extended fluorescence in the near-infrared region.
Article
Chemistry, Multidisciplinary
Cheng Ji, Zhongbo Zhang, Khalil D. Omotosho, Diana Berman, Byeongdu Lee, Ralu Divan, Supratik Guha, Elena V. Shevchenko
Summary: The use of PIM-1 in sequential infiltration synthesis allows for the fabrication of highly porous AlOx coatings with excellent mechanical properties. These coatings can be used as single-layer ARCs or graded-index double-layered coatings to significantly reduce Fresnel reflections, showing high hardness and scratch resistivity.
Article
Environmental Sciences
Zhongbo Zhang, Jing Fu, Wenwen Tang, Yuan Liu, Haibo Zhang, Xiaohong Fang
Summary: This study reveals the spatiotemporal variations of drought in the Hengyang-Shaoyang Drought Corridor (HSDC) and evaluates the effects of artificial precipitation enhancement. The results show that drought occurred frequently in the study area, with increasing drought intensity. However, summer droughts were relatively less severe. Artificial precipitation effectively eased drought in the area.
Article
Thermodynamics
Zhongbo Zhang, Wei Yu, Haibing Li, Weijian Wan, Wencan Zhang, Weiming Zhuo, Qin Liu
Summary: A novel lithium-ion battery with an inner cooling/heating structure is proposed in this paper to improve heat dissipation and low-temperature performance. Experimental results show that the inner cooling/heating structure can significantly enhance the battery's heat transfer characteristics and low-temperature performance.
APPLIED THERMAL ENGINEERING
(2023)
Article
Automation & Control Systems
Pengqiang Fu, Liangwei Lv, Bing Guo, Zhenfei Guo, Jianfei Jia, Zhongbo Zhang, Guicheng Wu, Yang Xiang
Summary: A micro-structured CVD diamond micro-grinding tool was studied to improve lubrication and chip removal performance in the grinding zone. First, the effects of micro-structure parameters on the deformation and stress distribution of the micro-grinding tool were analyzed using a commercial FEM software. Then, the coolant flow fields in the grinding zone, including the macro flow field, micro flow field, and chip evacuation, were simulated. The effects of micro-structure parameters and grinding parameters on flow field performance and chip transport capacity were obtained, providing a basis for the design and optimization of surface micro-structures in CVD diamond micro-grinding tools.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jovana Stanojkovic, Ronny William, Zhongbo Zhang, Israel Fernandez, Jingsong Zhou, Richard D. Webster, Mihaiela C. Stuparu
Summary: The authors demonstrate that mechanochemical Scholl reaction provides a direct route to chlorinated curved nanographenes from graphitization precursors. The chlorination is regioselective, high-yielding, and general. The resulting nanographenes can be chemically modified with precision through Suzuki or nucleophilic aromatic substitution reactions, leading to modulation of material properties via edge modification.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Yuanyuan Guo, Minjun Feng, Zhongbo Zhang, Senyun Ye, Yue Wang, Qiannan Zhang, Tomoki Furuhashi, Dongming Jia, Qichun Zhang, Tze Chien Sum
Summary: Singlet fission is a promising process for photovoltaics that converts singlet excitons into triplet excitons. In this study, a series of pyrene-fused azaacenes with varying conjugation lengths were designed, and their excited-state dynamics and energy levels were analyzed. The findings provide guidance for the construction of molecules with desired optoelectronic properties.
CHEMISTRY OF MATERIALS
(2023)
Article
Biology
Tiancong Du, Ke Zhang, Zhongbo Zhang, Aijia Guo, Guilin Yu, Yuanhong Xu
Summary: ITGBL1 is highly expressed in pancreatic cancer tissues and is associated with poor prognosis. Silencing ITGBL1 inhibits cell proliferation, migration, and invasion, and delays the cell cycle, while overexpressing ITGBL1 has the opposite effect. ITGBL1 also activates the TGF-β/Smad pathway in pancreatic cancer progression. Additionally, JDP2 suppresses the expression of ITGBL1.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Thermodynamics
Wencan Zhang, Weijian Wan, Weixiong Wu, Zhongbo Zhang, Xiao Qi
Summary: This study establishes a prediction model to reveal the internal temperature of lithium-ion batteries under various boundary conditions. Internal and surface temperatures are obtained by inserting thermocouples, and the thermal network method is used to calculate the battery internal temperature under different cooling modes. Experimental data verifies the accuracy of the model and highlights the importance of internal temperature.
APPLIED THERMAL ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Zhang Zhongbo, Li Xiuqin, Li Boxuan, Feng Xia, Zhang Beibei, Liu Yi
Summary: In this study, BP and GO were successfully dispersed using liquid-phase stripping technique, and a BP-GO composite carrier was prepared through covalent bonding. AgNPs were in situ reduced and loaded onto the surface of the BP-GO composite carrier. The results showed that the BP-GO-AgNPs composite coating exhibited better antibacterial properties compared to the GO-AgNPs composite coating under the same conditions.
RARE METAL MATERIALS AND ENGINEERING
(2022)
