Article
Oncology
Thomas B. Brunner, Dominik Bettinger, Michael Schultheiss, Lars Maruschke, Lukas Sturm, Nico Bartl, Ivana Koundurdjieva, Simon Kirste, Hannes P. Neeff, Christian Goetz, Nils Henrik Nicolay, Gabriele Ihorst, Fabian Bamberg, Robert Thimme, Anca-Ligia Grosu, Eleni Gkika
Summary: The study findings indicate that SBRT is an effective and well-tolerated local treatment for patients with hepatocellular carcinoma, providing high rates of local control and maintaining quality of life for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Quan Wang, Xiaoquan Ji, Jing Sun, Wengang Li, Xuezhang Duan, Aimin Zhang
Summary: There is a lack of evidence on the benefit of stereotactic body radiotherapy (SBRT) in combination with lenvatinib for advanced hepatocellular carcinoma (HCC). This study compared the efficacy and safety of SBRT plus lenvatinib versus SBRT alone in clinical practice for the treatment of advanced HCC. The results showed that SBRT plus lenvatinib significantly improved overall survival, progression-free survival, intrahepatic progression-free survival, and objective response rate compared to SBRT alone, with manageable adverse effects.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
James J. Harding, Richard K. Do, Amin Yaqubie, Ann Cleverly, Yumin Zhao, Ivelina Gueorguieva, Michael Lahn, Karim A. Benhadji, Robin K. Kelley, Ghassan K. Abou-Alfa
Summary: The study on patients with advanced HCC showed that the combination therapy of a TGF-beta receptor 1 inhibitor and an anti-VEGF receptor 2 antibody is safe and tolerable, but the results did not support the preclinical hypothesis that blocking TGF beta signaling enhances the efficacy of VEGF-targeted therapy.
Article
Oncology
Ying-Fu Wang, Yang-Hong Dai, Chun-Shu Lin, Hao-Chih Chang, Po-Chien Shen, Jen-Fu Yang, Chih-Weim Hsiang, Cheng-Hsiang Lo, Wen-Yen Huang
Summary: SBRT is a promising treatment for HCC patients awaiting liver transplantation, providing significant tumor control and acceptable adverse effects. Further prospective studies are needed to explore the feasibility of SBRT as a bridging therapy for LT.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Chi-Leung Chiang, Keith Wan-Hang Chiu, Francis Ann-Shing Lee, Feng-Ming Spring Kong, Albert Chi-Yan Chan
Summary: After translation, it is revealed that the combination of stereotactic SBRT-IO and TACE showed better survival and lower treatment toxicity in patients with locally advanced HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Ren Ji, Kelvin K. Ng, Wenqi Chen, Weihong Yang, Hongtao Zhu, Tan-To Cheung, Chi-Leung Chiang, Tiffany C. L. Wong, Feng-Ming Kong, G. Wu, Chung-Mau Lo
Summary: This study compared the clinical outcomes of SBRT and RFA for patients with unresectable HCC. The results showed that there was no significant difference in the short-term and long-term clinical outcomes between SBRT and RFA, including the complete remission rate and local tumor control rate. Both treatments had a low incidence of complications. Therefore, SBRT can be considered as an alternative to RFA for the treatment of unresectable HCC.
Article
Oncology
Ting-Shi Su, Qiu-Hua Liu, Xiao-Fei Zhu, Ping Liang, Shi-Xiong Liang, Lin Lai, Ying Zhou, Yong Huang, Tao Cheng, Le-Qun Li
Summary: This study found that higher radiotherapy doses are associated with better outcomes for HCC patients, with SaRT and SbRT showing better improvement in OS, PFS, and intrahepatic control compared to ScRT.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Luca Boldrini, Angela Romano, Silvia Mariani, Davide Cusumano, Francesco Catucci, Lorenzo Placidi, Gian Carlo Mattiucci, Giuditta Chiloiro, Francesco Cellini, Maria Antonietta Gambacorta, Luca Indovina, Vincenzo Valentini
Summary: Hepatocellular carcinoma in early stages can benefit from local ablative treatments such as radiofrequency ablation or transarterial chemoembolization. Radiotherapy has shown promising results for HCC treatment. Magnetic resonance-guided radiotherapy may represent a significant improvement in stereotactic body radiotherapy for liver tumors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Isaure Roquette, Emilie Bogart, Thomas Lacornerie, Massih Ningarhari, Jean-Emmanuel Bibault, Marie-Cecile Le Deley, Eric F. Lartigau, David Pasquier, Xavier Mirabel
Summary: This study describes the treatment efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC). The analysis of data from 318 patients showed that SBRT is efficient for the management of HCC with a favorable toxicity profile.
Article
Oncology
Feiqian Wang, Kazushi Numata, Atsuya Takeda, Katsuaki Ogushi, Hiroyuki Fukuda, Hiromi Nihonmatsu, Koji Hara, Makoto Chuma, Yuichirou Tsurugai, Shin Maeda
Summary: RFA and SBRT treatment may be potential options for patients with multifocal HCC in BCLC stage A4-B1 due to favorable prognosis and safety. Prospective, controlled, large-scale studies are needed to further confirm these conclusions before clinical application.
Article
Oncology
Aditya Juloori, Rohan R. Katipally, Jeffrey M. Lemons, Anurag K. Singh, Renuka Iyer, Jared R. Robbins, Ben George, William A. Hall, Sean P. Pitroda, Fauzia Arif, John Fung, Anjana Pillai, Chih-Yi Liao, Manish Sharma, Stanley L. Liauw
Summary: This study investigated the safety and efficacy of stereotactic body radiation therapy (SBRT) with immunotherapy in patients with hepatocellular carcinoma (HCC). The results showed that the combination of SBRT with nivolumab plus ipilimumab had better survival and efficacy compared to immunotherapy alone in HCC patients, suggesting the need for further investigation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Oncology
Alexander H. Shannon, Ashish Manne, Dayssy A. Diaz Pardo, Timothy M. Pawlik
Summary: Hepatocellular Carcinoma (HCC) is a common cancer with high mortality worldwide. Recent advancements in immune check point inhibitors (ICI) combined with radiotherapy have shown potential in the treatment of nonresectable HCC. ICI modulates the tumor microenvironment to inhibit tumor progression, while radiotherapy enhances its efficacy by manipulating the tumor microenvironment and reducing tumor resistance. Future directions include addressing challenges and exploring combination therapies.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biology
Chai Hong Rim, Hye Yoon Lee, Jung Sun Kim, Hakyoung Kim
Summary: Both radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) have demonstrated efficacy in treating early hepatocellular carcinoma (HCC), but their effectiveness has yet to be compared in randomized studies. Research has described the characteristics and indications of both treatment modalities and discussed recent comparative studies between them.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Review
Oncology
Kayla M. Daniell, Kara Michah Banson, Brett H. Diamond, Shirin Sioshansi
Summary: Patients with hepatocellular carcinoma (HCC) and underlying Child-Pugh B-7 cirrhosis benefit from management from an experienced, multidisciplinary team. Carefully selecting locoregional therapy takes into account various patient factors. Technological advances in external beam radiation therapy have allowed stereotactic body radiation therapy (SBRT) to emerge as a versatile option for patients with Child-Pugh B cirrhosis.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Oncology
Yukinori Matsuo
Summary: Stereotactic body radiotherapy (SBRT) is an effective alternative therapy for hepatocellular carcinoma (HCC) when standard treatments are not suitable. It has the potential to improve prognosis of HCC by achieving high local control rates. However, further research is needed to determine optimal use of SBRT in combination with other treatments and the evaluation of post-SBRT imaging.
Article
Oncology
Takahiro Tsujikawa, Todd Crocenzi, Jennifer N. Durham, Elizabeth A. Sugar, Annie A. Wu, Beth Onners, Julie M. Nauroth, Robert A. Anders, Elana J. Fertig, Daniel A. Laheru, Kim Reiss, Robert H. Vonderheide, Andrew H. Ko, Margaret A. Tempero, George A. Fisher, Michael Considine, Ludmila Danilova, Dirk G. Brockstedt, Lisa M. Coussens, Elizabeth M. Jaffee, Dung T. Le
CLINICAL CANCER RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
Akram Saad, Jeffrey Goldstein, Ofer Margalit, Einat Shacham-Shmueli, Yaacov R. Lawrence, Yu-Xiao Yang, Kim A. Reiss, Talia Golan, Ronac Mamtani, Naama Halpern, Dan Aderka, Meir Mouallem, Adam Goldstein, Bruce Giantonio, Ben Boursi
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Article
Immunology
Jeffrey H. Lin, Austin P. Huffman, Max M. Wattenberg, David M. Walter, Erica L. Carpenter, David M. Feldser, Gregory L. Beatty, Emma E. Furth, Robert H. Vonderheide
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Oncology
Ofer Margalit, Einat Shacham-Shmueli, Yu-Xiao Yang, Yaacov R. Lawerence, Idan Levy, Kim A. Reiss, Talia Golan, Naama Halpern, Dan Aderka, Bruce Giantonio, Ronac Mamtani, Ben Boursi
Summary: Upstaging of clinical T1N0 gastric adenocarcinoma is characterized by higher tumor grade and is mostly a result of a change in T stage. Thorough workup is needed to identify patients with clinically staged T1N0 disease requiring preoperative chemotherapy.
Article
Oncology
Shun Yu, Ronac Mamtani, Mark H. O'Hara, Peter J. O'Dwyer, Ofer Margalit, Bruce J. Giantonio, Einat Shmueli, Kim A. Reiss, Ben Boursi
Summary: The long-term overall survival characteristics of total neoadjuvant therapy (TNT) for locally advanced rectal cancer have not been clearly defined, but current research indicates that TNT is not associated with worse survival compared to standard adjuvant chemotherapy.
CLINICAL COLORECTAL CANCER
(2021)
Article
Medicine, Research & Experimental
Max M. Wattenberg, Veronica M. Herrera, Michael A. Giannone, Whitney L. Gladney, Erica L. Carpenter, Gregory L. Beatty
Summary: The study revealed a specific cellular response to chemoimmunotherapy, but it did not impact treatment outcomes. Instead, an inflammatory network in the peripheral blood was found to be associated with outcomes, indicating systemic inflammation as a potential resistance mechanism to CD40-based chemoimmunotherapy. Additionally, patients with systemic inflammation, identified by a neutrophil/lymphocyte ratio greater than 3.1, had a significantly shorter median overall survival compared to those with a lower ratio.
Article
Oncology
Kim A. Reiss, Robert H. Vonderheide
Summary: The development of multiagent chemotherapy for metastatic pancreatic cancer has shown promising results in certain patient subgroups, but long-term chemotherapy may have negative effects on quality of life and organ function. The POLO trial demonstrated the benefits of maintenance olaparib in patients with germline pathogenic variants in BRCA1 or BRCA2, suggesting potential for further alternative treatment strategies in a broader group of patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Kim A. Reiss, Rosemarie Mick, Mark H. O'Hara, Ursina Teitelbaum, Thomas B. Karasic, Charles Schneider, Stacy Cowden, Traci Southwell, Janae Romeo, Natallia Izgur, Zain M. Hannan, Rashmi Tondon, Katherine Nathanson, Robert H. Vonderheide, Max M. Wattenberg, Gregory Beatty, Susan M. Domchek
Summary: This study assessed the role of the PARPi rucaparib as maintenance therapy in advanced pancreatic cancer patients with germline or somatic pathogenic variants in BRCA1, BRCA2, or PALB2, and found it to be a safe and effective treatment option, showing efficacy in a subset of patients.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Oncology
Max M. Wattenberg, Kim A. Reiss
Summary: A subset of pancreatic cancer patients exhibit heightened response rates and prolonged survival to platinum chemotherapy and PARP inhibitors, primarily due to deficient homologous recombination (HR) DNA repair mechanism. In addition to HR gene mutations, diverse tumor intrinsic and extrinsic factors also impact the phenotype of homologous recombination deficiency (HRD).
Article
Multidisciplinary Sciences
Stacy K. Thomas, Max M. Wattenberg, Shaanti Choi-Bose, Mark Uhlik, Ben Harrison, Heather Coho, Christopher R. Cassella, Meredith L. Stone, Dhruv Patel, Kelly Markowitz, Devora Delman, Michael Chisamore, Jeremy Drees, Nandita Bose, Gregory L. Beatty
Summary: This study demonstrates that modulating macrophage polarization can prevent the metastasis of pancreatic cancer cells to the liver. The activation of liver-resident macrophages by beta-glucan leads to the suppression of cancer cell proliferation and the induction of T cell-mediated immune responses against liver metastasis. Moreover, beta-glucan also sensitizes metastatic lesions to anti-PD1 therapy.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Zain Hannan, Shun Yu, Susan Domchek, Ronac Mamtani, Kim A. Reiss
Summary: The study identified and profiled 22 patients with PDAC and ATM alterations, showing a significantly longer median overall survival for patients with ATM alterations compared to those without, suggesting that pathogenic ATM alterations may improve outcomes in pancreatic cancer patients.
JNCI CANCER SPECTRUM
(2021)
Letter
Oncology
Erin M. Bange, Kim A. Reiss, Ronac Mamtani
JCO ONCOLOGY PRACTICE
(2020)
Article
Oncology
Erin M. Bange, Abigail Doucette, Peter E. Gabriel, Florence Porterfield, James J. Harrigan, Robin Wang, Andrzej P. Wojcieszynski, Ben Boursi, Bethany I. Mooney, Kim A. Reiss, Ronac Mamtani
JCO ONCOLOGY PRACTICE
(2020)