Article
Oncology
Tianye Li, Zhenzhen Hao, Zihan Tang, Chunting Li, Linglin Cheng, Tao Wang, Xiaojin Zhu, Yunhao He, Yongye Huang, Bing Wang
Summary: BAP31 plays an important role in the migration of lung cancer cells, and its knockdown weakens cell migration. Treatment with TGF-beta can reduce cell migration and enhance proliferation, which is downregulated after BAP31 knockdown. Moreover, BAP31 regulates multiple signaling pathways, especially the Wnt signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Qingqing Zhou, Tengfei Liu, Wenjing Qian, Jun Ji, Qu Cai, Yangbing Jin, Jinling Jiang, Jun Zhang
Summary: BAP31 is upregulated in gastric cancer tissues and high expression is associated with poor survival of patients. BAP31 knockdown inhibits cell growth, induces G1/S arrest, and promotes cellular ferroptosis by increasing membrane lipid peroxidation. BAP31 directly binds to VDAC1, affecting its oligomerization and polyubiquitination, and is regulated by HNF4A at the promoter. Knockdown of BAP31 sensitizes gastric cancer cells to 5-FU and the ferroptosis inducer erastin.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Esben M. Quistgaard
Summary: BAP31 is a broadly expressed transmembrane protein involved in various cellular processes such as supporting organelle homeostasis, promoting proliferation and migration, regulating metabolism and the immune system, and controlling autophagy and apoptosis. Loss-of-function mutations in BAP31 lead to DDCH syndrome and it is implicated in multiple cancers and diseases, targeted by several viruses for their survival.
Article
Biochemistry & Molecular Biology
Jingjing Liu, Qi Zhang, Jiyu Wang, Changli Wang, Tian Lan, Tianyi Wang, Bing Wang
Summary: Knockdown of BAP31 in colorectal cancer cells enhances chemosensitivity to 5-FU and reduces stemness, potentially through the inhibition of the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qi Zhang, Changli Wang, Yufei Wu, Jingjing Liu, Tianyi Wang, Bing Wang
Summary: This study investigated the functions and molecular mechanism of BAP31 on the miR-206/133b cluster in colorectal cancer (CRC). The results showed that BAP31 overexpression led to a reduction in the expression of the miR-206/133b cluster, which was correlated with the transendothelial migration capability of CRC cells. The miR-206/133b cluster was found to directly regulate cell division cycle 42 (CDC42) and actin-related protein 2/3 complex subunit 5 (ARPC5) in the tight junction pathway (hsa04530), and the potential transcription regulator of the miR-206/133b cluster was identified as Homeobox D10 (HOXD10). The study further elucidated the molecular mechanisms and functional mechanisms of BAP31's regulatory role in the expression levels of the miR-206/133b cluster by inhibiting HOXD10 translocation from the cytoplasm to the nucleus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Hanqun Liu, Yuxuan Yong, Xingjian Li, Panghai Ye, Kai Tao, Guoyou Peng, Mingshu Mo, Wenyuan Guo, Xiang Chen, Yangfu Luo, Yuwan Lin, Jiewen Qiu, Zhiling Zhang, Liuyan Ding, Miaomiao Zhou, Xinling Yang, Lin Lu, Qian Yang, Pingyi Xu
Summary: The reduction of SMAD3 and up-regulation of LAMP2A in human-grade IV glioblastoma tissues suggest a relationship between the two proteins in regulating glioma cell growth. Excessive activation of the CMA pathway through SMAD3-LAMP2A mediation may be a promising target in anti-cancer therapy.
NEUROSCIENCE BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Bo Zhao, Lijun Sun, Qing Yuan, Zhenzhen Hao, Fei An, Wanting Zhang, Xiaoshuang Zhu, Bing Wang
Summary: The absence of BAP31 leads to an enlarged spleen and thymus in mice, accompanied by activated clustering and disrupted differentiation of CD4(+)T cells. In vitro co-culture studies show that the loss of BAP31 increases the expression of antigen presenting molecules, particularly MHC-II, on macrophages. These findings suggest that BAP31 regulates the activation and differentiation of CD4+T cells by modulating MHC class II molecule expression on macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Bin Song, Jiajian Wang, Yixin Ren, Yongnan Su, Xueye Geng, Fan Yang, Hao Wang, Jihong Zhang
Summary: p53 is a transcription factor that activates gene expression for genomic stability, but many cancers have mutations in p53 that render it inactive. Butein, a small molecule, has been identified as a potential drug that can reactivate mutant p53 and restore its tumor-suppressing function. Through various mechanisms, Butein restores the DNA-binding ability of mutant p53, activates p53 target genes, and stabilizes both wild-type and mutant p53 proteins. This study suggests that Butein could be a promising therapeutic agent for cancers with specific p53 mutations.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Qi Zhang, Changli Wang, Ruijia Li, Jingjing Liu, Jiyu Wang, Tianyi Wang, Bing Wang
Summary: BAP31 regulates colorectal cancer (CRC) angiogenesis by manipulating the tumor microenvironment. Exosomes from BAP31-overexpressing CRCs induce the transformation of normal fibroblasts into proangiogenic cancer-associated fibroblasts (CAFs). Moreover, miR-181a-5p, a microRNA present in the exosomes, directly targets the RECK gene and promotes endothelial cell angiogenesis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Naphannop Sereesongsaeng, James F. Burrows, Christopher J. Scott, Klaudia Brix, Roberta E. Burden
Summary: Our study found that CTSV has an impact on breast cancer cell proliferation, with depleted CTSV cells showing delayed progression through the G2/M phase of the cell cycle. Further investigation revealed that CTSV can regulate the expression levels of histones H3 and H4 in the nucleus by controlling the expression of their chaperone protein sNASP. We also discovered that CTSV is localized in the nuclear compartment of breast tumor cells and is required for cell cycle progression and histone stability.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Shuya Yang, Yuanjie Sun, Dongbo Jiang, Jing Wang, Erle Dang, Zichao Li, Jiayi Zhou, Yuchen Lu, Jingqi Shi, Liang Tao, Jun Wang, Boquan Jin, Lianhe Zheng, Kun Yang
Summary: Elevated BAP31 in cervical cancer is regulated by miR-362, which inhibits cell proliferation and promotes apoptosis, ultimately suppressing tumor progression. The BAP31/SPTBN1 complex modulates tumor progression through the Smad 2/3 pathway under miR-362 regulation.
Article
Biochemistry & Molecular Biology
Guo-xun Li, Xiao-han Jiang, Jing-nan Zang, Ben-zhi Zhu, Cong-cong Jia, Kun-wei Niu, Xia Liu, Rui Jiang, Bing Wang
Summary: This study found that BAP31 deficiency can alleviate acute lung injury (ALI) by reducing the adhesion and infiltration of neutrophils through the down-regulation of adhesion molecules CD11b/CD18 and PSGL-1. BAP31 may be a potential appealing protein to mediate the occurrence of ALI.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Review
Immunology
Aruma Watanabe, Izuru Mizoguchi, Hideaki Hasegawa, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Yuma Furusaka, Ami Sekine, Satomi Miyakawa, Fumihiro Murakami, Mingli Xu, Toshihiko Yoneto, Takayuki Yoshimoto
Summary: The interleukin-6 (IL-6)/IL-12 family of cytokines plays crucial roles in immune responses, with EBI3 having a novel intracellular role in promoting proper folding and expression of target proteins by binding to calnexin. This collaboration potentially increases target molecule expression under inflammatory conditions, highlighting the importance of chaperone activities in forming heterodimers and biologically active cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Luana S. Lenz, Juliano L. Faccioni, Paula A. Bracco, Jephesson A. F. Santos, Luiza C. Pereira, Julieti H. Buss, Mauricio T. Tamborindeguy, Daphne Torgo, Thayana Monteiro, Giovana B. Mantovani, Carolina N. Santo, Julia C. Marcolin, Eloisa Dalsin, Alvaro Vigo, Sidia M. Callegari-Jacques, Andrew O. Silva, Giovana R. Onzi, Karine R. Begnini, Guido Lenz
Summary: The fitness of cancer cells in colony formation is dynamic, influenced by factors such as ERK activity, cell-cycle duration, and DNA repair capacity. Colonies exhibit dynamic resistance to drugs, indicating an adaptability to drug presence.
Article
Biochemistry & Molecular Biology
Igor Tokarchuk, Felice A. Janser, Anna M. Schlafli, Marta Teixeira Pinto, Magali Humbert, Nicolas J. Niklaus, Sabina Berezowska, Rupert Langer, Mario P. Tschan
Summary: High expression of LAMP2A is associated with worse disease-free survival in breast cancer patients with HER2 negative tumors and serves as an independent prognostic parameter. Low levels of LAMP2A can reduce proliferation of breast cancer cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Energy & Fuels
Shuoshuo Tian, Yuezhong Di, Min Dai, Weiqiang Chen, Qi Zhang
Summary: The global aluminum industry has undergone significant changes over the past decade, with China emerging as a major producer. A comprehensive assessment framework was developed to explore energy conservation and CO2 emission reduction in China's aluminum industry. Results show that China's aluminum demand will continue to rise, but achieving a circular economy in the short term is challenging. Technology promotion and structural adjustments will gradually reduce energy consumption and CO2 emissions.
Article
Construction & Building Technology
Zhenbang Guo, Xiaogang Sun, Xiwei Zhang, Jingping Qiu, Haiqiang Jiang, Yingliang Zhao, Pinqi Wu, Qi Zhang
Summary: This study focuses on the effect of superplasticizer on the rheological properties and thixotropic properties of superfine-tailings cemented paste backfill, and proposes an improved dynamic yield stress model. It is found that the addition of SP affects the characteristic time of destructuration, and shear stress can be divided into three stages under steady-state shearing. An exponential relationship is observed between the rheological parameters of SCPB and WFT.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Green & Sustainable Science & Technology
Zhidong Tang, Qi Zhang, Yongsheng Sun, Peng Gao, Yuexin Han
Summary: This study investigated the treatment of flotation tailings and identified the best parameters to improve the grade and recovery of iron concentrate. The results showed that the HSMR process effectively transformed weakly magnetic hematite into highly magnetic magnetite, optimizing particle structure and reducing energy consumption. This pilot case provides insight into the potential of HSMR for green and low-carbon development in the iron and steel industry.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Engineering, Electrical & Electronic
Qi Zhang, Hailian Liu, Bin Li, Fan Zhang, Xin Yan, Xuenan Zhang, Fang Wang, Tonglei Cheng
Summary: A dual-channel surface plasmon resonance (SPR) sensor based on hollow-core fiber (HCF) is proposed for simultaneous measurement of liquid refractive index (RI) and ambient temperature. The sensor achieves high sensitivity in a relatively wide measurement range by using the dual-wavelength matrix method to solve the cross sensitivity of multi-parameter measurement.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Shuai Yuan, Ruofeng Wang, Qi Zhang, Yanjun Li, Peng Gao
Summary: By using suspension magnetizing roasting - magnetic separation technology, iron was successfully extracted from fine-grained complex hematite ore. The optimized conditions were a roasting temperature of 500 degrees Celsius, roasting time of 12 minutes, reductant concentration of 30%, and total gas flow of 200 mL/min. Analysis showed that hematite was transformed into magnetite during roasting, improving the porous structure of the product and enhancing internal gas diffusion and reduction rate.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Engineering, Chemical
Haiqiang Jiang, Lei Ren, Qi Zhang, Jingru Zheng, Liang Cui
Summary: The concentration of activator/silica modulus and curing temperature are important factors affecting the engineering performance of alkali-activated slag-based cemented paste backfill (AAS-CPB). The strength of AAS-CPB is more sensitive to changes in curing temperature and consistently higher than that of CPB made of OPC. The strength evolution of AAS-CPB is strongly influenced by the combined effect of curing temperature and activator concentration/silica modulus.
Article
Green & Sustainable Science & Technology
Peng Wang, Shen Zhao, Tao Dai, Kun Peng, Qi Zhang, Jiashuo Li, Wei-Qiang Chen
Summary: This study explores the regional emission performance of steel production across 44 countries and 5 regions from 2000 to 2015, comparing physical indicators such as CO2 emission, energy use, and carbon intensity. The results show a significant increase in global CO2 emission associated with steel production, indicating a worsening environmental performance. Both developed and developing nations experienced an increase in carbon intensity, highlighting the need to address regional disparities and inequalities in global decarbonization strategies for the steel industry.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Engineering, Chemical
Huihui Song, Qi Zhang, Defeng Hu, Zhongqiao Sun, Yide Han, Hao Meng, Ting Sun, Xia Zhang
Summary: In this study, a ternary hollow heterostructure (MIL-68/In2S3/ZnIn2S4) was designed and constructed through two-step in-situ growing procedures. The resulting heterostructure exhibited excellent photocatalytic activity and stability for visible-light induced hydrogen generation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Metallurgy & Metallurgical Engineering
Yonghong Qin, Jianwen Yu, Qi Zhang, Peng Gao, Songbo Ma
Summary: In this study, coal-based reduction was proposed to utilize ferronickel slag, and the optimal reduction conditions and effects were obtained through experiments. CaO and temperature played a promoting role in the reduction process, while reduction time and temperature had a positive correlation with reduction degree. The isothermal reduction process consisted of early stage, middle stage, and late stage, with corresponding mechanism functions and activation energy.
MINING METALLURGY & EXPLORATION
(2022)
Article
Engineering, Industrial
Qi Zhang, Shixin Liu, MengChu Zhou
Summary: This study formulates and investigates a steel grade design problem (SGDP) that arises from the production process of steelmaking continuous casting. For the first time, uncertain yield and demand are considered in the SGDP and a two-stage robust optimization model is constructed accordingly. An enhanced column-and-constraint generation algorithm is proposed to obtain high-quality solutions. The algorithm is tested on extensive instances based on actual production rules and shows effectiveness in solving large-scale SGDPs, outperforming a commonly-used standard algorithm.
INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Qi Zhang, Ruofei Ma, Yingzhi Zhang, Jing Zhao, Yue Wang, Zhangrun Xu
Summary: A ratiometric SERS biosensor was developed to detect breast cancer cell-derived exosomes, providing accurate identification of cancer patients and healthy individuals in clinical serum samples.
Article
Thermodynamics
Sheng Xie, Jingshu Zhang, Datao Shi, Qi Zhang
Summary: The multi-energy system in iron and steel plants poses challenges in energy distribution and management due to its strong coupling characteristic. This study establishes a multi-energy and multi-objective mixed integer non-linear programming model to optimize the energy system under the water-energy-carbon nexus. The model considers the coupling of gas-steam-electricity and includes multiple objectives such as economic performance, CO2 emissions, water generation, and global energy efficiency. The results show that the studied iron and steel plant has significant potential in reducing economic cost, emission mitigation, improving system water production, and enhancing global energy efficiency, thus helping achieve carbon peak and carbon neutrality targets.
APPLIED THERMAL ENGINEERING
(2023)
Review
Environmental Studies
Jingshu Zhang, Jialin Shen, Lisong Xu, Qi Zhang
Summary: China aims to peak CO2 emissions by 2030 and achieve carbon neutrality by 2060. The steel industry, accounting for 13% of China's total energy consumption and 15% of CO2 emissions, needs to adopt measures to cut energy consumption and reduce CO2 emissions. This paper analyzes the CO2 emission reduction path of the steel industry towards carbon neutrality, emphasizing the importance of industrial structure, material efficiency, energy efficiency, and low-carbon technologies. Collaboration and standardization in carbon accounting and carbon trading are also essential for effective carbon emission management.
ENVIRONMENTAL IMPACT ASSESSMENT REVIEW
(2023)
Article
Biochemistry & Molecular Biology
Bin Bai, Tong Li, Jiahui Zhao, Yanjiao Zhao, Xiaonan Zhang, Tao Wang, Na Zhang, Xipeng Wang, Xinlei Ba, Jialin Xu, Yang Yu, Bing Wang
Summary: PTPN22 inhibits T cell activation by modulating the TCR signaling pathway. Suppression of PTPN22 activity results in reduced thymocyte count, altered cytokine expression in the spleen and lymph nodes, and affects positive and negative selection of thymocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Bin Li, Fan Zhang, Wei Liu, Xiaoyu Chen, Yuanhongliu Gao, Qi Zhang, Xin Yan, Fang Wang, Xuenan Zhang, Takenobu Suzuki, Yasutake Ohishi, Tonglei Cheng
Summary: In this study, a fluorescence intensity ratio (FIR) temperature sensor based on ZnS:Cu was proposed to address the issues of long-term dependence on rare-earth (RE) ions and insufficient stability in a fluorescent optical fiber temperature sensor. The sensor showed excellent linear response, stability, and repeatability in the tested temperature range, indicating its potential in temperature sensing applications.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)