Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 518, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2020.111029
Keywords
Growth hormone; IGF; Hypothalamus; Neuroendocrine regulation; Dietary composition; Nutrient sensing mechanisms
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Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT, Argentina)
- Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET, Argentina)
- Emerging Leaders of the Americas Program (ELAP, Canada)
- National Science and Engineering Research Council (NSERC, Canada)
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This review covers the current knowledge on the regulation of the somatic growth axis and its interaction with metabolism and feeding regulation. The main endocrine and neuroendocrine factors regulating both the growth axis and feeding behavior will be briefly summarized. Recently discovered neuropeptides and peptide hormones will be mentioned in relation to feeding control as well as growth hormone regulation. In addition, the influence of nutrient and nutrient sensing mechanisms on growth axis will be highlighted. We expect that in this process gaps of knowledge will be exposed, stimulating future research in those areas.
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