Article
Biotechnology & Applied Microbiology
Liming Jiang, Rui Zheng, Qiangming Sun, Chenghua Li
Summary: The study showed that the isolated phage KM16 has potential anti-biofilm effects against Salmonella, and is correlated with genes of S. paratyphi. In addition, KM16 has a good lytic spectrum related to the host bacteria's pili (fimA).
Article
Microbiology
Pengbo Liu, Makoto Ibaraki, Renuka Kapoor, Nuhu Amin, Abhishek Das, Rana Miah, Asish K. Mukhopadhyay, Mahbubur Rahman, Shanta Dutta, Christine L. Moe
Summary: Enteric fever caused by Salmonella enterica serovar Typhi (ST) and Salmonella enterica serovar Paratyphi A (SPA) is a severe systemic infection. Detecting ST and SPA in wastewater can help identify infection burden and priority areas for interventions. This study developed and validated methods for concentrating and detecting ST/SPA in wastewater, demonstrating sensitive detection and quantitative results in endemic areas like Kolkata and Dhaka.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Ye Feng, Yi-Ching Chen, Rajendra Prasad Janapatla, Zeyu Wang, Ying-Jie Hsu, Chyi-Liang Chen, Cheng-Hsun Chiu
Summary: The genomic analysis in Taiwan showed a link to infections in South and Southeast Asia, as well as global circulation of typhoidal clones. Mutations at gyrA 83 aa were found in ciprofloxacin-resistant strains. Local transmission of international clones was also observed in the country.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Review
Biochemistry & Molecular Biology
Fahmida Jahan, Suresh V. Chinni, Sumitha Samuggam, Lebaka Veeranjaneya Reddy, Maheswaran Solayappan, Lee Su Yin
Summary: Salmonella enterica serovar Typhi is an intracellular pathogen capable of forming biofilms, which enable it to evade host immune response and cause long-term carrier status. Understanding the relationship between biofilm formation and pathogenicity can lead to therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
A. K. M. Ziaul Haque, Mir Rowshan Akter, S. K. Shaheenur Islam, Jahangir Alam, Sucharit Basu Neogi, Shinji Yamasaki, S. M. Lutful Kabir
Summary: This study aimed to analyze the antimicrobial resistance and molecular characteristics of Salmonella Gallinarum strains isolated from small-scale commercial layer flocks in Bangladesh. The findings revealed a high incidence of multidrug resistant (MDR) Salmonella Gallinarum in visceral organs of chicken, emphasizing the need for appropriate control measures in order to enhance egg production and ensure food safety.
VETERINARY SCIENCES
(2021)
Article
Food Science & Technology
Arome Ohiemi Shaibu, Emmanuel Chukwudi Okolocha, Beatty Viv Maikai, Olaolu Tosin Olufemi
Summary: The study found that most strains in sampled abattoirs in Nigeria exhibited resistance to multiple antibiotics, with cefepime, enrofloxacin, and ofloxacin showing the best efficacy. Although the overall isolation rate of Salmonella was low, it may be attributed to various factors such as hygiene practices and the existing Salmonella status of the animals.
Article
Microbiology
Susan M. Brewer, Christian Twittenhoff, Jens Kortmann, Sky W. Brubaker, Jared Honeycutt, Liliana Moura Massis, Trung H. M. Pham, Franz Narberhaus, Denise M. Monack
Summary: Bacterial pathogens adjust their virulence factor expression in response to temperature changes through an RNA thermosensor, impacting their survival and infection capability. Specific pathogens like Salmonella enterica serovar Typhi (S. Typhi) regulate gene expression to successfully infect hosts and evade immune responses.
Article
Medicine, Research & Experimental
Shania Vij, Reena Thakur, Raghwendra Pratap Singh, Rashmi Kumar, Preeti Pathania, Varsha Gupta, Chander Raman Suri, Praveen Rishi
Summary: This study explored the protective response of dual immunization using two different antigenic entities against lethal challenge of typhoidal serovars in a murine model. The results showed that the combination of both entities improved mice survival and reduced bacterial burden in organs. Passive immunization studies further determined the protective efficacy of generated antibodies by different mechanisms.
Review
Microbiology
Amber J. Barton, Jennifer Hill, Christoph J. Blohmke, Andrew J. Pollard
Summary: This review summarizes the advances in understanding the pathogenesis of enteric fever, including mechanisms of host restriction, intestinal invasion, interactions with innate immunity, and chronic carriage, and discusses how this knowledge may advance future vaccines and antimicrobials.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Microbiology
Miriam Cordovana, Norman Mauder, Markus Kostrzewa, Andreas Wille, Sandra Rojak, Ralf Matthias Hagen, Simone Ambretti, Stefano Pongolini, Laura Soliani, Ulrik S. Justesen, Hanne M. Holt, Olivier Join-Lambert, Simon Le Hello, Michel Auzou, Alida C. Veloo, Juergen May, Hagen Frickmann, Denise Dekker
Summary: Fourier transform infrared spectroscopy (FTIRS) is a promising technology for rapid and reliable differentiation of typhoidal and para-typhoidal Salmonella. After testing 359 isolates, specific automated classifiers built based on artificial neural networks achieved high accuracy rates ranging from 99.9% to 87.0% for different serogroups, demonstrating the potential of IR biotyping for surveillance and diagnostic purposes.
Review
Public, Environmental & Occupational Health
Abi Manesh, Eyal Meltzer, Celina Jin, Carl Britto, Divya Deodhar, Sneha Radha, Eli Schwartz, Priscilla Rupali
Summary: Enteric fever caused by Salmonella Typhi and Salmonella Paratyphi remains a significant infectious disease in Asia and Africa, with the highest prevalence reported in the Indian subcontinent. The emergence of widespread antimicrobial resistance has limited treatment options for travel-related EF, highlighting the importance of improving diagnosis, hygiene, and vaccination. Efforts to control typhoid include early detection of resistance, therapy with appropriate drugs, provision of safe drinking water, and vaccination among travellers and locals. improved vaccines against Salmonella Typhi and Salmonella Paratyphi A are needed to enhance control measures.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Food Science & Technology
Mina Nasiri, Shahram Hanifian
Summary: The study assessed the prevalence of enterococci in pasteurized milk samples from retail stores in Northwest Iran, finding that most isolates were identified as E. faecalis or E. faecium, carrying various virulence genes and showing high resistance to most antibiotics tested. Additionally, the isolates were able to produce biofilm, suggesting that pasteurized milk could potentially transmit multidrug-resistant virulent enterococci strains to humans.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
Mohammad S. Sajib, Arif M. Tanmoy, Yogesh Hooda, Hafizur Rahman, Jason R. Andrews, Denise O. Garrett, Hubert P. Endtz, Samir K. Saha, Senjuti Saha
Summary: The rising prevalence of antimicrobial resistance in Salmonella enterica serovars Typhi and Paratyphi A, especially against azithromycin, has raised concerns about untreatable infections. Cases of azithromycin-resistant strains with a single point mutation (AcrB-R717Q/L) have been reported in South Asia. Genomic analysis confirmed the spontaneous emergence of this mutation in different genotypes, with a specific genotype predicted to have acquired the mutation in 2010. The development of a low-cost PCR tool for real-time detection of this mutation may aid in early intervention against pan-oral drug resistance.
Article
Immunology
Jade A. Greear, A. Duncan Steele, Denise O. Garrett
Summary: To strengthen the global response against typhoid, the 12th International Conference on Typhoid and Other Invasive Salmonelloses was organized by the Coalition against Typhoid. This conference brought together researchers, advocates, and policymakers with the aim of enhancing the fight against typhoid. The topics discussed included advancements in diagnostics, improved data methodologies, environmental surveillance, the threat of drug resistance, and the use of typhoid conjugate vaccines.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Zulkiply Nor Amalina, Muhammad Fazli Khalid, Sjafri Faizul Rahman, Muhamad Nuramin Ahmad, Mohamad Ahmad Najib, Asma Ismail, Ismail Aziah
Summary: The developed mPCR-LFB system allows for rapid detection of Salmonella Typhi and Salmonella Paratyphi A with high sensitivity and specificity, outperforming conventional agarose gel electrophoresis in terms of speed. Through a prospective cohort study on stool samples of 1176 food handlers, the system showed potential for rapid detection of typhoid carriers in surveillance programs.
Article
Pathology
Arindam Ckakraborty, Prabha Adhikari, Shalini Shenoy, Shrikala Baliga, Gopalkrishna Bhat, Satish Rao, Dhanashree Biranthabail, Vishwas Saralaya
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2015)
Article
Immunology
Arindam Chakraborty, Prabha Adhikari, Shalini Shenoy, Satish Rao, B. Dhanashree, Vishwas Saralaya
MICROBIAL PATHOGENESIS
(2016)
Article
Infectious Diseases
Shrikala Baliga, Christina Murphy, Leesha Sharon, Suchitra Shenoy, Dhanashree Biranthabail, Helena Weltman, Steve Miller, Ranjan Ramasamy, Jyotsna Shah
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Archana Bhat, Suchetha S. Rao, Sevitha Bhat, Katara Vidyalakshmi, Biranthabail Dhanashree
Summary: This study aims to detect common paediatric viral and bacterial diarrhoea pathogens using microscopy, stool culture, and multiplex polymerase chain reaction (mPCR). The results showed that Shigella spp. and rotavirus are the main causative agents of childhood diarrhoea in the region. The rate of detection of bacterial aetiology by culture was low, while mPCR proved to be a better choice for early detection of pathogens, ensuring timely diagnosis, treatment, and a reduction in mortality.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Article
Infectious Diseases
M. Sreejisha, Shalini Shenoy Mulki, Suchitra Shenoy, Biranthabail Dhanashree, M. Chakrapani, Gopalakrishna Bhat
Summary: This study investigated infections caused by methicillin resistant Staphylococcus aureus (MRSA) in diabetic and non-diabetic patients in four tertiary care hospitals in Coastal Karnataka, South India, with a focus on heterogeneous vancomycin intermediate S. aureus (hVISA). The results showed that the rate of hVISA among all MRSA isolates was 6.4%, and the risk of hVISA infection was three times higher in diabetic patients.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, General & Internal
Pedduru Mallikarjuna, Biranthabail Dhanashree
Summary: This study assessed the colistin minimum inhibitory concentration (MIC), biofilm formation, presence of mod A and psl A genes, and types of motilities in multidrug-resistant (MDR) and multidrug-susceptible (MDS) P. aeruginosa. The findings revealed a significant association among strong biofilm formation, modA and pslA genes, and drug resistance in P. aeruginosa isolated from clinical samples.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Article
Microbiology
Munmun B. Marak, Biranthabail Dhanashree
INTERNATIONAL JOURNAL OF MICROBIOLOGY
(2018)
Article
Pediatrics
Raja Kannan, Suchetha S. Rao, Prasanna Mithra, B. Dhanashree, Shantharam Baliga, Kamalakshi G. Bhat
INTERNATIONAL JOURNAL OF PEDIATRICS
(2018)
Article
Medicine, General & Internal
Sevitha Bhat, Preetam R. Acharya, Dhanashree Biranthabail, Aseem Rangnekar, Sachin Shiragavi
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2015)
Article
Immunology
Sanal C. Fernandes, B. Dhanashree
INDIAN JOURNAL OF MEDICAL RESEARCH
(2013)
Article
Immunology
J. Sariya Mohammadi, B. Dhanashree
INDIAN JOURNAL OF MEDICAL RESEARCH
(2012)
Article
Medicine, General & Internal
Arindam Chakraborty, Prabha Adhikari, Shalini Shenoy, Shrikala Baliga, Satish Rao, B. Dhanashree
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2012)
Article
Medicine, General & Internal
B. Dhanashree, Shrikara P. Mallya
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2012)
Article
Multidisciplinary Sciences
Akshay Sharma, B. Dhanashree