Review
Food Science & Technology
V Rossini, V Tolosa-Enguis, C. Frances-Cuesta, Y. Sanz
Summary: SARS-CoV-2 primarily affects the respiratory system, but it also targets the gastrointestinal tract. Prolonged gut disorders in COVID-19 patients are associated with decreased richness and diversity of the gut microbiota, immune deregulation, and delayed viral clearance. The composition and function of the gut microbiome may play a role in the progression of COVID-19. Strategies to modulate the gut microbiome are being investigated for population stratification and management of COVID-19 infection.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Immunology
Minyan Zheng, Michael B. B. Schultz, David A. A. Sinclair
Summary: NAD(+) is a promising therapeutic target for COVID-19, and interventions that boost NAD(+) levels may enhance antiviral defense and suppress inflammation. Low NAD(+) concentrations are associated with risk factors for poor COVID-19 outcomes, and viral infections can further deplete NAD(+) and interfere with its roles in antiviral defense and inflammation. Coronaviruses can subvert NAD(+)-mediated actions, but ongoing approaches are exploring ways to boost NAD(+) concentrations to enhance antiviral responses and reduce hyperinflammation.
TRENDS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pawel Franczuk, Michal Tkaczyszyn, Maria Kulak, Esabel Domenico, Piotr Ponikowski, Ewa Anita Jankowska
Summary: Viral respiratory infections (VRI) are common and can worsen existing cardiovascular diseases and lead to new complications, especially in COVID-19.
Article
Multidisciplinary Sciences
Tyler N. Starr, Allison J. Greaney, Amin Addetia, William W. Hannon, Manish C. Choudhary, Adam S. Dingens, Jonathan Z. Li, Jesse D. Bloom
Summary: Research has found that mutations in the receptor binding domain (RBD) of SARS-CoV-2 may potentially escape the action of the REGN-COV2 cocktail, providing important information for interpreting mutations observed during viral surveillance.
Article
Virology
Olivier Uwishema, Irem Adanur, Abdulhammed Opeyemi Babatunde, Mohammad Mehedi Hasan, Osman Kamal Osman Elmahi, Kolawole Barakat Olajumoke, Abdullahi Tunde Aborode, Nzeribe Emmanuella, Ana Carla dos Santos Costa, Shoaib Ahmad, Mohammad Yasir Essar
Summary: Viral infections have been increasing in African countries, especially during the pandemic, putting a strain on the healthcare system. To alleviate this pressure, African countries need to strengthen immunization and education measures, and collaborate with other countries to create guidelines for reducing co-infections.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Materials Science, Paper & Wood
Thennakoon M. Sampath U. Gunathilake, Yern Chee Ching, Hiroshi Uyama, Nguyen Dai Hai, Cheng Hock Chuah
Summary: Nanocellulose/polyvinyl alcohol/curcumin (CNC/PVA/curcumin) nanoparticles were developed with enhanced drug loading capabilities. These nanoparticles have potential as inhalable nanotherapeutics for treating COVID-19, due to their physical and chemical properties.
Article
Gastroenterology & Hepatology
Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, Harika Nalluri, Thomas Kaiser, Shernan G. Holtan, Alexander Khoruts, Daniel J. Weisdorf, Christopher Staley
Summary: COVID-19 precautions alter the gut microbiota, reducing pathogen susceptibility and the incidence of nosocomial infections.
Article
Neurosciences
Benjamin Rosen, Alberim Kurtishi, Gonzalo R. Vazquez-Jimenez, Simon Geir Moller
Summary: SARS-CoV-2 infection can lead to neurological symptoms similar to Parkinson's disease, and both conditions share common biochemical pathways. Despite the unclear relationship between the two, research has identified similarities that provide guidance for future studies.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Sujin Yum, Kwan Hong, Sangho Sohn, Jeehyun Kim, Byung Chul Chun
Summary: The study found that the weekly positivity rates of 8 respiratory viruses in South Korea decreased overall from 2010-2019 to 2020. Pandemic control measures may have reduced the incidence of many viral respiratory infections, but not all.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Kelvin Li, Barbara A. Methe, Adam Fitch, Heather Gentry, Cathy Kessinger, Asha Patel, Vickie Petraglia, Pruthvi Swamy, Alison Morris
Summary: Imposition of social and health behavior measures during the COVID-19 pandemic may impact the human microbiota, but further research is needed to confirm this hypothesis. This study found that while there was a trend of reduced diversity, the microbiota remained stable overall during the early pandemic phase. Changes in microbiota composition were associated with reported health issues and pandemic-associated worries.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stela Dragomanova, Simona Miteva, Ferdinando Nicoletti, Katia Mangano, Paolo Fagone, Salvatore Pricoco, Hristian Staykov, Lyubka Tancheva
Summary: Alpha-lipoic acid, a natural compound with well-defined antioxidant and immunomodulatory properties, has been studied in various chronic immunoinflammatory conditions and is showing emerging pharmacological antiviral potential. Research on the use of alpha-lipoic acid in viral infections, including COVID-19, has attracted attention for its possible cotreatment benefits.
Review
Biochemistry & Molecular Biology
Shailendra Pratap Singh, Salomon Amar, Pinky Gehlot, Sanjib K. Patra, Navjot Kanwar, Abhinav Kanwal
Summary: Mitochondria are crucial organelles in regulating intracellular events, which can be altered by viruses to induce cellular stress and promote viral proliferation. Autophagy plays a key role in SARS-COV2-mediated COVID-19 and serves as a potential target for anti-viral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ying-yi Luan, Cheng-hong Yin, Yong-ming Yao
Summary: High levels of CRP in severe COVID-19 and other viral infections can indicate disease progression and guide clinical diagnosis and antibiotic therapy. Understanding the role of CRP in these diseases may lead to more effective prevention and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Varada Anirudhan, Hyun Lee, Han Cheng, Laura Cooper, Lijun Rong
Summary: The review provides information on potential treatment strategies for COVID-19 that target the essential proteins of the virus, specifically 3CL(pro) and PLpro, which are key in inhibiting viral replication and may offer insights from previous experience with SARS-CoV.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Letitia Toma, Mihai Dodot, Anca Zgura, Nicolae Bacalbasa, Andrei Silaghi, Razvan Simu, Teodora Isac, Adriana Mercan-Stanciu
Summary: This study compared serum and fecal calprotectin levels in patients with COVID-19 and HCV infection, finding that inflammatory markers were significantly higher in COVID-19 patients than in those with active or cured HCV infection, suggesting a potential correlation with disease severity.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mohammad Reza Tamadon, Alireza Soleimani, Fariba Keneshlou, Malihe Zarrati Mojarrad, Fereshteh Bahmani, Afshin Naseri, Hamed Haddad Kashani, Elahe Seyed Hosseini, Zatollah Asemi
HORMONE AND METABOLIC RESEARCH
(2018)
Article
Biotechnology & Applied Microbiology
Mansooreh Samimi, Adeleh Dadkhah, Hamed Haddad Kashani, Maryam Tajabadi-Ebrahimi, Elahe Seyed Hosseini, Zatollah Asemi
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2019)
Article
Cell Biology
Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Sadegh Babashah, Roohollah Nakhaei Sistani, Majid Sadeghizadeh, Hamad Haddad Kashani, Javad Amini Mahabadi, Fatemeh Izadpanah, Mohhamad Ali Atlasi, Hossein Nikzad
CELL BIOLOGY AND TOXICOLOGY
(2019)
Article
Virology
Elahe Seyed Hosseini, Narjes Riahi Kashani, Hossein Nikzad, Javid Azadbakht, Hassan Hassani Bafrani, Hamed Haddad Kashani
Review
Oncology
Elahe Seyed Hosseini, Ali Nikkhah, Amir Sotudeh, Marziyeh Alizadeh Zarei, Fatemeh Izadpanah, Hossein Nikzad, Hamed Haddad Kashani
Summary: In conclusion, dysregulated lncRNAs could serve as promising biomarkers for the diagnosis and prognosis of pancreatic cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Atiye Saeedi Sadr, Hassan Ehteram, Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hassan Alizadeh Bafrani, Hamed Haddad Kashani
Summary: The study found that irisin can inhibit the growth and metastasis of human prostate cancer cells by regulating the expression of MMP2 and MMP9, thereby promoting cell apoptosis.
ONCOLOGY AND THERAPY
(2022)
Review
Biotechnology & Applied Microbiology
Atefeh Parchebafi, Farzaneh Tamanaee, Hassan Ehteram, Ejaz Ahmad, Hossein Nikzad, Hamed Haddad Kashani
Summary: Microbial infection and cancer are major causes of global mortality. Cationic antimicrobial peptides (AMPs) have dual antimicrobial and anticancer activities and are considered the best choice. Improving the efficacy and stability of AMPs is still necessary, and various strategies such as nano-carrier application can enhance their effects.
MICROBIAL CELL FACTORIES
(2022)
Article
Immunology
Mohammad Mehdi Haghighat Lari, Hamid Reza Banafshe, Elahe Seyed Hosseini, Hamed Haddad Kashani
Summary: In this study, the chronic administration of risperidone was found to be effective in reducing heat hyperalgesia and allodynia in rats with neuropathic pain induced by the CCI model. However, acute administration of risperidone did not show any significant changes in behavioral tests. Gene expression analysis indicated an increase in IL-4 and IL-10 gene expression in the risperidone group compared to the sham group.
INFLAMMOPHARMACOLOGY
(2023)
Article
Reproductive Biology
Hassan Hassani Bafrani, Atiye Saeedi Sadr, Fatemeh Izadpanah, Hamed Haddad Kashani
Summary: This study investigated the protective effects of melatonin and the role of the MACS method in preventing oxidative damage in vitro and improving sperm quality parameters.
MIDDLE EAST FERTILITY SOCIETY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hamed Haddad Kashani, Morteza Salimian, Narjes Riahi Kashani, Hossein Nikzad
Summary: The study found that DNC significantly reduced viability of ovarian cancer cells compared to Cur. Additionally, DNC decreased expression levels of HOTAIR and H19 while increasing MEG3 expression.
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Article
Genetics & Heredity
Mahboobeh Mehrabani Natanzi, Fatemeh Soleimanifard, Hamed Haddad Kashani, Mohammad Javad Azadchehr, Ahmadreza Mirzaei, Zohre Khodaii
Article
Oncology
Amin Jourabchin, Tahereh Mazoochi, Hamed Haddad Kashani, Tahereh Khamechian
JOURNAL OF GASTROINTESTINAL CANCER
(2020)
Article
Genetics & Heredity
Amir Hassan Matini, Maryam Sadat Tayebi, Zahra Rezvani, Zarichehr Vakili, Hamed Haddad Kashani
Article
Pharmacology & Pharmacy
Hamed Najaran, Hassan Hassani Bafrani, Hamid Rashtbari, Fatemeh Izadpanah, Mohammad Reza Rajabi, Hamed Haddad Kashani, Abouzar Mohammadi
ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE
(2019)