Article
Oncology
Andreas G. Tsantes, Ilectra Loukopoulou, Dimitrios V. Papadopoulos, Ioannis G. Trikoupis, Anastasios G. Roustemis, Stavros Goumenos, Rozeta Sokou, Konstantina A. Tsante, Anastasios G. Kriebardis, Panagiotis Koulouvaris, Dimitra Houhoula, Daniele Piovani, Panayiotis J. Papagelopoulos, Stefanos Bonovas, Argirios E. Tsantes
Summary: Malignancy-associated coagulopathy (MAC) in surgical patients with bone tumors is characterized by activations of the coagulation cascade, platelet activation, and hypofibrinolysis, resulting in a hypercoagulable state. Rotational thromboelastometry (ROTEM) analysis is more effective than conventional coagulation tests in detecting these qualitative changes in the hemostatic profile of patients with bone tumors.
Article
Multidisciplinary Sciences
Jan Matthias Kruse, Daniel Zickler, Willie M. Luedemann, Sophie K. Piper, Inka Gotthardt, Jana Ihlow, Selina Greuel, David Horst, Andreas Kahl, Kai-Uwe Eckardt, Sefer Elezkurtaj
Summary: Cavitary lung lesions are a common complication in severely ill COVID-19 patients, likely related to the prothrombotic state associated with COVID-19. These cavitations may be related to lung infarcts undergoing liquefaction secondary to thrombotic pulmonary artery branch occlusions, with older age and higher body mass index as potential risk factors for their development.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Pawel Rogalski, Magdalena Rogalska, Diana Martonik, Malgorzata Rusak, Joanna Pawlus, Joanna Chociej-Stypulkowska, Milena Dabrowska, Robert Flisiak
Summary: This study investigated the relationship between ROTEM (R) parameters, inflammatory cytokine levels, and clinical outcomes in COVID-19 patients. The results showed hypercoagulability in COVID-19 patients in all ROTEM (R) tests and significantly elevated levels of inflammatory cytokines. FIBTEM parameters had the strongest correlations with inflammatory biomarkers and CT severity score, indicating that increased FIBTEM MCE may be associated with greater severity of COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Takeshi Yagi, Motoki Fujita, Kayoko Harada, Masaru Shin, Yusuke Esaki, Ryo Ayata, Yasutaka Koga, Kotaro Kaneda, Ryosuke Tsuruta
Summary: This study conducted a retrospective analysis of severe COVID-19 patients in the ICU. The results showed that there was a persistent hypercoagulable state and a worse hypofibrinolytic state at ICU discharge compared to admission. These findings provide valuable insights into the coagulopathies in the acute and subacute phases of severe COVID-19.
Article
Multidisciplinary Sciences
Rodrigo B. Aires, Alexandre A. de S. M. Soares, Ana Paula M. Gomides, Andre M. Nicola, Andrea Teixeira-Carvalho, Dayde Lane M. da Silva, Eliana T. de Gois, Flavia D. Xavier, Francielle P. Martins, Gabriela P. J. Santos, Heidi Luise Schulte, Isabelle S. Luz, Laila S. Espindola, Laurence R. do Amaral, Liza F. Felicori, Luciana A. Naves, Maira R. M. de Carvalho, Matheus de S. Gomes, Otavio T. Nobrega, Patricia Albuquerque, Wagner Fontes, Ciro M. Gomes, Patricia S. Kurizky, Cleandro P. Albuquerque, Olindo A. Martins-Filho, Licia Maria H. da Mota
Summary: Thromboelastometry parameters are useful in differentiating the coagulation profile between severe and non-severe COVID-19 patients, which is important for therapeutic intervention.
Article
Cardiac & Cardiovascular Systems
Marina Marchetti, Patricia Gomez-Rosas, Laura Russo, Sara Gamba, Eleonora Sanga, Cristina Verzeroli, Chiara Ambaglio, Francesca Schieppati, Francesco Restuccia, Ezio Bonanomi, Marco Rizzi, Stefano Fagiuoli, Andrea D'Alessio, Grigorios T. Gerotziafas, Luca Lorini, Anna Falanga
Summary: This study provides a comprehensive characterization of hemostatic alterations in hospitalized COVID-19 patients, highlighting the correlation with inflammatory status. Fibrinolytic proteins and NLR may serve as predictors of thrombotic and hemorrhagic complications, respectively.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Laure Calvet, Francois Thouy, Olivier Mascle, Anne-Francoise Sapin, Kevin Grapin, Jean Mathias Liteaudon, Bertrand Evrard, Benjamin Bonnet, Mireille Adda, Bertrand Souweine, Claire Dupuis
Summary: The objective of this study was to evaluate the characteristics of hypercoagulability in COVID-19 ICU patients and its association with new-onset thromboembolic (TE) events and the need for intubation and/or ICU death. The study found that most COVID-19 ICU patients had hypercoagulability on admission and almost all patients had it on day 4. Hyperfibrinogenemia and fibrinolysis shutdown on day 4 were associated with unfavorable outcomes.
Article
Medicine, Research & Experimental
Federico Capone, Alberto Cipriani, Leonardo Molinari, Anna Poretto, Nicolo Sella, Annalisa Boscolo, Elena Campello, Alois Saller, Roberto Vettor, Paolo Navalesi, Anna Maria Cattelan, Paolo Simioni, Luca Spiezia
Summary: This study aimed to investigate the association between cardiac injury and abnormal coagulative state in hospitalized COVID-19 patients. The results showed no significant differences in traditional coagulation parameters between patients with and without cardiac injury, but abnormal MCF levels were observed in 80% of patients in FIBTEM assay. Cardiac injury was found to be associated with mortality.
ADVANCES IN MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Lou M. Almskog, Agneta Wikman, Jonas Svensson, Michael Wanecek, Matteo Bottai, Jan van der Linden, Anna Agren
Summary: High prevalence of thrombotic events in severely ill COVID-19 patients has been reported, with hypercoagulopathy being present early in patients with mild to moderate disease and more pronounced in severe cases. ROTEM variables at admission show hypercoagulopathy, more prominent in patients with increased disease severity, suggesting that further studies are needed to predict the risk of thromboembolic complications.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Review
Biochemistry & Molecular Biology
Beatrice Ragnoli, Beatrice Da Re, Alessandra Galantino, Stefano Kette, Andrea Salotti, Mario Malerba
Summary: COVID-19 infection leads to a hypercoagulable state, potentially resulting in acute respiratory distress syndrome (ARDS) and COVID-19-associated coagulopathy (CAC). CAC is a key factor in the organ damage caused by SARS-CoV-2. The prothrombotic state of COVID-19 can be explained by increased levels of D-dimer, lymphocytes, fibrinogen, interleukin 6 (IL-6), and prothrombin time. Inflammatory cytokine storm, platelet activation, endothelial dysfunction, and prolonged stasis are potential mechanisms for this hypercoagulable process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Romein W. G. Dujardin, Gabriel Garcia Rosenbaum, Timo C. J. Klercq, Jecko Thachil, Nathan D. Nielsen, Nicole P. Juffermans
Summary: The study investigates the potential of ROTEM profiles in predicting thrombotic complications in critically ill COVID-19 patients. The results show that ROTEM profiles at ICU admission do not have the ability to differentiate between patients with a high and low risk for thrombotic complications.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Tomas Bolek, Matej Samos, Ingrid Skornova, Martin Schnierer, Jakub Jurica, Peter Banovcin, Jan Stasko, Peter Kubisz, Marian Mokan
Summary: This study compared the changes in hemostasis between diabetic and nondiabetic patients with mild COVID-19 pneumonia. The results showed hypercoagulation in patients with mild COVID-19 pneumonia, but diabetes did not affect ROTEM(R) parameters.
Article
Medical Laboratory Technology
Annabi Elaa, Chouchane Syrine, Mhamdi Haifa, Naija Walid, Ben Bnina Amene, Said Latiri Houyem, Chouech Ajmi, Oueslati Abderraouf, Bouatay Amina
Summary: This study found a hypercoagulable state in COVID-19 patients, especially in severe cases. It also highlighted the role of viscoelastic tests in assessing coagulopathy in COVID-19 patients.
CLINICAL LABORATORY
(2021)
Article
Pediatrics
Tomoaki Ishikawa, Yuto Nakajima, Takashi Omae, Kenichi Ogiwara, Keiji Nogami
Summary: This study assessed the coagulation and fibrinolytic function in pediatric patients with idiopathic nephrotic syndrome (INS). The results showed a hypercoagulable state in the acute phase of INS and a persistent hypofibrinolytic defect despite effective treatment.
PEDIATRIC NEPHROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elena Rezus, Bogdan Ionel Tamba, Minerva Codruta Badescu, Diana Popescu, Ioana Bratoiu, Ciprian Rezus
Summary: ONFH is a debilitating disease that affects young adults with complex pathophysiology and unclear etiology. Early diagnosis and treatment are crucial to prevent severe consequences, with hereditary thrombophilia and hypofibrinolysis being associated with ONFH. Anticoagulant treatment can alter disease progression and improve patient quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Daniele Piovani, Cesare Hassan, Alessandro Repici, Lorenza Rimassa, Carmelo Carlo-Stella, Georgios K. Nikolopoulos, Elio Riboli, Stefanos Bonovas
Summary: This study summarized the epidemiologic evidence and validity of associations between inflammatory bowel diseases (IBDs) and overall and site-specific cancer risk. The results showed varying levels of evidence and magnitude of risk for different types of malignancy. Further research is needed to investigate the impact of risk factors known to affect cancer risk.
Article
Gastroenterology & Hepatology
Mariangela Allocca, Cecilia Dell'Avalle, Vincenzo Craviotto, Federica Furfaro, Alessandra Zilli, Ferdinando D'Amico, Stefanos Bonovas, Laurent Peyrin-Biroulet, Gionata Fiorino, Silvio Danese
Summary: This study aimed to assess the predictive value of the Milan ultrasound criteria (MUC) on disease course in ulcerative colitis (UC) patients. The study found that patients with a MUC score <= 6.2 at baseline had a significantly lower cumulative probability of treatment escalation, need of corticosteroids, hospitalization, and colectomy compared to patients with a MUC score > 6.2.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Hematology
Andreas G. Tsantes, Aikaterini Konstantinidi, Stavroula Parastatidou, Georgios Ioakeimidis, Konstantina A. Tsante, Petros G. Mantzios, Anastasios G. Kriebardis, Argyri Gialeraki, Dimitra Houhoula, Nicoletta Iacovidou, Daniele Piovani, Stefanos Bonovas, Argirios E. Tsantes, Rozeta Sokou
Summary: This retrospective observational study investigates the agreement between EXTEM and NATEM measurements in ill neonates. The results show a strong correlation and good agreement between the two methods, indicating that they can be used interchangeably.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Health Care Sciences & Services
Holger J. Schunemann, Ignacio Neumann, Monica Hultcrantz, Romina Brignardello-Petersen, Linan Zeng, M. Hassan Murad, Ariel Izcovich, Gian Paolo Morgano, Tejan Baldeh, Nancy Santesso, Carlos Garcia Cuello, Lawrence Mbuagbaw, Gordon Guyatt, Wojtek Wiercioch, Thomas Piggott, Hans De Beer, Marco Vinceti, Alexander G. Mathioudakis, Martin G. Mayer, Reem Mustafa, Tommaso Filippini, Alfonso Iorio, Robby Nieuwlaat, Maura Marcucci, Pablo Alonso Coello, Stefanos Bonovas, Daniele Piovani, George Tomlinson, Elie A. Akl
Summary: This article introduces a new approach by GRADE for assessing uncertainty, which involves rating down by one, two, or three levels based on serious, very serious, and extremely serious concerns. The approach includes identifying thresholds and using them to evaluate imprecision, while also providing guidance on addressing implausible large effects and trivial or no effects.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Infectious Diseases
Andreas G. Tsantes, Dimitrios Papadopoulos, Eleftheria Markou, Konstantinos Zarokostas, Rozeta Sokou, Ioannis Trikoupis, Andreas F. Mavrogenis, Dimitra Houhoula, Daniele Piovani, Stefanos Bonovas, Argirios E. Tsantes, Athanasios Tsakris, Georgia Vrioni
Summary: This review investigates the management of Aspergillus spp. osteoarticular infections. The study shows that surgical debridement in addition to antifungal therapy improves infection eradication. Antifungal monotherapy has similar efficacy with combination/sequential therapy, and voriconazole has similar efficacy with amphotericin B.
Article
Surgery
Francesco Klinger, Valeriano Vinci, Alessia Lozito, Benedetta Agnelli, Andrea Lisa, Andrea Battistini, Stefanos Bonovas, Daniele Piovani, Marco Klinger, Luca Di Tommaso
Summary: This study used histological specimens and digital pathology software to analyze the differences in collagen fibers and elastic fibers in patients with tuberous breast deformity (TB) compared to normal breasts. The results showed increased concentrations of collagen fibers and decreased elastic fibers in TB, highlighting the correlation between abnormal extracellular matrix concentrations and the characteristic stenotic and less elastic morphology of the deformity.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Hematology
Andreas G. Tsantes, Dimitrios Papadopoulos, Anastasios G. Roustemis, Ioannis G. Trikoupis, Daniele Piovani, Konstantina A. Tsante, Petros G. Mantzios, Andreas F. Mavrogenis, Rozeta Sokou, Styliani Kokoris, Anastasios G. Kriebardis, Panayiotis J. Papagelopoulos, Stefanos Bonovas, Argirios E. Tsantes
Summary: This study aimed to assess the ability of ROTEM to identify patients at high risk for transfusion and excessive bleeding. The results showed that ROTEM analysis demonstrated high predictive ability for transfusion and excessive bleeding. This is important for ensuring adequate blood supply and implementing more effective blood-salvaging strategies.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Hematology
Rozeta Sokou, Petroula Georgiadou, Andreas G. Tsantes, Stavroula Parastatidou, Aikaterini Konstantinidi, Georgios Ioakeimidis, Athanasia Makrogianni, Martha Theodoraki, Styliani Kokoris, Nicoletta Iacovidou, Anastasios G. Kriebardis, Daniele Piovani, Stefanos Bonovas, Argirios E. Tsantes
Summary: This study aimed to investigate the hemostatic status of diseased neonates using nonactivated rotational thromboelastometry (ROTEM) assay (NATEM) and compare it to extrinsically activated ROTEM (EXTEM) parameters in predicting the risk of bleeding in critically ill neonates. The results showed that NATEM parameters had comparable predictive performance for clinical bleeding events with EXTEM parameters, and even outperformed them in some selected parameters.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Gastroenterology & Hepatology
Daniele Piovani, Andreas G. Tsantes, Holger J. Schunemann, Stefanos Bonovas
Summary: This study systematically searched and analyzed randomized and non-randomized studies to assess the risk of gastric cancer associated with the use of proton-pump inhibitors (PPIs). The results showed no association between PPIs and gastric cancer, especially based on non-randomized studies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Medicine, General & Internal
Stefanos Bonovas, Daniele Piovani
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Paschalia Kopanou Taliaka, Andreas G. Tsantes, Aikaterini Konstantinidi, Dimitra Houhoula, Konstantina A. Tsante, Aristeidis G. Vaiopoulos, Daniele Piovani, Georgios K. Nikolopoulos, Stefanos Bonovas, Nicoletta Iacovidou, Argirios E. Tsantes, Rozeta Sokou
Summary: This study aimed to consolidate evidence and enhance our understanding of neonatal liver abscesses due to invasive fungal infections. Fungal liver abscesses are rare in neonates, but clinicians should be aware of this condition in small, premature infants who do not respond to conventional treatment for sepsis.
Letter
Gastroenterology & Hepatology
Daniele Piovani, Andreas G. Tsantes, Holger J. Schunemann, Stefanos Bonovas
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Stefanos Bonovas, Daniele Piovani, Claudia Pansieri, Fabio Salvatore Macaluso, Ambrogio Orlando, Stefano Festa, Claudio Papi, Daniela Pugliese, Alessandro Armuzzi
Summary: This article systematically searched and synthesized current evidence on the use of biologic treatments in adult patients with Crohn's disease, and provided clinical practice recommendations based on the evaluated evidence.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Gastroenterology & Hepatology
Daniele Piovani, Alessandro Armuzzi, Stefanos Bonovas
Summary: A study found that individuals with a history of depression/depressive symptoms may be more susceptible to developing inflammatory bowel diseases (IBDs). In 13 studies, depression was significantly associated with the incidence of Crohn's disease and ulcerative colitis.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Stefanos Bonovas, Daniele Piovani
JOURNAL OF CLINICAL MEDICINE
(2023)