Article
Oncology
Zhongsong Zhao, Xueping Liu
Summary: This study found that high expression of SNHG7 in gastric cancer tissues and cells was associated with cell proliferation, migration, and invasion. Silencing of SNHG7 suppressed these processes by directly regulating miR-485-5p, providing new insights into the development of gastric cancer.
JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Guoqiang Yan, Wang Lei
Summary: This study investigated the role of ELK1 and its downstream pathway in colorectal cancer (CRC). The findings suggest that ELK1 regulates the progression of CRC through the miR-31-5p/CDIP1 axis, which could be a potential therapeutic target for CRC.
Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Biochemistry & Molecular Biology
Huyan Ting, Lina Gao, Na Gao, Chaochao Wang, Wuli Guo, Xiaojie Zhou, Qi Li
Summary: Bladder cancer impairs NK cell function and immune surveillance through exosomes. Specific miRNAs in exosomes may interfere with gene stability in NK cells and can be potential targets for BC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Na Lu, Yue Yin, Yuan Yao, Peng Zhang
Summary: The study found that HOXB8 is regulated by the SNHG3/miR-2682-5p axis to promote cell proliferation and migration in oral squamous cell carcinoma (OSCC).
Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Article
Immunology
Junkui Xu, Yanjiang Pei, Jun Lu, Xiaojun Liang, Yi Li, Junhu Wang, Yingang Zhang
Summary: The study revealed that SNHG7 was downregulated in OA while miR-214-5p was upregulated. SNHG7 enhanced cell viability and suppressed apoptosis and inflammation, whereas upregulation of miR-214-5p had opposite effects on chondrocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhengbin Zhao, Jing Gao, Shuangsheng Huang
Summary: Studies have shown that SNHG7 promotes the development of HCC by regulating FOXK2 through sponging miR-122-5p, offering new targeted therapeutic options for the treatment of HCC.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Junlong Zhuang, Lan Shen, Meiqian Li, Jingya Sun, Jiange Hao, Jiaxuan Li, Zhen Zhu, Shuning Ge, Dianzheng Zhang, Hongqian Guo, Ruimin Huang, Jun Yan
Summary: Cancer-associated fibroblasts (CAF) promote cancer stemness and chemoresistance in urothelial bladder cancer (UBC) by overexpressing miR-146a-5p. MiR-146a-5p also enhances UBC stemness and chemoresistance by targeting ARID1A and PRKAA2 mRNA in UBC cells. Elevated levels of exosomal miR-146a-5p in UBC patients' serum are associated with tumor stage and relapse risk.
Article
Medicine, Research & Experimental
Yu Jian, Qi Fan
Summary: Research showed that SNHG7 is highly expressed in pancreatic cancer tissues and cells, promoting the progression of PC by inducing miR-146b-5p and upregulating Robo1.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Wenbiao Ren, Jiao Hu, Huihuang Li, Jinbo Chen, Jian Ding, Xiongbing Zu, Benyi Fan
Summary: miR-616-5p is upregulated in bladder cancer and promotes invasion and migration; NR2C2 is a downstream target of miR-616-5p; High expression of NR2C2 correlates with better prognosis in bladder cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Jinhui Yang, Fuming Qi, Bo Tan, Guangcheng Dai, Rongxin Chen, Wenjie Wan, Bo Cheng, Boxin Xue
Summary: In this study, circSPECC1 was found to be significantly up-regulated in bladder cancer tissues and cell lines. Increased expression of circSPECC1 was associated with poor prognosis in bladder cancer. Knockdown of circSPECC1 was shown to impair the proliferation and migration of bladder cancer cells. Mechanistically, circSPECC1 was found to sponge miR-136-5p and promote the expression of GNAS, which reversed the effects of circSPECC1 suppression on cell proliferation and migration. This study suggested that circSPECC1 contributes to the growth and metastasis of bladder cancer and has potential as a non-invasive biomarker for diagnosis and therapeutic target for treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Environmental Sciences
Fandong Meng, Fengjie Shen, Xuan Chu, Hongwei Ling, Yun Qiao, Deshan Liu
Summary: Preliminary studies have shown that the number of apoptotic adipose tissue-derived stem cells (ADSCs) is increased in diabetic patients, leading to delayed wound healing. Circular RNAs (circRNAs) have been found to regulate apoptosis, but their role in ADSCs apoptosis is still unclear. In this study, ADSCs were cultured in normal glucose (NG) or high glucose (HG) medium, and it was observed that more apoptotic ADSCs were present in the HG group compared to the NG group. Furthermore, hsa_circ_0008500 was found to attenuate HG-induced ADSCs apoptosis by acting as a sponge for hsa-miR-1273h-5p and suppressing its downstream target, ELK1. These findings suggest that targeting the hsa_circ_0008500/hsa-miR-1273h-5p/ELK1 signaling pathway in ADSCs may have therapeutic potential for repairing diabetic wounds.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
