Journal
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume 101, Issue 7, Pages 2950-2960Publisher
WILEY
DOI: 10.1002/jsfa.10927
Keywords
Bacteroides; cellulose acetate; fermentation; human stool; short‐ chain fatty acid
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan [16K15020]
- Grants-in-Aid for Scientific Research [16K15020] Funding Source: KAKEN
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The study found that water-soluble cellulose acetate (WSCA) can increase acetate levels in the human gut, with CA-0.78-128 causing shifts in the microbial community and promoting an increase in Bacteroides. Selective proliferation of Bacteroides bacteria leads to an increase in short-chain fatty acids.
BACKGROUND Water-soluble cellulose acetate (WSCA), a synthetic fiber source, was applied to human stool cultures and to pure cultures of representative Bacteroides species to characterize the fermentation properties of WSCA in the human gut, and to assess the potential availability of WSCA as a food or additive candidate. RESULTS All nine of the different types of WSCA tested here provided increased acetate levels in human stool cultures. Greater levels of deacetylation were observed as the degree of substitution of hydroxyl groups by acetyl groups decreased. Among the nine tested types of WSCA, CA-0.78-128 caused the largest shifts of the microbial community, including an increased abundance of members of the genus Bacteroides, especially Bacteroides uniformis. Of four representative human gut Bacteroides species, only B. uniformis grew in pure culture on WSCA to produce acetate actively. CONCLUSION Water-soluble cellulose acetate has the potential for dietary application in human and other monogastric animals, based on the enhanced production of short-chain fatty acids (SCFAs), in particular acetate, in the hindgut. Short-chain fatty acid production is caused by selective proliferation of specific gut bacteria belonging to the genus Bacteroides. (c) 2020 Society of Chemical Industry
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