Journal
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Volume 35, Issue 5, Pages 1058-1066Publisher
WILEY
DOI: 10.1111/jdv.17029
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Funding
- Société Française de Dermatologie et de Pathologie Sexuellement Transmissible Funding Source: Medline
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Researchers are studying the central mechanisms of itch using various experimental methods, including histamine-induced and induction by other chemicals. Some studies suggest that the itch-processing network in the brain could be disrupted in certain diseases.
Itch is a sensation defined as the urge to scratch. The central mechanisms of itch are being increasingly studied. These studies are usually based on experimental itch induction methods, which can be classified into the following categories: histamine-induced, induction by other non-histamine chemicals (e.g. cowhage), physically induced (e.g. electrical) and mentally induced (e.g. audio-visual). Because pain has been more extensively studied, some extrapolations to itch can be proposed and verified by experiments. Recent studies suggest that the itch-processing network in the brain could be disrupted in certain diseases. This disruption could be related to the implication of new regions or the exclusion of already engaged brain regions from itch-processing network in the brain.
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