Article
Clinical Neurology
William Campanella, Angelo Corazza, Luca Puce, Laura Privitera, Riccardo Pedrini, Laura Mori, Leonardo Boccuni, Giovanni Turtulici, Carlo Trompetto, Lucio Marinelli
Summary: This study evaluated the effect of BoNT-A on muscle hypertonia in stroke survivors using both SWE and sEMG. The results showed that SWE can be a useful method to assess intrinsic muscular remodeling independently of spastic dystonia. Combining SWE and sEMG could aid clinicians in evaluating treatment responses.
FRONTIERS IN NEUROLOGY
(2022)
Review
Engineering, Biomedical
Xinliang Guo, Rebecca Wallace, Ying Tan, Denny Oetomo, Marlena Klaic, Vincent Crocher
Summary: A systematic review of technology-based methods for assessing spasticity was conducted, revealing a wide range of different approaches and outcome measures, with a focus on evaluating their psychometric properties and usability. Among the various assessment methods, those based on manual stretching and measuring muscle activity reaction, as well as those utilizing controlled stretches while isolating the stretch-reflex torque component, show promise as practical alternatives to clinical scales.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Computer Science, Artificial Intelligence
Rocio Urrutia, Ane Miren Gutierrez-Muto, Clara B. Sanz-Morere, Arantxa Gomez, Angela M. Politi, Francesca Lunardini, Marco Baccini, Francesca Cecchi, Natacha Leon, Antonio Oliviero, Jesus Tornero
Summary: The objective of this study was to verify the reliability and concurrent and discriminant validity of spasticity measurements offered by a robotic device. By comparing the measurements with the Modified Ashworth Scale and conducting tests on stroke patients and healthy volunteers, the study confirmed the reliability of the measurements and the ability to discriminate between different groups.
FRONTIERS IN NEUROROBOTICS
(2023)
Article
Pediatrics
Laerke Hartvig Krarup, Pia Kjaer Kristensen, Louise Strand, Sofie Langbo Bredtoft, Inger Mechlenburg, Kirsten Nordbye-Nielsen
Summary: Ankle contractures are common in children with cerebral palsy, with a prevalence of 32%, which remained stable over the years. Lower levels of gross motor function (GMFCS IV-V) and higher spasticity (MAS 2-4) were significantly associated with a higher prevalence of ankle contracture. Age was not found to be associated with ankle contracture.
Article
Engineering, Biomedical
Chieh-Hsiang Hsu, Yu-Chen Lin, Hsiu-Yun Hsu, Hsiao-Feng Chieh, Chien-Ju Lin, Shih-Fu Ling, Fong-Chin Su, Li-Chieh Kuo
Summary: This study introduces a reliable and clinically-feasible device, ACMES, for quantifying muscle tone of upper limbs without using mechanical torque transducers. The results showed that ACMES has high validity and reliability, and it can detect various muscle tone patterns between healthy and stroke subjects.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2022)
Article
Geriatrics & Gerontology
Kuen Lam, Joseph S. K. Kwan, Chi Wai Kwan, Iris Chi
Summary: This study aimed to examine the rate of new joint contractures in LTC residents and found that many residents developed new contractures during the first 5 years of admission, with immobility being the main modifiable risk factor. Further research is needed to identify potential strategies to prevent new contractures in this vulnerable group.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Veterinary Sciences
Koen M. Santifort, Paul J. J. Mandigers
Summary: Dystonia, characterized by abnormal muscle contractions causing repetitive movements or postures, is a common feature in movement disorders of both humans and animals. This review discusses the definition, phenomenology, and pathophysiology of dystonia, as well as diagnosis and treatment considerations specifically for dogs and cats. It also compares dystonia-related disorders in humans and animals. The authors suggest including specific information when describing dystonia in dogs and cats, such as activity at onset, severity, duration, and other neurological manifestations.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Keunhyo Lee, Seungchul Chon
Summary: This study aimed to compare muscle thickness, muscle tone, and maximum mouth opening in subjects with and without temporomandibular disorders (TMD). Patients with TMD showed decreased muscle thickness and increased muscle tone in the masseter and sternocleidomastoid (SCM) muscles, as well as reduced maximum mouth opening compared to non-TMD patients. Strong correlations were found between muscle thickness and tone in both relaxed and clenched states in the SCM muscle.
Article
Biochemistry & Molecular Biology
Laura Garcia-Rueda, Rosa Cabanas-Valdes, Carina Salgueiro, Jacobo Rodriguez-Sanz, Albert Perez-Bellmunt, Carlos Lopez-de-Celis
Summary: The aim of this study was to assess the effects of TECAR therapy on muscle properties in chronic stroke survivors. The results showed that a single session of TECAR therapy with functional massage can immediately reduce muscle tone and increase passive range of motion. However, there were no significant changes in neuromuscular properties.
Review
Rehabilitation
Etienne Ojardias, Edouard Ollier, Ludovic Lafaie, Thomas Celarier, Pascal Giraux, Laurent Bertoletti
Summary: A pharmacodynamic model-based meta-analysis revealed that injections of BoNT-A for post-stroke spasticity have maximal effect at 5 weeks for all BoNT-A preparations. The half-life of abobotulinumtoxinA is longer compared to other preparations.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xiaoye Cai, Guoping Qian, Siyuan Cai, Feng Wang, Yingjuan Da, Zbigniew Ossowski
Summary: The objective of this meta-analysis was to evaluate the effect of whole-body vibration training on lower limb motor function in children with cerebral palsy. Thirteen randomized-controlled trials were included in the analysis, and the results showed that whole-body vibration training could effectively improve the lower limb motor function of children with cerebral palsy.
Article
Biology
Marianne E. Emmert, Parul Aggarwal, Kritton Shay-Winkler, Se-Jin Lee, Qingnian Goh, Roger Cornwall
Summary: Neonatal brachial plexus injury (NBPI) leads to muscle contractures, and the study reveals sex dimorphism in the regulation of neonatal longitudinal muscle growth and contractures. It provides insights into finding potential muscle-specific therapeutic targets for contracture prevention and highlights the importance of sex as a biological variable in the pathophysiology of neuromuscular disorders.
Article
Medicine, General & Internal
Malgorzata Galczynska-Rusin, Malgorzata Pobudek-Radzikowska, Krzysztof Gawriolek, Agata Czajka-Jakubowska
Summary: Understanding the biomechanical properties of orofacial tissues is crucial for patients with increased activity of masticatory muscles like bruxism. This study aimed to evaluate the biomechanical properties of the masseter muscle using MyotonPRO in adults with probable bruxism and to examine gender relations. The results showed significant differences between genders in muscle tension and stiffness during muscle contraction, with women experiencing more frequent headaches and pain in the masseter muscles.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Caoimhe McLoughlin, Ingrid Hoeritzauer, Veronica Cabreira, Selma Aybek, Caitlin Adams, Jane Alty, Harriet A. Ball, Janet Baker, Kim Bullock, Chrissie Burness, Barbara A. Dworetzky, Sara Finkelstein, Beatrice Garcin, Jeannette Gelauff, Laura H. Goldstein, Anika Jordbru, Anne-Catherine M. L. Huys, Aoife Laffan, Sarah C. Lidstone, Stefanie Caroline Linden, Lea Ludwig, Julie Maggio, Francesca Morgante, Elizabeth Mallam, Clare Nicholson, Mary O'Neal, Suzanne O'Sullivan, Isabel Parees, Panayiota Petrochilos, Susannah Pick, Wendy Phillips, Karin Roelofs, Rachel Newby, Biba Stanton, Cordelia Gray, Eileen M. Joyce, Marina A. J. Tijssen, Trudie Chalder, Maxanne McCormick, Paula Gardiner, Indrit Begue, Margaret C. Tuttle, Isobel Williams, Sarah McRae, Valerie Voon, Laura McWhirter
Summary: Functional neurological disorder (FND) is often overlooked and misunderstood by clinicians, despite being a common and accurately diagnosable condition based on clinical signs. People with FND face discrimination from healthcare providers, researchers, and the public, reflecting the neglect of disorders primarily affecting women. We argue that FND is a feminist issue, drawing on historical and contemporary perspectives from clinical, research, and social domains. We call for equal attention and support for FND in medical education, research, and clinical services to ensure adequate care for those affected.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, General & Internal
T. S. Park, Susan Joh, Matthew D. Smyth, Nicole L. Meyer, Deanna M. Walter
Summary: Performing hemispherectomy can successfully treat medically intractable epilepsy, but can result in contralateral hemiparesis and increased muscle tone. It is unclear the extent to which spasticity and dystonia contribute to the high muscle tone.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Taihiko Yamaguchi, Saki Mikami, Masana Maeda, Taishi Saito, Toshinori Nakajima, Wataru Yachida, Akihito Gotouda
Summary: This article reviews the current state of portable/wearable EMG devices for assessment of bruxism. The results show that ultra-miniaturized wearable EMG devices with performance equivalent to conventional devices have been developed and used during sleep and in the daytime, with a high level of diagnostic accuracy for sleep bruxism. However, a definite cut-off value for awake bruxism has not been established.
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2023)
Review
Biotechnology & Applied Microbiology
Hongzhong Lu, Eduard J. Kerkhoven, Jens Nielsen
Summary: This review discusses the latest developments in multiscale models of yeast and demonstrates how incorporating enzymatic parameters and other cellular networks can enhance the comprehensive description of cellular physiology. These new models significantly improve predictive performance and expand the applications of Saccharomyces cerevisiae in cell factory design and basic studies of yeast physiology.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Abraham S. Meijnikman, Casper C. van Olden, Omrum Aydin, Hilde Herrema, Dorota Kaminska, Dimitra Lappa, Ville Mannisto, Valentina Tremaroli, Louise E. Olofsson, Maurits de Brauw, Arnold van de Laar, Joanne Verheij, Victor E. A. Gerdes, Thue W. Schwartz, Jens Nielsen, Fredrik Backhed, Paivi Pajukanta, Jussi Pihlajamaki, Tamar Tchkonia, James L. Kirkland, Folkert Kuipers, Max Nieuwdorp, Albert K. Groen
Summary: This article investigates the association between insulin levels and cellular senescence in the human liver and finds a significant correlation between high insulin levels and markers of cellular senescence. The results support the potential benefits of lowering insulin levels in obese individuals with insulin resistance.
Letter
Biotechnology & Applied Microbiology
Jens Nielsen, Markus J. Herrgard, Bobby Soni
NATURE BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Olena P. Ishchuka, Ivan Domenzain, Benjamin J. Sanchez, Facundo Muniz-Paredes, Jose L. Martinez, Jens Nielsen, Dina Petranovic
Summary: Heme synthesis can be increased by modifying certain genes, leading to higher production of heme proteins. This study identified 84 gene targets through computational simulations, of which 40 were confirmed to enhance heme production in experiments. Not only genes directly involved in heme biosynthesis, but also genes related to glycolysis, glycine, and succinyl-coenzyme A metabolism were found to affect heme production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Feiran Li, Yu Chen, Mihail Anton, Jens Nielsen
Summary: Enzyme parameters are crucial for understanding, modeling, and engineering cells. Experimental measurements only cover a small portion of enzyme-compound pairs, and even less in non-model organisms. Artificial intelligence techniques have accelerated the exploration of enzyme properties by predicting them in a high-throughput manner. GotEnzymes is a comprehensive database that provides predicted enzyme parameters using AI approaches, allowing for interactive web exploration and programmatic access.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Clinical Neurology
Alexander de Bruyn, Federica Montagnese, Sonja Holm-Yildiz, Nanna Scharff Poulsen, Tanya Stojkovic, Anthony Behin, Johanna Palmio, Manu Jokela, Jan L. De Bleecker, Marianne de Visser, Anneke J. van der Kooi, Leroy ten Dam, Cristina Dominguez Gonzalez, Lorenzo Maggi, Annamaria Gallone, Anna Kostera-Pruszczyk, Anna Macias, Anna Lusakowska, Velina Nedkova, Montse Olive, Rodrigo Alvarez-Velasco, Julia Wanschitz, Carmen Paradas, Fabiola Mavillard, Giorgia Querin, Gorka Fernandez-Eulate, Ros Quinlivan, Maggie C. Walter, Christophe E. Depuydt, Bjarne Udd, John Vissing, Benedikt Schoser, Kristl G. Claeys
Summary: This study examined the clinical and genetic spectrum of ANO5-related muscle diseases in a large European cohort, and searched for potential genotype-phenotype correlations. The results showed variable clinical phenotypes including limb-girdle muscular dystrophy type 12, distal muscular dystrophy type 3, pseudometabolic myopathy, and asymptomatic hyperCKaemia. Male patients had a higher prevalence in all subgroups, and there was no correlation between age, symptom onset, and motor outcomes. This study provides valuable information for clinical follow-up and the design of clinical trials.
Article
Biochemical Research Methods
Le Yuan, Hongzhong Lu, Feiran Li, Jens Nielsen, Eduard J. Kerkhoven
Summary: In this study, a computational toolbox called HGTphyloDetect was developed, which combines high-throughput analysis with phylogenetic inference to accurately identify horizontal gene transfer (HGT) events and illustrate the transmission pathway among evolutionarily distant or closely related species. The HGTphyloDetect toolbox is user-friendly, capable of detecting HGT events with high efficiency and low false discovery rate.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Chemistry, Analytical
Ivana Bardino Novosel, Anina Ritterband-Rosenbaum, Georgios Zampoukis, Jens Bo Nielsen, Jakob Lorentzen
Summary: This study developed and trained an image-based Convolutional Neural Network (CNN) to recognize specific movement classifiers relevant to individuals with cerebral palsy (CP). Monitoring and quantifying movement behavior in CP patients using multiple wearable sensors and CNN is of great value for improving their health outcomes.
Review
Rehabilitation
Carolina Climent-Sanz, Katrina R. Hamilton, Oriol Martinez-Navarro, Erica Briones-Vozmediano, Miguel Gracia-Lasheras, Helena Fernandez-Lago, Fran Valenzuela-Pascual, Patrick H. Finan
Summary: This study aimed to explore how adults with fibromyalgia manage their pain and their perceptions of prescribed treatments from healthcare professionals. The findings revealed that patients with fibromyalgia often do not benefit from seeking medical attention due to provider stigma, have varying views on medication effectiveness, find mixed effects from exercise, and consider psychological support essential. Combining cognitive-behavioral therapy with physical exercise appears more effective, while natural and complementary therapies have short-term benefits and high costs.
DISABILITY AND REHABILITATION
(2023)
Article
Materials Science, Multidisciplinary
Morteza Aghaee, Arun Akkala, Zulfi Alam, Rizwan Ali, Alejandro Alcaraz Ramirez, Mariusz Andrzejczuk, Andrey E. Antipov, Pavel Aseev, Mikhail Astafev, Bela Bauer, Jonathan Becker, Srini Boddapati, Frenk Boekhout, Jouri Bommer, Tom Bosma, Leo Bourdet, Samuel Boutin, Philippe Caroff, Lucas Casparis, Maja Cassidy, Sohail Chatoor, Anna Wulf Christensen, Noah Clay, William S. Cole, Fabiano Corsetti, Ajuan Cui, Paschalis Dalampiras, Anand Dokania, Gijs de Lange, Michiel de Moor, Juan Carlos Estrada Saldana, Saeed Fallahi, Zahra Heidarnia Fathabad, John Gamble, Geoff Gardner, Deshan Govender, Flavio Griggio, Ruben Grigoryan, Sergei Gronin, Jan Gukelberger, Esben Bork Hansen, Sebastian Heedt, Jesus Herranz Zamorano, Samantha Ho, Ulrik Laurens Holgaard, Henrik Ingerslev, Linda Johansson, Jeffrey Jones, Ray Kallaher, Farhad Karimi, Torsten Karzig, Cameron King, Maren Elisabeth Kloster, Christina Knapp, Dariusz Kocon, Jonne Koski, Pasi Kostamo, Peter Krogstrup, Mahesh Kumar, Tom Laeven, Thorvald Larsen, Kongyi Li, Tyler Lindemann, Julie Love, Roman Lutchyn, Morten Hannibal Madsen, Michael Manfra, Signe Markussen, Esteban Martinez, Robert McNeil, Elvedin Memisevic, Trevor Morgan, Andrew Mullally, Chetan Nayak, Jens Nielsen, William Hvidtfelt Padkaer Nielsen, Bas Nijholt, Anne Nurmohamed, Eoin OFarrell, Keita Otani, Sebastian Pauka, Karl Petersson, Luca Petit, Dmitry I. Pikulin, Frank Preiss, Marina Quintero-Perez, Mohana Rajpalke, Katrine Rasmussen, Davydas Razmadze, Outi Reentila, David Reilly, Richard Rouse, Ivan Sadovskyy, Lauri Sainiemi, Sydney Schreppler, Vadim Sidorkin, Amrita Singh, Shilpi Singh, Sarat Sinha, Patrick Sohr, Tomas Stankevic, Lieuwe Stek, Henri Suominen, Judith Suter, Vicky Svidenko, Sam Teicher, Mine Temuerhan, Nivetha Thiyagarajah, Raj Tholapi, Mason Thomas, Emily Toomey, Shivendra Upadhyay, Ivan Urban, Saulius Vaitiekenas, Kevin Van Hoogdalem, David Van Woerkom, Dmitrii V. Viazmitinov, Dominik Vogel, Steven Waddy, John Watson, Joseph Weston, Georg W. Winkler, Chung Kai Yang, Sean Yau, Daniel Yi, Emrah Yucelen, Alex Webster, Ruichen Zhao
Summary: In this study, measurements and simulations of semiconductor-superconductor heterostructure devices were conducted to observe topological superconductivity and Majorana zero modes. The devices were optimized to ensure robustness against nonuniformity and disorder. Experimental results indicate the presence of a topological superconducting phase, which is a prerequisite for experiments involving Majorana zero modes fusion and braiding.
Article
Biotechnology & Applied Microbiology
Tingting Xie, Min Chen, Jens Nielsen, Jianye Xia
Summary: The article investigates the previously unreported Crabtree effect under dynamic conditions and finds that citric acid shuttles play an important role in supporting the accumulation of alpha-ketoglutarate during the Crabtree effect.
FEMS YEAST RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Xinyi Tan, Jens Nielsen
Summary: The dependence on fossil fuels has led to excessive greenhouse gas emissions, causing climate changes and global warming. Biotechnology offers a promising solution for producing high-density liquid transportation fuels that can reduce emissions. Additionally, developing technologies to convert atmospheric CO2 into fossil fuel replacements is urgently needed.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Biotechnology & Applied Microbiology
Yu Chen, Feiran Li, Jens Nielsen
Summary: Yeast genome-scale metabolic models have a long history and diverse recent applications, including metabolic flux prediction, cell factory design, and multi-yeast comparative analysis. Integrating proteome constraints into the models can improve performance.
FEMS YEAST RESEARCH
(2022)
