Article
Polymer Science
Karen Zulema Meza-Valle, Rosa Alicia Saucedo-Acuna, Karla Lizzette Tovar-Carrillo, Juan Carlos Cuevas-Gonzalez, Erasto Armando Zaragoza-Contreras, Juana Melgoza-Lozano
Summary: The study demonstrates that Aloe vera hydrogel can enhance wound healing speed, reduce the total healing time, and achieve complete wound closure in 15 days. The results confirm the good interaction of the hydrogel with proteins and growth factors, as well as the microstructure and micro-roughness that promote good adhesion to the wound.
Article
Materials Science, Biomaterials
Qiuli Cheng, Zhihao Wang, Shumin Hu, Yi-Yang Peng, Rui Zhu, Leitao Zhang, Junbo Li, Ravin Narain
Summary: A multifunctional antibacterial hydrogel with rapid self-healing ability and excellent injectability was prepared. The hydrogel showed efficient antibacterial activities against Escherichia coli and Staphylococcus aureus, and exhibited good cytocompatibility and hemocompatibility. In vivo wound healing evaluation confirmed that the hydrogel effectively accelerated cutaneous regeneration and wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Junyao Li, Chunru Wang, Xiangsheng Han, Shuai Liu, Xintao Gao, Chuanlong Guo, Xiaochen Wu
Summary: A fibrous hydrogel containing nanofibers and an antibacterial drug was developed for the treatment of Staphylococcus aureus-infected burn wounds. The hydrogel exhibited favorable physicochemical properties and biocompatibility, and continuously released antibacterial drugs to promote wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Zifeng Yang, Rongkang Huang, Bingna Zheng, Wentai Guo, Chuangkun Li, Wenyi He, Yingqi Wei, Yang Du, Huaiming Wang, Dingcai Wu, Hui Wang
Summary: By grafting cationic polyelectrolyte brushes onto polydopamine/polyacrylamide hydrogels, the mechanical and antibacterial properties of the hydrogels were enhanced, leading to stable coverage, long-lasting antibacterial effects, and fast wound healing.
Review
Biotechnology & Applied Microbiology
Wentao Shu, Yinan Wang, Xi Zhang, Chaoyang Li, Hanxiang Le, Fei Chang
Summary: Burn treatment is a challenging clinical issue with the future lying in the development of active dressings such as hydrogel dressings that can accelerate wound healing. Various treatment strategies for burns are reviewed, emphasizing the clinical value of hydrogel dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Yangkun Liu, JinChuan Fan, MingQi Lv, Kepeng She, Jiale Sun, Qingqing Lu, Changhao Han, SongTao Ding, Shuang Zhao, GuiXue Wang, YuChan Zhang, GuangChao Zang
Summary: The Ag-AV-SF hydrogel developed in this study demonstrated excellent physical properties, strong antibacterial properties, satisfactory biocompatibility, and significant promoting effects on cell proliferation, migration, and wound healing. It showed great potential in promoting early healing, reconstructing blood vessels networks, and inhibiting scar formation.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yuanyuan Yang, Chong Zhang, Ming Gong, Yuan Zhan, Zhenkun Yu, Chang Shen, Yuhong Zhang, Li Yu, Zhaoxia Chen
Summary: In this study, a hybrid hydrogel made of polyvinyl alcohol -iodine (PAI), sodium carboxymethyl cellulose (CMC), and carbamino quantum dot (CQDs) was prepared by the cross-linking of hydrogen bonds. The composite hydrogels exhibited outstanding photothermal conversion efficiency and high antibacterial activity against Staphylococcus aureus and Escherichia coli. The elevated temperature of the hydrogels could stimulate epidermal cell migration and the real-time wound pH information was provided by the visible light and fluorescent light dual monitoring system.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Materials Science, Textiles
Lebo Maduna, Asis Patnaik
Summary: Natural wound dressings extracted from Aloe vera leaves are recognized for their ability to speed up wound healing and their non-toxicity. The treated dressings remove moisture and allow gas exchange while suppressing microbial growth. Aloe vera can be applied directly to fabric or electrospun into nanoparticles. Chemical antimicrobial agents are still used due to the limited effectiveness of natural agents against high concentrations of microorganisms. However, natural fabrics treated with Aloe vera can be an alternative for chemical agents, as they prevent microbial growth and promote wound healing without activating the immune response.
JOURNAL OF NATURAL FIBERS
(2023)
Article
Polymer Science
Mostafa Saberian, Ehsan Seyedjafari, Seyed Jalal Zargar, Fatemeh Sadat Mahdavi, Parisa Sanaei-rad
Summary: This study focused on utilizing natural biomaterials to develop a novel hydrogel for wound healing. The hydrogel showed a porous structure and good biocompatibility, making it promising for future tissue repair applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Vineeta Panwar, Anjana Sharma, Preethi Murugesan, Navita Salaria, Deepa Ghosh
Summary: This study introduces dehydrated microgel particles that rapidly swell and interconnect, forming an integrated hydrogel when exposed to fluid. These particles can significantly absorb fluid and release silver nanoparticles, effectively controlling infection. Studies validate the microgels' ability to regulate wound exudate, create a moist environment, and confirm their safety and hemostatic property. Results from full-thickness wounds in rats highlight the enhanced healing potential of these microgel particles, suggesting their potential as a new class of smart wound dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Majid Salehi, Sina Zamiri, Hadi Samadian, Jafar Ai, Laleh Foroutani, Arman Ai, Mehdi Khanmohammadi
Summary: The study aimed to develop a chitosan hydrogel containing Aloe vera gel and Ethylenediaminetetraacetic acid (EDTA) as wound healing materials, which showed inhibitory effects on the growth of Staphylococcus aureus and Pseudomonas aeruginosa. The hydrogels exhibited good hemocompatibility and biocompatibility, and significantly enhanced wound healing in animal models.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Review
Polymer Science
Erfan Rezvani Ghomi, Mina Niazi, Seeram Ramakrishna
Summary: Wound healing has always been a challenge throughout human history. Modern dressings offer advantages over traditional bandages, but they lack responsiveness to wound conditions. Smart dressings can interact with the environment, monitor healing stages, and provide valuable information for treatment.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Pharmacology & Pharmacy
Bianca P. Genesi, Raquel de Melo Barbosa, Patricia Severino, Andrea C. D. Rodas, Cristiana M. P. Yoshida, Monica B. Mathor, Patricia S. Lopes, Cesar Viseras, Eliana B. Souto, Classius Ferreira da Silva
Summary: Chitosan films containing aloe vera and copaiba oil were developed and evaluated for their antimicrobial activity, cytotoxicity, and in vivo healing potential. The results showed that these films had excellent properties in promoting wound healing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Bushra Ishfaq, Ikram Ullah Khan, Syed Haroon Khalid, Sajid Asghar
Summary: In this study, sodium alginate-based hydrogel films loaded with Betula utilis bark extract were successfully developed and evaluated for their wound healing activity. The optimized formulation exhibited good extract loading capacity, large zone of inhibition against bacteria, and significant wound contraction and reepithelization. The extract-loaded hydrogel dressing showed great potential for cutaneous wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Yan Wang, Mingrui Yang, Zheng Zhao
Summary: A novel hydrogen-bonded polysaccharide hydrogel consisting of cationic guar gum and CuCl2 was developed, which exhibited self-healing, injectable, and self-adapting properties. The hydrogel showed good mechanical strength, biocompatibility, antibacterial ability, and complete degradation in vivo. This study provides a simple and straightforward strategy for preparing self-healing polysaccharide hydrogels based on hydrogen bonding, expanding their applications in biomedicine and tissue regeneration.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Bengi Ozkahraman, Isil Acar, Gamze Guclu
Summary: In this study, copolymeric hydrogels based on N-vinylcaprolactam (VCL) and methacrylic acid (MAA) were synthesized to develop a temperature-sensitive and pH-sensitive biomaterial for drug delivery systems. The drug release properties of the hydrogels were investigated, and it was found that the hydrogels showed potential for long-term controlled drug release systems with varying pH values.
Article
Engineering, Chemical
Bengi Ozkahraman, Gulsah Torkay, Zehra Ozbas, Ayca Bal-Ozturk
Summary: This study demonstrates the potential of a pectin/modified alginate buccal patch as a drug delivery device for localized treatment of oral cavity diseases. The modified alginate showed enhanced mucoadhesive properties and the Vitamin C loaded patch exhibited accelerated wound healing. These positive results suggest that the pectin/modified alginate buccal patch could be a promising candidate for localized drug release in the buccal region.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2023)
Article
Engineering, Biomedical
Emine Alarcin, Burcin Izbudak, Elif Yuce Erarslan, Sherif Domingo, Rumeysa Tutar, Kariman Titi, Banu Kocaaga, F. Seniha Guner, Ayca Bal-Ozturk
Summary: Layered double hydroxides (LDHs) with superior mechanical properties, drug delivery capability and regulation cellular behaviors provide unique inspiration for the design of bone mimetic biomaterials. This study developed a straightforward strategy for extrusion bioprinting of cell laden nanocomposite hydrogel bioink of gelatin methacryloyl (GelMA) biopolymer and LDHs nanoparticles. The developed hydrogel bioinks showed precise control over extrudability, extrusion uniformity, and structural integrity, and were able to support encapsulated osteoblast survival, spreading, and proliferation. The results demonstrated the high potential of GelMA/LDHs nanocomposite hydrogel bioink for extrusion bioprinting to fabricate implantable 3D hydrogel constructs for bone defect repair.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Engineering, Biomedical
Yusuf Kanca, Bengi Ozkahraman
Summary: The in-vitro tribological performance of methacrylated kappa-carrageenan and gellan gum hydrogels (KA-MA and GG-MA) was evaluated under physiological conditions. Among them, GG-MA-H showed robust mechanical properties, increased wear resistance, and considerably low coefficient of friction, which suggests its potential usage as a cartilage substitute.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Polymer Science
Elif Yuce-Erarslan, Burcin Izbudak, Ahmet Akif Kizilkurtlu, Merve Topal, Ali Akpek, Ayca Bal-Ozturk
Summary: The use of biocompatible materials in tissue engineering has increased in recent years with the development of biomaterials. Hybrid tissue scaffolds containing methacrylated gelatin, chondroitin sulfate, hyaluronic acid, and eggshell particles were successfully fabricated. The addition of 10% eggshell particles improved the mechanical properties of the scaffold by 47% and showed no toxic effects on osteoblast cells.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ayca Bal-Ozturk, Sherif Domingo Tietilu, Oguz Yuecel, Tugba Erol, Zeynep Puren Akguner, Hakan Darici, Emine Alarcin, Serkan Emik
Summary: Hyperbranched polymers (HPB) have been attracting attention as drug delivery platforms due to their ability to encapsulate drugs. HPB-based nano-sized drug delivery platforms can be developed to enhance the efficacy of cancer treatment. Targeted drug delivery systems that can target malignant tissues are crucial in the treatment process. In this study, folic acid-modified HPB-based nanoparticles were synthesized and characterized, and their efficiency in folate receptor-positive cancer treatment was investigated.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Ayca Bal-Ozturk, Gulsah Torkay, Neslihan Idil, Bengi Ozkahraman, Zehra Ozbas
Summary: In this article, wound dressing films based on honey incorporated gellan gum and guar gum biopolymers were prepared using the solvent casting technique. The effects of honey concentration on film properties were investigated. The films showed improved tensile strength and decreased water vapor transmission rate with increasing honey concentration. They also exhibited good antioxidant activity and biocompatibility, supporting cell migration and proliferation.
Article
Materials Science, Multidisciplinary
Gokcen Yasayan, Omid Nejati, Asli F. Ceylan, Cimen Karasu, Pelin Kelicen Ugur, Ayca Bal-Ozturk, Atefeh Zarepour, Ali Zarrabi, Ebrahim Mostafavi
Summary: Chronic wounds, particularly in diabetes patients, are a major health challenge with high economic costs. Nanomaterials have shown promising results in treating chronic wounds by acting as carriers for therapeutic agents or directly as the therapeutic compound. This review provides the latest research progress and prospects on the application of different nanomaterials in chronic wound healing, with a focus on their effects on intracellular factors.
APPLIED MATERIALS TODAY
(2023)
Review
Chemistry, Medicinal
Ayca Bal-Ozturk, Ece Ozcan-Bulbul, Hazal Ezgi Gultekin, Berivan Cecen, Ebru Demir, Atefeh Zarepour, Sibel Cetinel, Ali Zarrabi
Summary: Eyes are crucial for providing the brain with information about the environment. Ocular diseases can severely impact quality of life and finding effective treatment methods has become a priority. Recent innovations in contact lenses, micro and nanoneedles, and in situ gels have shown promise in overcoming barriers in delivering therapeutic drugs into the eyes. This review aims to summarize the evidence on the effectiveness of these new techniques, their progression in preclinical and clinical studies, current limitations, and future prospects.
Article
Materials Science, Biomaterials
Beliz Taskonak, Guelguen Aylaz, Muege Andac, Eylem Guven, Bengi Ozkahraman, Isik Percin, Aysun Kilic Suloglu
Summary: HY-CH-NPs nanoparticles were prepared to increase the cytotoxic effect of HY on A549 lung cancer cells by prolonging its action time.
Article
Biochemistry & Molecular Biology
Gergely Kali, Bengi Ozkahraman, Flavia Laffleur, Patrick Knoll, Richard Wibel, Katrin Zoller, Andreas Bernkop-Schnurch
Summary: This study aimed to design and evaluate an anionic, thiolated cellulose derivative for its mucoadhesive and permeation-enhancing properties using enoxaparin as a model drug. The thiolated cellulose exhibited enhanced mucoadhesion on porcine intestinal mucosa and improved permeation in Caco-2 cell monolayer. In vivo studies in rats showed significantly higher oral bioavailability compared to the aqueous solution of the drug.
Article
Materials Science, Biomaterials
Busra Moran Bozer, Bengi Ozkahraman, Humeyra Mert
Summary: Oleuropein-loaded photocrosslinked hydrogels were developed as a new hydrogel wound dressing, composed of methacrylated pectin and methacrylated hyaluronic acid. The composite hydrogels were prepared by photocrosslinking of the methacrylated polymer precursors. The bioactivity studies demonstrated the potential of oleuropein-loaded photocrosslinked hybrid hydrogels for wound healing applications.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Engineering, Chemical
Omid Nejati, Busra Tisli, Gokcen Yasayan, Buse Tugba Zaman, Gulsah Torkay, Mustafa Donmez, Inci Kayin, Sezgin Bakirdere, Ayca Bal-Oztuerk
Summary: This study focuses on the fabrication and characteristics of hydrogels incorporated with selenium nanoparticles (SeNPs) as wound healing dressings. The results indicate that the hydrogel dressing containing SeNPs has a positive effect on promoting wound healing.
POLYMER ENGINEERING AND SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Hazal Ezgi Gultekin, Gokcen Yasayan, Ayca Bal-Ozurk, Ashkan Bigham, Abdolreza (Arash) Simchi, Atefeh Zarepour, Siavash Iravani, Ali Zarrabi
Summary: Wound healing is a complex process that requires effective management. Upconversion nanoparticles (UCNPs) have emerged as promising materials for wound dressing due to their unique properties. Functionalized with antibacterial agents, UCNPs have enhanced antibacterial properties and can deliver therapeutic agents to the wound site. They can also convert near-infrared light for therapy and diagnosis. However, the use of UCNPs in wound dressing faces challenges of stability, biocompatibility, efficient incorporation, scalability, and cost-effectiveness.
MATERIALS HORIZONS
(2023)
