Interaction of metformin hydrochloride with ionic surfactants in aqueous and NaCl solution: Effect of temperatures and compositions

Herein, the interaction of metformin hydrochloride (MNH) with cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) has been investigated by the conductometric technique in aqueous medium as well as in the existence of NaCl over a range of temperatures. MNH, an antidiabetic drug that belongs to the biguanide group, is generally prescribed for the patients to manage type II diabetes. The micellar parameters such as critical micelle concentration (CMC), the extent of counterion binding (beta), and different thermodynamic properties for MNH + surfactant systems were estimated and discussed elaborately. The CMC values of CTAB + MNH and SDS + MNH systems are dependent on the concentrations of NaCl at different temperatures. The significant decrease of CMC values in NaCl solution indicates that NaCl stabilizes MNH-mediated surfactant micelles. The CMC values versus T plots show a nonlinear pattern for the CTAB + MNH system, whereas the CMC values almost monotonically decrease with increasing temperature for the SDS + MNH system. The values of increment G(m)(0) were negative for both systems in all cases. Both increment G(m)(0) and increment G(m,t)(0) values indicate that the aggregation processes of MNH + surfactants mixture are spontaneous, which is also manifested in NaCl solution and with the change of temperatures in most of the cases. The obtained results proposed that surfactants may assist as a proficient drug delivery agent for antidiabetic drug, enhancing their bioavailability.

Automated summary

The interaction between metformin hydrochloride (MNH) and two surfactants as well as the influence of NaCl on this interaction were investigated. It was found that NaCl can stabilize the surfactant micelles mediated by MNH, and surfactants may enhance the bioavailability of antidiabetic drugs.