Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 144, Issue 4, Pages 212-217Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2020.09.003
Keywords
Microglia; Febrile seizure; Epilepsy; Dentate gyrus; Synapse
Categories
Funding
- JSPS [17H03988]
- JST [JPMJPR18H4, JPMJER1801]
- Grants-in-Aid for Scientific Research [17H03988] Funding Source: KAKEN
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The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are excessively activated, especially in the hippocampus. These findings suggest that microglia may contribute to the onset and aggravation of epilepsy; however, direct evidence for microglial involvement or the underlying mechanisms by which this occurs remain to be fully discovered. To date, neuron-microglia interactions have been vigorously studied in adult epilepsy models; such studies have clarified microglial responses to excessive synchronous firing of neurons. In contrast, the role of microglia in the postnatal brain of patients with epileptic seizures remain largely unclear. Some early-life seizures, such as complex febrile seizures, have been shown to cause structural and functional changes in the brain, which is a risk factor for future development of epilepsy. Because brain structure and function are actively modulated by microglia in both health and disease, it is essential to clarify the role of microglia in early-life seizures and its impact on epileptogenesis. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license
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