Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Article
Biochemistry & Molecular Biology
Xiangyu Zhang, Feiyu Chen, Peiran Huang, Xinyu Wang, Kaiqian Zhou, Cheng Zhou, Lei Yu, Yuanfei Peng, Jia Fan, Jian Zhou, Zuohua Lu, Jie Hu, Zheng Wang
Summary: MiR-148a-3p derived from activated HSCs accelerates HCC progression through ITGA5/PI3K/Akt signaling pathway. These findings contribute to a better understanding of the molecular mechanisms underlying the development of HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chen Xue, Ganglei Li, Juan Lu, Lanjuan Li
Summary: Circular RNAs (circRNAs) are covalently closed noncoding RNAs that regulate target gene expression and play important roles in cancer progression through the circRNA/PI3K/AKT axis. Aberrant regulation of circRNA expression is significantly associated with clinicopathological characteristics and plays crucial roles in biological functions.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Food Science & Technology
Mengfan Zhang, Turtushikh Damba, Zongmei Wu, Sandra Serna-Salas, Manon Buist-Homan, Klaas Nico Faber, Han Moshage
Summary: This study demonstrates that esculetin can induce HSC senescence and reverse the activated phenotype of HSC. The effect is dependent on PI3K-Akt-GSK3B signaling. This finding suggests that esculetin could be a potential drug for the treatment of hepatic fibrosis.
Article
Immunology
Zi Xuan Li, Xiao Dong Sheng, Yu Lian Wang, Xiong Wen Lv
Summary: This study found that P2X4 receptor plays an important role in alcoholic liver fibrosis. The expression of P2X4 receptor is significantly increased when exposed to alcohol. Experimental results showed that a specific inhibitor of P2X4 receptor, 5-BDBD, can alleviate the pathological features of fibrosis. Furthermore, the activation of P2X4 receptor may be related to the activation of the PI3K/AKT pathway and RAW264.7 cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chengdong Qin, Siyuan Liu, Shiqi Zhou, Xianghou Xia, Jiejie Hu, Yang Yu, Dening Ma
Summary: The study aims to assess the impact of Tanshinone IIA (Tan IIA) on tumor angiogenesis and architecture, as well as its effect on tumor hypoxia and susceptibility to Sorafenib. The results showed that Tan IIA can prevent Sorafenib from damaging the typical vascular structure and aid in blocking the recruitment of vascular endothelial cells by liver cancer cells. It significantly enhances the inhibitory effect of Sorafenib on liver cancer, alleviates tumor microenvironment hypoxia, and reduces lung metastasis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan
Summary: This study found that VCP is significantly increased in HCC tissues and is associated with advanced TNM stages and poorer prognosis. VCP overexpression promotes HCC cell proliferation, migration, and invasion via PI3K/AKT/mTOR pathway activation. Additionally, VCP interacts with HMGB1 and enhances its protein stability, contributing to HCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Plant Sciences
Xiao-Bian Xue, Tian-Ming Lv, Jiao-Yang Hou, Dan-Qi Li, Xiao-Xiao Huang, Shao-Jiang Song, Guo-Dong Yao
Summary: This study evaluated the antitumor mechanisms of vibsane-type diterpenoids against hepatocellular carcinoma (HCC) cells and confirmed their inhibitory effects on cell proliferation by regulating the PI3K/AKT pathway.
Article
Oncology
Pan Xu, Aoran Luo, Chuan Xiong, Hong Ren, Liang Yan, Qiang Luo
Summary: This study verified the role of SCUBE3 in hepatocellular carcinoma (HCC) progression and demonstrated that SCUBE3 promotes HCC cell proliferation by regulating CCNE1. The study also identified alterations in signaling pathways associated with SCUBE3, including the TGF beta signaling pathway and the PI3K/AKT signaling pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Houhong Wang, Wenli Chen, Yayun Cui, Huihui Gong, Amao Tang
Summary: Through bioinformatics analysis and in vitro experiments, it was confirmed that Bushen Huayu Decoction and its active ingredient AHI can fight against HCC. The potential mechanism may be associated with inhibiting the activation of the PI3K/AKT signal pathway, which could serve as a potential treatment for HCC therapy.
Article
Pharmacology & Pharmacy
Jing Man, Wanbiao Zhou, Shi Zuo, Xueke Zhao, Qiang Wang, Huaxing Ma, Hai-Yang Li
Summary: TANGO1 promotes hepatocellular carcinoma by activating the PI3K/AKT/mTOR signaling pathway through interaction with NRTN, leading to increased proliferation and EMT. The TANGO1/NRTN axis may serve as a potential therapeutic target for HCC.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Qihong Cai, Ninggao Dai, Liming Xu, Qiandong Zhu, Qiyu Zhang, Qingqing Zhou
Summary: The study aimed to investigate the inhibitory effect of capsaicin on the activation of hepatic stellate cells (HSCs) and elucidate the underlying mechanism. Capsaicin dose-dependently inhibited HSC cell proliferation and suppressed HSC cell fibrosis. It achieved this by downregulating the activation of the PI3K/AKT/mTOR pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Danyu Du, Shuai Wang, Tao Li, Zhengrui Liu, Mei Yang, Li Sun, Shengtao Yuan
Summary: The study reveals that RHNO1 is upregulated in HCC tumor tissues and its high expression predicts poor prognosis in HCC patients. Knockdown of RHNO1 inhibits proliferation and induces apoptosis of HCC cells both in vitro and in vivo. Mechanistically, RHNO1 regulates HCC proliferation and apoptosis through the PI3K/Akt pathway. These findings highlight the oncogenic role of RHNO1 in HCC and suggest it as a potential therapeutic and diagnostic target.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Jieun Bang, Mihyeon Jun, Soyun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: Hepatocellular carcinoma (HCC) is a significant global health concern, with its incidence steadily increasing. Recent progress has been made in understanding the molecular signaling pathways, particularly the EGFR/PI3K/AKT/mTOR pathway, which plays a central role in HCC. Preclinical studies have shown the effectiveness of targeting this signaling pathway for HCC therapy, offering potential therapeutic options for patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Min Kyung Park, Dong Ho Lee, Bo Yun Hur, Hyung-Chul Lee, Yun Bin Lee, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee
Summary: This study assessed the detection power of ultrasound (US) and the occurrence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) based on the US Liver Imaging Reporting and Data System (LI-RADS) visualization score. The results showed that patients with suboptimal visualization (score B or C) had a higher risk of HCC and a higher rate of false-negative findings on US.
Article
Medicine, General & Internal
Eun Ju Cho, Goh Eun Chung, Jeong-Ju Yoo, Yuri Cho, Dong Wook Shin, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Su Jong Yu
Summary: This study aimed to investigate whether the association between alcohol consumption and hepatocellular carcinoma (HCC) risk differs by fasting serum glucose level and diabetes. The results showed that mild-to-moderate alcohol consumption increased the risk of HCC in all glycemic statuses, but the risk was highest in patients with diabetes.
Article
Medicine, General & Internal
Jeong-Ju Yoo, Man Young Park, Eun Ju Cho, Su Jong Yu, Sang Gyune Kim, Yoon Jun Kim, Young Seok Kim, Jung-Hwan Yoon
Summary: This study investigates the effect of smoking on the incidence of hepatocellular carcinoma (HCC) and cardiovascular disease (CVD) in patients with metabolic-associated fatty liver disease (MAFLD). The analysis of a Korean health screening database shows that smoking significantly increases the risk of HCC and CVD in MAFLD patients. Complete smoking cessation is highly recommended for individuals with MAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jihye Kim, Moon Haeng Hur, Seung Up Kim, Jin-Wook Kim, Dong Hyun Sinn, Hyun Woong Lee, Moon Young Kim, Jae Youn Cheong, Yong Jin Jung, Han Ah Lee, Young-Joo Jin, Jun Sik Yoon, Sung-Jae Park, Chang Hun Lee, In Hee Kim, June Sung Lee, Young Youn Cho, Hyung Joon Kim, Soo Young Park, Yeon Seok Seo, Hyunwoo Oh, Dae Won Jun, Mi Na Kim, Young Chang, Jae Young Jang, Sang Youn Hwang, Yoon Jun Kim
Summary: This study compared the effectiveness of entecavir and tenofovir disoproxil fumarate in preventing hepatocellular carcinoma among patients with chronic hepatitis B. The study found that the two antivirals had similar efficacy in preventing HCC and had comparable rates of other outcomes. However, the tenofovir disoproxil fumarate group had more side effects, leading to some patients needing to switch initial antiviral medications.
Article
Gastroenterology & Hepatology
Cheol-Hyung Lee, Yun Bin Lee, Hyemi Moon, Jong-Won Chung, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Juneyoung Lee, Jung-Hwan Yoon
Summary: This study investigated the associations between aspirin use and risks of hepatocellular carcinoma (HCC), liver-related mortality, and major bleeding in non-cirrhotic patients with chronic hepatitis B (CHB). The results showed that aspirin use was associated with reduced risks of HCC and liver-related death, without an increase in the risk of major bleeding, in patients with CHB and a higher metabolic risk factor burden.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Scott K. Fung, Calvin Q. Pan, Grace Lai-Hung Wong, Wai-Kay Seto, Sang Hoon Ahn, Chi-Yi Chen, Hie-Won L. Hann, Maciej S. Jablkowski, Yoon Jun Kim, Cihan Yurdaydin, Cheng-Yuan Peng, Tuan Nguyen, Hiroshi Yatsuhashi, John F. Flaherty, Leland J. Yee, Frida Abramov, Hongyuan Wang, Dzhamal Abdurakhmanov, Young-Suk Lim, Maria Buti
Summary: Patients with CHB who switch from TDF to TAF show changes in lipid profiles but no significant impact on cardiovascular risk.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Heechul Nam, Hyun Yang, Ho Soo Chun, Han Ah Lee, Joon Yeul Nam, Jeong Won Jang, Yeon Seok Seo, Do Young Kim, Yoon Jun Kim, Si Hyun Bae
Summary: The study aimed to identify prognostic factors, including pre-treatment low skeletal muscle mass (LSMM), for survival outcomes in patients with hepatocellular carcinoma (HCC) undergoing trans-arterial radioembolization (TARE).
Article
Medicine, General & Internal
Heejoon Jang, Su Jong Yu, Hong Ghi Lee, Tae Min Kim, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Jung-Hwan Yoon, Yoon Jun Kim
Summary: The optimal duration of prophylactic antiviral therapy in patients with resolved HBV receiving rituximab is unclear. This study found that there is no significant difference in HBV reactivation between the 6-month and 12-month prophylactic TDF groups after completion of rituximab-based chemotherapy.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Ji Min Han, Youngil Koh, Sung Hwan Kim, Sung Yun Suh, Yoon Sook Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Hye Sun Gwak
Summary: This retrospective study evaluated the records of liver cirrhosis patients receiving dalteparin for portal vein thrombosis treatment. No history of variceal bleeding and newly developed thrombus before treatment were predictive factors associated with increased treatment response. Delay in starting treatment (more than three months or six months) was associated with a higher risk of relapse. Individualized dosing regimen (based on body weight) was more effective than fixed dosing regimen, with no observed bleeding complications.
MEDICINA-LITHUANIA
(2023)