Article
Agriculture, Dairy & Animal Science
Fuqing Huang, Kunling Teng, Yayong Liu, Tianwei Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Nisin Z has potential anti-inflammatory effects on mastitis by inhibiting the activation of the ERK1/2 and p38 MAPK signaling pathway and promoting the blood-milk barrier.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Pharmacology & Pharmacy
Yingying Chen, Dongyue Li, Liying Sun, Kai Qi, Lijun Shi
Summary: This study aimed to evaluate the effect and mechanism of toll-like receptor 4 (TLR4) inhibitor TLR4-IN-C34 on gut microbiota in mice with ulcerative colitis (UC). The results showed that TLR4-IN-C34 partially improved dysbiosis of intestinal flora, inflammatory infiltration, oxidative stress, and intestinal barrier function in UC mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meishan Yue, Jialu Huang, Xiaolan Ma, Peng Huang, Yisong Liu, Jianguo Zeng
Summary: This study found that PRO, an anti-inflammatory ingredient in Macleaya cordata, can alleviate inflammation symptoms and restore the intestinal barrier in DSS-induced colitis mice. PRO also regulates the composition of gut microbiota.
Article
Nutrition & Dietetics
Min Guo, Dehai Xing, Jin Wang, Ying Zhang, Zhuoyu Li, Xiangying Jiao
Summary: Ulcerative colitis (UC) is a growing burden globally, especially in developing countries. This study investigated the effect of N. commune polysaccharides on acute colitis in mice induced by DSS and its role in mediating the gut microbiota. The results showed that N. commune polysaccharides enhanced the intestinal mucosal barrier and exhibited prebiotic-like functions, suggesting its potential as an alternative or complementary treatment for UC.
Article
Biochemistry & Molecular Biology
Xiaohan Wu, Shuchun Wei, Meilin Chen, Jinting Li, Yuping Wei, Jixiang Zhang, Weiguo Dong
Summary: P2Y13 is highly expressed in ulcerative colitis and can aggravate intestinal mucosal barrier destruction by activating the IL-6/STAT3 pathway, making it a potential drug target for UC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Tanzhou Chen, Kaier Gu, Ruoyang Lin, Yang Liu, Yunfeng Shan
Summary: S1PR2 plays a crucial role in maintaining intestinal epithelial cell permeability and inducing ulcerative colitis by regulating the expression of SphK2, HDAC1, HDAC2, and the ERK1/2 signaling pathway, thus promoting intestinal epithelial cell proliferation and barrier maintenance.
Article
Biochemistry & Molecular Biology
Hongyu Xiao, Hailun Li, Yifan Wen, Dongxu Jiang, Shumin Zhu, Xueling He, Qingping Xiong, Jie Gao, Shaozhen Hou, Song Huang, Lian He, Jian Liang
Summary: TFP shows significant therapeutic effects on DSS-induced UC model by inhibiting inflammation and restoring intestinal barrier and mucus barrier function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Yukun Zhang, Feng Lu, Hang Zhang, Yuwei Ye, Penghu Liu, Dongmei Lin, Hong Zhou, Min Li, Baoxue Yang
Summary: This study investigated the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) and selenium-enriched Agaricus blazei Murrill polysaccharides (ABP-Se) on ulcerative colitis (UC) using a mouse model. The results showed that both ABP and ABP-Se alleviated UC symptoms and improved colonic barrier functions, while reducing inflammation and oxidative stress.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Pharmacology & Pharmacy
Bingyu Wang, Zhiqiang Gong, Jingyu Zhan, Lei Yang, Quanyu Zhou, Xingxing Yuan
Summary: Xianglian pill (XLP) has been found to alleviate DSS-induced acute colitis in mice by inhibiting pro-inflammatory cytokines secretion, repairing intestinal epithelial barrier dysfunction, enhancing autophagy, and blocking the activation of the PI3K/Akt/mTOR pathway. Blocking autophagy attenuated the protective effects of XLP on colitis, suggesting that the underlying mechanism may involve Xianglian pill promoting autophagy by blocking the activation of the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Hui Jiang, Gao-Feng Shi, Yu-Xi Fang, You-Qian Liu, Qi Wang, Xian Zheng, Dong-Jian Zhang, Jian Zhang, Zhi-Qi Yin
Summary: AA can prevent colitis by enhancing intestinal barrier function through suppressing the Notch signaling pathway. Oral administration of AA can alleviate colitis symptoms, inhibit inflammation, promote normal cell proliferation, and increase the expression of tight junction proteins and mucus secretion in the intestinal wall.
Review
Pharmacology & Pharmacy
Jingyi Shan, Suxian Liu, Haoyue Liu, Jianye Yuan, Jiang Lin
Summary: Ulcerative colitis is a difficult-to-treat inflammatory bowel disease, and current therapies have unsatisfactory outcomes. Research has shown that the abnormality of the intestinal mucosal barrier is involved in the pathogenesis of UC. Qingchang Suppository, an herbal preparation, has been effective in treating ulcerative proctitis. This review elucidates the potential mechanism of Qingchang Suppository from the perspective of the intestinal mucosal barrier to guide future research directions.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yichen Zong, Jie Meng, Tangyou Mao, Qiang Han, Peng Zhang, Lei Shi
Summary: This article summarizes the evidence of traditional Chinese medicine (TCM) in treating ulcerative colitis (UC) by protecting and repairing the intestinal mucosal barrier. The mechanisms involve increasing intestinal epithelial cells, tight junction proteins, and mucins, promoting intestinal stem cell proliferation, restoring the abundance of the intestinal microbiota, and modulating the innate and adaptive immunity in the gut. Future studies should focus on patients' samples and animal models of UC, conducting rescue experiments, exploring more upstream regulators, and adopting new technical methods.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Qian Xie, Hongyan Li, Rong Ma, Mihong Ren, Yong Li, Jinxiu Li, Hai Chen, Zhuoping Chen, Daoyin Gong, Jian Wang
Summary: In this study, the therapeutic effects of Coptis chinensis Franch and Magnolia officinalis on TNBS-induced ulcerative colitis in rats were investigated. It was found that these herbal medicines could improve disease indicators, reduce colonic mucosal damage, and regulate intestinal flora. They also showed anti-inflammatory effects and protected the integrity of the tight junction, indicating their potential in preventing intestinal barrier damage.
Article
Food Science & Technology
Dong He, Wen Zeng, Yi Wang, Yifan Xing, Kang Xiong, Nan Su, Chong Zhang, Yuan Lu, Xinhui Xing
Summary: Ulcerative colitis (UC), an incurable and complex digestive disease, affects millions of people worldwide. This study investigated the potential of bioactive peptides as functional foods or drugs for UC prevention and treatment, with a focus on alcohol-soluble components from fermentation broth by fresh wheat germ and apple (AC-WGAF). Four novel peptides were identified from AC-WGAF, and peptide T24 exhibited the most significant anti-colitis activity. T24 prevented tight junction protein loss, maintained epithelial barrier integrity, and promoted cell proliferation by regulating mitogen-activated protein kinase signaling pathways. Overall, T24 shows promise as a functional food or novel drug for UC prevention and treatment.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Environmental Sciences
Siquan Wang, Libo Wu, Zijuan Wang, Huihong Du, Jincai Zhu, Yongyu Li, Minghong Cai, Xinhong Wang
Summary: This study investigated the pollution characteristics of Organic amine pesticides (OAPs) in the East China Sea (ECS) and the South China Sea (SCS) and found that OAPs concentrations were higher in deep layers compared to surface seawater. Preliminary risk assessment indicated that OAPs in the water pose no significant risk to aquatic organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Pharmacology & Pharmacy
Marek Pajak, Magdalena Wozniczka, Miroslawa Swiatek, Bartlomiej Czerwinski, Jakub Wlodarczyk, Jakub Fichna
Summary: The complexation properties of two synthetic nucleosides, beta-D-ribofuranoside-4-pyrimidinone (ribo) and beta-D-deoxyribofuranoside-4-pyrimidinone (deoxy), with Ag(I) ions in aqueous solution were investigated. The stability constants of the coordination entities formed were calculated and the percentage of each entity in solution was estimated. The results suggest that these coordination entities have potential antiviral, antibacterial, and antitumor properties, as well as potential applications in nanobiotechnology.
ACTA POLONIAE PHARMACEUTICA
(2023)
Article
Agricultural Engineering
Xinlong Zhao, Yankun Peng, Yongyu Li, Qinghui Guo, Bingwei Wang
Summary: This study explored the monitoring ability of a micro-Unmanned Aerial Vehicle (UAV) in orchards by using a force sensor and gyroscope to observe changes in force and posture of growing apples during spectral collection. The UAV carried a visible/near-infrared multispectral sensor to collect internal information of the apples. A prediction model for internal quality was established using destructive testing and pre-treatments, and apple maturity was evaluated using the Streif index. Results showed that detecting apples on trees using UAV did not affect their growth and provided valuable internal quality information. The prediction model had a correlation coefficient of 0.8593 and a root mean square error of 0.0102, indicating the potential of this study in detecting quality and maturity changes in growing apples and its usefulness in overall orchard perception.
BIOSYSTEMS ENGINEERING
(2023)
Review
Agriculture, Multidisciplinary
Shaojin Ma, Yongyu Li, Yankun Peng
Summary: Legumes have significant importance in human consumption, animal foraging, and sustainable farming. Spectroscopy and computer vision techniques offer rapid and noninvasive analysis for assessing the quality and safety of legumes. Spectroscopy approaches include visible and near-infrared, near-infrared, mid-infrared, Raman, fluorescence, and terahertz spectroscopy, while computer vision methods include traditional CV, hyperspectral imaging, and multispectral imaging. However, challenges regarding spectral correction algorithms, hardware and instrument development, and image processing techniques need to be addressed for wider application in the agriculture industry.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2023)
Review
Pharmacology & Pharmacy
Karolina Merecz, Mikolaj Hirsa, Olga Biniszewska, Jakub Fichna, Aleksandra Tarasiuk
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that affects approximately 10% of the global population. Recent studies have shown that antagonism of the serotonin 5-HT3 receptor is an effective treatment for IBS-D. The modulation of serotonin function plays a crucial role in maintaining intestinal homeostasis.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jakub Wlodarczyk, Julia Krajewska, Lukasz Szeleszczuk, Patrycja Szalwinska, Agata Gurba, Szymon Lipiec, Przemyslaw Taciak, Remigiusz Szczepaniak, Izabela Mlynarczuk-Bialy, Jakub Fichna
Summary: Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are global health problems with increasing frequency and unclear pathogenesis. Current treatment involves drugs like corticosteroids and derivative compounds, but more specific and effective therapies are desired. In this study, novel gold complexes were tested and found to have anti-inflammatory potential both in vitro and in vivo, particularly TGS 703, which was able to alleviate inflammation in a mouse model of colitis and showed a link to antioxidant systems. These findings suggest that gold(III) complexes may have therapeutic applications in the treatment of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jacek Burzynski, Jakub Fichna, Aleksandra Tarasiuk
Summary: Acute pancreatitis (AP) and chronic pancreatitis (CP) are severe diseases that pose a great threat to human health in high-income countries. Oxidative stress plays a significant role in the development of AP and CP, and there is growing interest in the use of antioxidant therapy to manage these conditions. Vitamin A, a well-known antioxidant, has been understudied in relation to its impact on oxidative stress in AP and CP. This review aims to evaluate the molecular targets of vitamin A and its potential role in attenuating oxidative stress in AP and CP. The findings suggest that vitamin A may influence several molecular pathways involved in antioxidative defense and cytoprotection, indicating its potential to alter the disease course of AP and CP.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Toxicology
Szymon Lipiec, Agata Gurba, Izabela M. Agnieszczak, Andrzej Antoni Szczepankiewicz, Przemyslaw Szymanski, Przemyslaw Taciak, Remigiusz Szczepaniak, Lukasz Szeleszczuk, Hanna Nieznanska, Jakub Wlodarczyk, Jakub Fichna, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Metal-based agents in cancer therapy, like cisplatin and its derivates, have established clinical applications but also can induce serious side effects. Thus, metallotherapeutic alternatives for platinum derivatives are developed and intensively studied. Platinum is replaced by several transition metals including gold. Especially gold (III) complexes can have the same square-planar structure and are isoelectric with platinum (II).
TOXICOLOGY IN VITRO
(2023)
Article
Plant Sciences
Jia-Le Li, Wen-Hao Su, He-Yi Zhang, Yankun Peng
Summary: Tomato is a globally grown vegetable crop with high economic and nutritional values. Weed management in the early stages of tomato plant growth is critical due to the threat posed by weeds. Smart weeders are being developed to address the increasing labor cost and negative impact caused by the overuse of herbicides. A new approach using a sensing system consisting of camera and color mark sensors is proposed in this study to accurately locate tomato and pakchoi plants in real time for weed control. The experimental results demonstrate the effectiveness and reliability of the proposed sensor-based system in automatically localizing vegetable plants.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Yongsheng Lin, Ziwen Qiu, Xiaojie Lin, Yingxiang Wu, Xianqian Niu, Guanwen Yin, Dandan Shao, Xuwen Xiang, Yongyu Li, Chao Yang
Summary: The study found that the leaves of Melaleuca bracteata contain 90.46% methyleugenol, which is an attractant for insect pollination and has antibacterial and antioxidant properties. By using gene expression and gene silencing technologies, it was confirmed that the MbEGS1 and MbEGS2 genes play important roles in the biosynthesis of methyleugenol.
Article
Chemistry, Analytical
Bo Liang, Xiang -Yu Xiao, Zong-Yin Song, Yong-Yu Li, Xin Cai, Rui-Ze Xia, Shi-Hua Chen, Meng Yang, Pei-Hua Li, Chu-Hong Lin, Xing-Jiu Huang
Summary: The mutual interference in the sensing detection of heavy metal ions is serious and complex. A promising approach of partial peak area analysis was proposed to study the mutual interference, and its applicability was verified on Cu2+/As(III) interference. This work provides a meaningful guidance for accurate detection of heavy metal ions in water environment.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Yong -Yu Li, Zong-Yin Song, Zhi-Wei Gao, Xiang-Yu Xiao, Yong-Huan Zhao, Pei-Hua Li, Xing-Jiu Huang, Wen-Qing Liu
Summary: In the field of electrocatalytic reduction, single atom catalysts (SACs) have been extensively researched. However, the metal active sites are easily weakened or poisoned during complex multi-step proton-electron reactions. Therefore, it remains a great challenge to improve the adsorption-desorption capacity and enhance rapid surface reactions for superior electrocatalytic performance. In this study, the electron synergism of neighbouring Fe and Co diatoms on graphene (FeCoN6-Gra) was found to promote the electrocatalytic reduction of arsenious acid (As(III)), surpassing single-atomic catalysts containing only Fe or Co. The electron allocation mechanism associated with Co injection was observed to trigger two-site adsorption and efficiently regulate electron transport between surface sites and As(III). Furthermore, the dynamic migration of As(III) driven by Co during the reduction process was emphasized, playing a crucial role in breaking the As-O bond and achieving efficient catalysis of the diatomic model.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Review
Food Science & Technology
Shaojin Ma, Yongyu Li, Yankun Peng, Wei Wang
Summary: Assessing food safety and quality is crucial, especially in the face of climate change challenges. Fluorescence radiation, with its high sensitivity and selectivity, has become a popular non-destructive technique in the food industry. To overcome the challenge of on-site detection of excitation-emission matrices (EEMs), laser-induced fluorescence (LIF) and light emitting diode-induced fluorescence (LED-IF) have been implemented. This review provides an overview of commercially available LIF/LED-IF devices for non-destructive food measurement and discusses recent studies on their development for commercial applications.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Cell Biology
Xiangyong Wei, Xinmiao Tan, Qi Chen, Yan Jiang, Guozhen Wu, Xue Ma, Jialong Fu, Yongyu Li, Kai Gang, Qifen Yang, Rui Ni, Jianbo He, Lingfei Luo
Summary: A major cause of intestinal failure is intestinal epithelium necrosis and loss of enterocytes, particularly in the jejunum. The mechanisms behind jejunal epithelial regeneration after extensive loss of enterocytes are unknown. In this study, zebrafish were used to induce extensive damage to jejunal enterocytes, mimicking the necrosis observed in intestinal failure. It was found that ileal enterocytes migrate and transdifferentiate into jejunal enterocytes to fulfill the regeneration process. The IL1b-NFkB axis and its agonist play a role in activating dedifferentiation and promoting regeneration. This research provides insights into the intersegmental migration mechanism of intestinal regeneration and potential therapeutic targets for intestinal failure caused by jejunal epithelium necrosis.
Article
Clinical Neurology
Shihan Lin, Yongyu Li, Chunyan Lei, Xinlian Zhou, Xiaoyan Zhu, Xinglong Yang, Chun Chen
Summary: This study aimed to compare the clinical features, treatment, and clinical outcome of patients with tandem occlusion and isolated intracranial occlusion through endovascular treatment (EVT). The study found that patients with tandem occlusion had higher rates of large artery atherosclerosis, symptomatic intracerebral hemorrhage, bilateral infarction, and longer time for endovascular procedure compared to isolated intracranial occlusion. However, there was no significant difference in 90-day mRS score between the two groups. Multivariate logistic regression analysis identified several independent predictors of poor functional outcome.
NEUROSURGICAL REVIEW
(2023)