Article
Medicine, Research & Experimental
Bettina Sobottka, Marta Nowak, Anja Laura Frei, Martina Haberecker, Samuel Merki, Mitchell P. Levesque, Reinhard Dummer, Holger Moch, Viktor Hendrik Koelzer
Summary: CD8+ tumor-infiltrating T cells play a crucial role in predicting responses to immune checkpoint inhibitors in immune-oncology. A computational diagnostic algorithm was established to quantitatively measure the spatial densities of these cells in tumor compartments, leading to the successful classification into immune diagnostic categories. This approach allows for efficient immune phenotyping of metastatic lesions, even in the absence of material from the invasive margin, providing valuable insights for immunotherapy strategies in metastatic melanoma.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Meredith S. Pelster, Stephen K. Gruschkus, Roland Bassett, Dan S. Gombos, Michael Shephard, Liberty Posada, Maura S. Glover, Rinata Simien, Adi Diab, Patrick Hwu, Brett W. Carter, Sapna P. Patel
Summary: The combination regimen of nivolumab plus ipilimumab shows activity in metastatic uveal melanoma, yielding deep and sustained confirmed responses.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Dermatology
Hannah-Lou Schilling, James A. Hutchinson, Sebastian Haferkamp
Summary: The introduction of clinical antibodies against PD-1 and CTLA-4 has greatly impacted cancer treatment, but immune-related adverse events remain a challenge. A recent study revealed that a subset of melanoma patients treated with PD-1 and CTLA-4 blockade is prone to develop hepatitis, and this risk is associated with the expansion of effector memory CD4+ T cells in blood before treatment. This finding highlights the potential of using T-EM cell expansion as a biomarker for identifying patients who may need prophylactic treatment against CMV.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Oncology
Julia Lai-Kwon, Sarah Jacques, Matteo Carlino, Naima Benannoune, Caroline Robert, Clara Allayous, Barouyr Baroudjian, Celeste Lebbe, Lisa Zimmer, Zeynep Eroglu, Turkan Ozturk Topcu, Florentia Dimitriou, Andrew Haydon, Serigne N. Lo, Alexander M. Menzies, Georgina Long
Summary: This study investigates the efficacy of a combination therapy strategy involving low-dose ipilimumab (IPI) and an anti-PD1 antibody in advanced melanoma. The results show that the majority of patients who progress following low-dose IPI and subsequently receive IPI 3 mg/kg (IPI3) have a positive response to this treatment. This suggests that the dosage of IPI is critical for certain patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Andrew Patterson, Noam Auslander
Summary: This study identifies key mutated processes associated with immune checkpoint inhibitor response in melanoma patients, demonstrating improved predictive capability compared to tumor mutational burden.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Adi Diab, Scott S. Tykodi, Gregory A. Daniels, Michele Maio, Brendan D. Curti, Karl D. Lewis, Sekwon Jang, Ewa Kalinka, Igor Puzanov, Alexander Spira, Daniel C. Cho, Shanhong Guan, Erika Puente, Tuan Nguyen, Ute Hoch, Sue L. Currie, Wei Lin, Mary A. Tagliaferri, Jonathan Zalevsky, Mario Sznol, Michael E. Hurwitz
Summary: This study found that the combination of BEMPEG and NIVO showed promising antitumor activity in first-line metastatic melanoma, including extended median progression-free survival. Early on-treatment blood biomarkers were associated with treatment response.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Oncology
Lucia Vazquez-Montero, Maria del Carmen Alamo de la Gala, Luis de la Cruz-Merino
Summary: The development of immune checkpoint inhibitors has transformed the treatment of advanced melanoma. Nivolumab plus ipilimumab, along with other immunotherapy options, has shown efficacy for advanced melanoma. However, the combination therapy is associated with severe immune-related toxicity. This article reviews the efficacy and safety of nivolumab plus ipilimumab in advanced melanoma and explores the potential benefits for different patient subgroups.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leanne Perez, Wolfram Samlowski, Ruby Lopez-Flores
Summary: Checkpoint inhibitor therapy has significantly improved outcomes for metastatic melanoma. This study demonstrates that most patients who achieve complete remission can safely discontinue treatment without relapse. This approach may reduce drug toxicities, financial burden, and improve patients' quality of life.
Article
Oncology
Amod A. Sarnaik, Omid Hamid, Nikhil Khushalani, Karl D. Lewis, Theresa Medina, Harriet M. Kluger, Sajeve S. Thomas, Evidio Domingo-Musibay, Anna C. Pavlick, Eric D. Whitman, Salvador Martin-Algarra, Pippa Corrie, Brendan D. Curti, Judit Olah, Jose Lutzky, Jeffrey S. Weber, James M. G. Larkin, Wen Shi, Toshimi Takamura, Madan Jagasia, Harry Qin, Xiao Wu, Cecile Chartier, Friedrich Graf Finckenstein, Maria Fardis, John M. Kirkwood, Jason A. Chesney
Summary: This study showed that Lifileucel is effective in treating advanced melanoma, especially in patients who are refractory to PD-1 or PD-L1 therapy. The product provides durable responses and addresses a major unmet need in patients with limited treatment options after approved therapy.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Patrick Demkowicz, Renelle Pointdujour-Lim, Sofia Miguez, Yesung Lee, Bailey S. C. L. Jones, Christopher A. Barker, Marcus Bosenberg, David H. Abramson, Alexander N. Shoushtari, Harriet Kluger, Jasmine H. Francis, Mario Sznol, Mathieu F. Bakhoum
Summary: This study retrospectively analyzed clinical data of patients with metastatic uveal melanoma and found that female sex, treatment with immune checkpoint inhibitors, and the absence of liver metastasis were associated with better survival outcomes. These findings highlight the potential of immunotherapy in treating metastatic uveal melanoma.
Article
Medicine, General & Internal
Alexander S. Watson, Siddhartha Goutam, Igor Stukalin, Benjamin W. Ewanchuk, Michael Sander, Daniel E. Meyers, Aliyah Pabani, Winson Y. Cheung, Daniel Y. C. Heng, Tina Cheng, Jose G. Monzon, Vishal Navani
Summary: This study examines the association between immune-related adverse events (irAEs) and survival in patients with metastatic melanoma, particularly those receiving combination immune checkpoint blockade (ICB).
Article
Immunology
W. J. Mullally, F. J. Cooke, I. M. Crosbie, S. Kumar, V. E. Abernethy, E. J. Jordan, M. O'Connor, A. M. Horgan, R. Landers, J. Naidoo, P. M. Calvert
Summary: This is a case of a man in his early 50s who presented with small bowel obstruction and was found to have metastatic melanoma without a primary lesion. After receiving immunotherapy, the patient developed a series of symptoms and eventually died from immune-related thrombotic thrombocytopenic purpura (TTP).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Toulsie Ramtohul, Axel Cohen, Manuel Rodrigues, Sophie Piperno-Neumann, Luc Cabel, Nathalie Cassoux, Livia Lumbroso-Le Rouic, Denis Malaise, Sophie Gardrat, Gaelle Pierron, Pascale Mariani, Vincent Servois
Summary: This study found that TGR(3m) is an important indicator for predicting the survival of patients with liver metastatic uveal melanoma, while the RECIST-based response assessment is no longer significant in the overall survival analysis. Immunotherapy regimens were associated with higher overall survival in the low TGR(3m) subgroup. TGR(0), disease-free interval, and the sum of target lesions at baseline were predictive factors for low TGR(3m), which can help in making treatment decisions for first-line immunotherapy.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Lili Mao, Meiyu Fang, Yu Chen, Xiaoting Wei, Jun Cao, Jing Lin, Peng Zhang, Ling Chen, Xiao Cao, Yujun Chen, Jun Guo, Lu Si
Summary: Atezolizumab in combination with bevacizumab shows promising efficacy and manageable safety in patients with advanced mucosal melanoma.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Richard D. Carvajal, Marcus O. Butler, Alexander N. Shoushtari, Jessica C. Hassel, Alexandra Ikeguchi, Leonel Hernandez-Aya, Paul Nathan, Omid Hamid, Josep M. Piulats, Matthew Rioth, Douglas B. Johnson, Jason J. Luke, Enrique Espinosa, Serge Leyvraz, Laura Collins, Howard M. Goodall, Koustubh Ranade, Chris Holland, Shaad E. Abdullah, Joseph J. Sacco, Takami Sato
Summary: In a study of previously treated metastatic uveal melanoma patients, treatment with Tebentafusp showed promising clinical activity and acceptable safety profile. Early reduction in circulating tumor DNA was strongly associated with overall survival.
Article
Gastroenterology & Hepatology
Mauricio Garcia-Saenz-de-Sicilia, Chitharanjan Duvoor, Jose Altamirano, Roberta Chavez-Araujo, Veronica Prado, Ana de Lourdes Candolo-Martinelli, Patricia Holanda-Almeida, Bernardo Becerra-Martins-de-Oliveira, Simony Fernandez-de-Almeida, Ramon Bataller, Juan Caballeria, Andres Duarte-Rojo
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2017)
Editorial Material
Gastroenterology & Hepatology
Mauricio Garcia-Saenz-De-Sicilia, Andres Duarte-Rojo
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
Naga S. Addepally, Nayana George, Roberto Martinez-Macias, Mauricio Garcia-Saenz-de-Sicilia, W. Ray Kim, Andres Duarte-Rojo
DIGESTIVE DISEASES AND SCIENCES
(2018)
Letter
Gastroenterology & Hepatology
Passisd Laoveeravat, Abhilash Perisetti, Mauricio Garcia-Saenz-de-Sicilia, Shashank Garg, Benjamin Tharian
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Jasmohan S. Bajaj, Andres Duarte-Rojo, Jesse J. Xie, Chathur Acharya, James B. Wade, Carlos Robles, Leroy R. Thacker, Christopher Flud, Andrew Fagan, Mauricio Garcia-Saenz-de-Sicilia, Melanie B. White, Megan Kelly, Vy Nguyen, Edith A. Gavis, Hugo E. Vargas
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Sabha Bhatti, Blanca Lizaola-Mayo, Mohammad Al-Shoha, Mauricio Garcia-Saenz-de-Sicilia, Fuad Habash, Karam Ayoub, Michael Karr, Zubair Ahmed, Daniel Borja-Cacho, Andres Duarte-Rojo
Summary: This study found that coronary artery calcium score (CAC) is a promising tool to guide coronary artery disease (CAD) risk stratification and the need for left heart catheterization (LHC) during liver transplantation (LT) evaluation. Patients with CAC < 100 can safely undergo LT without the need for LHC or cardiac stress testing, whereas a CAC < 346 accurately rules out significant CAD stenosis (>= 70%) on LHC, outperforming other CAD risk-stratification strategies.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Review
Oncology
Brianna Ruch, Josiah Wagler, Kayla Kumm, Chi Zhang, Nitin N. Katariya, Mauricio Garcia-Saenz-de-Sicilia, Emmanouil Giorgakis, Amit K. Mathur
Summary: Hepatocellular carcinoma (HCC) is a common indication for liver transplantation, and the use of alpha fetoprotein (AFP) as an independent predictor for HCC patients undergoing transplantation has gained importance. Recent studies have shown that the dynamic response of AFP to downstaging therapy provides more accurate prognostic information compared to static AFP alone. Despite changes in allocation policy, the US allocation system continues to treat HCC patients uniformly, without considering differences in tumor biology. This review emphasizes the need for a reevaluation of the HCC organ allocation model in the US, incorporating AFP dynamics to better stratify waitlist dropout risk.
Review
Gastroenterology & Hepatology
Mohit Girotra, Kaartik Soota, Amaninder S. Dhaliwal, Rtika R. Abraham, Mauricio Garcia-Saenz-de-Sicilia, Benjamin Tharian
WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Nayana George, Abhilash Perisetti, Mohammad Al-Shoha, Sameer Siddique, Saikiran Raghavapuram, Debdeep Banerjee, Mauricio Garcia-Saenz-de-Sicilia, Benjamin Tharian
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
Nayana George, Abhilash Perisetti, Debdeep Banerjee, Saikiran Raghavapuram, Mauricio Garcia-Saenz-de-Sicilia, Benjamin Tharian
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
N. S. Addepally, Mauricio Garcia-Saenz-de-Sicilia, Peter A. Goulden, Andres Duarte-Rojo
Meeting Abstract
Gastroenterology & Hepatology
Nayana George, Saad Khan, Mohammad Al-Shoha, Mohit Girotra, Mauricio Garcia-Saenz-de-Sicilia, Benjamin Tharian
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2016)
Meeting Abstract
Gastroenterology & Hepatology
Mohammad Al-Shoha, Nayana George, Saikiran Raghavapuram, Mohit Girotra, Mauricio Garcia-Saenz-de-Sicilia, Benjamin Tharian
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2016)
Meeting Abstract
Gastroenterology & Hepatology
Chitharanjan Duvoor, Jagpal Singh Klair, Abhishek Agarwal, Mohit Girotra, Dileep S. Atluri, Mauricio Garcia-Saenz-de-Sicilia, Farshad Aduli
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2015)