Article
Oncology
Astha Thakkar, Jesus D. Gonzalez-Lugo, Niyati Goradia, Radhika Gali, Lauren C. Shapiro, Kith Pradhan, Shafia Rahman, So Yeon Kim, Brian Ko, R. Alejandro Sica, Noah Kornblum, Lizamarie Bachier-Rodriguez, Margaret McCort, Sanjay Goel, Roman Perez-Soler, Stuart Packer, Joseph Sparano, Benjamin Gartrell, Della Makower, Yitz D. Goldstein, Lucia Wolgast, Amit Verma, Balazs Halmos
Summary: Most cancer patients show high seroconversion rates after receiving COVID-19 vaccines, but those with hematologic malignancies, especially after highly immunosuppressive therapies, exhibit lower conversion rates. Patients on immune checkpoint inhibitor therapy or hormonal therapy display high conversion rates.
Article
Multidisciplinary Sciences
Kenji Nakamichi, Jolie Z. Shen, Cecilia S. Lee, Aaron Lee, Emma A. Roberts, Paul D. Simonson, Pavitra Roychoudhury, Jessica Andriesen, April K. Randhawa, Patrick C. Mathias, Alex L. Greninger, Keith R. Jerome, Russell N. Van Gelder
Summary: The COVID-19 epidemic of 2019-20 is caused by the novel coronavirus SARS-CoV-2, which has infected millions worldwide. This study aimed to determine if SARS-CoV-2 sequence variants are linked to different outcomes among COVID-19 patients in a single medical system. The virus has shown rapid mutation with two major clades of sequence variants identified.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Nobuaki Matsunaga, Kayoko Hayakawa, Mari Terada, Hiroshi Ohtsu, Yusuke Asai, Shinya Tsuzuki, Setsuko Suzuki, Ako Toyoda, Kumiko Suzuki, Mio Endo, Naoki Fujii, Michiyo Suzuki, Sho Saito, Yukari Uemura, Taro Shibata, Masashi Kondo, Kazuo Izumi, Junko Terada-Hirashima, Ayako Mikami, Wataru Sugiura, Norio Ohmagari
Summary: This study in Japan examined hospitalized patients with COVID-19, finding that they are typically middle-aged males with close contact to confirmed or suspected cases. The most common comorbidities were hypertension and diabetes. Most patients admitted were nonsevere cases, with a majority not requiring oxygen support during hospitalization.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Zhen Xie, Hao Hui, Zhihan Zhao, Wenjin Yu, Rui Wu, Yanzhao Zhu, Yuan Song, Bingqing Cao, Wenzhen Shi, Di Zhao, Yunsong Zhao, Junchao Lv, Qian Yao, Yan Duan, Jingwen Li, Haijun Zhang, Linfu Zhou, Xiaotian Wang, Ye Tian, Gang Zhao
Summary: This review summarizes the effects and mechanisms of SARS-CoV-2 on the nervous system, including the pathways of invasion, direct and indirect effects, and associated neuropsychiatric diseases, to deepen our knowledge and understanding of the relationship between COVID-19 and the nervous system.
BRAIN RESEARCH BULLETIN
(2022)
Review
Immunology
Robert Weissert
Summary: The effects of SARS-CoV-2 infection on the nervous system are not fully understood, but it may have long-term consequences and induce autoimmune diseases. Understanding the immune responses related to the nervous system in COVID-19 can support the development of therapeutic approaches, and vaccination is the best strategy to prevent SARS-CoV-2 infection of the nervous system.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jozica Sikic, Zrinka Planinic, Vid Matisic, Tea Friscic, Vilim Molnar, Dorijan Jagacic, Lovro Vujicic, Neven Tudoric, Lana Postruzin Grsic, Divo Ljubicic, Dragan Primorac
Summary: SARS-CoV-2 has been circulating worldwide for a year and a half, leading to a vast amount of scientific literature. The cardiovascular system plays a crucial role in infection, and thorough diagnostics and patient monitoring are beneficial for patient recovery.
Review
Clinical Neurology
Sasan Andalib, Jose Biller, Mario Di Napoli, Narges Moghimi, Louise D. McCullough, Clio A. Rubinos, Christa O'Hana Nobleza, M. Reza Azarpazhooh, Luciana Catanese, Isabel Elicer, Mostafa Jafari, Fabrizio Liberati, Claudia Camejo, Michel Torbey, Afshin A. Divani
Summary: This review discusses the peripheral nervous system manifestations associated with COVID-19, including nerve pain, muscle injury, Guillain-Barre syndrome, and other disorders. COVID-19 not only affects the central nervous system but also involves the PNS, potentially due to immune system dysregulation.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Infectious Diseases
Emmanuel Lafont, Helene Pere, David Lebeaux, Geoffrey Cheminet, Eric Thervet, Romain Guillemain, Adrien Flahault
Summary: This study suggests that targeted treatment for COVID-19, including antiviral drugs or monoclonal antibodies, is safe and effective in immunocompromised patients, especially those at high risk.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Erin M. Bange, Nicholas A. Han, Paul Wileyto, Justin Y. Kim, Sigrid Gouma, James Robinson, Allison R. Greenplate, Madeline A. Hwee, Florence Porterfield, Olutosin Owoyemi, Karan Naik, Cathy Zheng, Michael Galantino, Ariel R. Weisman, Caroline A. G. Ittner, Emily M. Kugler, Amy E. Baxter, Olutwatosin Oniyide, Roseline S. Agyekum, Thomas G. Dunn, Tiffanie K. Jones, Heather M. Giannini, Madison E. Weirick, Christopher M. McAllister, N. Esther Babady, Anita Kumar, Adam J. Widman, Susan DeWolf, Sawsan R. Boutemine, Charlotte Roberts, Krista R. Budzik, Susan Tollett, Carla Wright, Tara Perloff, Lova Sun, Divij Mathew, Josephine R. Giles, Derek A. Oldridge, Jennifer E. Wu, Cecile Alanio, Sharon Adamski, Alfred L. Garfall, Laura A. Vella, Samuel J. Kerr, Justine Cohen, Randall A. Oyer, Ryan Massa, Ivan P. Maillard, Kara N. Maxwell, John P. Reilly, Peter G. Maslak, Robert H. Vonderheide, Jedd D. Wolchok, Scott E. Hensley, E. John Wherry, Nuala J. Meyer, Angela M. DeMichele, Santosha A. Vardhana, Ronac Mamtani, Alexander C. Huang
Summary: In patients with cancer and COVID-19, those with hematologic cancer show impaired immune responses compared to solid cancer patients. CD8 T cells play a crucial role in survival, even in the presence of limited humoral responses. The presence of SARS-CoV-2-specific T cell responses in hematologic cancer patients suggests a potential therapeutic target.
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Infectious Diseases
Karl Hagman, Magnus Hedenstierna, Jacob Widaeus, Emelie Arvidsson, Berit Hammas, Lena Grillner, Jan Jakobsson, Patrik Gille-Johnson, Johan Ursing
Summary: Remdesivir treatment did not significantly change the duration of SARS-CoV-2 viraemia, decline of serum viral load, 60 day mortality or in-hospital adverse outcomes in patients with ≤10 days of symptoms at admission. However, remdesivir appeared to reduce the duration of viraemia in a subgroup of patients with ≤7 days of symptoms at admission.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Article
Medicine, General & Internal
Peter Chen, Ajay Nirula, Barry Heller, Robert L. Gottlieb, Joseph Boscia, Jason Morris, Gregory Huhn, Jose Cardona, Bharat Mocherla, Valentina Stosor, Imad Shawa, Andrew C. Adams, Jacob Van Naarden, Kenneth L. Custer, Lei Shen, Michael Durante, Gerard Oakley, Andrew E. Schade, Janelle Sabo, Dipak R. Patel, Paul Klekotka, Daniel M. Skovronsky
Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Clinical Neurology
Mohammad Ali Sahraian, Masoud Ghiasian, Abdorreza Naser Moghadasi, Maryam Shafaei, Mehran Ghaffari
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2019)
Article
Immunology
Somayeh Mahmoodi Baram, Saeed Karima, Somayeh Shateri, Abbas Tafakhori, Akbar Fotouhi, Behnam Safarpour Lima, Shima Rajaei, Meisam Mahdavi, Hessam Sepasi Tehrani, Vajiheh Aghamollaii, Seyed Hossein Aghamiri, Behnam Mansouri, Sina Gharahje, Samaneh Kabiri, Maryamosadat Hosseinizadeh, Shima Zare Shahamati, Amir Taher Alborzi
INFLAMMOPHARMACOLOGY
(2019)
Article
Clinical Neurology
Masoud Ghiasian, Mohaddeseh Nouri, Abdorreza Naser Moghadasi, Mehran Ghaffari
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)
Article
Clinical Neurology
M. Mehrpour, A. Shuaib, M. Farahani, H. R. Hatamabadi, Z. Fatehi, M. Ghaffari, N. B. Moghadam, S. H. Aghamiri, B. Mansouri, F. Assarzadegan, B. S. Lima, O. Hesami
Summary: The COVID-19 pandemic resulted in a significant decrease in acute stroke admissions, but did not significantly impact the treatment plans and care of patients. Stroke cases with COVID-19 had higher age, more large vessel ischemic strokes, and more severe strokes compared to those without COVID-19.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Oncology
Ahmad Ameri, Pooya Ameri, Nazanin Rahnama, Majid Mokhtari, Meghdad Sedaghat, Fahimeh Hadavand, Rama Bozorgmehr, Mehrdad Haghighi, Farzad Taghizadeh-Hesary
Summary: Low-dose whole-lung irradiation (LD-WLI) with a single fraction of 0.5 Gy or 1 Gy showed feasibility in treating COVID-19 pneumonia. The study demonstrated a response rate of 63.6% and clinical recovery rate of 55.5% among patients who received the treatment. Additional randomized trials without radiation are needed to assess the efficacy of LD-WLI for COVID-19.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Clinical Neurology
Farhad Assarzadegan, Foroogh Mohammadi, Behnam Safarpour Lima, Behnam Mansouri, Seyed Hossein Aghamiri, Navideh Sahebi Vaighan
Summary: This study aimed to assess the diagnostic accuracy of neurovascular ultrasound in detecting cerebral artery stenosis compared to DSA, finding it to be a valuable, noninvasive, and repeatable method with high diagnostic accuracy.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Behnam Safarpour Lima, Alireza Mohamadzadeh, Morvarid Dadras, Ali Mahdavi, Behnam Mansouri, Mohsen Farazdaghi
Summary: The study found that epicardial adipose tissue thickness and carotid intima-media thickness were thicker in patients with epilepsy compared to healthy controls. Patients had abnormal lipid profiles, with longer duration of follow-up associated with increased EATT. It is important to consider using anti-seizure medications with lower chances of affecting cardiovascular risk factors.
EPILEPSY & BEHAVIOR
(2021)
Article
Primary Health Care
Farhad Assarzadegan, Seyedeh Parya Hosseinpanahi, Omid Hesami, Behnam Mansouri, Behnam Safarpour Lima
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2019)
Article
Emergency Medicine
Masoomeh Raoufi, Seyed Amir Ahmad Safavi Naini, Zahra Azizan, Fatemeh Jafar Zade, Fatemeh Shojaeian, Masoud Ghanbari Boroujeni, Farzaneh Robatjazi, Mehrdad Haghighi, Ali Arhami Dolatabadi, Hossein Soleimantabar, Simindokht Shoaee, Hamidreza Hatamabadi
ARCHIVES OF ACADEMIC EMERGENCY MEDICINE
(2020)