Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Sudhiranjan Gupta, Rakeshwar S. Guleria
Summary: Post-traumatic stress disorder (PTSD) is a severe psychiatric condition associated with neurological circuit impairment, dysregulation of the sympathetic nervous system and hypothalamic-pituitary adrenal axis, and inflammatory response. NF-kappa B signaling pathway plays a crucial role in inflammation, memory restoration, and stress-related behaviors, potentially serving as a therapeutic target for PTSD.
Article
Dermatology
Ping Xia, Lorenzo Pasquali, Chenying Gao, Ankit Srivastava, Nupur Khera, Jan Cedric Freisenhausen, Longlong Luo, Einar Rosen, Ankevan Lierop, Bernhard Homey, Andor Pivarcsi, Eniko Sonkoly
Summary: The study reveals that miR-378a plays an amplifying role in IL-17A-induced NF-kappa B signaling in psoriasis, enhancing skin inflammation through nuclear translocation and production of inflammatory mediators.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Xiaohe Li, Qing Liang, Shaoyan Gao, Qiuyan Jiang, Fangxia Zhang, Ruiqin Zhang, Hao Ruan, Shuangling Li, Jiaoyan Luan, Ruxia Deng, Honggang Zhou, Hui Huang, Cheng Yang
Summary: Lenalidomide has potential anti-fibrotic effects by suppressing inflammation-related signaling pathways, thereby reducing pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xuejun He, Yimin Huang, Yuan Liu, Xincheng Zhang, Quanji Wang, Yanchao Liu, Xiaopeng Ma, Xiaobing Long, Yang Ruan, Hongxia Lei, Chao Gan, Xiaochuan Wang, Xin Zou, Bo Xiong, Kai Shu, Ting Lei, Huaqiu Zhang
Summary: This study revealed that an exosomal long non-coding RNA from astrocytes attenuates microglial activation after traumatic brain injury by up-regulating Smad7, providing a potential therapeutic target.
Article
Pharmacology & Pharmacy
Mingxin Dong, Xiaohao Zhang, Haotian Yu, Yan Wang, Ying Chang, Chengbiao Sun, Jianxu Zhang, Na Zhao, Kaikai Yu, Guangchao Sun, Guiru Zhao, Na Xu, Wensen Liu
Summary: This study identified circEpc1 as a promoter in RT-induced inflammation, functioning as a miR-5114 sponge to activate NF-kappa B and MAPK signaling pathways. The results provide new insights into the functions of circRNA in innate immunity and suggest potential immunotherapy targets for controlling RT-induced inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Review
Clinical Neurology
Shiqi Mao, Jinhan Wu, Jingkai Yan, Weijun Zhang, Feng Zhu
Summary: miR-146a is an NF-κB-dependent miRNA that acts as an anti-inflammatory miRNA via the Toll-like receptor (TLR) pathway. It targets multiple genes and regulates processes other than inflammation, such as intracellular Ca changes, apoptosis, oxidative stress, and neurodegeneration. Abnormal expression patterns of miR-146a in different types and stages of epilepsy indicate its potential as a biomarker for diagnosis, prognosis, and treatment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Cell Biology
Jia-Ni Yuan, Yu Hong, Zhuo-Lin Ma, Rui-Ping Pang, Qing-Qing Lei, Xiao-Fei Lv, Jia-Guo Zhou, Hui Huang, Ting-Ting Zhang
Summary: miR-302a acts as an effective suppressor of vascular inflammation by inhibiting the NF-kappa B pathway in endothelial cells, indicating its potential as a novel target for relieving vascular inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhousheng Yang, Tianyu Li, Chunyan Wang, Mingyu Meng, Shenglan Tan, Lei Chen
Summary: Dihydromyricetin (DMY), a natural flavonoid compound extracted from Ampelopsis grossedentata, has been identified as a potential therapeutic chemical for treating atherosclerosis. This study investigates the mechanism by which DMY suppresses M1 macrophage polarization in atherosclerosis. The results showed that DMY treatment significantly reduced M1 macrophage markers and p65-positive macrophage numbers in the vessel wall of Apoe-deficient (Apoe(-/-)) mice.
MEDIATORS OF INFLAMMATION
(2023)
Article
Cell Biology
Haiwei Ma, Chenglong Xie, Gaolu He, Zhengtai Chen, Hongwei Lu, Hongqiang Wu, Hancheng Cai, Zihan Dai, Baolong Li, Cong Xu, Enxing Xue
Summary: This study demonstrates the potential therapeutic effects of traditional Chinese medicine Sparstolonin B (Ssn B) in inhibiting inflammatory responses and extracellular matrix degradation caused by free fatty acids, as well as in treating obesity-related osteoarthritis in animal models. The mechanisms underlying these effects involve the blocking of TLR4/MD-2 complex formation and subsequent inactivation of MyD88-dependent NF-kappa B cascade by Ssn B.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Xiaoying Ma, Jinfang Xu, Qingsheng Lu, Xiang Feng, Jiajun Liu, Chaoyi Cui, Chao Song
Summary: This study investigates the role of circRNA in abdominal aortic aneurysms (AAA) and macrophages. The researchers found that hsa_circ_0087352, a circRNA, is up-regulated in human AAA specimens and is related to the inflammatory response in THP-1 macrophages. Further experiments revealed that hsa_circ_0087352 promotes IL-6 transcription and the secretion of inflammatory cytokines by sponging endogenous hsa-miR-149-5p in macrophages, potentially through the ERK/NF-kappa B pathway. Additionally, hsa_circ_0087352 overexpression induces apoptosis in human vascular smooth muscle cells. These findings suggest the potential of hsa_circ_0087352 as a biomarker and therapeutic target for AAA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hougang Xia, Dandan Wang, Xiaohui Guo, Kaidi Wu, Fuwei Huang, Yanjiang Feng
Summary: The study revealed that treatment with CTP could improve functional recovery in SCI mice, suppress apoptosis, alleviate inflammatory response, and oxidative stress. Moreover, CTP was found to regulate the HMGB1/TLR4/NF-kappa B pathway through miR-142, thus providing protective effects against apoptosis, inflammation, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Ayodele Olaolu Oladejo, Yajuan Li, Bereket Habte Imam, Xiaoyu Ma, Wenxiang Shen, Xiaohu Wu, Wei Jiang, Jie Yang, Yanan Lv, Xuezhi Ding, Shengyi Wang, Zuoting Yan
Summary: The study investigates the regulatory role of miR-24-3p and TRAF6 in the innate immune response of endometritis. Overexpression of miR-24-3p can suppress the secretion of inflammatory cytokines and deactivation of the NF-kappa B/MAPK pathway, thereby attenuating endometrial inflammation and expression of pro-inflammatory mediators.
JOURNAL OF INFLAMMATION RESEARCH
(2022)