A Disorder-to-Order Transition Activates an ATP-Independent Membrane Protein Chaperone

Conditional Disorder in Small Heat-shock Proteins

(2020) T. Reid Alderson et al.   JOURNAL OF MOLECULAR BIOLOGY

Release of a disordered domain enhances HspB1 chaperone activity toward tau

(2020) Hannah E. R. Baughman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-Bound Clients: The Importance of Being Dynamic

(2019) Sebastian Hiller   TRENDS IN BIOCHEMICAL SCIENCES

Local unfolding of the HSP27 monomer regulates chaperone activity

(2019) T. Reid Alderson et al.   Nature Communications

Two distinct sites of client protein interaction with the chaperone cpSRP43

(2018) Camille Z. McAvoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic analysis of the multistep aggregation pathway of human transthyretin

(2018) Xun Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

Structural basis for the antifolding activity of a molecular chaperone

(2016) Chengdong Huang et al.   NATURE

Conformational dynamics of a membrane protein chaperone enables spatially regulated substrate capture and release

(2016) Fu-Cheng Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular mechanism of chaperone-client recognition

(2016) L. He et al.   Science Advances

Phosphomimics Destabilize Hsp27 Oligomeric Assemblies and Enhance Chaperone Activity

(2015) Blagojce Jovcevski et al.   CHEMISTRY & BIOLOGY

Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates

(2015) Feng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins

(2015) Johannes Thoma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction

(2015) Annemarie Horn et al.   Nature Communications

Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins

(2015) Johannes Thoma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of an ATP-independent Protein Disaggregase

(2013) Peera Jaru-Ampornpan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Molecule FRET Reveals the Native-State Dynamics of the IκBα Ankyrin Repeat Domain

(2013) Jorge A. Lamboy et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Refinement from Restrained-Ensemble Simulations Based on EPR/DEER Data: Application to T4 Lysozyme

(2013) Shahidul M. Islam et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Conformation and dynamics of the periplasmic membrane-protein–chaperone complexes OmpX–Skp and tOmpA–Skp

(2013) Björn M Burmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chaperone activation by unfolding

(2013) L. Foit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping Molecular Flexibility of Proteins with Site-Directed Spin Labeling: A Case Study of Myoglobin

(2012) Carlos J. López et al.   BIOCHEMISTRY

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

(2012) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Quantitative In Vivo Redox Sensors Uncover Oxidative Stress as an Early Event in Life

(2012) Daniela Knoefler et al.   MOLECULAR CELL

Chromodomains read the arginine code of post-translational targeting

(2012) Iris Holdermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative bacterial two-component small heat shock protein systems

(2012) A. Bepperling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional disorder in chaperone action

(2012) James C.A. Bardwell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Binding of chloroplast signal recognition particle to a thylakoid membrane protein substrate in aqueous solution and delineation of the cpSRP43–substrate interaction domain

(2011) Peter Cain et al.   BIOCHEMICAL JOURNAL

Interaction Studies between the Chloroplast Signal Recognition Particle Subunit cpSRP43 and the Full-length Translocase Alb3 Reveal a Membrane-embedded Binding Region in Alb3 Protein

(2011) Beatrix Dünschede et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones

(2011) A. Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dynamic cpSRP43-Albino3 Interaction Mediates Translocase Regulation of Chloroplast Signal Recognition Particle (cpSRP)-targeting Components

(2010) Nathaniel E. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit

(2010) Peera Jaru-Ampornpan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

The C Terminus of the Alb3 Membrane Insertase Recruits cpSRP43 to the Thylakoid Membrane

(2009) Sebastian Falk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding

(2009) T. L. Tapley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cavity-chaperone Skp protects its substrate from aggregation but allows independent folding of substrate domains

(2009) Troy A. Walton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Observing biological dynamics at atomic resolution using NMR

(2009) Anthony K. Mittermaier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Folding landscapes of ankyrin repeat proteins: experiments meet theory

(2008) Doug Barrick et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Assembly of Chloroplast Signal Recognition Particle Involves Structural Rearrangement in cpSRP43

(2008) Karuppanan Muthusamy Kathir et al.   JOURNAL OF MOLECULAR BIOLOGY

Transfer of Flexibility between Ankyrin Repeats in IκBα upon Formation of the NF-κB Complex

(2008) Shih-Che Sue et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for Specific Substrate Recognition by the Chloroplast Signal Recognition Particle Protein cpSRP43

(2008) K. F. Stengel et al.   SCIENCE