Article
Dermatology
Camilla Pasternack, Kaisa Hervonen, Eriika Mansikka, Timo Reunala, Pekka Collin, Katri Kaukinen, Teea Salmi
Summary: Dermatitis herpetiformis, a cutaneous manifestation of coeliac disease, can result in prolonged and ongoing skin symptoms even after long-term adherence to a gluten-free diet. Factors such as severity of rash at diagnosis, duration of dietary treatment, and adherence to a strict diet are associated with the presence and persistence of cutaneous symptoms in patients with dermatitis herpetiformis.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Dermatology
Camilla Pasternack, Kaisa Hervonen, Eriika Mansikka, Timo Reunala, Katri Kaukinen, Teea Salmi
Summary: This study found that long-term treated female patients with dermatitis herpetiformis have better adherence to a gluten-free diet, but they also experience more severe clinical symptoms compared with males.
ACTA DERMATO-VENEREOLOGICA
(2022)
Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Article
Nutrition & Dietetics
Vincenza Lombardo, Alice Scricciolo, Andrea Costantino, Luca Elli, Giorgia Legnani, Angel Cebolla, Luisa Doneda, Federica Mascaretti, Maurizio Vecchi, Leda Roncoroni
Summary: The aim of this study was to evaluate the clinical efficacy of urinary gluten immunogenic peptides (uGIP) in the follow-up of celiac disease (CD). The results showed that uGIP test can accurately assess the adherence to gluten-free diet and correlated significantly with duodenal biopsy results.
Review
Medicine, General & Internal
Jing-Zhan Zhang, Dilinuer Abudoureyimu, Man Wang, Shi-Rong Yu, Xiao-Jing Kang
Summary: Celiac disease (CD) and vitiligo are both autoimmune diseases with a global incidence rate of approximately 1% and are associated with similar diseases. Research suggests that a gluten-free diet may improve symptoms in patients with vitiligo.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Nutrition & Dietetics
Herbert Wieser, Veronica Segura, Angela Ruiz-Carnicer, Carolina Sousa, Isabel Comino
Summary: A gluten-free diet is currently the only effective treatment for celiac disease, but it is difficult for patients to maintain this diet for life. Commercial immunochemical assays are used to detect gluten, but the lack of official reference materials may lead to systematic deviations in the quantitation results.
Article
Food Science & Technology
Diana Vukman, Petra Vilicnik, Nada Vahcic, Dario Lasic, Tena Niseteo, Ines Panjkota Krbavcic, Ksenija Markovic, Martina Bituh
Summary: The study outlines the design, implementation, and validation of an HACCP protocol for preparing gluten-free meals in a children's hospital. Results from analyzing the gluten content in prepared meals showed that they did not exceed the standard limits, with patients on a gluten-free diet consuming less than 10 mg of gluten per day.
Review
Nutrition & Dietetics
Malgorzata Szczuko, Anhelli Syrenicz, Katarzyna Szymkowiak, Aleksandra Przybylska, Urszula Szczuko, Jakub Poblocki, Danuta Kulpa
Summary: The popularization of the gluten-free diet may harm the treatment of Hashimoto's disease, but the existing studies do not confirm any positive changes from this type of diet. The presence of other comorbid autoimmune diseases in this patient group is also increasing, which has important implications for test interpretation and the necessity of a gluten-free diet.
Article
Medicine, General & Internal
Noora Nilsson, Joonas Leivo, Pekka Collin, Inka Koskinen, Katri Kaukinen, Heini Huhtala, Johanna Palmio, Timo Reunala, Kaisa Hervonen, Teea Salmi, Camilla Pasternack
Summary: This cohort study investigated the risk for vascular diseases in dermatitis herpetiformis (DH) and coeliac disease patients. The results showed that compared to coeliac disease patients, DH patients had a decreased risk for cerebrovascular diseases, while coeliac disease patients had an increased risk for cerebrovascular and cardiovascular diseases. Coeliac disease, but not DH, was associated with an increased risk for venous thrombosis.
ANNALS OF MEDICINE
(2023)
Review
Nutrition & Dietetics
Aner Cardo, Itziar Churruca, Arrate Lasa, Virginia Navarro, Maialen Vazquez-Polo, Gesala Perez-Junkera, Idoia Larretxi
Summary: Celiac disease (CD) is an autoimmune disorder of the small intestine that requires a gluten-free diet (GFD) for effective treatment. Nutritional imbalances may occur in adults with CD following GFD, but deficiencies can improve as intestinal mucosa recovers over time. Monitoring nutrient intake, especially plant proteins and essential nutrients, is important to prevent nutritional deficiencies in the long term.
Review
Food Science & Technology
Kimberly N. Weaver, Hans Herfarth
Summary: This review examines the clinical associations of celiac disease (CeD), non-celiac gluten sensitivity (NCGS), and IBD, focusing on the therapeutic efficacy of gluten-free diets (GFD) or low-gluten diets in the therapy of IBD. While some cross-sectional reports suggest that a GFD may improve symptoms in IBD patients, current data do not support the universal use of a GFD in IBD due to a lack of high-quality prospective clinical studies.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Rheumatology
Miriam Almirall, Francesc Casellas, Joan Dot, Ines de Torres, Hegoi Segurola, Sara Marsal
Summary: The prevalence of non-coeliac gluten sensitivity (NCGS) in fibromyalgia patients is low, and a gluten-free diet (GFD) can improve their intestinal symptoms. However, not all patients meet the diagnostic criteria, and diarrhea, intraepithelial lymphocytosis, and lower levels of anxiety are associated with diet response.
Review
Medicine, General & Internal
Alice Verdelli, Alberto Corra, Elena Biancamaria Mariotti, Cristina Aimo, Lavinia Quintarelli, Valentina Ruffo di Calabria, Marta Elettra Donati, Veronica Bonciolini, Emiliano Antiga, Marzia Caproni
Summary: Gluten-related disorders (GRD) refer to a range of clinical manifestations triggered by gluten ingestion in genetically susceptible individuals, including coeliac disease (CD), wheat allergy, and non-celiac gluten sensitivity (NCGS). Besides the well-established association between CD and dermatitis herpetiformis, other muco-cutaneous disorders have been linked to GRD. This review focuses on analyzing dermatological diseases associated with GRD and those that improve with a gluten-free diet, with a particular focus on newly described cutaneous manifestations of NCGS. The hypothesis is put forward that cutaneous-gluten sensitivity could be a specific diagnostic marker of NCGS.
FRONTIERS IN MEDICINE
(2023)
Article
Nutrition & Dietetics
Pamela Mayara de Oliveira, Renata Puppin Zandonadi, Amanda Moreira Veloso Cutrim, Eduardo Yoshio Nakano, Fabiana Lopes Nalon de Queiroz, Raquel B. A. Botelho, Ariana Saraiva, Antonio Raposo
Summary: This cross-sectional study assessed eating competence and aspects related to a gluten-free diet in Brazilian adults with gluten-related disorders. The study found that the main difficulty in adhering to a gluten-free diet was the high cost of gluten-free foods. Individuals under 40 years old had lower eating competence scores, while increasing socioeconomic status, schooling, and culinary practices increased the total score.
Article
Nutrition & Dietetics
Noe Ontiveros, Raul Emilio Real-Delor, Jose Antonio Mora-Melgem, Carlos Eduardo Beltran-Cardenas, Oscar Gerardo Figueroa-Salcido, Marcela de Jesus Vergara-Jimenez, Feliznando Isidro Cardenas-Torres, Lilian Karem Flores-Mendoza, Jesus Gilberto Aramburo-Galvez, Francisco Cabrera-Chavez
Summary: The study found that a significant number of Paraguayan adults suffer from gluten-related disorders, with a higher prevalence among women than men. Most individuals adhering to a gluten-free diet do so based on recommendations from healthcare professionals.
Letter
Dermatology
Louise F. Risnes, Marketa Chulbnova, Elio Magistrelli, Esko Kemppainen, Kaisa Hervonen, Eriika Mansikka, Katri Lindfors, Teea Salmi, Shiva Dahal-Koirala, Ludvig M. Solid
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Marisa Stahl, Qian Li, Kristian Lynch, Sibylle Koletzko, Pooja Mehta, Loren Gragert, Jill M. Norris, Carin Andren Aronsson, Katri Lindfors, Kalle Kurppa, Jorma Ilonen, Jeffrey Krischer, Beena Alkolkar, Anette-G Ziegler, Jorma Toppari, Marian J. Rewers, Daniel Agardh, William Hagopian, Edwin Liu, TEDDY Study Grp
Summary: The study examines regional differences in celiac disease (CD) development among children in Europe and the United States. The incidence of CD varied by region, with Swedish children having the highest incidence at 3%. In the United States, the incidence was highest in Colorado at 2.4%.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Pooja Mehta, Qian Li, Marisa Stahl, Ulla Uusitalo, Katri Lindfors, Martha D. Butterworth, Kalle Kurppa, Suvi Virtanen, Sibylle Koletzko, Carin Aronsson, William J. Hagopian, Marian Rewers, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey Krischer, Daniel Agardh, Edwin Liu
Summary: This study aimed to describe the adherence rates to a gluten-free diet in children with screening-identified celiac disease and determine the factors associated with adherence. The results showed that approximately two-thirds of the children remained strictly adherent to a gluten-free diet at 2 and 5 years after diagnosis. Parent-reported adherence did not correlate with actual gluten intake based on food records. Having a first-degree relative with celiac disease was associated with higher adherence.
Article
Dermatology
Anna Poyry, Teija Kimpimaeki, Ilkka Kaartinen, Teea T. Salmi
Summary: This study evaluated the completeness, accuracy, timeliness, and case coverage of the Tampere Wound Registry (TWR). The results showed that the TWR is a reliable tool for health care documentation and a more reliable data source than patient medical records.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Alina Popp, Pilvi Laurikka, Diana Czika, Kalle Kurppa
Summary: Duodenal biopsy is the best method for diagnosing celiac disease, but there is increasing use of serology. Gluten challenge may be necessary if a person has reduced gluten intake before diagnosis. The optimal protocol for the challenge is still unclear.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Hanna Riekki, Linnea Aitokari, Laura Kivela, Siiri Lahti, Pauliina Hiltunen, Nina Vuorela, Heini Huhtala, Timo A. Lakka, Kalle Kurppa
Summary: This study investigated the prevalence, risk factors, and metabolic co-morbidities of metabolic-associated fatty liver disease (MAFLD) in overweight children. The prevalence of MAFLD was 15%, with higher rates in boys than girls, and was associated with gender, puberty stage, disturbances in glucose and lipid metabolism, age, and BMI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Noora Nilsson, Joonas Leivo, Pekka Collin, Inka Koskinen, Katri Kaukinen, Heini Huhtala, Johanna Palmio, Timo Reunala, Kaisa Hervonen, Teea Salmi, Camilla Pasternack
Summary: This cohort study investigated the risk for vascular diseases in dermatitis herpetiformis (DH) and coeliac disease patients. The results showed that compared to coeliac disease patients, DH patients had a decreased risk for cerebrovascular diseases, while coeliac disease patients had an increased risk for cerebrovascular and cardiovascular diseases. Coeliac disease, but not DH, was associated with an increased risk for venous thrombosis.
ANNALS OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Iida Ahonen, Pilvi Laurikka, Sara Koskimaa, Heini Huhtala, Katri Lindfors, Katri Kaukinen, Kalle Kurppa, Laura Kivela
Summary: Vomiting and nausea appear to be specific symptoms associated with gluten ingestion in treated celiac disease. However, the overall prevalence and factors related to these symptoms during chronic gluten exposure and acute re-exposure remain unclear.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Elli Turjanmaa, Kaisa Hervonen, Heini Huhtala, Sanna Arnala, Timo Reunala, Katri Kaukinen, Teea Salmi
Summary: This study aimed to investigate the frequency, severity, and quality of life effects of skin disorders in coeliac disease patients compared to controls, as well as the impacts of a gluten-free diet on these skin diseases. The results showed that coeliac disease patients were not at an increased risk for certain skin diseases, but they still experienced a burden on their quality of life due to skin symptoms.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Saykat Das, Jorunn Stamnaes, Esko Kemppainen, Kaisa Hervonen, Knut E. A. Lundin, Naveen Parmar, Frode L. Jahnsen, Jorgen Jahnsen, Katri Lindfors, Teea Salmi, Rasmus Iversen, Ludvig M. Sollid
Summary: Dermatitis herpetiformis (DH) is an inflammatory skin disorder often considered as an extra intestinal manifestation of celiac disease (CeD). Hallmarks of CeD and DH are auto-antibodies to transglutaminase 2 (TG2) and transglutaminase 3 (TG3), respectively. DH patients have auto-antibodies reactive with both transglutaminase enzymes.
Article
Gastroenterology & Hepatology
Juha Taavela, Kalle Kurppa, Tuija Jaaskelainen, Niina E. Kaartinen, Harri Rissanen, Heini Huhtala, Markku Maki, Katri Kaukinen
Summary: The prevalence of coeliac disease in Finland has been increasing over the years, with positive TGA without EmA, TGA values in the upper normal range, and pre-existing autoimmune diseases as predictors of developing the disease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
