Article
Medicine, General & Internal
Kunihisa Uchita, Hideki Kobara, Kenji Yorita, Yuriko Shigehisa, Chihiro Kuroiwa, Noriko Nishiyama, Yohei Takahashi, Yuka Kai, Jun Kunikata, Toshio Shimokawa, Uiko Hanaoka, Kenji Kanenishi, Tsutomu Masaki, Koki Hirano, Noriya Uedo
Summary: The study investigated the feasibility of targeted endoscopic forceps biopsy (E-Bx) guided by ME-NBI for diagnosing CIN, showing that the proportion of sufficient samples with E-Bx was similar to that with traditional P-Bx, and had high sensitivity, specificity, and accuracy. Further investigation of the diagnostic accuracy of ME-NBI-guided E-Bx samples for CIN is warranted.
Article
Oncology
Ugo Indraccolo, Erica Santi, Piergiorgio Iannone, Chiara Borghi, Pantaleo Greco
Summary: The study found that patients who undergo more cervical biopsies are more likely to be diagnosed with CIN-2, but do not affect the diagnosis of CIN-0/1 or CIN-3.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Hideki Kobara, Kunihisa Uchita, Noriya Uedo, Jun Kunikata, Kenji Yorita, Naoya Tada, Noriko Nishiyama, Yuriko Shigehisa, Chihiro Kuroiwa, Noriko Matsuura, Yohei Takahashi, Yuka Kai, Uiko Hanaoka, Yumiko Kiyohara, Shoji Kamiura, Kenji Kanenishi, Tsutomu Masaki, Koki Hirano
Summary: This multicenter prospective study aimed to investigate the diagnostic ability of magnifying endoscopy with narrow band imaging (ME-NBI) for cervical intraepithelial neoplasia grade 2 or worse (CIN2+). The study found that ME-NBI exhibited a better sensitivity than colposcopy in detecting CIN2+ lesions, while also demonstrating a higher patient acceptability.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Min Liu, Jianqiao Lu, Yong Zhi, Yetian Ruan, Guangxu Cao, Xinxin Xu, Xin An, Jinli Gao, Fang Li
Summary: This study used high-resolution microendoscopy combined with methylene blue cell staining technology to perform real-time imaging of the cervix for the first time. The overall consistency of microendoscopy diagnosis with pathological diagnosis was 95.12%. This provides a basis for a novel clinical strategy for triage of women with abnormal cervical screening results using in vivo non-invasive optical diagnosis technology.
INFECTIOUS AGENTS AND CANCER
(2023)
Article
Biochemistry & Molecular Biology
Margarita Kniazeva, Lidia Zabegina, Andrey Shalaev, Olga Smirnova, Olga Lavrinovich, Igor Berlev, Anastasia Malek
Summary: Cervical cancer is a common gynecological malignancy that can be prevented through yearly diagnosis and treatment of pre-cancerous cervical disease. The NOVAprep-miR-CERVIX is a new method that assesses cervical dysplasia by analyzing six marker miRNAs. This study aims to evaluate the performance and diagnostic potency of this new approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Frederik A. Stuebs, Anna K. Dietl, Annika Behrens, Werner Adler, Carol Geppert, Arndt Hartmann, Antje Knoell, Matthias W. Beckmann, Grit Mehlhorn, Carla E. Schulmeyer, Paul Gass, Martin C. Koch
Summary: This research aims to estimate the rate of concordance, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of colposcopy for high-grade squamous lesions and carcinomas (HSIL+). The results show that colposcopy is an important, feasible, and effective method. The concordance rate is lowest for TZ3 and highest for colposcopists with more than 10 years' experience. Careful examination is needed for women with TZ3 who are over 35 years old, as they are at the highest risk of being misdiagnosed.
Article
Oncology
Takayuki Takahashi, Hikaru Matsuoka, Rieko Sakurai, Jun Akatsuka, Yusuke Kobayashi, Masaru Nakamura, Takashi Iwata, Kouji Banno, Motomichi Matsuzaki, Jun Takayama, Daisuke Aoki, Yoichiro Yamamoto, Gen Tamiya
Summary: This study developed an artificial intelligence (AI) algorithm that can accurately detect high-grade lesions associated with prognosis using colposcopic images. The results provide insight into the additional utility of colposcopy for managing patients with CIN2.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Mandy Man-Yee Chu, Charleen Sze-Yan Cheung, Siew-Fei Ngu, Ka-Yu Tse, Philip Pun-Ching Ip, Annie Nga-Yin Cheung, Hextan Yuen-Sheung Ngan, Karen Kar-Loen Chan
Summary: This study aimed to compare the diagnostic efficacy of colposcopic-directed biopsy and four-quadrant biopsy in detecting high-grade cervical intra-epithelial neoplasia (CIN). A total of 1311 women attending routine cervical screening were recruited, with 118 cases of high-grade CIN diagnosed. Four-quadrant biopsy detected significantly more high-grade CIN than colposcopic-directed biopsy, especially in patients with low-grade/normal/unsatisfactory colposcopy. Four-quadrant cervical biopsies should be considered for all women with an abnormal smear or positive HPV testing.
Article
Obstetrics & Gynecology
Neal M. Lonky, Lanfang Xu, Diane M. Da Silva, Juan C. Felix, Chun Chao
Summary: This study aimed to evaluate the risk of high-grade cervical lesion diagnosed through colposcopy in women with human papillomavirus vaccination compared to women without vaccination. The results showed that vaccination history did not significantly lower the odds of a cervical intraepithelial neoplasm grade 2+ diagnosis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Diede L. Loopik, Lisanne M. Koenjer, Albert G. Siebers, Willem J. G. Melchers, Ruud L. M. Bekkers
Summary: This study compared the effectiveness of the new high-risk human papillomavirus-based cervical cancer screening program with the previous cytology-based screening program in the Netherlands. The findings showed that high-risk human papillomavirus-based screening can increase the detection of high-grade cervical intraepithelial neoplasia, but also comes with a higher risk of overdiagnosis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Line Winther Gustafson, Anne Hammer, Mary Holten Bennetsen, Christina Blach Kristensen, Huda Majeed, Lone Kjeld Petersen, Berit Andersen, Pinar Bor
Summary: The detection of CIN2+ in women aged >= 45 years with TZ3 is underestimated if relying on biopsy results alone. To reduce the risk of underdiagnosis and overtreatment, future studies should explore the use of new biomarkers for risk stratification.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Immunology
Violante Di Donato, Giuseppe Caruso, Marco Petrillo, Evangelos Kontopantelis, Innocenza Palaia, Giorgia Perniola, Francesco Plotti, Roberto Angioli, Ludovico Muzii, Pierluigi Benedetti Panici, Giorgio Bogani
Summary: This meta-analysis demonstrated that adjuvant HPV vaccination is associated with a reduced risk of recurrent CIN 1+ and CIN 2+ after surgical treatment, based on the analysis of 11 selected studies.
Article
Obstetrics & Gynecology
Priscila Thais S. Mantoani, Millena P. Jammal, Juliana M. Caixeta, Nayara A. Cordeiro, Ana Cristina M. Barcelos, Eddie Fernando C. Murta, Rosekeila S. Nomelini
Summary: The study showed that the size of lesion in colposcopic imaging is related to the severity of CIN, with lesions larger than 30,337.03 pixels(2) being associated with HSIL and invasive cancer. By considering the lesion size, management of cervical intraepithelial lesions can be more accurate and less invasive, leading to better outcomes for patients.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Immunology
Barbara Gardella, Alberto Agarossi, Mattia Dominoni, Isabella Pagano, Susanna Del Frati, Maria Di Giminiani, Selene Cammarata, Chiara Melito, Marianna Francesca Pasquali, Lucia Zanchi, Valeria Savasi, Arsenio Spinillo
Summary: The aim of this study is to evaluate the risk factors for development of CIN2+ in women living with HIV. The results show that women with good immune status and negative Pap smear and HR-HPV test have a low risk for CIN2+.
Review
Oncology
Yoshihide Inayama, Yukio Yamanishi, Eiji Nakatani, Junichi Aratake, Nanayo Sasagasako, Kaori Yamada, Rei Gou, Atsuko Kawamura, Megumi Yamanishi, Kenzo Kosaka
Summary: The study revealed that Imiquimod has a certain efficacy in treating vaginal intraepithelial neoplasia 2-3, with a high complete response rate and response rate regardless of whether patients have a history of hysterectomy.
GYNECOLOGIC ONCOLOGY
(2021)