Article
Gastroenterology & Hepatology
Arunkumar Krishnan, Laura Prichett, Xueting Tao, Saleh A. Alqahtani, James P. Hamilton, Esteban Mezey, Alexandra T. Strauss, Ahyoung Kim, James J. Potter, Po-Hung Chen, Tinsay A. Woreta
Summary: Abnormal liver chemistries are common in hospitalized COVID-19 patients and are closely related to disease severity and prognosis. Elevated levels of ALT, AST, ALP, and T-Bil can be used to assess risk and predict the need for advanced therapies in these patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Gang Li, Yitian Yang, Danyang Gao, Yongxing Xu, Jianwen Gu, Pengfei Liu
Summary: The study found that defining liver injury by transaminase levels above the normal limit in COVID-19 patients may lead to an overestimation of liver injury prevalence, with only a small fraction of patients having clinically significant liver injury. Additionally, hypertransaminasemia was significantly more common in severe cases of COVID-19, suggesting the need for increased attention to liver function tests in severe patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Immunology
Zeming Liu, Di Hu, Jinpeng Li, Qing Xia, Yan Gong, Zhengwei Li, Qian Wu, Meilin Yi, Yihui Huang, Meng Wu, Liang Guo, Xiaohui Wu
Summary: Elevated levels of AST and AST/ALT are correlated with severity and mortality of COVID-19. Liver function tests may aid clinicians in determining prognosis for patients undergoing treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Karn Wijarnpreecha, Patompong Ungprasert, Panadeekarn Panjawatanan, Denise M. Harnois, Himesh B. Zaver, Aijaz Ahmed, Donghee Kim
Summary: A meta-analysis study found that a quarter of COVID-19 patients had elevated liver enzymes, and it was associated with disease severity. The prevalence of elevated AST was significantly higher in severe cases, and the proportion of patients with co-existing chronic liver disease was also notable.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Medical Laboratory Technology
Elena Aloisio, Giulia Colombo, Claudia Arrigo, Alberto Dolci, Mauro Panteghini
Summary: AST levels are often elevated in COVID-19 patients due to hepatocellular and muscle damage. While AST elevation may not independently predict worse outcomes, it could be related to tissue damage and its clinical significance remains unclear.
CLINICA CHIMICA ACTA
(2021)
Article
Pharmacology & Pharmacy
Yu-Ting Yen, Joo-Hyun Park, Seung-Hyun Kang, Today Su, Howard Cheng, Wu-Che Wen, Shin-Shiou Lin, Yu-Ling Tai, Pei-Ni Chen, Shih-Chang Tsai
Summary: This study evaluated the protective effects of Golden-Antrodia camphorata on liver function in human subjects after alcohol consumption.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xuejiao Liao, Dapeng Li, Zhenghua Ma, Lina Zhang, Baoqi Zheng, Zhiyan Li, Guobao Li, Lei Liu, Zheng Zhang
Summary: This study characterized the dynamic changes in liver function abnormalities in patients with COVID-19 during the acute and recovery phases. The findings showed that liver damage in COVID-19 patients was usually temporary and could return to normal at the end of the 12-month follow-up.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Justin Y. Lu, Harnadar Anand, Shalom Z. Frager, Wei Hou, Tim Q. Duong
Summary: This study identified key clinical variables predictive of liver injury in COVID-19, which may prove useful for management of liver injury. Late onset of severe liver injury and more aggressive care are suggestive of treatment-related hepatotoxicity.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Pei-Hsuan Lai, Dah-Ching Ding
Summary: This study presents a case of a COVID-19 patient with mild respiratory symptoms but significantly elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indicating acute liver injury (ALI).
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Immunology
Lu Zhang, Liu Yang, Yuanjiao Gao, Xiaoyue Bi, Yanjie Lin, Wen Deng, Tingting Jiang, Yao Lu, Hongxiao Hao, Gang Wan, Wei Yi, Yao Xie, Minghui Li
Summary: The purpose of this study was to develop an effective non-invasive nomogram for assessing liver inflammation in untreated HBeAg positive patients with chronic HBV infection. A nomogram was created using a model cohort of 292 treatment-naive HBeAg positive patients with normal ALT at Beijing Ditan Hospital. It was then validated in a separate cohort of 88 patients. The nomogram showed good consistency with real observations and performed well in predicting liver inflammation in HBV patients.
Article
Medical Laboratory Technology
Shuyun Li, Dingbin Liu, Qiang Wang
Summary: This study established a novel diagnostic model combining PIVKA-II, AFP, AST, ALT, and T-Bil for early-stage HBV-related HCC. The results showed that the diagnostic efficacy of the novel model was superior to PIVKA-II and AFP alone, especially for patients with abnormal AFP levels.
CLINICAL LABORATORY
(2023)
Article
Gastroenterology & Hepatology
Narayanasamy Krishnasamy, Karthick Rajendran, Parimita Barua, Arunkumar Ramachandran, Priyadarshini Panneerselvam, Muthukumaran Rajaram
Summary: This study found that comorbidity combined with elevated liver enzymes at admission independently increased the risk of death in COVID-19 by at least 5-fold.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Hend Ibrahim Shousha, Ahmed Ramadan, Rania Lithy, Mohamed El-Kassas
Summary: COVID-19 can cause liver disturbance, leading to liver disease. The molecular mechanism is still unknown, but it may be related to pre-existing liver diseases.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Nutrition & Dietetics
Evelyn Ferri, Paolo D. Rossi, Martina Scichilone, Tiziano A. Lucchi, Beatrice Arosio
Summary: Dysfunctions in liver metabolic activities may be associated with an increased risk of cognitive impairment and dementia, with attention to sex differences in liver function.
Article
Integrative & Complementary Medicine
Leyla Arabnezhad, Mahtab Mohammadifard, Ladan Rahmani, Zahra Majidi, Gordon A. Ferns, Afsane Bahrami
Summary: This study found that curcumin supplementation has a significant improvement on vitamin D levels and liver function enzymes in women with premenstrual syndrome (PMS) and dysmenorrhea.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Junnan Liang, Ganxun Li, Jingyu Liao, Zhao Huang, Jingyuan Wen, Yu Wang, Zeyu Chen, Guangzhen Cai, Weiqi Xu, Zeyang Ding, Huifang Liang, Pran K. Datta, Liang Chu, Xiaoping Chen, Bixiang Zhang
Summary: This study reveals the role of SNORD17 in hepatocellular carcinoma (HCC) and its interaction with p53, suggesting it as a potential therapeutic target for HCC.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Xiaochao Zhang, Yabing Hu, Yonglong Pan, Yixiao Xiong, Yuxin Zhang, Mengzhen Han, Keshuai Dong, Jia Song, Huifang Liang, Zeyang Ding, Xuewu Zhang, He Zhu, Qiumeng Liu, Xun Lu, Yongdong Feng, Xiaoping Chen, Zhanguo Zhang, Bixiang Zhang
Summary: DDR1 is upregulated in hepatocellular carcinoma (HCC) tissues and high expression of DDR1 is associated with poor prognosis. DDR1 promotes HCC metastasis through collagen-induced signaling.
Article
Oncology
Yonglong Pan, Mengzhen Han, Xiaochao Zhang, Yi He, Chaoyi Yuan, Yixiao Xiong, Xinxin Li, Chenglong Zeng, Kan Lu, He Zhu, Xun Lu, Qiumeng Liu, Huifang Liang, Zhibin Liao, Zeyang Ding, Zhanguo Zhang, Xiaoping Chen, Wanguang Zhang, Bixiang Zhang
Summary: The study reveals that DDR1 promotes liver cancer cell proliferation and tumor growth, while downregulation of DDR1 has the opposite effect. DDR1 interacts with SLC1A5 to regulate the mTORC1 signaling pathway. DDR1 serves as an independent prognostic marker, and its expression is positively correlated with SLC1A5 in clinical samples, providing new insights into HCC development and potential targets for treatment.
Article
Oncology
Yachong Liu, Jia Song, Hongwei Zhang, Zhibin Liao, Furong Liu, Chen Su, Weijian Wang, Mengzhen Han, Lu Zhang, He Zhu, Zhanguo Zhang, Huifang Liang, Lei Zhang, Bixiang Zhang, Xiaoping Chen
Summary: In this study, it was found that EIF4A3-induced circTOLLIP promotes the progression of HCC through the circTOLLIP/miR-516a-5p/PBX3/EMT axis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Guangzhen Cai, Jinghan Zhu, Deng Ning, Ganxun Li, Yuxin Zhang, Yixiao Xiong, Junnan Liang, Chengpeng Yu, Xiaoping Chen, Huifang Liang, Zeyang Ding
Summary: The role of hypoxia in hepatocellular carcinoma and its impact on the tumor microenvironment and drug sensitivity are not well understood. This study found that the Hypoxia_DEGs_Score model has excellent predictive value for survival. Hypoxia is closely related to somatic mutation, copy number variation, and DNA methylation, which affect tumor development, metastasis, and drug resistance. Aggravated hypoxic stress leads to immune exclusion phenotype and increased infiltration of immunosuppressive cells. Patients with high Hypoxia_DEGs_Score have worse immunotherapeutic outcomes and prognosis, and may benefit from drugs targeting cell cycle signaling pathways rather than those inhibiting the PI3K/mTOR pathway. Hypoxia_DEGs_Score can predict changes in the tumor microenvironment, the efficacy of immunotherapy, and drug response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xiaojin Liu, Yimin Huang, Yiwei Qi, Shiqiang Wu, Feng Hu, Junwen Wang, Kai Shu, Huaqiu Zhang, Jorg W. Bartsch, Christopher Nimsky, Fangyong Dong, Ting Lei
Summary: This study revealed a malignant positive feedback loop between tumor-associated macrophages (TAMs) and GBM cells mediated by ADAM8 under TMZ treatment. This loop involves the activation of the HB-EGF/EGFR signaling pathway and up-regulation of CCL2 expression, leading to TAM recruitment and further enhancing ADAM8 expression in GBM cells, resulting in TMZ resistance in GBM.
Review
Cell Biology
Chengpeng Yu, Dean Rao, Tiantian Wang, Jia Song, Lei Zhang, Wenjie Huang
Summary: As a member of the TRIM protein family, TRIM27 is an important protein that plays multiple roles in regulating cellular processes under physiological and pathological conditions. It is implicated in the development of various diseases, particularly cancer and other human diseases. However, there is still limited understanding of TRIM27, and further investigations are needed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Yiyang Liu, Yufei Wang, Sheng Sun, Zeyu Chen, Shuai Xiang, Zeyang Ding, Zhao Huang, Bixiang Zhang
Summary: This article investigates the role of EpCAM in cancer and its communication with other signaling pathways. It introduces the impact on the biology of cancers and the latest clinical applications of EpCAM, aiming to shed light on its translational prospects.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Cell Biology
Chengpeng Yu, Dean Rao, Tiantian Wang, Jiaqi Sheng, Enjun Lv, Long Zhang, Xun Lu, Jingjing Yu, Huifang Liang, Jia Song, Wenjie Huang
Summary: This study found that high expression of RNF12 is associated with liver cancer and is correlated with worse clinicopathological features and a poor prognosis. Mechanistically, RNF12 interacts with EGFR to activate EGF/EGFR signalling. Additionally, PI3K-AKT signalling is involved in the regulation of liver cancer cell proliferation and migration by RNF12.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Chen Xiao, Jiayuan Li, Xing Wang, Shiyou Li, Chen Xu, Zhijie Zhang, Ao Hua, Ze-yang Ding, Bi-xiang Zhang, Xiangliang Yang, Zifu Li
Summary: Cancer stem cells (CSCs) are responsible for tumor progression, treatment resistance, metastasis, and recurrence, but few drugs have successfully eliminated CSCs by increasing oxidative stress. In this study, we introduced hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles (CuET@HES NPs) that effectively suppressed CSCs in vitro and in various in vivo tumor models. The CuET@HES NPs also showed great efficacy in inhibiting CSCs in fresh tumor tissues from hepatocellular carcinoma patients. This research has significant implications for the development of CSC-targeting nanomedicines.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Urology & Nephrology
Chaoyi Yuan, Guannan Jin, Pengcheng Li, Wei Wang, Chang Ge, Yonglong Pan, Qiaofeng Zhang, Jie Mo, Dong Kuang, Liu Liu, Xuewu Zhang, Huifang Liang, Wanguang Zhang, Xi Tang, Zifu Li, Jihong Liu, Gang Xu, Xiaoping Chen, Ze-yang Ding, Bixiang Zhang
Summary: Tubulointerstitial fibrosis is the final path of progressive chronic kidney diseases regardless of the cause. The transcriptional intermediary factor 1y (TIF1y) has been found to be highly expressed in the kidney tubules and inhibits the progression of fibrosis. Loss of TIF1y exacerbates tubular cell polyploidy and fibrosis, while overexpression protects against kidney fibrosis. TIF1y exerts its antifibrotic role by inhibiting TGF-D and EGFR signaling pathways.
KIDNEY INTERNATIONAL
(2023)
Article
Oncology
Qian Jiang, Zhuowei Lei, Zihan Wang, Quanji Wang, Zhuo Zhang, Xiaojin Liu, Biao Xing, Sihan Li, Xiang Guo, Yanchao Liu, Xingbo Li, Yiwei Qi, Kai Shu, Huaqiu Zhang, Yimin Huang, Ting Lei
Summary: The tumor microenvironment, especially tumor-associated fibroblasts (TAFs), has been extensively studied in cancer, but not as much in pituitary adenoma (PA). Our study proved that TAFs promote PA progression through exosomal circDennd1b. Moreover, the suppression of ONECUT2 and TAFs can improve the efficacy of clinical drugs for PA.
Article
Biochemistry & Molecular Biology
Dongyi Wan, Ran Li, Haohao Huang, Xiaohua Zhu, Ganxun Li
Summary: This study developed an integrated computational algorithm, ImmPI, for analyzing and identifying the regulatory roles of piRNAs in immune pathways. The results show that immunology piRNAs are overexpressed in immune cells, perturb tumors, and have prognostic value. They also contribute to distinguishing different subtypes of SKCM and provide potential targets for piRNA-based immunotherapies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ran Li, Dongyi Wan, Junnan Liang, Huifang Liang, Haohao Huang, Ganxun Li
Summary: This study systematically evaluated the impact of genetic variants on promoter activity and identified over 1.0 million paQTLs. The study also discovered associations between paQTLs and patient prognosis, antitumor therapy responses, and immune cell abundance. Furthermore, a user-friendly data portal, Pancan-paQTL, was constructed for users to browse, search, and download data of interest. This study provides important insights into the genetic basis and biological processes related to promoter activity.
Review
Cell Biology
Kan Lu, Yonglong Pan, Zhao Huang, Huifang Liang, Ze-Yang Ding, Bixiang Zhang
Summary: The TRIM protein family is a versatile and highly conserved group of proteins that function as E3 ligases, regulating the development of hepatocellular carcinoma.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)