Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism

Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma

(2020) Pingping Dong et al.   JOURNAL OF HEPATOLOGY

LMNA functions as an oncogene in hepatocellular carcinoma by regulating the proliferation and migration ability

(2020) Heng Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma

(2018) Zhigang Ren et al.   GUT

Regulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair

(2017) Franklin Mayca Pozo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

(2017) Sara Torrecilla et al.   JOURNAL OF HEPATOLOGY

Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo

(2017) Suhua Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antagonizing NOD2 Signaling with Conjugates of Paclitaxel and Muramyl Dipeptide Derivatives Sensitizes Paclitaxel Therapy and Significantly Prevents Tumor Metastasis

(2017) Yi Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

The gut microbiome and liver cancer: mechanisms and clinical translation

(2017) Le-Xing Yu et al.   Nature Reviews Gastroenterology & Hepatology

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways

(2017) S.M. Nashir Udden et al.   Cell Reports

Causes and consequences of nuclear envelope alterations in tumour progression

(2016) Emily S. Bell et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

(2015) Ian Gibbs-Seymour et al.   AGING CELL

Nucleotide-Binding Oligomerization Domain 2 Receptor Is Expressed in Platelets and Enhances Platelet Activation and ThrombosisCLINICAL PERSPECTIVE

(2015) Si Zhang et al.   CIRCULATION

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair

(2015) Shrestha Ghosh et al.   Cell Reports

Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice

(2014) Maria E. Johansson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

(2014) Jean Charles Nault et al.   HEPATOLOGY

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids

(2014) Lirui Wang et al.   JOURNAL OF HEPATOLOGY

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

(2013) David J. Rickard et al.   PLoS One

Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction

(2012) Ulrich Meinzer et al.   Cell Host & Microbe

Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats

(2012) Hui-Lu Zhang et al.   JOURNAL OF HEPATOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A dual role for A-type lamins in DNA double-strand break repair

(2011) Abena B. Redwood et al.   CELL CYCLE

Hepatocytes express functional NOD1 and NOD2 receptors: A role for NOD1 in hepatocyte CC and CXC chemokine production

(2010) Melanie J. Scott et al.   JOURNAL OF HEPATOLOGY

Diseases of the Nuclear Envelope

(2010) H. J. Worman et al.   Cold Spring Harbor Perspectives in Biology

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Design of Peptide Inhibitors for the Importin α/β Nuclear Import Pathway by Activity-Based Profiling

(2008) Shunichi Kosugi et al.   CHEMISTRY & BIOLOGY

NOD2: a potential target for regulating liver injury

(2008) Mathilde Body-Malapel et al.   LABORATORY INVESTIGATION