Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

On the responsible use of digital data to tackle the COVID-19 pandemic

(2020) Marcello Ienca et al.   NATURE MEDICINE

Covid-19 and the Need for Health Care Reform

(2020) Jaime S. King   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

(2020) Shuofeng Yuan et al.   PHARMACOLOGICAL RESEARCH

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease

(2020) Donald C. Hall et al.   Travel Medicine and Infectious Disease

Hydroxychloroquine in the management of critically ill patients with COVID-19: the need for an evidence base

(2020) Fabio S Taccone et al.   Lancet Respiratory Medicine

Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19

(2020) Loukman Omarjee et al.   CLINICAL IMMUNOLOGY

No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection

(2020) J.M. Molina et al.   MEDECINE ET MALADIES INFECTIEUSES

The Covid-19 Vaccine-Development Multiverse

(2020) Penny M. Heaton   NEW ENGLAND JOURNAL OF MEDICINE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of SARS-CoV 3CL protease by flavonoids

(2019) Seri Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drugs Library

(2018) Peilin Wang et al.   JOURNAL OF VIROLOGY

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

(2016) Nicholas J. Barrows et al.   Cell Host & Microbe

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

(2016) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model

(2016) Aeri Shim et al.   Scientific Reports

Structures of theMiddle East respiratory syndrome coronavirus3C-like protease reveal insights into substrate specificity

(2015) Danielle Needle et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tranylcypromine Reduces Herpes Simplex Virus 1 Infection in Mice

(2014) H.-W. Yao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus

(2013) Nathalie Lejal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling

(2013) Yuko Murakami et al.   MICROBES AND INFECTION

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

(2013) L. M. Johansen et al.   Science Translational Medicine

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Potential use of rapamycin in HIV infection

(2010) Marco Donia et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Saquinavir, the pioneer antiretroviral protease inhibitor

(2009) Charles JL la Porte   Expert Opinion on Drug Metabolism & Toxicology