Article
Chemistry, Physical
Revathi Nagaraj, Sankarganesh Murugesan, Dhaveethu Raja Jeyaraj, Sakthivel Arumugam, Gurusamy Shunmugasundaram, Nandini Asha Radhakrishnan
Summary: This study synthesized a series of pyrimidine-based mixed ligand complexes and elucidated their structures. The compounds exhibited potential biological activities in terms of anticancer, antioxidant, and antimicrobial properties.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Ahmed M. Abu-Dief, Nouf H. Alotaibi, Eida S. Al-Farraj, Hamza A. Qasem, Seraj Alzahrani, Metwally K. Mahfouz, Aly Abdou
Summary: Coordination compounds of Ag(I), Cu(II), Ni(II), Fe(III), and VO(II) ions were synthesized and their structures were investigated. The ligand formed specific structures with the ions. The structures of the compounds were optimized using density functional theory, and critical theoretical factors were calculated. Furthermore, the biological activities of the compounds were studied using molecular docking and in vitro experiments.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Adriana Castro Pinheiro, Ianka Jacondino Nunes, Wesley Vieira Ferreira, Paula Pellenz Tomasini, Cristiano Trindade, Carolina Cristovao Martins, Ethel Antunes Wilhelm, Robson da Silva Oliboni, Paulo Augusto Netz, Rafael Stieler, Osvaldo de Lazaro Casagrande Jr, Jenifer Saffi
Summary: Synthesis and characterization of Cu(II) complexes with NNO-donor Schiff base ligands (2a, b). X-ray analysis revealed a mononuclear and a dinuclear complex in the solid state for 2a. Density Functional Theory (DFT) calculations were used to optimize the electronic structures of the complexes. 2a showed better antioxidant activity, while all compounds exhibited high cytotoxicity but no selectivity for tumor cell lines.
Article
Biochemistry & Molecular Biology
Mohammad Ibrahim, Hazrat Un Nabi, Niaz Muhammad, Muhammad Ikram, Momin Khan, Musadiq Ibrahim, Abdullah F. AlAsmari, Metab Alharbi, Abdulrahman Alshammari
Summary: Currently, ongoing studies are exploring the interaction between free radicals and biological systems. This study evaluated the synthesis, characterization, antioxidant properties, DNA binding, and molecular docking of Schiff base ligand and its Ni(II), Co(II), Cu(II), and Zn(II) complexes. The metal complexes showed significant dose-dependent antioxidant activities, but lower than ascorbic acid. The DNA binding constants (K-b) and molecular docking analysis supported the experimental results. The study highlights the importance of synthesis complexes as synthetic antioxidants and anticancer drugs.
Article
Chemistry, Inorganic & Nuclear
Mohamed Shaker S. Adam, Ahmed M. Abu-Dief, M. M. Makhlouf, Saad Shaaban, Seraj O. Alzahrani, Fatmah Alkhatib, Ghada S. Masaret, Mamdouh A. Mohamed, Mosa Alsehli, Nashwa M. El-Metwaly, Ahmad Desoky M. Mohamad
Summary: A green synthetic pathway was used to synthesize two mononuclear M(II)-complexes (M = Ni2+ and ZrO2+) with an imino-naphthalenol sodium sulfonate ligand. The biological potential and DNA binding properties of the complexes were investigated, showing improved antimicrobial and anticancer activities compared to the free ligand. The ZrOLig complex exhibited the most active biological reactivity.
Article
Chemistry, Inorganic & Nuclear
Arif Mermer, Burak Tuzun, Sevgi Durna Dastan, Ozge Cevik
Summary: The study investigated the antimicrobial, antioxidant, and cytotoxic activities as well as pBR322 Plasmid DNA interaction potentials of newly synthesized Schiff bases and their copper complexes in vitro. The compounds showed moderate antimicrobial activity and oxidative stress index. The compound Bis-Napht exhibited the highest cytotoxic activity in HeLa, MCF-7, and L929 cells. Ligand compounds and their metal complexes were optimized and compared against crystal structures of breast cancer associated protein (BRCA1) and cervical cancer cell proteins (CDK2 receptor). Protein-Ligand Interaction Profiler analysis was performed to examine the chemical interactions occurring.
Article
Chemistry, Multidisciplinary
Laila H. Abdel-Rahman, Mohamed Shaker S. Adam, Nabil Al-Zaqri, Mohamed R. Shehata, Hanan El-Sayed Ahmed, Shaaban K. Mohamed
Summary: In this study, a new Schiff base ligand and its metal chelates were synthesized and characterized. The compounds showed anticancer, antibacterial, and antifungal activities, and exhibited good binding affinity to DNA.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Sreenu Daravath, Aveli Rambabu, Nirmala Ganji, Gali Ramesh, P. V. Anantha Lakshmi, Shivaraj
Summary: In this study, three new Schiff base ligands and their Cu(II) complexes were synthesized and characterized. The complexes showed significant DNA binding and antioxidant activities, as well as good cytotoxicity against human lung and breast cancer cell lines. The complexes exhibited higher biological activities compared to the free Schiff bases.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Nahid Shahabadi, Mohammad Mahdavi
Summary: The aim of this study was to synthesize silver nanoparticles using Stachys schtschegleevii extract and characterize their composition, morphology, and size. The green synthesized silver nanoparticles exhibited strong antioxidant, antibacterial, and antifungal activities, which were supported by molecular docking studies. The interaction between the nanoparticles and target proteins was consistent with the experimental results, providing insights into their mechanism of action.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Applied
Laila H. Abdel-Rahman, Maram T. Basha, Badriah Saad Al-Farhan, Mohamed R. Shehata, Ehab M. Abdalla
Summary: In this study, five novel metal ion complexes were synthesized and characterized, showing anticancer potential with antiproliferative effects on cancer cell lines, as well as antioxidant and antibacterial activities. The binding nature of the complexes with CT-DNA was investigated to determine intercalation or replacement mode.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Qi-Yan Liu, Yong-Yu Qi, Dai-Hong Cai, Yun-Jun Liu, Liang He, Xue-Yi Le
Summary: Two new copper(II) complexes of sparfloxacin were synthesized and displayed good antitumor activity by inducing apoptosis through DNA damage and loss of mitochondrial functions.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Applied
Hanaa A. El-Boraey, Aya Abdel-Qader, Mostafa A. Hussien
Summary: The new ligand and its metal complexes were synthesized and characterized. Irradiation of the complexes resulted in enhanced anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Siddappa A. Patil, Vishal Kandathil, Anjali Sobha, Sasidhar B. Somappa, Max R. Feldman, Alejandro Bugarin, Shivaputra A. Patil
Summary: This review summarizes the antimicrobial, anticancer, antioxidant, anthelmintic, pesticidal, and nematocidal properties of coumarin-derived imine-metal complexes and discusses the progress in medicinal chemistry in this field. The findings suggest a promising future for the development of new drugs and encourage researchers to identify investigational new drug (IND) candidates.
Article
Biochemistry & Molecular Biology
Paulraj Adwin Jose, Murugesan Sankarganesh, Jeyaraj Dhaveethu Raja, Gurusamy Sankararaj Senthilkumar, Radhakrishnan Nandini Asha, Samuelraj Johnson Raja, Clarence Dorothy Sheela
Summary: The interactions of DMPMM and DMPMM-NiNPs with biomolecules were studied using various methods, revealing that DMPMM-NiNPs exhibited higher activity in biological systems. The synthesized compounds showed good performance in DNA and BSA binding, antimicrobial, anticancer, and antioxidant activities.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Jiahe Li, Min Chen, Jinzhang Jiang, Jieyou Huang, Hailan Chen, Lixia Pan, Dmytro S. Nesterov, Zhen Ma, Armando J. L. Pombeiro
Summary: This study synthesized and characterized eleven manganese 4'-substituted-2,2':6',2''-terpyridine complexes with different substituents. In vitro experiments showed that these complexes exhibited higher antiproliferative activities against human carcinoma cell lines compared to cisplatin. Compound 2d demonstrated the strongest antiproliferative effect on A549 and HeLa cells, while compounds 2h, 2g, and 2c were most effective against Bel-7402, Eca-109, and MCF-7 cells, respectively. The DNA binding ability of these complexes was investigated using circular dichroism spectroscopy and molecular modeling methods, revealing the involvement of pi-pi stacking and hydrogen bonds. The anticancer activity was enhanced by modifying oxygen-containing substituents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ali Alsalme, Malak Faisal Altowairqi, Afnan Abdullah Alhamed, Rais Ahmad Khan
Summary: In this study, SCAPS-1D was used for the numerical simulation of lead-free perovskite solar cells (PSCs), and the thickness of the zinc oxysulphide, MAGeI(3), and spiro-OMeTAD layers was optimized. The optimized PSCs showed excellent power conversion efficiency of 21.62%.
Article
Chemistry, Applied
Umer Rashid, Balkis Hazmi, Rose Fadzilah Abdullah, Siti Fadhilah Ibrahim, Ali Alsalme, Toshiki Tsubota
Summary: In this study, palm kernel shell-based char was developed and utilized for synthesizing bifunctional carbon catalyst. The catalyst showed higher surface area and stronger acid-base properties, making it suitable for efficient esterification and transesterification reactions.
TOPICS IN CATALYSIS
(2023)
Article
Nanoscience & Nanotechnology
Ahmed M. Abu-Dief, Mosa Alsehli, Aziz Awaad
Summary: Surface coating of silica nanoparticles (SiNPs) with polyethylene glycol (PEG) can control their biodistribution and in vivo interaction. SiNPs with higher coating density of PEG showed prolonged circulation time in the blood compared to SiNPs with lower coating density of PEG or amine surface coating. PEG surface coating plays an important role in controlling the biodistribution and immunogenicity of SiNPs-based drug delivery systems.
APPLIED NANOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Meshal Alzaid, W. S. Mohamed, Rakan Alanazi, Ibrahim Hotan Alsohaimi, Hassan M. A. Hassan, N. M. A. Hadia, Mohammed Ezzeldien, M. R. El-Aassar, Ahmed M. Abu-Dief
Summary: In this study, (Y2O3) x (CdO) 1-x mixed oxides nanocomposites with different Y2O3 loadings were synthesized via a precipitation approach. The NCs showed crystalline and cubic-phase purity, and their crystallite size ranged from 45 to 52 nm. By adding Y2O3, the optical band gap of the NCs decreased, and the surface area and pore volume increased, indicating increased porosity. UV-vis spectroscopy revealed that Y2O3 loading significantly improved the photocatalytic activities of the NCs, and the (Y2O3) 0.2 (CdO) 0.8 NCs showed the highest photodegradation efficiency for methylene blue under solar irradiation.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Materials Science, Multidisciplinary
Gulsum Ersu, Yigit Sozen, Estrella Sanchez-Viso, Sruthi Kuriakose, Beatriz H. Juarez, Federico J. Mompean, Mar Garcia-Hernandez, Lea Visscher, Alvaro J. Magdaleno, Ferry Prins, Abdullah M. Al-Enizi, Ayman Nafady, Carmen Munuera, Joshua O. Island, Andres Castellanos-Gomez
Summary: The use of low-cost benchtop plotters combined with refillable writing pens and markers has been studied as an effective method to print nanomaterial-based inks on paper substrates. The approach is robust and precise, allowing for the printing of various solution-processable nanomaterials with narrow pattern features. The study also illustrates the versatility of this printing platform by successfully printing a range of materials with different properties.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Chemistry, Analytical
Razium A. Soomro, Jai Kumar, Rana R. Neiber, Sirajuddin, Amerah M. Alotaibi, Shoyebmohamad F. Shaikh, Nazeer Ahmed, Ayman Nafady
Summary: A photo-active TiO2/Ti3C2Tx platform was constructed by partially oxidizing few-layered MXene (Ti3C2Tx), enabling selective detection of folate receptors (FR), particularly FR-expressing breast cancer cells (MDA-MB-231). The platform was adapted for biorecognition by conjugating chitosan and folic acid (FA) networks, allowing sensitive detection of FR-expressed cells.
ANALYTICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Ali Alsalme, Hilal Ahmad, Rais Ahmad Khan, Bon Heun Koo, Ghadah M. M. Alharbi, Shahad I. I. Alhadlaq
Summary: This study chemically introduced thioglycolic acid to improve the selectivity of graphene oxide (GO) nanosheets for metal ion extraction. A solid phase extraction method was developed and optimized, which showed good reliability, accuracy, and low detection limits for arsenic and mercury ions. Real samples were analyzed to validate the established procedure.
Article
Green & Sustainable Science & Technology
Ragab Rabeiy, Saud Almutairi, Ahmed Birima, Lamyaa Kassem, Ayman Nafady
Summary: Solid waste management is highly considered in the Kingdom of Saudi Arabia for the protection of the environment, preserving resources, and producing energy. A study at Qassim University in Saudi Arabia evaluated the stakeholders' knowledge and practices related to solid waste separation, as well as the current collection system of solid waste on the university's campus. The results showed a high level of awareness among respondents, although waste separation at the generation point was poor. The study suggests the implementation of teaching courses, workshops, and advertisements to increase awareness of the benefits of waste separation at the source.
Article
Chemistry, Physical
Sameerah I. I. Al-Saeedi, Muhammad Ali Bhatti, Aneela Tahira, Ghadah M. M. Al-Senani, Nada S. S. Al-Kadhi, Ayman Nafady, Zafar Hussain Ibupoto
Summary: In this study, a mild pyrolytic process was used to synthesize luminescent carbon material from phalsa and used for the photodegradation of methylene blue in aqueous solution. The carbon material exhibited graphitic nature and carbon dot-like properties. Various photodegradation aspects were investigated, and the optimal conditions for the highest degradation efficiency were determined.
Article
Materials Science, Multidisciplinary
Iqra Ameen, Sadia Iqbal, Murid Hussain, Asma A. Alothman, Huda A. Algahtani, Mohammed Sheikh Saleh Mushab, Amjad Iqbal, Shehla Perveen, Sara Musaddiq
Summary: In this study, a plant mediated synthesis method was used to prepare Metal/metal oxide@Reduced graphene oxide nanocomposites, including silver, gold, and zirconia. These nanocomposites showed high catalytic activity in Suzuki cross-coupling reaction between aryl halides and phenylboronic acid, achieving comparable yields to palladium-based catalysts. The enhanced reactivity of the reduced graphene oxide substrate contributed to the successful coupling reaction.
MATERIALS RESEARCH EXPRESS
(2023)
Article
Biochemistry & Molecular Biology
Ayman Nafady, Asma A. Alothman, Shoyebmohamad F. Shaikh
Summary: The pad dry cure method was used to coat linen fibers with a smart nanocomposite that has various properties. The treated linen showed improved flame resistance and superhydrophobicity. It also exhibited photoluminescence and remarkable antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemical Research Methods
Kareem Yusuf, Osama Shekhah, Seetah Alharbi, Asma A. Alothman, Ali S. Alghamdi, Reem M. Aljohani, Zeid A. Alothman, Mohamed Eddaoudi
Summary: In this study, a preconcentration technique using divinylbenzene monolithic polymer and zeolite-like metal-organic frameworks (ZMOFs) was developed for explosive markers. Incorporating ZMOFs into the polymer increased the percentage of micropores and improved the adsorption performance. This research provides an initial step towards the development of a portable explosive detector or a trace preconcentrator for explosive markers.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Materials Science, Multidisciplinary
Sreenivasa Kumar Godlaveeti, Rajababu Chintaparty, Adinarayana Reddy Somala, Asma A. Alothman, Saikh Mohammad, Ramamanohar Reddy Nagireddy
Summary: CeO2 nanoparticles were successfully synthesized by the hydrothermal method and characterized using various instrument techniques. The influence of different annealing conditions on the supercapacitor and dielectric performance of CeO2 nanoparticles was also investigated.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ahmed M. Abu-Dief, Musa A. Said, O. Elhady, Seraj Alzahrani, Faizah S. Aljohani, Thomas Nady A. Eskander, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: Three novel complexes were synthesized by reacting BSP benzothiazol-2-yl-(4,6-dimethyl-1H-pyrimidin-2-ylidene)-amine with Fe3+, Ni2+, and Pd2+. The structural details of the ligand and metal complexes were characterized using various experimental techniques and theoretical calculations. The complexes exhibited antibacterial and antioxidant activities, and showed promising cytotoxicity against cancer cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ali H. Bashal, Khaled D. Khalil, Ahmed M. Abu-Dief, Mohamed A. El-Atawy
Summary: This research focused on the preparation, characterization, and investigation of chitosan-cobalt (II) oxide hybrid nanocomposites. The results showed that the CS-CoO nanocomposite exhibited enhanced antibacterial, anticancer, and antioxidant activities compared to chitosan alone. Increasing the content of cobalt oxide nanoparticles further improved the biological efficacy of the prepared nanocomposites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)