Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

(2020) Barnaby Edward Young et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

(2020) Annabelle Gérard et al.   NATURE BIOTECHNOLOGY

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19

(2020) Ling Li et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

(2020) Peter Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled study

(2019) Ellie Hershberger et al.   EBioMedicine

Monoclonal Antibody Treatment of RSV Bronchiolitis in Young Infants: A Randomized Trial

(2019) Khalid Alansari et al.   PEDIATRICS

Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study

(2019) Martin R Gaudinski et al.   LANCET

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

(2019) Aimin Tang et al.   Nature Communications

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

(2019) Sabue Mulangu et al.   NEW ENGLAND JOURNAL OF MEDICINE

ZMapp Reinforces the Airway Mucosal Barrier Against Ebola Virus

(2018) Bing Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates

(2018) Kristen E Pascal et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence and Significance of Substitutions in the Fusion Protein of Respiratory Syncytial Virus Resulting in Neutralization Escape From Antibody MEDI8897

(2018) Qing Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy adults: a randomised, first-in-human phase 1 study

(2018) Sumathi Sivapalasingam et al.   LANCET INFECTIOUS DISEASES

Microfluidic single-cell technology in immunology and antibody screening

(2018) Yu Fen Samantha Seah et al.   MOLECULAR ASPECTS OF MEDICINE

Herpes simplex virus-binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition

(2018) Holly A. Schroeder et al.   Mucosal Immunology

Single-Cell Droplet Microfluidic Screening for Antibodies Specifically Binding to Target Cells

(2018) Nachiket Shembekar et al.   Cell Reports

Evaluation of MEDI8852, an Anti-Influenza A Monoclonal Antibody, in Treating Acute Uncomplicated Influenza

(2018) S. Omar Ali et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants

(2017) Qing Zhu et al.   Science Translational Medicine

A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors

(2017) Jay Newby et al.   Nature Communications

The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome

(2016) Tatiana Baranovich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

(2016) Nicole L. Kallewaard et al.   CELL

Influenza-binding antibodies immobilise influenza viruses in fresh human airway mucus

(2016) Ying-Ying Wang et al.   EUROPEAN RESPIRATORY JOURNAL

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

(2016) D. Corti et al.   SCIENCE

Protein stability in pulmonary drug delivery via nebulization

(2015) Sebastian P. Hertel et al.   ADVANCED DRUG DELIVERY REVIEWS

Direct Administration in the Respiratory Tract Improves Efficacy of Broadly Neutralizing Anti-Influenza Virus Monoclonal Antibodies

(2015) Victor H. Leyva-Grado et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pulmonary monoclonal antibody delivery via a portable microfluidic nebulization platform

(2015) Christina Cortez-Jugo et al.   Biomicrofluidics

Broadly Neutralizing Influenza Hemagglutinin Stem-Specific Antibody CR8020 Targets Residues that Are Prone to Escape due to Host Selection Pressure

(2014) Kannan Tharakaraman et al.   Cell Host & Microbe

Efficacy and Safety of Treatment With an Anti-M2e Monoclonal Antibody in Experimental Human Influenza

(2014) Eleanor L. Ramos et al.   JOURNAL OF INFECTIOUS DISEASES

Effect of formulation on the stability and aerosol performance of a nebulized antibody

(2014) Renaud Respaud et al.   mAbs

IgG in cervicovaginal mucus traps HSV and prevents vaginal Herpes infections

(2014) Y-Y Wang et al.   Mucosal Immunology

An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

(2013) Gerald Nakamura et al.   Cell Host & Microbe

Motavizumab Treatment of Infants Hospitalized With Respiratory Syncytial Virus Infection Does Not Decrease Viral Load or Severity of Illness

(2013) Octavio Ramilo et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Human Metapneumovirus

(2013) J. E. Schuster et al.   PEDIATRICS IN REVIEW

Sensitive Detection Assays for Influenza RNA Do Not Reveal Viremia in US Blood Donors

(2012) Susan L. Stramer et al.   JOURNAL OF INFECTIOUS DISEASES

Immunoglobulin Responses at the Mucosal Interface

(2011) Andrea Cerutti et al.   Annual Review of Immunology

A Randomized Controlled Trial of Motavizumab Versus Palivizumab for the Prophylaxis of Serious Respiratory Syncytial Virus Disease in Children With Hemodynamically Significant Congenital Heart Disease

(2011) Timothy F Feltes et al.   PEDIATRIC RESEARCH

Apical Transport of Influenza A Virus Ribonucleoprotein Requires Rab11-positive Recycling Endosome

(2011) Fumitaka Momose et al.   PLoS One

Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential

(2011) Melissa M. Coughlin et al.   REVIEWS IN MEDICAL VIROLOGY

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Ron J. Keizer et al.   CLINICAL PHARMACOKINETICS

Culturing the Unculturable: Human Coronavirus HKU1 Infects, Replicates, and Produces Progeny Virions in Human Ciliated Airway Epithelial Cell Cultures

(2010) K. Pyrc et al.   JOURNAL OF VIROLOGY

Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses

(2010) Andres G. Grandea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of respiratory syncytial virus with palivizumab: a systematic review

(2010) Jia Hu et al.   World Journal of Pediatrics

Motavizumab for Prophylaxis of Respiratory Syncytial Virus in High-Risk Children: A Noninferiority Trial

(2009) X. Carbonell-Estrany et al.   PEDIATRICS

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One